Matches in Nanopublications for { ?s ?p "OMIM summary: Human: Telethonin is a sarcomeric protein of 19 kD found exclusively in striated and cardiac muscle ({3:Valle et al., 1997}). It appears to be localized to the Z-disc of adult skeletal muscle and cultured myocytes. Telethonin is a substrate of titin (TTN; {188840}), which acts as a molecular 'ruler' for the assembly of the sarcomere by providing spatially defined binding sites for other sarcomeric proteins. After activation by phosphorylation and calcium/calmodulin binding, titin phosphorylates the C-terminal domain of telethonin in early differentiating myocytes." ?g. }
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- _5 value "OMIM summary: Human: Telethonin is a sarcomeric protein of 19 kD found exclusively in striated and cardiac muscle ({3:Valle et al., 1997}). It appears to be localized to the Z-disc of adult skeletal muscle and cultured myocytes. Telethonin is a substrate of titin (TTN; {188840}), which acts as a molecular 'ruler' for the assembly of the sarcomere by providing spatially defined binding sites for other sarcomeric proteins. After activation by phosphorylation and calcium/calmodulin binding, titin phosphorylates the C-terminal domain of telethonin in early differentiating myocytes." provenance.