Matches in Nanopublications for { ?s ?p "Treatment of human umbilical vein endothelial cells (HUVECs) with betacellulin (BTC, 10 ng/ml) increased phosphorylation of two MAPKs, ERK1 (p44MAPK) and ERK2 (p42MAPK) and AKT as early as 1 minute and produced a maximal effect at 5 minutes, which declined and returned to control levels at 60 minutes. BTC treatment also phosphorylated all three Erb receptors ErbB2, ErbB3, and ErbB4 but not ErbB1. BTC induced phosphorylation of MAPK and AKT was not suppressed by a selectilvely inhibitory concentration of ErbB1 receptor inhibitor, AG1478), suggesting that BTC induced MAPK and AKT activation was mediated through ErbB4 homodimer, ErbB2/ErbB3, or ErbB2/ErbB4." ?g. }
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- _5 value "Treatment of human umbilical vein endothelial cells (HUVECs) with betacellulin (BTC, 10 ng/ml) increased phosphorylation of two MAPKs, ERK1 (p44MAPK) and ERK2 (p42MAPK) and AKT as early as 1 minute and produced a maximal effect at 5 minutes, which declined and returned to control levels at 60 minutes. BTC treatment also phosphorylated all three Erb receptors ErbB2, ErbB3, and ErbB4 but not ErbB1. BTC induced phosphorylation of MAPK and AKT was not suppressed by a selectilvely inhibitory concentration of ErbB1 receptor inhibitor, AG1478), suggesting that BTC induced MAPK and AKT activation was mediated through ErbB4 homodimer, ErbB2/ErbB3, or ErbB2/ErbB4." provenance.
- _5 value "Treatment of human umbilical vein endothelial cells (HUVECs) with betacellulin (BTC, 10 ng/ml) increased phosphorylation of two MAPKs, ERK1 (p44MAPK) and ERK2 (p42MAPK) and AKT as early as 1 minute and produced a maximal effect at 5 minutes, which declined and returned to control levels at 60 minutes. BTC treatment also phosphorylated all three Erb receptors ErbB2, ErbB3, and ErbB4 but not ErbB1. BTC induced phosphorylation of MAPK and AKT was not suppressed by a selectilvely inhibitory concentration of ErbB1 receptor inhibitor, AG1478), suggesting that BTC induced MAPK and AKT activation was mediated through ErbB4 homodimer, ErbB2/ErbB3, or ErbB2/ErbB4." provenance.