Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Increase+of+DNMT1+expression+is+associated+with+multiple+myeloma+and+plasma+cell+leukemias. assertion.
- assertion asSentence In+human+hepatocellular+carcinoma%2C+increased+DNMT1+expression+is+negatively+correlated+with+SHP+levels. assertion.
- assertion asSentence Expression+of+microRNA+is+inversely+correlated+with+DNMT3A+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence There+is+no+significant+association+between+the+DeltaDNMT3B+C%3ET+SNP+and+early+onset+CRC+in+HNPCC+patients. assertion.
- assertion asSentence The+association+between+sequence+variants+of+DNMT1+and+3B+and+mutagen+sensitivity+induced+by+BPDE+supports+the+involvement+of+these+DNMTs+in+protecting+the+cell+from+DNA+damage. assertion.
- assertion asSentence Upregulated+in+synovial+fluid+monocytes+in+patients+juvenile+rheumatoid+arthritis. assertion.
- assertion asSentence D6+cooperates+with+CD26+in+the+negative+regulation+of+CCL14+by+the+selective+degradation+of+its+biologically+active+isoform. assertion.
- assertion asSentence The+rs10260404+polymorphism+is+not+associated+with+an+increased+risk+of+sporadic+amyotrophic+lateral+sclerosis+in+Chinese+patients. assertion.
- assertion asSentence Dihydropyrimidine+dehydrogenase+gene+coding+sequence+variants+is+associated+with+the+development+of+fluoropyrimidine-related+toxicity+in+colorectal+cancer. assertion.
- assertion asSentence DPYSL2+does+not+have+a+major+function+in+schizophrenia+in+Japanese+subjects. assertion.
- assertion asSentence Receptor+occupancy+and+plasma+olanzapine+concentrations+are+significantly+correlated+in+treatment+of+schizophrenic+patients. assertion.
- assertion asSentence An+association+exists+between+drug+addiction+and+DRD2+single+nucleotide+polymorphism+only+in+males+in+a+Spanish+sample. assertion.
- assertion asSentence One+SNP+of+the+DRD3+gene%2C+rs167771%2C+achieved+significant+association+with+extrapyramidal+symptom+risk+after+Bonferroni+correction+%28nominal+P-value+1.3+x+10%28-4%29%29+in+patients+treated+with+risperidone+%28132+patients%29. assertion.
- assertion asSentence The+DRD4+gene+plays+a+role+in+the+development+of+attachment+behavior+in+low-risk%2C+non-clinical+populations. assertion.
- assertion asSentence Significant+differences+in+inhibitory+control+between+individuals+with+at+least+one+7-repeat+allele+of+the+dopamine+receptor+D4+protein+polymorphism. assertion.
- assertion asSentence The+platelet-derived+growth+factor+receptor+beta+%28PDGFRbeta%29+transactivation+by+the+dopamine+receptor+D4+%28DRD4%29+is+not+dependent+on+ligands+for+PDGFRbeta. assertion.
- assertion asSentence Histone+deacetylase+inhibition+up-regulates+desmosomal+cadherins+and+prevents+the+loss+of+adhesion+induced+by+Dsg1+truncation. assertion.
- assertion asSentence The+T+cellular+autoimmune+response+against+immunodominant+peptides+of+Dsg3+in+patients+with+pemphigus+vulgaris+is+monitored+with+highly+specific+HLA-DRbeta1%2A0402+tetramers. assertion.
- assertion asSentence DTDST+is+upregulated+by+dexamethasone+stimulation+of+HT1080+fibrosarcoma+cells+and+is+required+for+fibronectin+%28FN%29+extracellular+matrix+deposition+by+these+cells. assertion.
- assertion asSentence ATP+induces+HB-EGF+synthesis+and+release+by+interacting+with+the+P2+purinergic+receptor+and+through+p38+and+ERK1%2F2+signaling+in+response+to+a+challenging+environment. assertion.
- assertion asSentence MKP-1+upregulation+by+oxidative+stress+is+potently+influenced+by+increased+mRNA+stability+and+translation%2C+mediated+at+least+in+part+by+the+RNA-binding+proteins+HuR+and+NF90. assertion.
- assertion asSentence Ritonavir+%28at+100+mg+once+daily+and+100+mg+twice+daily+significantly+down-regulated+dual+specificity+phosphatase+1+in+20+healthy+individuals. assertion.
- assertion asSentence Increased+DUSP4+expression+in+activated+T+cells+in+the+elderly+in+part+accounts+for+defective+adaptive+immune+responses. assertion.
- assertion asSentence Multiple+founder+effects+in+Japanese+families+with+primary+torsion+dystonia+harboring+the+GAG+deletion+in+the+Tor1A+%28DYT1%29+gene. assertion.
- assertion asSentence In+response+to+DNA+damage%2C+E2F1+is+directed+from+cell+cycle+progression+to+apoptotic+E2F+target+genes. assertion.
- assertion asSentence E2F-1+expression+is+inversely+correlated+with+tumor+growth+in+colon+adenocarcinoma. assertion.
- assertion asSentence E2F1-induced+Mre11-Rad50-Nbs1+%28MRN%29+foci+generate+a+cell+cycle+checkpoint+that+with+sustained+E2F1+activity+eventually+yields+to+apoptosis. assertion.
- assertion asSentence Nutlin-3+treatment+upregulated+TAp73+and+E2F1+protein+levels. assertion.
- assertion asSentence Cdh1+reciprocally+regulates+the+Rb+pathway+through+competing+with+E2F1+to+bind+the+hypophosphorylated+form+of+Rb. assertion.
- assertion asSentence There+is+over-expression+of+E2F-1+gene+and+deletion+of+p14%28ARF%29+gene+in+the+tumorigenesis+of+the+lung+cancer+in+Gejiu+and+Xuanwei+regions+in+Yunnan+Province. assertion.
- assertion asSentence E2F3+controls+the+ubiquitination+of+PCNA+through+the+transcriptional+regulation+of+Rad18. assertion.
- assertion asSentence Enzyme+expression+can+precisely+predict+5%27-dFUR+sensitivity+in+colorectal+cancer. assertion.
- assertion asSentence S1P%281%29+signaling+linked+to+cell+migration+is+facilitated+by+a+functional+interaction+with+P-Rex1+via+a+mechanism+that+involves+the+maintenance+of+S1P%281%29+receptors+at+the+cell+membrane. assertion.
- assertion asSentence SphK%2FS1P%2FS1PRs+signaling+axis+plays+an+important+role+in+liver+fibrosis+and+is+involved+in+the+directed+migration+of+hepatic+myofibroblasts+into+the+damaged+areas. assertion.
- assertion asSentence Persistent+activated+STAT3+colocalizes+with+elevated+expression+of+S1PR1%2C+a+G-protein-coupled+receptor+for+sphingosine-1-phosphate+%28S1P%29%2C+in+the+tumor+cells+of+the+activated+B+cell-like+subtype+of+diffuse+large+B-cell+lymphoma. assertion.
- assertion asSentence ET-1+enhances+the+ability+of+lung+fibroblasts+to+contract+extracellular+matrix+through+the+Akt%2Fphosphoinositide+3-kinase+%28PI3-kinase%29+pathway+to+induce+de+novo+protein+synthesis+of+proteins+that+contribute+to+a+contractile+phenotype. assertion.
- assertion asSentence Fetuin-A+concentration+decreased+in+parallel+with+the+increase+in+ET-1+and+IL-6+levels+as+renal+function+declined+in+chronic+kidney+disease. assertion.
- assertion asSentence ET-1+and+BMP2+have+opposing+effects+on+chloride+channel+activity+in+human+fibroblasts. assertion.
- assertion asSentence The+microvascular+pericyte+plays+a+role+in+endothelin-1-mediated+pathophysiology+of+traumatic+brain+injury. assertion.
- assertion asSentence Associations+between+endothelin+receptors+A+and+B+in+aystemic+ssclerosis+subsets+supports+the+role+of+endothelin+and+its+receptors+in+the+pathogenesis+of+this+disease. assertion.
- assertion asSentence In+p-stage+I+NSCLC+patients%2C+those+in+the+higher+EphA2+expression+and+higher+ephrin-A1+expression+groups+shared+almost+the+same+clinicopathological+backgrounds+which+are+generally+considered+to+be+better+prognostic+factors. assertion.
- assertion asSentence There+is+a+significant+loss+of+ELF-1+and+reduced+Smad4+expression+in+gastrointestinal+neoplasms. assertion.
- assertion asSentence Unreported+mutation+in+EFNB1+predicts+occurrence+of+congenital+diaphragmatic+hernia%2C+phenotypic+differences+between+males+and+female. assertion.
- assertion asSentence Epidermal+growth+factor+and+ionizing+radiation+up-regulate+the+DNA+repair+genes+XRCC1+and+ERCC1+in+DU145+and+LNCaP+prostate+carcinoma+through+MAPK+signaling. assertion.
- assertion asSentence Recombinant+epidermal+growth+factor+maintains+follicular+ultrastructure+and+promotes+the+transition+to+primary+follicles+in+caprine+ovarian+tissue+cultured+in+vitro. assertion.
- assertion asSentence EGF+inhibits+intestinal+NHE8+gene+expression+by+reducing+its+basal+transcription. assertion.
- assertion asSentence Knockdown+of+PTK6+in+the+BPH-1+human+prostate+epithelial+cell+line+led+to+decreased+AKT+activation+in+response+to+EGF. assertion.
- assertion asSentence EGF+Stimulates+migration+of+HepG2+cells+in+vitro. assertion.
- assertion asSentence Cell+proliferation+and+expression+of+EGFR+of+tumor+cells+can+be+inhibited+by+transfection+of+CKLFSF8. assertion.
- assertion asSentence Conventional+PKC+isoforms%2C+especially+PKCalpha%2C+mediate+feedback+inhibition+of+G-protein-coupled+receptor+-induced+EGFR+transactivation. assertion.
- assertion asSentence Mutations+in+the+EGFR+tyrosine+kinase+domain+correlate+with+the+clinical+response+to+Gefitinib+in+lung+cancer+patients. assertion.
- assertion asSentence EGFR+signalling+plays+a+central+role+in+cyclooxygenase-2+induction+by+transforming+growth+factor-beta+1+in+human+bronchial+epithelial+cells. assertion.
- assertion asSentence There+are+sex+differences+in+the+effects+of+PKG-I+activation+on+the+regulation+of+adipose+tissue+function+and+diet-induced+obesity. assertion.
- assertion asSentence Downregulation+of+PKR+expression+by+antisense+oligonucleotide+treatment+blocked+IFN-alpha-induced+growth+inhibition. assertion.
- assertion asSentence TRBP+controls+PACT+activation+of+PKR%2C+an+activity+that+is+reversed+by+stress. assertion.
- assertion asSentence Physiological+levels+of+Copper+promote+internalization+of+PrP. assertion.
- assertion asSentence Increased+hippocampal+glutamatergic+transmission+in+Prnp+null+mice+is+related+to+the+enhanced+plasticity+and+persistence+of+the+dentate+long+term+potentiation. assertion.
- assertion asSentence Measurements+of+the+tight+complex+of+recombinant+mouse+PrP+binding+to+an+18-base+pair+DNA+sequence+reveal+that+the+globular+domain+of+PrP+participates+importantly+in+the+formation+of+the+complex. assertion.
- assertion asSentence Amyloid+features+and+neuronal+toxicity+of+mature+prion+fibrils+are+highly+sensitive+to+high+pressure. assertion.
- assertion asSentence Prox1+contributes+to+the+allocation+of+an+adequate+supply+of+islet+cells+throughout+pancreas+ontogeny+by+preventing+exocrine+cell+differentiation+of+multipotent+pancreatic+progenitors. assertion.
- assertion asSentence Peripherin+is+not+a+key+contributor+of+motor+neuron+degeneration+associated+with+toxicity+of+mutant+superoxide+dismutase+1. assertion.
- assertion asSentence Unrestricted+legumain+activity+is+involved+in+disturbed+epidermal+cornification+in+cystatin+M%2FE+deficient+mice. assertion.
- assertion asSentence Psen1+regulates+epidermal+growth+factor+receptor+turnover+and+signaling+in+the+endosomal-lysosomal+pathway. assertion.
- assertion asSentence BK+channel+activity+in+dorsal+root+ganglion+neurons+through+epigenetic+and+transcriptional+mechanisms+in+neuropathic+pain. assertion.
- assertion asSentence PS2+is+necessary+for+the+proteolytic+activity+of+gamma-secretase. assertion.
- assertion asSentence Age+and+sex+dependent+alteration+in+presenilin+expression. assertion.
- assertion asSentence A+missense+mutation+in+pstpip2+is+associated+with+the+autoinflammatory+disorder+chronic+multifocal+osteomyelitis. assertion.
- assertion asSentence PTBP1+is+not+required+for+the+earliest+isovolumetric+divisions+and+differentiation+steps+of+the+zygote+up+to+the+formation+of+the+blastocyst. assertion.
- assertion asSentence Estrogens+stimulate+germ+cell+growth+via+an+Akt%2FPTEN+pathway. assertion.
- assertion asSentence PTEN+loss+causes+reduced+NKX3.1+expression+in+both+murine+and+human+prostate+cancers. assertion.
- assertion asSentence PTEN+and+SHIP2%2C+the+phosphatases+widely+implicated+as+negative+regulators+of+insulin+signaling%2C+are+responsible+for+dephosphorylation+of+FAK. assertion.
- assertion asSentence Pten+%28phosphatase+and+tensin+homolog%29+deletion+affected+differentiation+of+various+lung+epithelial+cell+lineages%2C+with+a+decreased+number+of+terminally+differentiated+cells+and+confered+relative+resistance+to+airway+injury. assertion.
- assertion asSentence Akt2+deletion+is+not+sufficient+to+markedly+inhibit+tumorigenesis+in+Pten%28%2B%2F-%29+mice+in+most+tested+tissues. assertion.
- assertion asSentence Loss+of+Pten+is+associated+with+myeloproliferative+disorders. assertion.
- assertion asSentence Loss+of+Pten+enhances+Th+cell+function+without+obvious+deleterious+effects. assertion.
- assertion asSentence In+long-term+potentiation+of+the+visual+cortex%2C+release+of+activated+PGE2+receptors+from+the+postsynaptic+membranes+is+regulated+by+trafficking+of+the+differential+PGE2+receptor+subtypes+in+an+activity-dependent+bidirectional+manner. assertion.
- assertion asSentence The+decrease+in+acid+secretion+in+the+damaged+stomach+is+mediated+by+endogenous+PGs+derived+from+COX-1%2C+through+PGE%282%29%2FEP3+receptors+and+prostacyclin%2FIP+receptors. assertion.
- assertion asSentence Disruption+of+the+EP4+gene+in+bone+marrow+cells+abrogates+osteoclast+formation+in+cocultures+of+cancer+cell+lines+with+bone+marrow+cells+from+COX-2+knockout+%28-%2F-%29%2C+EP2+-%2F-+or+EP4+-%2F-+mice+compared+to+wild-type+mice. assertion.
- assertion asSentence PGIS%2F+IP+transgenic+animals+with+lung-specific+PPARgamma+overexpression+also+developed+fewer+lung+tumors. assertion.
- assertion asSentence Proinflammatory+conditions+lead+to+COX-2+up-regulation+and+the+concomitant+production+of+PGJ2+are+autotoxic. assertion.
- assertion asSentence Cyclooxygenase-2+inhibits+UVB-induced+apoptosis+in+mouse+skin+by+activating+the+prostaglandin+E2+receptors%2C+EP2+and+EP4. assertion.
- assertion asSentence 5-aminoimidazole-4-carboxamide+riboside+%28AICAR%29inhibited+lipopolysaccharide+%28LPS%29-induced+protein+expression+of+inducible+nitric+oxide+synthase+%28iNOS%29+and+cyclooxygenase-2+%28COX-2%29+in+macrophages+and+microglial+cells. assertion.
- assertion asSentence NS398+protects+cells+from+sodium+nitroprusside-mediated+cytotoxicity+through+enhancing+HO-1+induction+independent+of+COX-2+inhibition. assertion.
- assertion asSentence Cyclooxygenase-2+inhibitors+down-regulate+osteopontin+and+Nr4A2-new+therapeutic+targets+for+colorectal+cancers. assertion.
- assertion asSentence Nur77+is+induced+by+oxLDL+via+p38+MAPK+signal+pathway+and+subsequently+protects+against+inflammation+by+the+inhibition+of+proinflammatory+COX-2+pathway+in+activated+macrophages. assertion.
- assertion asSentence The+full-length+calcium-sensing+receptor+dampens+the+calcemic+response+to+1alpha%2C25%28OH%292+vitamin+D3+in+vivo+independently+of+parathyroid+hormone. assertion.
- assertion asSentence During+lactation+mammary+epithelial+cells+are+a+source+of+circulating+PTHrP+that+promotes+bone+loss+by+increasing+rates+of+bone+resorption. assertion.
- assertion asSentence PTHrP+contributes+to+the+progression+of+cardiac+dysfunction+in+the+pressure+overloaded+heart. assertion.
- assertion asSentence PLC+signaling+through+the+PTHR+is+required+for+skeletal+homeostasis. assertion.
- assertion asSentence HB-GAM+functions+as+an+endogenous+inhibitor+of+FGF-2+in+stem+cell+proliferation+in+the+developing+cortex. assertion.
- assertion asSentence In+cones+and+cone-derived+cultured+cells+both+Prl-1+activity+and+Prl-1+gene+expression+are+modulated+under+oxidative+stress. assertion.
- assertion asSentence Protein+tyrosine+phosphatase-1B+regulates+receptor+tyrosine+kinase+signaling. assertion.
- assertion asSentence SHP-2+regulates+central+checkpoints+of+T+cell+differentiation+by+the+activation+of+distinct+signaling+cascades. assertion.
- assertion asSentence Noonan+syndrome-causing+SHP2+mutants+inhibit+growth+hormone-induced+IGF-1+release+through+RAS%2FERK1%2F2+hyperactivation. assertion.
- assertion asSentence The+dephosphorylation+of+Pyk2+requires+dynamin%27s+GTPase+activity+and+is+mediated+by+the+tyrosine+phosphatase+PTP-PEST. assertion.
- assertion asSentence MKP-1+plays+a+role+in+the+maintenance+of+bone+mass+and+does+so+by+negatively+regulating+MAPK-dependent+osteoclast+signaling. assertion.
- assertion asSentence TCPTP+is+a+critical+negative+regulator+of+TCR+signaling+that+sets+the+threshold+for+TCR-induced+naive+T+cell+responses+to+prevent+autoimmune+and+inflammatory+disorders+arising. assertion.
- assertion asSentence Insulin-like+growth+factor-I-stimulated+insulin+receptor+substrate-1+negatively+regulates+Src+homology+2+domain-containing+protein-tyrosine+phosphatase+substrate-1+function+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence CD45+regulates+Ly49D%2FDAP12-mediated+cytokine+production+in+natural+killer+%28NK%29+cells+with+little+effect+on+cytotoxicity. assertion.
- assertion asSentence ICAM-deficient+or+LFA-deficient+recipients+of+heart+transplantation+are+resistant+to+tolerance+induced+by+anti-CD45RB. assertion.