Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence In+human+osteosarcoma+cells%2C+the+C-terminal+fragment+of+transforming+growth+factor+beta-induced+protein+%28TGFBIp%29+is+required+for+apoptosis. assertion.
- assertion asSentence Vitamin+D+fulfillment+is+prerequisite+for+the+TGF-beta1+genotype+in+exerting+its+full+effect+on+the+fracture+prevalence. assertion.
- assertion asSentence GPR56+binds+specifically+to+tissue+transglutaminase%2C+TG2%2C+a+widespread+component+of+tissue+and+tumor+stroma+previously+implicated+as+an+inhibitor+of+tumor+progression. assertion.
- assertion asSentence Transcriptional+control+is+not+involved+in+the+induction+of+thrombospondin-1+by+heat+shock. assertion.
- assertion asSentence p53+upregulated+miR-194+expression+in+THBS1+retrovirus-transduced+HCT116+cells%2C+leading+to+decreased+thrombospondin-1+%28TSP-1%29+levels. assertion.
- assertion asSentence Pericellular+production+of+HOCl+by+phagocytes%2C+generated+by+the+MPO-H2O2-chloride+system%2C+is+a+pathogenic+mechanism+for+impairing+TIMP-1+activity+during+inflammation. assertion.
- assertion asSentence TIMP-1+is+clinically+useful+for+predicting+liver+fibrosis+in+HCV+pediatric+patients. assertion.
- assertion asSentence ZO-1%2C+by+interacting+with+Cx43%2C+plays+a+role+in+the+down-regulation+and+decreased+size+of+Cx43+gap+junctions+in+congestive+heart+failure. assertion.
- assertion asSentence CD14+directly+binds+to+triacylated+lipopeptides+and+facilitates+recognition+of+the+lipopeptides+by+the+TLR2%2FTLR1+complex+without+binding+to+the+receptor+complex. assertion.
- assertion asSentence Chlamydophilal+antigens+induce+foam+cell+formation+mainly+via+Toll-like+receptor+2+and+c-Jun+NH2+terminal+kinase. assertion.
- assertion asSentence There+is+no+association+of+the+TLR2+polymorphisms+Arg677Trp+and+Arg753Gln+with+either+the+onset+or+the+course+of+chronic+obstructive+pulmonary+disease. assertion.
- assertion asSentence Human+esophageal+epithelial+cells+can+sense+endogenous+danger+signals%2C+in+part+through+TLR3+signaling. assertion.
- assertion asSentence Genetic+polymorphisms+in+the+TLR3+and+CD44+genes+are+associated+with+the+persistence+of+the+immune+response+to+serogroup+C+meningococcal+vaccines+1+to+6+years+after+vaccination. assertion.
- assertion asSentence Toll-like+receptor+2+and+4+expression+correlates+with+the+extent+and+severity+of+coronary+artery+disease. assertion.
- assertion asSentence Syntenin+is+a+physiological+suppressor+of+TRAF6+and+plays+an+inhibitory+role+in+IL-1R-+and+TLR4-+mediated+NF-kappaB+activation+pathways. assertion.
- assertion asSentence PKCepsilon+mediates+its+effects+on+TNFalpha-+based+apoptosis+partly+by+preventing+activation+and+translocation+of+Bax+to+the+mitochondria. assertion.
- assertion asSentence Both+TNF-alpha+and+IL-1+beta+are+downstream+mediators+and+as+single+mediators+play+a+limited+role+within+the+complex+inflammatory+reactions+induced+by+E.+coli. assertion.
- assertion asSentence In+human+pulmonary+microvascular+endothelial+cells%2C+MAP-kinase-activated+kinase+2+regulates+TNF-alpha-induced+expression+of+ICAM-1+and+IL-8+via+tristetraprolin+at+the+mRNA+decay+level. assertion.
- assertion asSentence A+TNF-alpha-mediated+down-regulation+of+CDX2+can+be+related+to+suppressed+expression+of+MEP1A+during+intestinal+inflammation. assertion.
- assertion asSentence FOXO3a+regulates+oxygen-dependent+changes+in+expression+of+TNFR2+in+HDMECs%2C+controlling+sensitivity+to+TNF-mediated+apoptosis. assertion.
- assertion asSentence Preoperative+plasma+TNF-alpha+and+sTNF-Rs+levels+in+epithelial+ovarian+cancer+patients+correlated+with+the+highest+risk+of+cancer+progression. assertion.
- assertion asSentence The+hypoxia-induced+activation+of+the+XB-S+promoter+is+regulated+through+dissociation+of+HDAC1+from+an+Sp1-binding+hypoxia-responsive+element+site. assertion.
- assertion asSentence Impairment+of+transcriptionally+active+p53+in+response+to+replication+blockade+is+not+a+general+phenomenon. assertion.
- assertion asSentence The+249%28Ser%29+p53+mutation+in+plasma+is+strongly+associated+with+hepatocellular+carcinoma+%28HCC%29. assertion.
- assertion asSentence Progression+of+esophageal+squamous+cell+carcinoma+is+controlled+by+a+p53-dependent+pathway. assertion.
- assertion asSentence Chk2+regulates+the+transcription-independent+mechanism+of+p53-mediated+apoptosis+by+inducing+stabilization+of+p53+in+response+to+IR. assertion.
- assertion asSentence The+tumor+suppressor+pVHL+has+an+unexpected+function+to+upregulate+the+tumor+suppressor+p53. assertion.
- assertion asSentence GTPBP4+knockdown+induces+p53+accumulation+and+activation+in+the+absence+of+nucleolar+disruption. assertion.
- assertion asSentence MDM2+and+MDMX+are+responsible+for+the+functional+inactivation+of+p53+in+testicular+germ+cell+tumors. assertion.
- assertion asSentence The+growth-suppressive+effect+of+CHK1+inhibition+in+BRCA2-mutant+tumors+can+be+opposed+by+concurrent+KRAS+activation+and+TP53+mutations. assertion.
- assertion asSentence The+association+between+Zta+and+53BP1+is+involved+in+the+viral+replication+cycle. assertion.
- assertion asSentence TPH1+does+not+play+a+major+role+in+aggressive+behavior+via+anger+in+schizophrenic+patients. assertion.
- assertion asSentence TRAF6+is+not+required+for+atherogenesis+in+mice+and+does+not+associate+with+clinical+disease+in+humans. assertion.
- assertion asSentence A+hydrophobic+cluster%2C+comprising+residues+652-656+of+extracellular+loop+3%2C+strongly+influences+intramolecular+signal+transduction+and+G+protein+activation+of+the+TSHR. assertion.
- assertion asSentence Chromium%28III%29+and+thyroxine+cooperatively+suppress+in+vitro+fibril+formation+due+to+the+stabilization+of+WT-transthyretin+%28TTR%29+and+V30M-TTR. assertion.
- assertion asSentence HSF1+regulated+genes+are+involved+in+familial+amyloidotic+polyneuropathy%2C+modulating+TTR+tissue+deposition. assertion.
- assertion asSentence Snail1+controls+Zeb1+expression+at+multiple+levels+and+acts+cooperatively+with+Twist+in+the+ZEB1+gene+transcription+induction. assertion.
- assertion asSentence Induction+of+PDGFRalpha+and+invadopodia+is+essential+for+Twist1+to+promote+tumor+metastasis. assertion.
- assertion asSentence Twist1+induces+the+repression+of+claudin-4+expression+during+the+epithelial-mesenchymal+transition+in+esophageal+carcinoma. assertion.
- assertion asSentence Rs55762744+is+a+rare+variant+of+modest+effect+on+multiple+sclerosis+risk+affecting+a+subset+of+patients. assertion.
- assertion asSentence The+expression+of+TS+provides+an+alternative+source+of+substrate+for+DNA+synthesis+and+positively+correlates+with+GEM+resistance+and+shortened+patient+survival. assertion.
- assertion asSentence All+the+Y-family+polymerases+have+ubiquitin+binding+domains+that+bind+to+mono-ubiquitinated+PCNA+to+effect+the+switching+from+replicative+to+Y-family+polymerase. assertion.
- assertion asSentence DNA+damage-induced+ubiquitination+or+sumoylation+of+PCNA+prevents+CRL4Cdt2-dependent+degradation+by+inhibiting+binding+of+Cdt1+to+PCNA. assertion.
- assertion asSentence The+high+risk+human+papillomavirus+E6+proteins+reduce+the+intracellular+quantity+of+the+sole+SUMO+conjugation+enzyme%2C+Ubc9%2C+concomitant+with+decreased+host+sumoylation. assertion.
- assertion asSentence The+silencing+of+astrin+induce+a+p53-dependent+apoptosis+and+has+an+additive+effect+on+paclitaxel+treatment. assertion.
- assertion asSentence LANA2+is+covalently+conjugated+to+SUMO1+and+SUMO2+both+in+vitro+and+in+latently+KSHV-infected+B-cells. assertion.
- assertion asSentence SUMO+interaction+motif-mediated+HIPK2+targeting+to+PML-NBs+is+crucial+for+HIPK2-mediated+p53+activation+and+induction+of+apoptosis. assertion.
- assertion asSentence Vaccinia+virus+E3+interacts+with+SUMO1+through+a+small+ubiquitin-like+modifier+%28SUMO%29-interacting+motif+%28SIM%29. assertion.
- assertion asSentence Insulin+resistance+caused+by+the+-112C+allele+influences+the+susceptibility+to+type+2+diabetes. assertion.
- assertion asSentence The+UGT2B17+deletion+polymorphism+is+not+associated+with+prostate+cancer+risk+in+Caucasians. assertion.
- assertion asSentence LXR-beta+activation+altered+all+of+the+cellular+cholesterol+fluxes. assertion.
- assertion asSentence Drp1-dependent+mitochondrial+positioning+and+activity+controls+T-cell+activation+by+fuelling+central+supramolecular+activation+cluster+assembly+at+the+immune+synapse. assertion.
- assertion asSentence HDAC3+plays+a+significant+role+in+the+regulation+of+TNF-alpha-mediated+VCAM-1+expression. assertion.
- assertion asSentence Increased+MIP-1alpha%2Fbeta+production+enhances+multiple+myeloma+cell+binding+to+stromal+cells+by+VLA-4-VCAM-1+adhesion%2C+forming+a+%22vicious+cycle%22+between+MM+cell+adhesion+to+stromal+cells+and+MIP-1+production+via+VLA-4-VCAM-1+interaction. assertion.
- assertion asSentence VDR+polymorphisms+are+not+associated+with+the+risk+of+hip+fracture+in+older+women+of+this+Region+of+Southern+Chile. assertion.
- assertion asSentence Over-expression+of+S100A4+and+VEGF+plays+an+important+role+in+the+development+of+pancreatic+cancer. assertion.
- assertion asSentence Activation+of+estrogen-related+receptor+alpha+in+several+different+breast+cancer+cell+lines+leads+to+a+significant+increase+in+VEGF+mRNA+expression%2C+an+activity+that+translates+into+an+increase+in+VEGF+protein+secretion. assertion.
- assertion asSentence Microalbuminuria+and+high+VEGF+level+in+type+1+diabetic+patients+are+related+to+disturbances+in+myocardial+perfusion. assertion.
- assertion asSentence It+is+primarily+Hh-induced+VEGF-A+that+promotes+angiogenesis+in+vitro+and+augments+tumor-derived+VEGF+to+promote+angiogenesis+in+vivo. assertion.
- assertion asSentence Hsp70+acts+to+promote+substrate+binding+to+TRiC. assertion.
- assertion asSentence Chaperonin+TRiC+binding+is+specified+by+two+short+hydrophobic+beta+strands+in+the+von+Hippel-Lindau+protein+that%2C+upon+folding%2C+become+buried+within+the+native+structure. assertion.
- assertion asSentence In+two+metastatic+cell+lines+integrin-linked+N-oligosaccharides+influence+the+VN+adhesion+receptor+activity+and+function. assertion.
- assertion asSentence Integrin+alpha%282%29beta%281%29%2C+glycoprotein+Ib+and+vWf+interactions+with+collagen+I+and+III+contribute+to+platelet+adhesion+under+high+shear+flow. assertion.
- assertion asSentence Defects+in+antigen+presentation+caused+by+loss+or+mutation+of+WT1+or+downregulation+of+HLA+molecules+are+not+the+major+basis+for+escape+from+the+immune+response+induced+by+WT1+peptide+vaccination. assertion.
- assertion asSentence IRE1alpha+activity+controls+a+subset+of+the+ER+stress+response+and+mediates+proliferation+through+tight+control+of+Xbp-1+splicing. assertion.
- assertion asSentence hOGG1+Ser326Cys+and+XRCC1+Arg399Gln+polymorphisms+are+associated+with+the+susceptibility+to+chronic+obstructive+pulmonary+disease. assertion.
- assertion asSentence Elevated+Yin+Yang+1+%28YY1%29+expression+correlates+with+higher+morphologic+grades+or+malignant+histological+phenotypes+in+prostate+cancer. assertion.
- assertion asSentence Multiple+proteins+involved+in+human+decapping+are+important+subunits+of+processing+bodies+and+are+activated+on+ARE-mRNAs+by+the+protein+TTP. assertion.
- assertion asSentence miR-346+controls+TNF-alpha+synthesis+by+regulating+TTP+expression. assertion.
- assertion asSentence Mel-18+regulates+Bmi-1+expression+during+senescence+via+down-regulation+of+c-Myc. assertion.
- assertion asSentence EFP+functions+as+a+cofactor+for+ERalpha-mediated+transcription. assertion.
- assertion asSentence The+therapeutic+efficacy+by+CXCR4+antagonists+appeared+to+involve+interference+with+the+tumor-promoting+signals+delivered+by+CXCL12. assertion.
- assertion asSentence The+tumor+suppressor+function+of+pp32+can+be+attributed+to+its+ability+to+disrupt+HuR+binding+to+target+mRNAs+encoding+key+proteins+for+cancer+cell+survival+and+drug+efficacy. assertion.
- assertion asSentence RECK+protein+is+inversely+correlated+with+tissue+damage+and+MMP-9+secretion+in+systemic+lupus+erythematosus. assertion.
- assertion asSentence DYRK2+regulates+p53+to+induce+apoptosis+in+response+to+DNA+damage. assertion.
- assertion asSentence GCM1+is+a+critical+factor+in+controlling+placental+cell+fusion+through+transcriptional+regulation+of+syncytin+2+and+MFSD2A+gene+expression+in+placenta. assertion.
- assertion asSentence KSRP+functions+as+a+limiting+factor+in+inflammatory+gene+expression. assertion.
- assertion asSentence TGFbeta-dependent+cell+migration%2C+invasion+and+metastasis+are+empowered+by+mutant-p53+and+opposed+by+p63. assertion.
- assertion asSentence SOCS+proteins+are+expressed+in+human+melanoma+cell+lines+and+their+modulation+can+influence+the+responsiveness+of+melanoma+cells+to+IFN-alpha+and+IFN-gamma. assertion.
- assertion asSentence A+Beclin1-binding+autophagic+tumour+suppressor%2C+UVRAG%2C+interacts+with+the+class+C+Vps+complex%2C+a+key+component+of+the+endosomal+fusion+machinery. assertion.
- assertion asSentence EMAP-II+sensitises+endothelial+cells+to+apoptosis+by+facilitating+TNF-R1+apoptotic+signalling+via+TRADD+mobilization. assertion.
- assertion asSentence XIAP+antagonists+in+combination+with+Fas+ligand+%28FasL%29+or+the+death+receptor+5+%28DR5%29+agonist+antibody+synergistically+stimulate+death+in+cancer+cells+and+inhibit+tumor+growth. assertion.
- assertion asSentence TRAIL+receptor+genes+are+frequently+methylated+in+gastric+cancer%2C+predominantly+for+death+receptor+4. assertion.
- assertion asSentence Transcriptional+repression+of+CD133+is+caused+by+promoter+hypermethylation+of+the+CD133+CpG+islands+in+some+of+colorectal+cancer+cell+lines. assertion.
- assertion asSentence p62+and+ALFY+interact+to+organize+misfolded%2C+ubiquitinated+proteins+into+protein+bodies+that+become+degraded+by+autophagy. assertion.
- assertion asSentence WAVE+and+the+Arp2%2F3+complex+jointly+orchestrate+different+types+of+actin-based+plasma+membrane+protrusions+by+promoting+ruffling+and+inhibiting+mDia2-induced+filopodia. assertion.
- assertion asSentence REDD1+is+subject+to+ubiquitin-mediated+degradation+mediated+by+the+CUL4A-DDB1-ROC1-beta-TRCP+E3+ligase+complex+and+through+the+activity+of+glycogen+synthase+kinase+3beta. assertion.
- assertion asSentence Semaphorin+5A+%28Sema5A%29+and+plexin-B3+inhibit+glioma+cell+invasion+through+Rac1+inactivation. assertion.
- assertion asSentence Elevated+DnaJA3+induces+dynamin-related+protein+1+%28Drp1%29-depedendent+mitochondrial+fragmentation+and+decreased+cell+viability. assertion.
- assertion asSentence Eps15b+is+an+endosomally+localized+isoform+of+Eps15+that+is+present+in+the+Hrs+complex+via+direct+Hrs+interaction+and+important+for+the+sorting+function+of+this+complex. assertion.
- assertion asSentence LPS-induced+NF-kappaB+activation+and+IL-8+synthesis+in+endothelial+cells+are+regulated+by+the+MyD88+pathway+and+GEF-H1-RhoA+pathway. assertion.
- assertion asSentence SNP45TG+in+adiponectin+gene+is+associated+with+the+occurrence+of+GDM. assertion.
- assertion asSentence Genetic+variants+of+FADS1+and+FADS2+influence+blood+lipid+and+breast+milk+essential+fatty+acids+in+pregnancy+and+lactation. assertion.
- assertion asSentence There+are+differences+between+cell+lines+in+the+regulation+mechanism+of+ABCG2+expression+by+sex+hormone+treatment. assertion.
- assertion asSentence These+highly+prevalent+ABCG2+34GA%2FAA+genotypes+are+associated+with+poor+prognosis+of+Chinese+patients+with+acute+leukaemia+and+BMT+patients. assertion.
- assertion asSentence NRAGE%2C+via+the+same+XIAP-Tak1-Tab1+complex%2C+is+required+for+the+phosphorylation+of+IKK+-alpha%2Fbeta+and+subsequent+transcriptional+activation+of+the+p65+subunit+of+NF-kappaB. assertion.
- assertion asSentence ADAMTS-1+has+both+the+opportunity+in+bone+and+capability+in+vitro+to+induce+collagen+type+I+processing%2C+together+with+a+positive+influence+on+osteoblastic+three-dimensional+growth. assertion.
- assertion asSentence A+promoter+haplotype+containing+the+-3148G+variant+increases+GDF15+transcription+activity+and+is+associated+with+favourable+left+ventricular+remodelling+in+human+essential+hypertension. assertion.
- assertion asSentence Increased+mPGES-1+expression+in+non-cancerous+liver+tissues+is+closely+associated+with+the+early+recurrence+of+HCC+after+curative+resection. assertion.
- assertion asSentence Inactivation+of+EI24+and+CHEK1+through+two+independent+mechanisms+contributes+to+the+development+of+CACX. assertion.