Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CD45+regulates+thymocyte+survival+during+development+in+fetal+thymic+organ+culture. assertion.
- assertion asSentence Integrin+activation+regulates+cyt-PTPe+via+Src-dependent+Y638+phosphorylation.+cyt-PTPe+affects+osteoclast+podosome+stability+by+a+feedback+loop+ensuring+proper+Src+activation+downstream+of+integrins%2C+linking+their+signaling+with+Src+activation. assertion.
- assertion asSentence The+cytokine+midkine+and+its+receptor+RPTPzeta+regulate+B+cell+survival+in+a+pathway+induced+by+CD74. assertion.
- assertion asSentence Structural+role+for+certain+core+arginine+residues+in+forming+a+conformationally+stable+Pur+beta+protein+capable+of+physical+interactions+necessary+for+smooth+muscle+alpha-actin+gene+repression. assertion.
- assertion asSentence Paxillin+is+required+for+the+tyrosine+phosphorylation+of+FAK+in+ES+cells. assertion.
- assertion asSentence Deficiency+of+both+Rac1+and+Rac2+led+to+massive+mobilization+of+hematopoietic+stem+cells+%28HSCs%29+from+the+marrow+associated+with+ineffective+hematopoiesis+and+intense+selection+for+Rac-expressing+HSCs. assertion.
- assertion asSentence The+sex+difference+in+TNF-alpha+expression+is+estrogen-dependent+and+mediated+via+Rac1+dependent+NADPH+oxidase%2FERK1%2F2+and+p38+MAPK+pathway+in+lipopolysaccharide-stimulated+hearts. assertion.
- assertion asSentence Rad50+mutant+mice+%28Rad50%28S%2FS%29+mice%29+exhibited+growth+defects+and+cancer+predisposition. assertion.
- assertion asSentence RAG-mediated+V%28D%29J+recombination+is+not+essential+for+tumorigenesis+in+Atm-deficient+mice. assertion.
- assertion asSentence Sin1-mTORC2+suppresses+rag1%2C2+and+il7r+gene+expression+through+Akt2+in+B+cells. assertion.
- assertion asSentence Pax-2%2FRB+binding+reverses+repression+of+Rig-1+protein. assertion.
- assertion asSentence Contact+inhibition+imposed+by+the+RB1+pathway+performs+a+tumor+suppressor+function+by+preventing+cell+outgrowth+into+structures+where+cells+with+properties+of+cancer+stem+cells+can+be+generated+from+differentiated+somatic+cells+in+advancing+cancers. assertion.
- assertion asSentence Pax-2%2FRB+binding+reverses+repression+of+Rig-1+protein. assertion.
- assertion asSentence p107+regulates+neural+precursor+cells+in+the+mouse+brain. assertion.
- assertion asSentence RDH11+has+a+measurable+role+in+regenerating+the+visual+pigment+by+complementing+RDH5+in+retinal+pigment+epithelium. assertion.
- assertion asSentence Murine+gammaherpesvirus+68+subverts+early+NF-kappaB+activation+and+cytokine+production+through+vrial+RTA-induced+RelA+degradation. assertion.
- assertion asSentence Reelin+signaling+regulates+perikaryal+translocation+and+positioning. assertion.
- assertion asSentence Role+for+Reelin+and+LDL+receptors+reinforce+the+idea+of+a+prominent+role+of+extracellular+matrix+proteins+in+postnatal+maturation. assertion.
- assertion asSentence Reelin-induced+activation+of+Cdc42+contributes+to+the+regulation+of+the+cytoskeleton+of+individual+responsive+neurons+and+converges+with+other+signaling+cascades+to+orchestrate+Rho+GTPase+activity+and+promote+neuronal+development. assertion.
- assertion asSentence RET+signaling+is+not+critical+for+the+normal+physiology+of+the+substantia+nigra+compacta+%28SNC%29+and+ventral+tegmental+area+%28VTA%29+in+adult+mice. assertion.
- assertion asSentence The+2.9+A+crystal+structure+of+the+enigmatic%2C+neuronal+G+protein+Galpha%28o%29+in+the+GTP+hydrolytic+transition+state%2C+complexed+with+RGS16. assertion.
- assertion asSentence This+death+domain+kinase+has+an+essential+role+in+DNA+damage-induced+NF-kappa+B+activation. assertion.
- assertion asSentence Rnf4+possesses+ubiquitin+E3+ligase+activity. assertion.
- assertion asSentence Primary+Spi-1%2FPU.1+downregulation+acts+on+late+erythroid+differentiation+through+at+least+two+pathways%2C+one+of+which+requires+TRIM10%2FHERF1+upregulation+and+parallels+the+Spi-1%2FPU.1-induced+Fli-1+shutoff+regulatory+cascade. assertion.
- assertion asSentence HGF%2Fc-Met+plays+a+crucial+role+in+host+and+donor+cells+of+the+liver+for+the+cursiv+selection+of+transplanted+hepatocytes. assertion.
- assertion asSentence Aromatic+residues+in+the+substrate+cleft+of+RPE65+protein+govern+retinol+isomerization+and+modulate+its+progression. assertion.
- assertion asSentence Effects+of+retinoic+acid+receptor+beta+%28RARbeta%29+and+retinoid+X+receptor+alpha+%28RXRalpha%29+on+the+regulation+of+the+alpha%282%29%28I%29+collagen+promoter. assertion.
- assertion asSentence A+combination+of+FXR+deficiency+and+high-fat+diet+is+a+risk+factor+for+nonalcoholic+steatohepatitis. assertion.
- assertion asSentence Nrf2+activation+inhibits+LXRalpha+activity+and+LXRalpha-dependent+liver+steatosis+by+competing+with+FXR+for+p300%2C+causing+FXR+activation+and+FXR-mediated+SHP+induction. assertion.
- assertion asSentence Loss+of+farnesoid+X-activated+receptor+protects+against+diet+induced+obesity+or+weight+gain. assertion.
- assertion asSentence The+conformational+changes+induced+by+DP4+regulate+both+orthograde+excitation-contraction+coupling+and+retrograde+RyR1-DHPR+signaling. assertion.
- assertion asSentence Regardless+of+their+in+vivo+location%2C+myeloid-derived+suppressor+cells+synthesize+and+secrete+the+inflammatory+mediator+S100A8+that+accumulates+in+the+serum+of+tumor-bearing+mice. assertion.
- assertion asSentence S100A8+and+S100A9+proteins+are+crucially+involved+in+synovial+activation+and+cartilage+destruction+during+osteoarthritis. assertion.
- assertion asSentence Sustained+activation+of+S100A8%2FA9+critically+contributes+to+the+development+of+post-ischemic+heart+failure+%28HF%29+driving+the+progressive+course+of+HF+through+activation+of+RAGE. assertion.
- assertion asSentence S100A9+is+upregulated+after+arylhydrocarbon+receptor+activation+and+involved+in+thymocyte+emigration. assertion.
- assertion asSentence Skin-specific+Scd1+knockout+%28SKO%29+mice+still+remain+resistant+to+obesity. assertion.
- assertion asSentence Sodium+channel+beta1+regulatory+subunit+deficiency+reduces+pancreatic+islet+glucose-stimulated+insulin+and+glucagon+secretion. assertion.
- assertion asSentence The+unique+properties+of+Na%28V%291.6+channels%2C+together+with+the+resurgent+currents+that+they+conduct+in+neurons%2C+make+these+channels+well-suited+to+provide+the+driving+force+for+sustained+repetitive+firing%2C+a+crucial+property+of+neurons. assertion.
- assertion asSentence Voltage-gated+sodium+channel+Nav1.6+mediates+the+hyperpolarizing+threshold+response+of+peripheral+myelinated+nerve+fibers. assertion.
- assertion asSentence Control+of+ENaC+by+purinergic+signaling+%28P2Y2%29+is+necessary+for+aldosterone+escape. assertion.
- assertion asSentence TK%2C+like+several+other+proteases%2C+can+activate+ENaC+in+the+kidney+and+the+colon. assertion.
- assertion asSentence SCP-2+expression+plays+a+significant+role+in+HDL-mediated+cholesterol+efflux+by+regulating+the+size+of+rapid+vs.+slow+cholesterol+efflux+pools+and%2For+eliciting+concomitant+upregulation+of+L-FABP+in+cultured+primary+hepatocytes. assertion.
- assertion asSentence The+class+A+macrophage+scavenger+receptor+%28SR-A%29+regulates+the+initial+phase+of+granulocytic+infiltration+in+sterile+peritonitis+by+limiting+the+initial+magnitude+of+the+proinflammatory+pathway. assertion.
- assertion asSentence SR-AI+and+SR-AII+are+crucial+receptors+involved+in+mediating+severe+cartilage+destruction+in+antigen-induced+arthritis. assertion.
- assertion asSentence SR-A+on+circulating+leukocytes+rather+than+resident+renal+cells+predominantly+mediates+lipid-induced+kidney+injury+and+its+deletion+is+renoprotective. assertion.
- assertion asSentence The+transforming+growth+factor+%28TGF%29beta+type+II+receptor%2FMCP-5+axis+is+an+essential+crossroad+for+joint+development+and+endochondral+growth. assertion.
- assertion asSentence Intestinal+metaplasia+and+gastric+carcinoma+themselves+induce+MCP-1+expression+independently+of+Helicobacter+pylori+infection. assertion.
- assertion asSentence Mouse+MCP1+C-terminus+significantly+decreases+the+chemotactic+potency+of+human+MCP1+and+diminishes+the+blood+brain+barrier+compromise+normally+induced+by+the+human+protein. assertion.
- assertion asSentence The+early+onset%2C+inferior+retinal+degeneration+does+segregate+independently+of+either+of+the+chemokine+knockout+alleles+%28Ccl2+or+Cx3cr1%29+in+an+autosomal%2C+recessive+Mendelian+trait. assertion.
- assertion asSentence CXCL12-CXCR4+and+CCL20-CCR6+systems+are+involved+in+T+lymphocyte-endothelial+interaction+in+microvessels+of+the+small+and+large+intestines. assertion.
- assertion asSentence The+infectious+complications+of+cecal+ligation+and+puncture+can+be+controlled+in+SCID+chimeras+and+burned+mice+by+therapeutic+or+prophylactic+administration+of+MIP-1+alpha. assertion.
- assertion asSentence Both+MCP-3+and+MCP-1+chemokines+are+required+for+optimal+innate+immune+defense+against+L.+monocytogenes+infection. assertion.
- assertion asSentence High+tidal+volume+ventilation+in+absence+of+underlying+injury+induces+intrapulmonary+TNF-alpha+and+MIP-2+expression+in+mice. assertion.
- assertion asSentence TNF-alfa+and+CXCL-2+mRNAs+is+induced+in+mice+infected+with+Leptospira. assertion.
- assertion asSentence CX%283%29CL1%2C+along+with+AR%281%29+%28adenosine+receptor-1%29+are+critical+players+for+counteracting+Glu-mediated+neurotoxicity+in+the+brain+and+AR%281%29+mediates+neuromodulatory+action+of+CX%283%29CL1+on+hippocampal+neurons. assertion.
- assertion asSentence CX3CL1-CX3CR1+axis+can+regulate+the+expression+of+iNOS%2C+a+crucial+mediator+of+DSS-induced+colitis. assertion.
- assertion asSentence SDF-1+plays+a+major+role+in+physiologic+neovascularization+through+the+up-regulation+of+heme+oxygenase+1. assertion.
- assertion asSentence CXCR4+and+SDF-1alpha+mediate+cell+migration+response+to+liver+injury. assertion.
- assertion asSentence CXCL12+secreted+from+stromal+cells+or+podocytes+acts+on+endothelial+cells+to+regulate+vascular+development+in+the+kidney. assertion.
- assertion asSentence SDF-1alpha+is+acted+by+Shp2+in+in+guiding+granule+cell+migration+during+cerebellar+development. assertion.
- assertion asSentence High+SDF-1+is+associated+with+liver+dissemination+of+leukemia. assertion.
- assertion asSentence An+essential+role+for+SEL1L+in+protein+quality+control+during+mouse+embryonic+development. assertion.
- assertion asSentence E-+and+P-selectins+synergistically+inhibit+lung+fibrosis+by+promoting+the+recruitment+of+NKT+cells. assertion.
- assertion asSentence L-selectin+dimerization+enhances+tether+formation+to+properly+spaced+ligand. assertion.
- assertion asSentence The+binding+of+L-selectin+to+its+vascular+and+extravascular+ligands+is+differentially+regulated+by+pH. assertion.
- assertion asSentence P-selectin+expression+on+systemic+venular+endothelial+cells+contributes+to+a+proinflammatory+phenotype+after+mechanical+stretch+and+can+be+selectively+modulated+by+voltage-gated+calcium+channel+inhibition. assertion.
- assertion asSentence The+cytoplasmic+domain+provides+a+key+signal+to+export+precursors+of+PSGL-1+from+the+ER+to+the+Golgi+apparatus+en+route+to+the+cell+surface. assertion.
- assertion asSentence Sema3A+is+essential+for+the+inhibition+of+axonal+regeneration+and+other+regenerative+responses+after+spinal+cord+injury. assertion.
- assertion asSentence Sema3a+regulates+endothelial+cell+number+and+podocyte+differentiation+during+glomerular+development. assertion.
- assertion asSentence Sema4A+activates+a+specialized+and+restricted+genetic+program+in+macrophages+able+to+sustain+angiogenesis+and+participates+in+their+recruitment+and+activation+in+inflammatory+injuries. assertion.
- assertion asSentence Sema5A+and+Sema5B+inhibit+retinal+neurite+outgrowth+through+PlexinA1+and+PlexinA3+receptors+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence Selenoprotein+P+is+required+for+development+of+functional+spermatozoa+and+is+an+essential+component+of+the+selenium+delivery+pathway+for+developing+germ+cells. assertion.
- assertion asSentence Both+genetic+deletion+and+RNA+interference-mediated+knockdown+of+selenoprotein+P+improved+systemic+insulin+sensitivity+and+glucose+tolerance+in+mice. assertion.
- assertion asSentence The+transcription+factors+Smad3+and+NFAT+are+required+for+activity+of+the+Foxp3+enhancer. assertion.
- assertion asSentence Secreted+frizzled+related+protein+1+is+a+target+to+improve+fracture+healing. assertion.
- assertion asSentence SGK1+is+involved+in+mediating+fibrosis+associated+with+obstructive+nephropathy. assertion.
- assertion asSentence Rictor+forms+a+complex+with+Cullin-1+to+promote+SGK1+ubiquitination+and+destruction. assertion.
- assertion asSentence p66SHC+mediates+mitochondrial+dysfunction+in+renal+proximal+tubule+cells+during+oxidative+injury. assertion.
- assertion asSentence Shh+is+transcriptionally+regulated+by+RORa+in+cerebellar+Purkinje+cells. assertion.
- assertion asSentence The+Shh+deficient+mutant+mouse+demonstrates+complete+agenesis+of+genital+tubercle+outgrowth. assertion.
- assertion asSentence Redundant+5%27Hoxd+genes+regulate+digit+pattern+downstream+of+Shh+and+Gli3. assertion.
- assertion asSentence Shh+signaling+to+distinct+cell+types+differentially+regulates+coronary+artery+and+vein+development. assertion.
- assertion asSentence Selective+targeting+of+Shh+machinery+to+primary+cilia+confers+to+astrocyte-like+neural+precursors+the+ability+to+differentially+respond+to+Shh+mitogenic+signals+compared+to+neighboring+cells. assertion.
- assertion asSentence Different+molecular+signalling+cascades+of+Wnt11+and+Shh+would+play+crucial+roles+in+specific+morphogenesis+and+pattern+formation+of+CVP+during+early+mouse+embryo+development. assertion.
- assertion asSentence Shh+stimulation+of+progenitor+proliferation+and+cell+diversification+requires+Gli2+and+Hes1+activity. assertion.
- assertion asSentence Spatiotemporally+separable+Shh+domains+in+the+midbrain+define+distinct+dopaminergic+progenitor+pools. assertion.
- assertion asSentence Cdx2+reduced+Shh+expression+by+binding+to+the+unmethylated+Shh+promoter+in+the+intestinal+metaplastic+mucosa+of+Cdx2-transgenic+mouse+stomach. assertion.
- assertion asSentence Regulates+P-selectin+ligand+protein%2C+the+molecule+responsible+for+L-selectin-mediated+leukocyte+interactions+in+inflammation. assertion.
- assertion asSentence AKT+is+a+direct+substrate+of+PTK6+and+AKT+tyrosine+residues+315+and+326+are+phosphorylated+by+PTK6. assertion.
- assertion asSentence Stil+protein+regulates+centrosome+integrity+and+mitosis+through+suppression+of+Chfr. assertion.
- assertion asSentence ESET+histone+methyltransferase+can+form+a+large%2C+multi-protein+complex%28es%29+with+mSin3A%2FB+co-repressors+and+HDAC1%2F2+that+participates+in+multiple+pathways+of+transcriptional+repression. assertion.
- assertion asSentence ESET+histone+methyltransferase+can+form+a+large%2C+multi-protein+complex%28es%29+with+mSin3A%2FB+co-repressors+and+HDAC1%2F2+that+participates+in+multiple+pathways+of+transcriptional+repression. assertion.
- assertion asSentence Six6+plays+an+important+role+in+the+regulation+of+GnRH+expression+and+hypothalamic+control+of+fertility. assertion.
- assertion asSentence Inhibition+of+NF+kappa+B+in+TNF+alpha-treated+primary+mouse+hepatocytes+is+associated+with+increased+S-phase+cell+cycle+retention+and+decreased+stem+loop+binding+protein. assertion.
- assertion asSentence Demonstrate+a+posttranscriptional+modulation+of+ileal+ASBT+function+and+membrane+expression+by+phorbol+ester+via+a+PKCzeta-dependent+pathway. assertion.
- assertion asSentence Regulation+of+bumetanide-sensitive+cotransporter+type+1+by+norepinephrine+proceeds+via+the+beta-adrenoceptor+receptor-cAMP-protein+kinase+A+pathway+that+involves+in+part+mitogen-activated+protein+kinases. assertion.
- assertion asSentence Noradrenaline+induces+an+increase+in+neuronal+MCT2+protein+expression+by+a+mechanism+involving+stimulation+of+phosphoinositide+3-kinase%2FAkt+and+translational+activation+via+the+mTOR%2FS6+kinase+pathway. assertion.
- assertion asSentence Cellular+expression+of+a+sodium-dependent+monocarboxylate+transporter+%28Slc5a8%29+and+the+MCT1%2F2+in+the+mouse+kidney. assertion.
- assertion asSentence In+GABARAP-deficient+mice+renal+NaPi-IIa+is+up-regulation+and+intestinal+NaPi-IIb+is+downregulated. assertion.
- assertion asSentence Wnt%2Fbeta-catenin+signaling+regulates+the+expression+of+the+BBB-specific+glucose+transporter+glut-1. assertion.