Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence This+transporter+is+essential+for+glucose+sensing+by+pancreatic+beta-cells%2C+by+the+hepatoportal+sensor+and+by+sensors+in+the+ANS. assertion.
- assertion asSentence GLUT4+expression+is+restricted+to+brown+and+white+adipose+tissue+during+insulin+deficiency. assertion.
- assertion asSentence Expression+of+a+synapsin+site+1+phosphorylation+mutant+in+adipocytes+inhibits+basal+intracellular+retention+of+Glut4. assertion.
- assertion asSentence Resistin+impairs+insulin-stimulated+glucose+uptake+by+mechanisms+involving+reduced+plasma+membrane+GLUT4+translocation. assertion.
- assertion asSentence Simultaneous+disruption+of+VAMPs+2%2C+3+and+8+completely+inhibited+insulin-stimulated+GLUT4+insertion+into+the+plasma+membrane. assertion.
- assertion asSentence Expression+of+activated+NHE1+elicits+specific+pathways+of+gene+activation+in+the+myocardium+that+lead+to+cardiac+hypertrophy%2C+cell+death+and+infarction. assertion.
- assertion asSentence Concomitant+deletion+of+Chd4+and+Brg1+rescued+vascular+abnormalities+seen+in+Brg1+mutant+yolk+sacs+to+the+same+extent+as+LiCl+treatment. assertion.
- assertion asSentence Inactivation+of+SNF5+cooperates+with+p53+loss+to+accelerate+tumor+formation. assertion.
- assertion asSentence Used+scAAV9-mediated+postnatal+day+1+vascular+gene+delivery+to+replace+survival+motor+neuron+%28SMN%29+in+spinal+muscular+atrophy+pups+and+rescue+motor+function%2C+neuromuscular+physiology+and+life+span. assertion.
- assertion asSentence Somatostatin+receptor+subtype+4+couples+to+the+M-current+to+regulate+seizures. assertion.
- assertion asSentence Snail1+controls+bone+mass+by+repressing+the+transcription+of+both+the+osteoblast+differentiation+factor+Runx2+and+the+vitamin+D+receptor+%28VDR%29+genes+in+osteoblasts. assertion.
- assertion asSentence Elevated+mRNA+expression+in+hyperglycemic+KKAy+mice+in+the+kidney+and+heart. assertion.
- assertion asSentence SOD1+deficiency+causes+salt+sensitivity+and+aggravates+hypertension+in+hydronephrosis. assertion.
- assertion asSentence Chestnut+inner+shell+extract+treatment+with+ethanol+decreased+CYP2E1+expression+and+increased+activities+of+catalase+and+superoxide+dismutase. assertion.
- assertion asSentence Mitigating+oxidative+stress+by+superoxide+dismutase+1+overexpression+blocks+maternal+hyperglycemia-induced+activation+of+specific+protein+kinase+C+isoforms+and+downstream+cascades. assertion.
- assertion asSentence Alsin+and+SOD1%28G93A%29+proteins+regulate+endosomal+reactive+oxygen+species+production+by+glial+cells+and+proinflammatory+pathways+responsible+for+neurotoxicity. assertion.
- assertion asSentence Calorie+restriction+reduces+oxidative+stress+by+SIRT3-mediated+SOD2+activation. assertion.
- assertion asSentence EC-SOD+plays+an+important+role+in+reducing+the+magnitude+of+lung+injury+from+extracellular+free+radicals+after+bleomycin+administration. assertion.
- assertion asSentence Negative+regulation+of+Sox10+by+TGF-beta+signaling+promotes+the+generation+of+mesenchymal+progenitors+from+Neural+Crest+Stem+Cells. assertion.
- assertion asSentence Egr2+and+Sox10+activity+are+directly+involved+in+mediating+the+developmental+induction+of+Pmp22+expression+through+an+intronic+enhancer. assertion.
- assertion asSentence Sox11+represents+a+synergistic+factor+for+WT1+in+regulating+the+Wnt4+gene+expression+that+is+critical+for+nephrogenesis+during+kidney+ontogeny. assertion.
- assertion asSentence Sox17%2C+a+gene+required+for+early+endoderm+formation%2C+activates+the+cell+cycle+and+reinitiates+multipotent+progenitor+cell+behavior+in+mature+lung+cells. assertion.
- assertion asSentence SOX18+plays+role+in+the+vascular+dysfunction+in+hypotrichosis-lymphedema-telangiectasia+syndrome. assertion.
- assertion asSentence STAT3+directly+regulates+the+Sox2+promoter+leading+to+Sox2+expression+and+subsequent+nestin+expression+and+commitment+to+the+neural+precursor+cell+fate. assertion.
- assertion asSentence Zfp206+is+a+key+component+of+the+transcriptional+regulatory+network+and+together+with+Oct4+and+Sox2+regulates+differentiation+of+embryonic+stem+cells. assertion.
- assertion asSentence SOX2+is+differentially+expressed+between+radial+glial+and+intermediate+progenitor+populations. assertion.
- assertion asSentence SOX7+regulates+the+expression+of+VE-cadherin+in+the+haemogenic+endothelium+at+the+onset+of+haematopoietic+development. assertion.
- assertion asSentence FOG2+is+a+limiting+factor+in+the+formation+of+a+functional+GATA4%2FFOG2+transcription+complex+that+is+required+for+Sox9+expression+during+gonadogenesis. assertion.
- assertion asSentence Mutated+ras+induced+PLD1+gene+expression+through+increased+Sp1+transcription+factor. assertion.
- assertion asSentence A+stress-induced+decline+in+the+monosaccharide+O-linked+N-acetylglucosamine+content+of+Sp1+drives+expression+of+p75NTR. assertion.
- assertion asSentence Sp1+plays+a+crucial+role+in+the+regulation+of+the+dok-7+gene. assertion.
- assertion asSentence Expression+patterns+of+SP1+and+SP3+during+mouse+spermatogenesis. assertion.
- assertion asSentence The+osteopontin+is+up-regulated+in+response+to+SE+in+distinct+temporal+sequences+in+the+hippocampus%2C+specifically+in+degenerating+neurons+and+axons. assertion.
- assertion asSentence The+expression+and+activities+of+SPT+in+mouse+liver+increased+significantly+following+fumonisin+B1+treatment. assertion.
- assertion asSentence SR-BI+plays+an+important+physiological+role+in+the+metabolism+of+very+low+density+lipoproteins. assertion.
- assertion asSentence Glycine+dimerization+motif+in+the+N-terminal+transmembrane+domain+of+the+high+density+lipoprotein+receptor+SR-BI+required+for+normal+receptor+oligomerization+and+lipid+transport. assertion.
- assertion asSentence C-Src%2C+with+its+lipopolysaacharide+induction%2C+has+an+unperceived+role+in+transmitting+LPS+signaling+in+macrophages. assertion.
- assertion asSentence Src+is+expressed+in+spinal+lateral+motor+neurons+of+mouse+embryo+at+the+time+of+limb+trajectory+selection. assertion.
- assertion asSentence Srf+acts+as+a+key+regulator+of+stem+cells+and+progenitors+adhesion+through+regulation+of+membrane-associated+cytoskeleton+genes+and+appears+dispensable+for+their+cell-cycle+progression. assertion.
- assertion asSentence During+toxoplasmosis+the+major+role+of+STAT1+is+not+in+the+development+of+protective+T+cell+responses%2C+but%2C+rather%2C+STAT1+is+important+in+the+development+of+antitoxoplasma+effector+mechanisms. assertion.
- assertion asSentence Suppressors+of+cytokine+signaling+modulate+JAK%2FSTAT-mediated+cell+responses+during+atherosclerosis. assertion.
- assertion asSentence Two+distinct+Stat3+signaling+pathways+emanating+from+gp130+are+utilized+in+mammary+tissue. assertion.
- assertion asSentence IL-11+signals+through+the+Jak2%2FStat3+pathway+in+decidual+cells+to+stimulate+the+expression+of+alpha%282%29-MG%2C+a+protease+inhibitor+essential+for+normal+placentation+in+pregnancy. assertion.
- assertion asSentence Activation+of+hepatocellular+STAT3+ameliorates+alcoholic+fatty+liver+via+inhibition+of+sterol+regulatory+element-binding+protein+1c+expression. assertion.
- assertion asSentence Inflammation-mediated+STAT3+activation+attenuates+hepatocellular+injury+induced+by+CCl%284%29+in+myeloid-specific+STAT3+knockout+mice. assertion.
- assertion asSentence Compared+with+wild-type+animals%2C+mutant+s%2Fs+mice+exhibit+enhanced+pulmonary+bacterial+clearance+after+an+intratracheal+challenge+with+Streptococcus+pneumoniae. assertion.
- assertion asSentence The+N-terminal+domain+is+essential+for+the+formation+of+unphosphorylated+STAT3+dimers+and+nuclear+accumulation+of+STAT3+upon+phosphorylation. assertion.
- assertion asSentence The+absence+of+STAT3+in+hepatocytes+leads+to+exacerbation+of+liver+fibrosis+during+cholestasis. assertion.
- assertion asSentence STAT3+promotes+the+transcription+of+PTEN+by+directly+binding+on+the+PTEN+promoter. assertion.
- assertion asSentence The+differential+development+of+EAE+in+transgenic+mice+correlates+with+increased+IFN-gamma+and+IL-17+in+Stat4beta-expressing+cells+in+situ%2C+contrasting+increased+IL-10+production+by+Stat4alpha-expressing+cells. assertion.
- assertion asSentence Lyn+deficient+mice+display+extramedullary+stress+erythropoiesis+and+reduced+production+of+Gata-1%2C+EKLF+and+STAT5. assertion.
- assertion asSentence Stat5a%2Fb+have+an+essential%2C+nonredundant+role+in+regulating+Treg+cells. assertion.
- assertion asSentence STAT5b+signaling+is+critical+for+leukemia+stem+cell+self-renewal+in+MN1-+and+HOXA9-expressing+leukemias. assertion.
- assertion asSentence IL-4+promotes+Stat6-dependent+survival+of+autoreactive+B+cells+in+vivo+without+inducing+autoantibody+production. assertion.
- assertion asSentence In+neurons%2C+Stm1+protein+is+involved+in+store+operated+calcium+entry. assertion.
- assertion asSentence LKB1+directly+phosphorylates+Thr-172+of+AMPKalpha+in+vitro+and+activates+its+kinase+activity. assertion.
- assertion asSentence Conditional+Aurora-A+ablation+in+cultured+embryonic+fibroblasts+causes+impaired+mitotic+entry+and+mitotic+arrest+with+a+profound+defect+in+bipolar+spindle+formation. assertion.
- assertion asSentence Dec1+upregulates+CD25+expression+during+thymocyte+development+and+increases+the+number+of+Treg+cells+in+the+periphery. assertion.
- assertion asSentence In+both+the+male+and+female+germ+lines%2C+meiosis+is+initiated+through+retinoic+acid+induction+of+Stra8. assertion.
- assertion asSentence STRA8+is+involved+in+the+process+that+leads+to+stable+commitment+to+the+meiotic+cell+cycle. assertion.
- assertion asSentence Mice+lacking+sulfonylurea+receptor+2+%28SUR2%29+ATP-sensitive+potassium+channels+are+resistant+to+acute+cardiovascular+stress. assertion.
- assertion asSentence Matrilysin-mediated+shedding+of+syndecan-1%2FKC+complexes+from+the+mucosal+surface+directs+and+confines+neutrophil+influx+to+sites+of+injury. assertion.
- assertion asSentence Heparan+sulfate+and+syndecan-1%2C+the+predominant+intestinal+epithelial+heparan+sulfate+proteoglycan%2C+are+essential+in+maintaining+intestinal+epithelial+barrier+function. assertion.
- assertion asSentence Substance+P+%281-7%29+formed+by+substance+P+degradation+is+involved+in+potentiated+antinociceptive+response+of+morphine+at+the+spinal+cord+level. assertion.
- assertion asSentence Substance+P+and+NK-1R+alters+adipose+tissue+responses+to+high-fat+diet+and+insulin+action. assertion.
- assertion asSentence Tac2+homozygous+null+mice+responded+normally+to+a+series+of+algogenic+%28pain-inducing%29+and+pruritic+%28itch-inducing%29+stimuli. assertion.
- assertion asSentence A+significant+higher+number+of+corporra+lutea+in+the+NK1-R+deficient+mice+in+comparison+to+the+wild-type+group. assertion.
- assertion asSentence Changes+in+signaling+pathways+regulating+neuroplasticity+induced+by+neurokinin+1+receptor+knockout. assertion.
- assertion asSentence Substance+P+and+NK-1R+alters+adipose+tissue+responses+to+high-fat+diet+and+insulin+action. assertion.
- assertion asSentence NK3-receptors+are+not+involved+in+the+development+of+lung+inflammation+and+inflammatory+cell+recruitment+into+airways+of+antigen-challenged+mice. assertion.
- assertion asSentence Role+of+metalloproteases+in+vaccinia+virus+epitope+processing+for+transporter+associated+with+antigen+processing+%28TAP%29-independent+human+leukocyte+antigen+%28HLA%29-B7+class+I+antigen+presentation. assertion.
- assertion asSentence Furthermore%2C+taut-%2F-+and+taut%2B%2F-+mice+develop+moderate+unspecific+hepatitis+and+liver+fibrosis+beyond+1+year+of+age+where+hepatocyte+apoptosis+and+activation+of+the+CD95+system+are+pronounced. assertion.
- assertion asSentence Tight+regulation+of+WAP+gene+expression+parallels+variations+in+the+chromatin+structure+and+DNA+methylation+profile+throughout+the+Ramp3-WAP-Tbrg4+locus. assertion.
- assertion asSentence Tbx1+acts+upstream+in+a+genetic+network+that+positively+regulates+secpmd+heart+field+cell+proliferation+and+negatively+regulates+differentiation%2C+cell-autonomously+in+the+caudal+pharyngeal+region. assertion.
- assertion asSentence Tbx1+expression+must+be+tightly+regulated+to+be+compatible+with+normal+embryonic+development. assertion.
- assertion asSentence T-box+transcription+factor+Tbx2+represses+differentiation+and+formation+of+the+cardiac+chambers. assertion.
- assertion asSentence Tbx5+overexpression+favors+a+first+heart+field+lineage+in+murine+embryonic+stem+cells+and+in+Xenopus+laevis+embryos. assertion.
- assertion asSentence Hox+genes+act+upstream+of+Tbx5+to+control+the+axial+position+of+forelimb+formation. assertion.
- assertion asSentence Contol+of+Tbx6+gene+expression+during+development. assertion.
- assertion asSentence TP+-%2F-+mice+have+a+basal+increase+in+renal+vascular+resistance+and+filtration+fraction+associated+with+reactive+oxygen+species. assertion.
- assertion asSentence HNF1alpha+primarily+regulatea+both+growth+and+function+of+islet+beta-cells. assertion.
- assertion asSentence Collectrin-deficient+mice+activate+a+number+of+adaptive+mechanisms+to+defend+energy+homeostasis+in+the+setting+of+ongoing+nutrient+losses. assertion.
- assertion asSentence Critical+steps+in+the+recovery+of+the+adult+thymus+include+expansion+of+thymic+epithelial+cell+progenitors+and+elevated+expression+of+Trp63%2C+cMyc+and+Tcf3+transcription+factors+in+the+thymic+stroma. assertion.
- assertion asSentence The+ZEB1+transcription+factor+regulates+the+accumulation+of+adipose+tissue. assertion.
- assertion asSentence E2A+proteins+are+required+for+interleukin+7-dependent+proliferation+due%2C+in+part%2C+to+a+role+for+E2A+in+optimal+expression+of+N-myc. assertion.
- assertion asSentence E12+mutants+resistant+to+Ca%282%2B%29-loaded+calmodulin+%28CaM%29+inhibit+MyoD-initiated+myogenic+conversion+of+transfected+fibroblasts. assertion.
- assertion asSentence Genetic+alleles+in+NOD+mice+condition+ineffective+clonal+deviation+toward+the+CD8alphaalpha+lineage%2C+a+peculiar+population+of+TCRalphabeta+lymphocytes+that+electively+colonizes+the+intraepithelial+lymphocyte+pool+in+the+gut. assertion.
- assertion asSentence Cripto-1+mutants+with+impaired+Nodal+signaling+are+still+active+in+a+Nodal-independent+signaling+pathway. assertion.
- assertion asSentence Prdx2+is+a+specific+peroxidase+that+inhibits+atherogenic+responses+in+vascular+and+inflammatory+cells+in+ApoE+deficient+mice. assertion.
- assertion asSentence Adam12+contributes+to+Tgfb+signaling+through+interaction+with+the+type+II+receptor. assertion.
- assertion asSentence TGF-beta1%2C+an+important+immunoregulatory+cytokine%2C+plays+a+critical+role+in+anti-CD3-mediated+diabetes+reversion+and+immune+tolerance. assertion.
- assertion asSentence Membrane-bound+transforming+growth+factor-beta1+on+myeloid-derived+suppressor+cells+is+critical+for+the+suppression+of+natural+killer+%28NK%29+cells+in+liver+cancer-bearing+mice. assertion.
- assertion asSentence Expression+levels+of+Tgfb1+in+circulating+lymphocytes+are+not+sufficiently+specific+to+diagnose+transitory+postsurgical+complications+such+as+symptomatic+infection+after+liver+transplantation. assertion.
- assertion asSentence BMP-2%2F4+and+TGF-beta+have+a+synergistic+effect+on+the+induction+of+Foxp3%2B+Treg. assertion.
- assertion asSentence The+targeted+inhibition+of+MMP-2+and%2For+TGFbeta+would+be+beneficial+for+the+treatment+of+bone+metastases. assertion.
- assertion asSentence Active+cross-talk+between+the+TGF-beta+and+Cdk5+pathways+contributes+to+inflammatory+pain+signaling. assertion.
- assertion asSentence Hic-5%2FARA55+expression+in+response+to+castration-enabled+epithelial+regression+through+the+repression+of+c-myc+gene+at+the+chromatin+level. assertion.
- assertion asSentence The+Smad2%2C4%2FLEF1+complex+replaces+beta-catenin%2FLEF1+during+activation+of+epithelial+mesenchymal+transition+in+vivo+by+TGFbeta3. assertion.
- assertion asSentence TGF-beta%2FSmad+co-repressor+TGIF1+plays+a+role+in+radiation-induced+normal+tissue+damage+by+a+Smad-independent+mechanism. assertion.
- assertion asSentence Alpha-synuclein+is+involved+in+the+ability+of+tyrosine+to+enhance+tyrosine+hydroxylase+phosphorylation+or+hinder+its+inactivation+during+accelerated+neuronal+activity. assertion.