Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Recombinant+thrombomodulin+domains+2+and+3+protein+significantly+reduces+atherosclerosis+and+neointima+formation+through+its+thrombin-binding+ability. assertion.
- assertion asSentence The+balance+between+VEGF+and+TSP-1+plays+a+critical+role+in+the+control+of+angiogenesis+and+vascular+regression+induced+by+acute+UVB+irradiation. assertion.
- assertion asSentence TPO+downmodulates+c-Myb+expression+through+induction+of+miR-150. assertion.
- assertion asSentence TRalpha1%28PV%29+mutants+exhibited+skeletal+hypothyroidism. assertion.
- assertion asSentence The+dominant+negative+thyroid+hormone+receptor+beta-mutant+Delta337T+alters+PPARalpha+signaling+in+heart. assertion.
- assertion asSentence TIEG1+is+a+negative+regulator+of+the+myoblast+pool+that+causes+inhibition+of+myotube+formation+during+myogenic+differentiation. assertion.
- assertion asSentence Tat+decreased+mRNA+levels+of+ZO-1+and+marked+disruption+of+ZO-1+continuity+and+induced+oxidative+stress%2C+affecting+the+integrity+of+the+blood-brain+barrier+through+the+ERK+1%2F2+pathway. assertion.
- assertion asSentence Effects+of+GFP-fused+mTalin+expression+on+growth+and+development+of+A.+thaliana. assertion.
- assertion asSentence Talin+recruitment+to+alphaIIbbeta3+by+RIAM+mediates+agonist-induced+alphaIIbbeta3+activation%2C+with+implications+for+hemostasis+and+thrombosis. assertion.
- assertion asSentence Toll-like+receptor+2+and+4+cooperate+in+the+brain+immune+response+to+challenge+with+cell+wall+components+derived+from+bacteria. assertion.
- assertion asSentence Intact+TLR4+signaling+in+the+lung+is+required+for+induction+of+both+the+p19+transcript+of+IL-23+and+IL-17+protein+elaboration+following+Klebsiella+pneumoniae+challenge. assertion.
- assertion asSentence Dual+roles+for+caspase-8+in+apoptotic+and+nonapoptotic+functions+and+demonstrates+its+requirement+for+TLR+signaling+and+in+the+regulation+of+NFkappaB+function. assertion.
- assertion asSentence TLR4+plays+a+critical+role+in+the+response+to+intraperitoneal+E.+coli+through+effects+on+phagocytosis+by+macrophages. assertion.
- assertion asSentence Transcription+factor+PU.1+controls+transcription+start+site+positioning+and+alternative+TLR4+promoter+usage. assertion.
- assertion asSentence Deficiency+of+toll-like+receptor+4+%28TLR4%29+greatly+diminishes+acute+lung+inflammation+induced+by+bacterial+lipoteichoic+acid+in+vivo. assertion.
- assertion asSentence TLR4+ligands%2C+rather+than+endotoxin+%28lipopolysaccharide+%5BLPS%5D%29%2C+are+instrumental+in+the+activation+of+liver+TLR4+leading+to+local+inflammation+response+that+culminates+in+liver+ischemia%2Freperfusion+injury. assertion.
- assertion asSentence The+activity+of+TLR4+plays+a+critical+role+in+the+mediation+of+pressure+overload-induced+myocardial+hypertrophy+and+fibrosis. assertion.
- assertion asSentence In+mice+that+lack+both+IL-10-+and+TLR4-mediated+signals%2C+aberrant+regulatory+T-cell+function+and+dysregulated+control+of+epithelial+homeostasis+combine+to+exacerbate+Helicobacter-dependant+colitis. assertion.
- assertion asSentence Rosiglitazone+downregulates+Ang+II-induced+TLR4+expression+in+RAW264.7+cells. assertion.
- assertion asSentence Ozone+activates+lung+dendritic+cells+and+promotes+allergic+sensitization+through+a+TLR4+mechanism. assertion.
- assertion asSentence TLR4-TRIF+axis+has+an+important+role+in+stimulating+protective+innate+immunity+against+H5N1+influenza+A+virus+infection. assertion.
- assertion asSentence Peritoneal+macrophages+from+mice+abundantly+produce+IL-27%28p28%29+after+engagement+of+either+the+TLR3+or+TLR4+receptor. assertion.
- assertion asSentence Ll-like+receptor+4+signaling+in+T+cells+promotes+autoimmune+inflammation. assertion.
- assertion asSentence Innate+immune+detection+of+Aspergillus+fumigatus+is+mediated+by+TLR4+and+TLR2+together+with+TLR1+or+TLR6+in+mice. assertion.
- assertion asSentence Radiation-induced+TNF-alpha%2C+acting+through+TNFRp75%2C+protects+against+the+development+of+late+complications+of+brain+irradiation. assertion.
- assertion asSentence Carbon+monoxide+generated+by+heme+oxygenase-1+protects+endothelial+cells+from+tumor+necrosis+alpha-mediated+apoptosis. assertion.
- assertion asSentence TNF-alpha+regulates+the+production+of+borreliacidal+antibody+and+the+development+of+vaccine-induced+destructive+Lyme+osteoarthritis. assertion.
- assertion asSentence Tnf-induced+protection+of+the+myocardium+is+independent+of+p38-MAPK+activation. assertion.
- assertion asSentence TNF-alpha+and+IL-1beta+are%2C+in+part%2C+responsible+for+the+ability+of+septic+plasma+to+activate+cardiac+myocytes. assertion.
- assertion asSentence PPARgamma+activity+regulates+the+production+of+the+pro-inflammatory+cytokine+TNFalpha. assertion.
- assertion asSentence TNF-alpha+regulates+myogenesis+and+muscle+regeneration+as+a+key+activator+of+p38+MAP+kinase. assertion.
- assertion asSentence TNF-alpha+is+involved+in+the+regulation+of+myocardial+ICAM-1+expression+by+TLR4. assertion.
- assertion asSentence TNF-alpha+promote+aortic+Msx2-Wnt3a-Wnt7a+programs+that+contribute+to+aortic+calcium+accumulation+in+Ldr+receptor+deficient+mice+with+type+2+diabetes+mellitus. assertion.
- assertion asSentence Increased+T+cell+activation+and+proliferation+in+the+presence+of+TNF+contribute+to+the+exacerbation+of+the+gld+syndrome. assertion.
- assertion asSentence SIRT1-NF-kappaB+signaling+is+involved+in+regulating+LPS-+and+metabolites-of-ethanol-mediated+TNF-alpha+production+in+rat+Kupffer+cells+and+in+murine+macrophages. assertion.
- assertion asSentence CD11b%28high%29+DC+is+a+major+source+of+IL-12%2F23p40+during+mycobacterial+infection+in+situ+and+both+soluble+mycobacterial+products+and+TNF-alpha+stimulate+sustained+production+of+p40+by+these+cells. assertion.
- assertion asSentence Dexamethasone+suppressed+TNF-alpha+production+by+the+macrophages+co-cultured+with+Penicillium+marneffei. assertion.
- assertion asSentence Nrf2+plays+an+important+protective+role+in+limiting+the+spinal+cord+upregulation+of+TNF-alpha+and+MMP-9+after+spinal+cord+injury. assertion.
- assertion asSentence TIMP3+differentially+impacts+apoptosis+and+inflammatory+cell+influx%2C+based+on+involvement+of+TNF%2C+during+the+process+of+mammary+involution. assertion.
- assertion asSentence Uncoupling+protein-2+increases+nitric+oxide+production+and+TNFAIP3+pathway+activation+in+pancreatic+islets. assertion.
- assertion asSentence Tumor+necrosis+factor+alpha-induced+protein+6+%28TNFAIP6%29+is+essential+for+catalyzing+heavy+chains+of+inter-alpha-trypsin+inhibitor+to+be+covalently+linked+to+hyaluronan+in+expanding+mouse+oocyte-cumulus+cell+complexes. assertion.
- assertion asSentence The+RANK-RANKL+signaling+pathway+is+critically+involved+in+regulating+the+function+of+CD4%28%2B%29CD25%28%2B%29+T%28R%29+cells+in+colitis. assertion.
- assertion asSentence RelA+antagonizes+TNFR1-JNK+proliferative+signals+in+epidermis+and+plays+a+nonredundant+role+in+restraining+epidermal+growth. assertion.
- assertion asSentence CD40-stimulated+B+cells+produce+TNF+that+triggers+signaling+to+the+B+cells+through+CD120b+as+an+important+component+of+CD40-mediated+IgM+production. assertion.
- assertion asSentence TNFR-associated+factor+6+signaling+downstream+of+CD40+alters+the+pattern+of+response+of+macrophages+to+TNF-alpha+leading+to+induction+of+antimicrobial+activity. assertion.
- assertion asSentence Differentiation+of+CD4+memory+T+cells+to+produce+interferon-gamma+requires+CD40. assertion.
- assertion asSentence TACI+and+CD40+signaling+converge+to+promote+B-cell+differentiation+into+plasmablasts. assertion.
- assertion asSentence CD27+mediates+interleukin-2-independent+clonal+expansion+of+the+CD8%2B+T+cell+without+effector+differentiation. assertion.
- assertion asSentence In+vivo+CD137+stimulation+enhances+and+broadens+the+CD8%2B+T+cell+response+to+influenza+virus+and+can+restore+the+CD8%2B+T+cell+response+when+CD28+costimulation+is+absent. assertion.
- assertion asSentence The+4-1BB+costimulator+receptor+induces+the+proliferation+of+the+CD4%28%2B%29CD25%28%2B%29+regulatory+T+cells+both+in+culture+and+in+vivo. assertion.
- assertion asSentence The+cellular+responses+in+cell-to-cell+interactions+between+T+cells+and+osteoclasts+are+regulated+through+reciprocal+regulations+of+CD137%2FCD137L+and+RANK%2FRANKL+interactions. assertion.
- assertion asSentence RANKL+is+an+important+mediator+of+humoral+hypercalcemia+of+malignancy%2C+particularly+in+the+early+stages+of+the+condition. assertion.
- assertion asSentence RANKL+induces+osteoclastogenesis+from+homopoietic+cell+precursors. assertion.
- assertion asSentence The+RANKL+signaling+axis+is+sufficient+to+elicit+ductal+side-branching+and+alveologenesis+in+the+mammary+gland+of+the+virgin+mouse. assertion.
- assertion asSentence CSF-1+inhibits+RANKL+expression+in+osteoblasts. assertion.
- assertion asSentence Topical+infusion+of+mevastatin+increases+bone+mass+of+isografted+bone+by+increasing+bone+turnover+and+by+promoting+the+expression+of+BMP-2+and+RANKL+mRNA. assertion.
- assertion asSentence Inflammatory+cytokines%2C+such+as+TWEAK+and+TNFalpha%2C+downregulate+Klotho+expression+through+an+NFkappaB-dependent+mechanism. assertion.
- assertion asSentence The+expression+of+CD154+on+B+cells+is+not+required+for+the+generation+of+germinal+centers%2C+isotype+switching%2C+or+sustained+antibody+production. assertion.
- assertion asSentence Thr144+in+cardiac+TnI+modulates+cardiac+myofilament+length-dependent+activation. assertion.
- assertion asSentence Loss+of+troponin+I+leads+to+myofibril+hypersensitivity+to+Ca%282%2B%29+causing+impaired+relaxation+in+restrictive+cardiomyopathy. assertion.
- assertion asSentence TR4+plays+vital+roles+in+mitochondrial+function. assertion.
- assertion asSentence Fyn-catalyzed+Tyr-phosphorylation+of+Grp94+is+an+event+required+to+promote+the+chaperone+export+from+the+endoplasmic+reticulum+occurring+in+the+early+phase+of+myoblast+differentiation. assertion.
- assertion asSentence sCD40L+enhances+agonist-induced+platelet+activation+and+aggregation+through+a+CD40-dependent+tumor+necrosis+factor+receptor-associated+factor-2%2FRac1%2Fp38+mitogen-activated+protein+kinase+signaling+pathway. assertion.
- assertion asSentence Both+TRAF2+and+TRAF5+are+involved+in+TNF-induced+NF-kappaB+activation+and+protection+from+cell+death. assertion.
- assertion asSentence Distinct+contributions+of+different+CD40+TRAF+binding+sites+to+CD154-induced+dendritic+cell+maturation+and+IL-12+secretion. assertion.
- assertion asSentence MAST205+functions+as+a+scaffolding+protein+controlling+TRAF6+activity+and%2C+therefore%2C+plays+an+important+role+in+regulating+inflammatory+responses. assertion.
- assertion asSentence Tumor+necrosis+factor+receptor-associated+factor+6+%28TRAF6%29+associates+with+huntingtin+protein+and+promotes+its+atypical+ubiquitination+to+enhance+aggregate+formation. assertion.
- assertion asSentence The+modified+vectors+containing+Q-dots+demonstrated+32-fold+greater+tumor-targeting+efficiency+than+wild-type+HVJ-E. assertion.
- assertion asSentence Three+distinct+and+discontinuous+regions+of+the+TSHR+%28aa+246-260+and+277-296+on+the+TSHR+A+subunit%29+and+aa+381-385+%28on+the+TSHR+B+subunit%29+fold+together+to+form+a+complex+TSH+binding+pocket. assertion.
- assertion asSentence TRIP6+in+lysophosphatidic+acid+signaling+is+regulated+by+c-Src-mediated+phosphorylation+of+TRIP6+at+the+Tyr-55+residue. assertion.
- assertion asSentence Tob1+is+a+crucial+check+point+molecule+that+modulates+the+expression+and+activity+of+cell+cycle+proteins. assertion.
- assertion asSentence p53+loss+accelerates+plasmacytoma+development+and+causes+a+shift+in+the+typical+translocation+patterns. assertion.
- assertion asSentence Unique+mechanism+for+p53+regulation+by+the+p65%2FRelA+subunit+of+NF-kappaB. assertion.
- assertion asSentence Sulindac+is+an+effective+chemopreventive+agent+in+the+presence+of+p53+dysfunction+or+loss+in+knockout+mice. assertion.
- assertion asSentence The+involvement+of+PUMA-alpha+in+p53-mediated+renal+cell+apoptosis+during+cisplatin+nephrotoxicity. assertion.
- assertion asSentence p53+plays+a+role+in+serum-induced+cell+migration. assertion.
- assertion asSentence Runx3-%2F-p53-%2F-+gastric+epithelial+cells+differentiate+into+intestinal+type+cells+in+vitro+in+the+absence+of+other+cell+types. assertion.
- assertion asSentence The+functional+role+of+the+intrinsic+activation+of+p53+during+Mk+differentiation+is+to+control+polyploidization+and+the+transition+to+endomitosis+by+impeding+cell+cycling+and+promoting+apoptosis. assertion.
- assertion asSentence p53+retains+tumor+suppressor+activity+in+the+absence+of+Atm. assertion.
- assertion asSentence A+mechanism+underlying+the+SENP2-mediated+regulation+of+Mdm2+that+is+critical+for+genome+integrity+in+p53-dependent+stress+responses. assertion.
- assertion asSentence Hsf1+is+required+for+establishment+of+the+microtubule+network+in+cells+and+for+nuclear+localization+of+p53. assertion.
- assertion asSentence Mitochondrial+dysfunction+impairs+tumor+suppressor+p53+expression%2Ffunction. assertion.
- assertion asSentence p53+binds+to+the+Bax+promoter+in+response+to+DNA+damage. assertion.
- assertion asSentence Testes+weight+and+sperm+concentration+depended+on+both+the+genetic+background+and+p53+genotype. assertion.
- assertion asSentence Mediates+apoptotic+pathway+in+tumor+cells. assertion.
- assertion asSentence p73+ensures+normal+adult+neurogenesis+by+promoting+the+long-term+maintenance+of+neural+stem+cells. assertion.
- assertion asSentence TSC2+reexpression+in+these+ELT3+cells+rescued+them+from+the+inhibitory+effect+of+FTS. assertion.
- assertion asSentence Controls+X+chromosome+activation+and+distorts+sex+ratio. assertion.
- assertion asSentence SPAG16L+can+be+phosphorylated+by+TSSK2+in+vitro. assertion.
- assertion asSentence Truncation+of+titin%27s+elastic+PEVK+region+leads+to+cardiomyopathy+with+diastolic+dysfunction. assertion.
- assertion asSentence Calcium+sensitivity+and+the+Frank-Starling+mechanism+of+the+heart+are+increased+in+titin+N2B+region-deficient+mice. assertion.
- assertion asSentence High+betaIII-tubulin+is+associated+with+tumorigenesis+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Twist+regulates+cytokine+gene+expression+through+a+negative+feedback+loop+that+represses+NF-kappaB+activity. assertion.
- assertion asSentence Twist+plays+an+essential+role+in+tumor+metastasis. assertion.
- assertion asSentence Twist+participated+in+the+angiogenesis+of+oxygen+induced+retinopathy. assertion.
- assertion asSentence Repressing+Twist+with+RNAi%2C+represses+cell+transition+and+inhibits+retinal+neovascularization. assertion.
- assertion asSentence OX40+is+expressed+on+different+T+cell+subsets+or+at+different+times+in+vivo+and+acts+independently+and+nonredundantly+to+promote+robust+CD4+T+cell+secondary+responses. assertion.
- assertion asSentence CD4%2B+T+cell+differentiation+to+effector+function+is+an+important+effect+of+OX40+engagement+under+conditions+of+ubiquitous+antigen+presentation. assertion.
- assertion asSentence Adiponectin+haploinsufficiency+facilitated+mammary+tumorigenesis+by+down-regulation+of+PTEN+activity+and+activation+of+PI3K%2FAkt+signalling+pathway+through+a+mechanism+involving+Trx1%2FTrxR1+redox+regulations. assertion.
- assertion asSentence Activation+of+extracellular+transglutaminase+2+by+thioredoxin. assertion.