Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Consistent+and+selective+association+of+the+IDO-competent+phenotype+with+down-modulation+of+the+Tyrobp+gene. assertion.
- assertion asSentence Increased+diabetes+development+and+decreased+function+of+CD4%2BCD25%2B+Treg+in+the+absence+of+a+functional+DAP12+adaptor+protein. assertion.
- assertion asSentence The+Tyrp1b+mutation+modifies+the+pathways+and+gene+networks+in+which+Tyrp1+functions. assertion.
- assertion asSentence The+ability+of+SUMO+isoforms+to+substitute+for+one+another+has+important+implications+for+rational+targeting+of+the+SUMO+pathway. assertion.
- assertion asSentence Urocortin+induces+macrophage+apoptosis+via+Corticotropin-Releasing+Factor+Receptor-2. assertion.
- assertion asSentence An+essential+role+of+IRS-1+through+the+PI+3-kinase%2FAkt+signaling+pathway+inducing+UCP-1+gene+expression+by+insulin. assertion.
- assertion asSentence Role+of+UCP2+in+glutamine+metabolism+appears+independent+from+the+uncoupling+activity+of+UCP2. assertion.
- assertion asSentence Nutrient+starvation+elicits+an+acute+autophagic+response+mediated+by+Ulk1+dephosphorylation+and+its+subsequent+dissociation+from+AMPK. assertion.
- assertion asSentence ULK1+and+ULK2+are+functionally+redundant+protein+kinases+required+to+mediate+autophagy+under+nutrient-deprived+conditions+in+fibroblasts. assertion.
- assertion asSentence Urinary+uromodulin+is+generated+by+a+conserved+C-terminal+proteolytic+cleavage+and+retains+its+entire+ZP+domain. assertion.
- assertion asSentence Cyclic+AMP+rescue+of+priming+defects+caused+by+Munc13-1+deficiency+signaling+pathways+requires+downstream+Munc13-1-Rim2+interaction. assertion.
- assertion asSentence USP4+interacts+directly+with+and+deubiquitinates+ARF-BP1%2C+leading+to+the+stabilization+of+ARF-BP1+and+subsequent+reduction+of+p53+levels. assertion.
- assertion asSentence Downregulates+11beta-hydroxysteroid+dehydrogenase+type+1+expression+and+activity. assertion.
- assertion asSentence LXRalpha+is+a+direct+transcriptional+inhibitor+of+beta-adrenergic-receptor-mediated%2C+cyclic+AMP-dependent+Ucp1+gene+expression+through+its+binding+to+the+critical+enhancer+region+of+the+Ucp1+promoter. assertion.
- assertion asSentence Females+are+found+to+have+significantly+higher+expression+levels+of+Utx+than+males+in+most+brain+regions+except+the+amygdala. assertion.
- assertion asSentence VAMP8+has+a+specific+function+in+the+thymic+stroma+affecting+the+proliferation+and+apoptosis+of+T+lymphocytes+during+maturation+in+the+thymus. assertion.
- assertion asSentence The+phosphorylation+of+VASP+performs+a+key+function+for+the+formation+of+platelet-neutrophil+complexes+that+is+crucially+important+for+the+extent+of+myocardial+ischemia-reperfusion+injury. assertion.
- assertion asSentence Dectin-1+activates+the+integrin+Mac-1+in+neutrophils+via+Vav1+and+Vav3+signaling+to+promote+Candida+albicans+clearance. assertion.
- assertion asSentence Delayed+up-regulation+of+VCAM-1+adhesion+molecules+in+response+to+Pneumocystis+carinii+infection+is+involved+in+the+sluggish+recruitment+of+inflammatory+cells+into+neonatal+lungs+compared+with+adults. assertion.
- assertion asSentence 18F-4V+for+PET-CT+imaging+of+VCAM-1+expression+in+atherosclerosis. assertion.
- assertion asSentence Cell+mechanical+processes+are+differently+affected+by+the+focal+adhesion+proteins+vinculin+and+FAK+than+by+the+nuclear+matrix+protein%2C+p53. assertion.
- assertion asSentence Phosphorylation+on+position+Y1065+is+essential+for+accurate+incorporation+of+vinculin+into+FAs+and+mechanical+behavior+of+cells. assertion.
- assertion asSentence Snail1+controls+bone+mass+by+repressing+the+transcription+of+both+the+osteoblast+differentiation+factor+Runx2+and+the+vitamin+D+receptor+%28VDR%29+genes+in+osteoblasts. assertion.
- assertion asSentence Endogenous+VEGF+has+an+important+physiologic+role+in+vascular+repair. assertion.
- assertion asSentence VEGF+cells+produced+rapidly+growing+tumors+in+nude+mice+that+exhibited+extensive+pseudo-epithelial+ductal+architecture+and+supporting+vasculature. assertion.
- assertion asSentence Salivary-derived+VEGF-A+is+involved+in+adaptive+response+to+massive+small+bowel+resection. assertion.
- assertion asSentence VEGF+is+coordinately+regulated+as+part+of+the+myogenic+differentiation+program+and+serves+an+autocrine+function+regulating+skeletal+myogenesis. assertion.
- assertion asSentence VEGF-A+functions+in+nucleus+pulposus+survival+in+an+autocrine%2Fparacrine+manner. assertion.
- assertion asSentence Upregulation+of+vegf+is+associated+with+acoustic+trauma+induced+changes+in+cochlear+pericytes+accompanied+by+sensorineural+hearing+loss. assertion.
- assertion asSentence mBMSC+transfected+with+BMP2+and+VEGF%28165%29+genes+can+induce+ectopic+osteogenesis. assertion.
- assertion asSentence Vezf1+is+involved+in+the+regulation+of+angiogenesis%2C+at+least+in+part%2C+through+the+expression+of+stathmin%2FOP18+in+endothelial+cells. assertion.
- assertion asSentence VHL+has+a+crucial+role+in+endochondral+bone+development+and+is+necessary+for+normal+chondrocyte+proliferation+in+vivo. assertion.
- assertion asSentence The+vesicular+GABA+transporter+%28VGAT%29+possesses+an+uneven+number+of+transmembrane+domains%2C+with+the+N+terminus+facing+the+cytoplasm+and+the+C+terminus+residing+in+the+synaptic+vesicle+lumen. assertion.
- assertion asSentence Photoreceptor+degeneration+and+retinal+inflammation+are+induced+by+Vldlr+deficiency. assertion.
- assertion asSentence Activation+of+VLDLR+and+apoER2+by+reelin+and+apoE+induces+ABCA1+expression+and+cholesterol+efflux+via+a+Dab1-PI3K-PKCzeta-Sp1+signaling+cascade. assertion.
- assertion asSentence The+epigenetic+profile+of+immunoglobulin+light+chain+%28IgL%29+genes+is+strongly+influenced+by+pre-B+cell+receptor+signaling+and+by+the+differentiative+stage+of+the+progenitor+lymphocytes. assertion.
- assertion asSentence Pre-B+cell+receptor+%28BCR%29+signals+establish+the+molecular+network+for+BCR+signaling+even+before+the+production+of+an+IgL+Chain+and+induce+the+expression+of+KLF2%2C+a+candidate+for+controlling+clonal+expansion+and+migration+of+functional+pre-B+cells. assertion.
- assertion asSentence Insulin+treatment+induces+the+acceleration+of+the+exocytotic+response+by+insertion+of+TrpV2+into+the+plasma+membrane+in+beta+cells. assertion.
- assertion asSentence Mammalian+diaphanous-related+formin+1+%28mDia1%29+and+WASp+colocalize+at+the+leading+edge+of+polarized+neutrophils. assertion.
- assertion asSentence Fluctuations+of+BMP2+signaling+pathway+during+hair+cycles+in+skin+with+mutant+genes+we%2C+wal+and+Fgf5%28go%29. assertion.
- assertion asSentence Mammalian+Wee1+plays+a+critical+role+in+maintaining+genome+integrity+and+is+essential+for+embryonic+survival+at+the+pre-implantation+stage+of+mouse+development. assertion.
- assertion asSentence The+regulation+of+Wee1+by+SadA+and+SadB+kinases+is+essential+for+the+differentiation+of+polarized+neurons. assertion.
- assertion asSentence The+Wnt%2Fbeta-catenin+pathway+functions+as+a+master+regulator+of+the+expression+of+both+phase+I+and+phase+II+drug-metabolizing+enzymes+in+perivenous+hepatocytes+from+mouse+liver. assertion.
- assertion asSentence Mechanisms+downstream+of+beta-catenin+are+required+for+Wnt6%2C+Wnt10a+and+Wnt10b+to+influence+differentiation+of+mesenchymal+precursors. assertion.
- assertion asSentence Signals+through+the+canonical+Wnt+signaling+pathway+to+regulate+midfacial+development+and+lip+fusion. assertion.
- assertion asSentence Transgenic+overexpression+of+Wnt9b+in+the+ureteric+bud+causes+reduced+branching+in+multiple+founder+lines. assertion.
- assertion asSentence Wnt3a+regulates+somitogenesis+by+activating+a+network+of+interacting+target+genes+that+promote+mesodermal+fates%2C+activate+the+segmentation+clock. assertion.
- assertion asSentence The+fate+of+the+gonad+is+controlled+by+antagonism+between+Fgf9+and+Wnt4. assertion.
- assertion asSentence Wnt5a+improves+the+differentiation+and+functional+integration+of+stem+cell-derived+DA+neurons+in+vivo+and+define+Wnt5a-treated+neural+stem+cells+as+an+efficient+and+safe+source+of+DA+neurons+for+cell+replacement+therapy+in+PD. assertion.
- assertion asSentence Wnt5a+is+essential+for+normal+prostate+development+where+it+regulates+bud+outgrowth%2C+ductal+elongation%2C+branching%2C+cell+polarity+and+lumenization. assertion.
- assertion asSentence Sox11+represents+a+synergistic+factor+for+WT1+in+regulating+the+Wnt4+gene+expression+that+is+critical+for+nephrogenesis+during+kidney+ontogeny. assertion.
- assertion asSentence Centromeric+ATRX+is+required+for+correct+chromosome+alignment+and+organization+of+a+bipolar+meiotic+metaphase+II+spindle. assertion.
- assertion asSentence ATRX+is+required+for+centromere+stability+and+the+epigenetic+control+of+heterochromatin+function+during+meiosis+and+the+transition+to+the+first+mitosis. assertion.
- assertion asSentence ATRX+and+the+androgen+receptor+%28AR%29+physically+interact+in+the+testis+and+in+the+Sertoli+cell+line+TM4+and+co-operatively+activate+the+promoter+of+Rhox5. assertion.
- assertion asSentence Y-box+binding+protein-1+down-regulates+expression+of+carbamoyl+phosphate+synthetase-I+by+suppressing+CCAAT+enhancer-binding+protein-alpha+function+in+mice. assertion.
- assertion asSentence 14-3-3+eta+plays+a+regulatory+role+in+chondrogenic+differentiation. assertion.
- assertion asSentence Rai+interferes+with+the+TCR+signaling+cascade+one+of+the+earliest+steps--recruitment+of+the+initiating+kinase+ZAP-70+to+the+phosphorylated+subunit+of+the+TCR%2FCD3+complex. assertion.
- assertion asSentence A+complex+syndrome+of+left-right+axis%2C+central+nervous+system+and+axial+skeleton+defects+in+Zic3+mutant+mice. assertion.
- assertion asSentence Osr1+gene+expression+is+regulated+by+Runx2+and+Ikzf1+transcription+factors. assertion.
- assertion asSentence Znt1+provides+an+essential+function+during+early+embryonic+development. assertion.
- assertion asSentence Conserved+furin+cleavage+site+not+essential+for+secretion+and+integration+of+ZP3+into+the+extracellular+egg+coat+of+transgenic+mice. assertion.
- assertion asSentence A+physiological+function+of+ADAMTS5+in+dermal+fibroblasts+is+to+maintain+optimal+versican+content+and+PCM+volume+by+continually+trimming+versican+in+hyaluronan-versican+aggregates. assertion.
- assertion asSentence Apelin%2FAPJ+signaling+pathways+play+a+critical+role+in+the+development+of+the+functional+vascular+network+in+adipose+tissue. assertion.
- assertion asSentence Disruption+of+apelin-APJ+signaling+can+exacerbate+pulmonary+hypertension+mediated+by+decreased+activation+of+AMP-activated+kinase+and+eNOS. assertion.
- assertion asSentence The+range+of+discrete+and+divergent+processing+activities+in+mice+reconstituted+with+different+presenilin+genes+and+alleles+argues+against+gamma-secretase+being+a+single+enzyme. assertion.
- assertion asSentence Endogenous+beta2+processing+and+Na%28v%291.1+protein+levels+are+elevated+in+brains+of+BACE1-transgenic+mice+and+Alzheimer%27s+disease+patients+with+high+BACE1+levels. assertion.
- assertion asSentence Calpain+10+levels+specifically+decrease+in+kidney+tissues+when+renal+function+decreases. assertion.
- assertion asSentence HAX1+is+expressed+in+liver%2C+kidney+and+testis+and+localised+in+the+keratinocyte+and+neuronal+cell+line. assertion.
- assertion asSentence The+association+between+SHIP2+and+the+adaptor+protein+Aps+has+an+impact+on+biochemical+properties+of+both+partners. assertion.
- assertion asSentence Bile+acids+inhibit+duodenal+secretin+expression+via+orphan+nuclear+receptor+small+heterodimer+partner+%28SHP%29. assertion.
- assertion asSentence MATER+co-localizes+with+PADI6+at+the+oocyte+cytoplasmic+lattices. assertion.
- assertion asSentence Syndapin+I+acts+as+pivotal+membrane+anchoring+factor+for+dynamins+during+regeneration+of+synaptic+vesicles. assertion.
- assertion asSentence As+water+intake+rises%2C+pendrin+becomes+increasingly+critical+in+the+maintenance+of+Cl%28-%29+and+I%28-%29+balance. assertion.
- assertion asSentence Na%28v%291.9+is+expressed+by+photoreceptors+and+Muller+glia+in+retina+f+mice. assertion.
- assertion asSentence Nav1.9+sodium+channel+provides+an+important+link+between+inflammatory+processes+and+changes+in+urodynamic+properties+that+occur+during+urinary+bladder+inflammation. assertion.
- assertion asSentence Systemic+delivery+of+an+immune-activating+signal+using+CCL19+transduced+embryonic+endothelial+progenitor+cells+suppresses+metastasis+of+murine+ovarian+cancer. assertion.
- assertion asSentence Sub-physiological+sarcoglycan+expression+plays+a+critical+role+in+ameliorating+muscle+disease+in+mdx+mice. assertion.
- assertion asSentence SIGIRR+is+expressed+constitutively+in+intestinal+epithelial+cells+to+maintain+gut+innate+immunity+and+then+down-regulated+during+inflammation+by+inhibition+of+an+SP1-mediated+pathway. assertion.
- assertion asSentence mSprouty2+inhibits+FGF10-activated+MAP+kinase+by+differentially+binding+to+upstream+target+proteins. assertion.
- assertion asSentence Kif7+regulates+the+activity+of+Gli+transcription+factors+through+both+Sufu-dependent+and+-independent+mechanisms. assertion.
- assertion asSentence Severe+impairment+of+interleukin-1+and+Toll-like+receptor+signalling+in+mice+lacking+IRAK-4. assertion.
- assertion asSentence Bacterial+products+exacerbate+acute+inflammation+via+TLR2-signaling+and+direct+the+recruitment+of+neutrophils+and+regulatory+T-cells+to+intestinal+sites. assertion.
- assertion asSentence Role+in+regulation+of+bacterial+clearing+and+in+the+inflammatory+response+during+Group+B+Streptococcal-induced+sepsis+and+arthritis. assertion.
- assertion asSentence RAW+264.7+cells+most+closely+mimic+bone+marrow-derived+macrophages+in+terms+of+cell+surface+receptors+and+response+to+microbial+ligands+that+initiate+cellular+activation+via+Toll-like+receptors+2%2C3+and+4. assertion.
- assertion asSentence Ata+demonstrate+that+PKC-alpha+is+induced+by+several+MyD88-dependent+TLR%2FIL-1R+ligands+and+regulates+cytokine+expression+in+human+and+murine+DC. assertion.
- assertion asSentence Toll-like+receptor+2-mediated+peptidoglycan+uptake+by+immature+intestinal+epithelial+cells+from+apical+side+and+exosome-associated+transcellular+transcytosis. assertion.
- assertion asSentence Astrocytes+exposed+to+activated+microglia+assume+a+different+functional+phenotype+involving+longer+term+TLR2+responsiveness%2C+even+after+the+initial+stimulation+by+inflammatory+mediators+has+ended. assertion.
- assertion asSentence The+existence+of+a+close+relationship+between+B-cell+homeostasis%2C+BAFF+response+and+the+susceptibility+to+develop+EAE. assertion.
- assertion asSentence The+functional+plasma+membrane+transport+of+TPRA40+that+regulates+cell+division+of+mouse+embryos+is+mediated+by+NA14. assertion.
- assertion asSentence Abcg2+is+a+direct+downstream+target+of+HIF-2alpha+which+functions+with+other+factors+to+initiate+a+cytoprotective+program+for+this+progenitor+cell+population+that+resides+in+the+adult+heart. assertion.
- assertion asSentence Both+P-gp+and+Bcrp1+reduce+the+brain+penetration+of+erlotinib. assertion.
- assertion asSentence ClC-7+knockout+mice+display+neurodegeneration+and+severe+lysosomal+storage+disease+despite+unchanged+lysosomal+pH+in+cultured+neurons. assertion.
- assertion asSentence The+t+allele+of+Fgd2+is+overexpressed+in+testis+compared+with+wild+type%2C+a+loss-of-function+allele+of+Fgd2+generated+by+gene+targeting+reduces+the+transmission+ratio+of+the+t+haplotype+t%28h49%29%2C+directly+demonstrating+the+role+of+Fgd2+as+Distorter. assertion.
- assertion asSentence p202+plays+a+role+in+regulating+the+proliferative+capacity+of+hematopoietic+cells. assertion.
- assertion asSentence AT%282%29R-mediated+eNOS+NO+production+and+vasorelaxation+through+a+MEK+pathway+are+enhanced+in+aortas+from+db%2Fdb+mice. assertion.
- assertion asSentence MK2-HSP27+pathway+is+a+target+for+therapeutic+control+of+localized+inflammatory+diseases. assertion.
- assertion asSentence Cytoprotective+effects+of+carbon+monoxide+are+mediated+by+selective+activation+of+the+MKK3%2Fp38+beta+protein+MAP+kinase+pathway. assertion.
- assertion asSentence MKK6-p38+and+insulin+growth+factor+1+%28IGF1%29-induced+PI3K%2FAKT+pathways+converge+on+the+chromatin+of+muscle+genes+to+target+distinct+components+of+the+muscle+transcriptosome. assertion.
- assertion asSentence MLK3+contributes+to+the+TNF+signaling+pathway+that+activates+JNK. assertion.
- assertion asSentence Apoptosis+signal-regulating+kinase+1+inhibits+hepatocarcinogenesis+by+controlling+the+tumor-suppressing+function+of+stress-activated+mitogen-activated+protein+kinase. assertion.