Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity." provenance.
- _6 value "Perfusion of hearts with 100 microM PE caused a rapid (maximal at 10 min) 12-fold activation of twop38-MAPK isoforms" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _6 value "SAPKs/JNKs were also rapidly activated" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Overexpression of hAxin strongly promoted the downregulation of wild-type beta-catenin in colon cancer cells," provenance.
- _4 value "IL-1beta markedly stimulated both control and FSH-supported 20alpha-hydroxysteroid dehydrogenase activity (4.8- and 3.3-fold, respectively) and transcripts (16.4- and 7.5-fold, respectively)" provenance.
- _3 value "IL-1beta markedly stimulated both control and FSH-supported 20alpha-hydroxysteroid dehydrogenase activity (4.8- and 3.3-fold, respectively) and transcripts (16.4- and 7.5-fold, respectively)" provenance.
- _5 value "while Ser246 is phosphorylated by the c-Jun N-terminal kinase." provenance.
- _3 value "12 up-regulated distinct genes including 5 cell growth-related genes (two phosphatases CL100 and B23/hVH-3, gravin, activating transcription factor-4, and heparin-binding epidermal growth factor-like growth factor), 3 thrombosis-related genes (plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombomodulin), and 4 others (stanniocalcin, NAD-dependent methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, BENE, and reducing agents and tunicamycin-responsive protein)" provenance.
- _3 value "Ariadne: In the pituitary gland, LPS stimulates MIF gene expression and the subsequent release of MIF protein ( 1 , 5 )." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Angiotensin II leads to the activation of ERK 1/2 phosphorylation." provenance.
- _4 value "Angiotensin II leads to the activation of ERK 1/2 phosphorylation." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "To investigate mechanisms underlying PKC inhibition, we examined whether TGF-eta 2 induced changes in the protein levels of PKCepsilon, the most abundant PKC isoenzyme present in GH 3 cells (Akita et al ., 1994 )." provenance.
- _5 value "Saltzman et al. (1998) demonstrated that JAK2 phosphorylates STAT1 (600555), STAT2 (600556), STAT3 (102582), STAT4 (600558), and STAT5 (see STAT5A, 601511, and STAT5B, 604260)" provenance.
- _3 value "This region also mediates the transcriptional activation of the p21 promoter by members of the Smad family of proteins, which play important role in the transduction of extracellular signals such as transforming growth factor beta, activin, etc." provenance.
- _6 value "Modified assertion" provenance.
- _6 value "Similar responses were observed when neutrophils were stimulated with chemotactic N-formyl-methionyl-leucyl-phenylalanine, phorbol ester, or the calcium ionophore ionomycin." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Following extracellular stimuli, stathmin is phosphorylated on four serines (Ser16, Ser25, Ser38, and Ser63) by several kinases, such as mitogen-activated protein (MAP), cdc2 kinase, protein kinase A, and Ca2+/calmodulin-dependent kinase-Gr." provenance.
- _5 value "Following extracellular stimuli, stathmin is phosphorylated on four serines (Ser16, Ser25, Ser38, and Ser63) by several kinases, such as mitogen-activated protein (MAP), cdc2 kinase, protein kinase A, and Ca2+/calmodulin-dependent kinase-Gr." provenance.
- _5 value "LPS evoked a time- and concentration-dependent generation of TNF-alpha (t1/2 = 4.5 h; EC50 = 273 pg/mL), which was inhibited by exogenous human recombinant (h) IL-10 (IC50 = 124 pg/mL), and by rolipram (EC50 = 420 nM), 8-Br-cAMP (EC50 = 77 (microM), PGE2 (EC50 = 15 nM) and salbutamol" provenance.
- _4 value "LPS evoked a time- and concentration-dependent generation of TNF-alpha (t1/2 = 4.5 h; EC50 = 273 pg/mL), which was inhibited by exogenous human recombinant (h) IL-10 (IC50 = 124 pg/mL), and by rolipram (EC50 = 420 nM), 8-Br-cAMP (EC50 = 77 (microM), PGE2 (EC50 = 15 nM) and salbutamol" provenance.
- _3 value "LPS evoked a time- and concentration-dependent generation of TNF-alpha (t1/2 = 4.5 h; EC50 = 273 pg/mL), which was inhibited by exogenous human recombinant (h) IL-10 (IC50 = 124 pg/mL), and by rolipram (EC50 = 420 nM), 8-Br-cAMP (EC50 = 77 (microM), PGE2 (EC50 = 15 nM) and salbutamol" provenance.
- _3 value "Modified assertion" provenance.
- _5 value "Certain growth factors can mimic estrogen responses by activating the estrogen receptor via its phosphorylation by mitogen-activated protein (MAP) kinase." provenance.
- _2 value "Normal breast tissue as well as most breast tumors are dependent on estrogen for growth." provenance.
- _5 value "Human 293 cells were transfected with expression vectors that direct the synthesis of FGFR1 together with either the wild type or the 1F, 4F, or 5F mutant. This experiment demonstrates that Y196, Y306, Y349, Y392, and Y436 are the major tyrosine phosphorylation sites of FRS2." provenance.
- _3 value "Consistent with this observation, overexpression of p300/CREB binding protein-associated factor (P/CAF), a transcriptional coactivator with intrinsic HAT activity, activated the wild-type MDR1 promoter" provenance.
- _3 value "mice lacking CXCR4 die in utero and are defective in vascular development, haematopoiesis and cardiogenesis" provenance.
- _4 value "DU-145 cells treated with 5000 U/ml of IFNgamma and IFN alpha, both reduced EGF production with IFN gamma reduction more significant." provenance.
- _4 value "DU-145 cells treated with 5000 U/ml of IFNgamma and IFN alpha, both reduced EGF production with IFN gamma reduction more significant." provenance.
- _5 value "TRANK activated NF-kappa B and induced the degradation of the inhibitory subunit of NF-kappa B." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _4 value "When VSMCs were pre-treated with geldanamycin, a Src inhibitor, and then stimulated with Angiotensin II, geldanamycin completely blocked the Angiotensin II dependent phosphorylation of p130Cas.The cells were next pre-treated with PP1, a specific Src family kinase inhibitor, and then stimulated with Angiotensin II, the tyrosine phosphorylation of p130Cas was completely eliminated, indicating that an active Src family kinase is critical for Angiotensin II mediated p130Cas tyrosine phosphorylation." provenance.
- _5 value "Forced Gax expression led to Bcl-2 down-regulation and Bax up-regulation" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "calcineurin binding protein named Cabin 1 that inhibits calcineurin-mediated signal transduction. signal transduction. The interaction between Cabin 1 and calcineurin is dependent on PKC activation." provenance.
- _3 value "LIM 1215 cells, the expression of ITF was potently and dose-dependently inhibited by short-chain fatty acids (butyrate > propionate > acetate)" provenance.
- _4 value "The inhibitory effect of butyrate was ablated by actinomycin D" provenance.
- _4 value "LPS and selected cytokines upregulate xanthine dehydrogenase/xanthine oxidase (XDH/XO) in cellular systems" provenance.
- _4 value "TNF and IL-1 both inhibit cAMP-stimulated testosterone production as well as mRNA and protein levels of cholesterol side chain cleavage enzyme (P450scc) and 17 alpha-hydroxylase/C17,20 lyase (P450c17) in mouse Leydig cells." provenance.
- _5 value "A juxtamembrane segment of FGFR-1 and the phosphotyrosine-binding domain of SNTs are both necessary and sufficient for interaction in yeast and in vitro, and FGFR-mediated SNT tyrosine phosphorylation in vivo requires these segments of receptor and SNT. " provenance.
- _5 value "U0126 a noncompetitive inhibitor with respect to both MEK substrates, ATP and ERK" provenance.
- _5 value "IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3 hours of cytokine stimulation. IL1 treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1." provenance.
- _5 value "IL6, which is also considered a proinflammatory mediator in synovitis, when added to fibroblast like synoviocytes at a concentration of 10ng/ml, induced HSF1 activation but weaker upregulation of hsp70." provenance.
- _4 value "Furthermore, activated Rac and Cdc42, but again not Rho, are capable of inducing cyclin D1 accumulation and pRB hyperphosphorylation in serum-deprived cells, outlining one route leading to enhanced E2F-mediated transcription." provenance.
- _5 value "Furthermore, activated Rac and Cdc42, but again not Rho, are capable of inducing cyclin D1 accumulation and pRB hyperphosphorylation in serum-deprived cells, outlining one route leading to enhanced E2F-mediated transcription." provenance.
- _6 value "Here we show that HMG-1 and the highly related HMG-2 stimulate DNA binding by other steroid receptors, including estrogen, androgen, and glucocorticoid receptors" provenance.
- _6 value "HBP1 inhibited transcriptional activation by the MyoD family members. The inhibition of MyoD family function by HBP1 required binding to RB and/or p130. HBP1 probably blocked differentiation by disrupting Myf5 function, thus preventing expression of MyoD and myogenin." provenance.
- _4 value "From mutations file" provenance.
- _4 value "ET-1 enhanced VEGF mRNA expression and stimulated VEGF secretion. ET-1-induced VEGF mRNA expression was abolished by a selective ET(A) receptor antagonist, BQ-485, but not by an ET(B)-selective blocker, BQ-788" provenance.
- _5 value "Using GST-Rb pull down assay and mammalian two-hybrid system, we report here that Rb can bind specifically to AR in an androgen-independent manner. Transient transfection assay demonstrates that cotransfection of AR and Rb can further induce AR transcriptional activity 4-fold in the presence of 1 nM dihydrotestosterone in DU145 cells." provenance.
- _3 value "ApoE also inhibited PDGF-induced cyclin D1 mRNA expression, suggesting that the apoE effect was mediated by growth arrest at the G0 to G1 phase." provenance.
- _3 value "50 ng/ml of TNFalpha induced phosphorylation of DAG and ceramide using [gamma p<sup>32</sup>] ATP as substrate. The contents of DAG were much higher than ceramide. There was a time-dependent increase in the production of ceramide with a 3-fold increase after 45 min of TNFalpha treatment." provenance.
- _4 value "Pretreatment of Jurkat T-cells with 8-bromo cAMP (8-Br-cAMP) or prostaglandin E2 increased PDE3 and PDE4 activity" provenance.
- _4 value "Transcription of the sodium/myo-inositol cotransporter gene is markedly stimulated in response to hypertonicity, leading to an increase in the activity of the cotransporter, which in turn drives the osmoprotective accumulation of myo-inositol." provenance.
- _3 value "Transcription of the sodium/myo-inositol cotransporter gene is markedly stimulated in response to hypertonicity, leading to an increase in the activity of the cotransporter, which in turn drives the osmoprotective accumulation of myo-inositol." provenance.
- _4 value "Non-confluent HT29 cells over-expressing p27Kip1 are also more resistant to doxorubicin, etoposide and 5-fluorouracil. Our results suggest that p27Kip1 contributes to the confluence-dependent resistance phenotype. " provenance.
- _5 value "A combination of fusion gene and protein-binding analyses revealed that the accessory factor binding region A is hepatocyte nuclear factor-1." provenance.
- _6 value "A combination of fusion gene and protein-binding analyses revealed that the accessory factor binding region A is hepatocyte nuclear factor-1." provenance.
- _6 value "A combination of fusion gene and protein-binding analyses revealed that the accessory factor binding region A is hepatocyte nuclear factor-1." provenance.
- _5 value "A combination of fusion gene and protein-binding analyses revealed that the accessory factor binding region A is hepatocyte nuclear factor-1." provenance.
- _5 value "Transcription of the gene encoding the glucose-6-phosphatase catalytic subunit (G6Pase) is stimulated by cAMP and glucocorticoids whereas insulin strongly inhibits both this induction and basal G6Pase gene transcription." provenance.
- _4 value "Transcription of the gene encoding the glucose-6-phosphatase catalytic subunit (G6Pase) is stimulated by cAMP and glucocorticoids whereas insulin strongly inhibits both this induction and basal G6Pase gene transcription." provenance.
- _5 value "We show herein that recombinant IKK-alpha and IKK-beta can, in fact, directly phosphorylate IkappaB alpha at Ser-32 and Ser-36, as well as homologous residues in IkappaB beta in vitro, and thus are bona fide IkappaB kinases. " provenance.
- _4 value "TNFA induces threonine and tyrosine phosphorylation of p38 MAP kinase(MAPK14), Erk (p42/ p44 MAP kinase), and JNK(MAPK8)." provenance.
- _4 value "These data show that the exogenous overexpression of the c-erbB-2 gene in hormone-dependent breast cancer cells inhibits proliferation and induces differentiation." provenance.
- _2 value "In HL60 cells, other cAMP-eliciting reagents (8-bromo-cAMP, Sp-cAMP and forskolin) also inhibited apoptosis" provenance.
- _2 value "PDE4 specific inhibitors (rolipram and RO-20-1724) promoted apoptosis within 5 h." provenance.
- _3 value "As shown in Tables 1 and 2, changes in environmental temperature (42, 58, and O Boss, H Ghezraoui, J Seydoux, J-P Giacobino & P Muzzin P, unpublished observations), variations in food intake (41, 42, and I Cusin, K E Zakrzewska, O Boss, P Muzzin, J P Giacobino, D Ricquier, B Jeanrenaud & F Rohner-Jeanrenaud, unpublished observations), and administration of T3 (41, 58) or glucocorticoids (41) affect identically UCP3 and UCP1 mRNA expressions in BAT. One exception is the absence of effect of the b3-adrenergic agonist CL 316,243 on UCP3 mRNA expression in BAT reported by Gong et al. (41)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "we demonstrate that overexpression of IRF-3 significantly enhances virus-mediated transcription of the IFNA and IFNB genes in infected cells as well as IFN synthesis" provenance.
- _3 value "AICAR was also found to inhibit activation of the L-PK gene promoter by glucose in transiently transfected hepatoma cells." provenance.
- _3 value "At a concentration which induces phosphorylation-dependent inactivation of HMG-CoA reductase, AICAR blocked glucose activation of three glucose responsive genes, namely L-type pyruvate kinase (L-PK), Spot 14 and fatty acid synthase genes in primary cultured hepatocytes" provenance.
- _3 value "At a concentration which induces phosphorylation-dependent inactivation of HMG-CoA reductase, AICAR blocked glucose activation of three glucose responsive genes, namely L-type pyruvate kinase (L-PK), Spot 14 and fatty acid synthase genes in primary cultured hepatocytes" provenance.
- _6 value "CREG was shown to inhibit activation by E2F. Since both the adenovirus E1A protein and transcriptional activation by E2F" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Neutralizing anti-neuropilin-1 blocked the repellant influence of E12 arch Ib in the presence of NT-4/5 (Fig. 3 F ) or in its absence (Fig. 3 G )." provenance.
- _3 value "USF Interacts at the Minimal Promoter E Box Element...alpha USF-1 and alpha USF-2 antibodies were used in supershift assays. Both antibodies were able to supershift the DNA-protein complexes to similar degrees" provenance.
- _3 value "More important as a cause of respiratory chain dysfunction is a de�ciency of the adenine nucleotide translocator (ANT). This has been described in one child with mitochondrial myopathy, and has been attributed to a speci�c defect of the muscle/heart subunit ANT1 [25]. The lack of cardiac symptoms in that child at age 8 is a little surprising, because a `knockout' mouse de�cient in ANT1 showed not only mitochondrial myopathy but also hypertrophic cardiomyopathy with mitochondrial proliferation [26]." provenance.
- _3 value "More important as a cause of respiratory chain dysfunction is a de�ciency of the adenine nucleotide translocator (ANT). This has been described in one child with mitochondrial myopathy, and has been attributed to a speci�c defect of the muscle/heart subunit ANT1 [25]. The lack of cardiac symptoms in that child at age 8 is a little surprising, because a `knockout' mouse de�cient in ANT1 showed not only mitochondrial myopathy but also hypertrophic cardiomyopathy with mitochondrial proliferation [26]." provenance.
- _4 value "The signalling inhibitors rapamycin and wortmannin blocked the phosphorylation of 4E-BP1 and abolished the translational component of the c-myc response. " provenance.
- _3 value "MRP14 (Macrophage migration inhibitory related protein) and MRP8, two S-100 proteins contained in high concentrations in these cells are obviously essential for adhesion and migration of monocytes and granulocytes." provenance.
- _3 value "Histamine significantly stimulated the TPA-induced HGF production and release in these cells, depending on incubation time and its dose." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "PC-12 cells showed induction of TGF-beta1 5 hours after treatment with NGF." provenance.
- _6 value "ANPK is a nuclear protein that is widely expressed in mammalian tissues. Its overexpression enhances AR-dependent transcription in various cell lines." provenance.
- _3 value "Eight mRNAs were overexpressed in ob/ob muscle: Id2 (a negative regulator of the basic helix-loop-helix family of transcription factors), fast skeletal muscle troponin T, ribosomal protein L3, the integral protein of the peroxisomal membrane 22PMP, the mammalian homolog of geranylgeranyl pyrophosphate synthase, an mRNA related to phosphatidylinositol-glycan-specific phospholipase D, and two unknown mRNAs." provenance.