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- _5 value "IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3 hours of cytokine stimulation. IL1 treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1." provenance.
- _5 wasQuotedFrom 9664071 provenance.