Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence RANKL-mediated+osteoclast+differentiation+and+signaling+is+dependent+upon+the+interaction+between+TAB2%2FTAB3+and+TAK1. assertion.
- assertion asSentence Tumor+progression+locus+2+%28Tpl2%29+is+an+important+mediator+for+collaboration+of+pattern+recognition+receptors+with+danger-associated+molecular+patterns+to+induce+tumor+necrosis+factor+%28TNF%29+and+interleukin+%28IL%29-1beta+production+and+optimal+host+defense. assertion.
- assertion asSentence Cbl+is+not+required+for+ERK1%2F2-dependent+Bim%28EL%29+turnover+in+fibroblasts+and+epithelial+cells. assertion.
- assertion asSentence PAK1+signals+via+ERK1%2F2+to+regulate+lamellipodial+stability. assertion.
- assertion asSentence Sphingosine-1-phosphate+inhibits+high+glucose-mediated+ERK1%2F2+action+in+endothelium+through+induction+of+MAP+kinase+phosphatase-3. assertion.
- assertion asSentence gp96+interacts+with+PP5+and+controls+TLR2-mediated+induction+of+ERK1%2F2+in+post-hypoxic+renal+tubule+cells. assertion.
- assertion asSentence Leptin+has+a+positive+short-term+effect+on+the+regulation+of+OB-Rb+mRNA+in+C2C12+cells%2C+involving+both+Sam68+and+ERKs. assertion.
- assertion asSentence Interleukin+17+inhibits+myogenic+and+promotes+osteogenic+differentiation+of+C2C12+myoblasts+by+activating+ERK1%2C2+mitogen+activated+protein+kinase+signaling. assertion.
- assertion asSentence MAP+kinase+p38+alpha+is+not+an+essential+component+of+signaling+pathways+required+for+robust+B+and+T+lymphocyte+development%2C+nor+is+MAP+kinase+p38+alpha+essential+for+the+proliferation+of+mature+B+and+T+cells. assertion.
- assertion asSentence Kringle+domain+of+uPA+induces+smooth+muscle+cell+migration+through+a+G-protein-coupled+PI3-K-dependent+process+involving+both+ERK+1%2F2+and+p38%28MAPK%29+and+is+mediated+in+part+through+EGFR. assertion.
- assertion asSentence Oxidative+stress+activates+ADAM17%2FTACE+and+induces+its+target+receptor+shedding+in+platelets+in+a+p38-dependent+fashion. assertion.
- assertion asSentence A%282A%29Rs+play+a+crucial+role+in+the+development+of+Abeta-induced+synaptotoxicity+leading+to+memory+dysfunction+through+a+p38+MAPK+%28mitogen-activated+protein+kinase%29-dependent+pathway. assertion.
- assertion asSentence Activation+of+distinct+p38MAPK+isoforms+is+regulated+by+the+selective+and+synchronized+action+of+two+kinases%2C+MKK3+and+MKK6%2C+in+response+to+cell+stress. assertion.
- assertion asSentence Ceramide+1-phosphate+stimulation+of+macrophage+proliferation+involves+ERK1+activation. assertion.
- assertion asSentence A+function+of+p44%2F42+MAPK+for+adrenal+growth+and+a+role+of+p44%2F42+MAPK+for+the+integration+of+different+endocrine+stimuli. assertion.
- assertion asSentence The+beta-arrestin+1-dependent+ERK1%2F2+activation+engaged+by+GLP-1+mediates+the+Ser-112+phosphorylation+of+Bad. assertion.
- assertion asSentence Complement+C5b-9+induce+a+JNK%2FBid-dependent+and+JNK-independent+necrotic+cell+death. assertion.
- assertion asSentence Fibromodulin+suppresses+nuclear+factor-kappaB+activity+by+inducing+the+delayed+degradation+of+IKBA+via+a+JNK-dependent+pathway+coupled+to+fibroblast+apoptosis. assertion.
- assertion asSentence Osteoclastic+protein-tyrosine+phosphatase+%28PTP-oc%29+activates+osteoclast+activity+in+part+by+promoting+osteoclast+survival+through+the+PTP-oc-mediated+c-Src-dependent+activation+of+NFkappaB+and+JNK2. assertion.
- assertion asSentence JNK2+prevents+replicative+stress+by+coordinating+cell+cycle+progression+and+DNA+damage+repair+mechanisms. assertion.
- assertion asSentence SF-1+and+AP-1+cooperate+to+activate+CYP11A1+transcription+in+vitro+and+in+vivo. assertion.
- assertion asSentence Inhibition+of+SF-1-mediated+transcription+by+SUMOylation+in+adrenocortical+cancer+cells+is+mediated+through+reduced+CDK7-induced+phosphorylation+of+SF-1. assertion.
- assertion asSentence Liver+receptor+homolog-1+is+critical+for+adequate+up-regulation+of+Cyp7a1+gene+transcription+and+bile+salt+synthesis+during+bile+salt+sequestration. assertion.
- assertion asSentence OASIS+regulates+skeletal+development+by+osteoblast-dependent+and+-independent+mechanisms. assertion.
- assertion asSentence Lysyl+hydroxylase-2b+directs+collagen+cross-linking+pathways+through+its+action+on+telopeptidyl+lysine+residues. assertion.
- assertion asSentence Abnormal+expression+of+PrPLP%2Fdoppel+in+PrP-knockout+mice+is+caused+by+functional+dissociation+between+the+pre-mRNA+machineries%2C+in+particular+those+of+cleavage%2Fpolyadenylation+and+splicing. assertion.
- assertion asSentence Stimulation+of+fatty+uptake+by+isoproterenol+required+both+protein+kinase+A+and+mitogen-activated+kinase+signaling+and+is+completely+dependent+on+FATP1+expression. assertion.
- assertion asSentence sPLA2-X+induces+potent+arachidonic+acid+release+without+activation+of+cytosolic+phospholipase+A2+alpha. assertion.
- assertion asSentence Jab1+overexpression+contributes+to+pancreatic+cancer+cell+proliferation+and+survival. assertion.
- assertion asSentence Adh4+metabolizes+the+omega-oxidation+of+20-HETE+in+cerebral+microvascular+smooth+muscle+and+endothelium. assertion.
- assertion asSentence Functions+in+mutation+avoidance+and+is+essential+for+male+and+female+meiosis. assertion.
- assertion asSentence NHERF-1+uniquely+transduces+the+cAMP+signals+that+inhibit+sodium-hydrogen+exchange+in+renal+apical+membranes. assertion.
- assertion asSentence TRIM24+regulates+AR-mediated+transcription+in+collaboration+with+TIP60+and+BRD7. assertion.
- assertion asSentence NKG2D+recognition+by+natural+killer+cells+is+crucial+for+their+ability+to+limit+tumor+metastases+in+vivo+in+both+liver+and+lungs+using+perforin-dependent+effector+mechanisms. assertion.
- assertion asSentence The+two+CAPS+family+proteins+are+complementarily+distributed+throughout+the+various+brain+regions+of+mice. assertion.
- assertion asSentence GCN2+acts+as+a+molecular+sensor+in+T+cells%2C+allowing+them+to+detect+and+respond+to+conditions+created+by+indoleamine+2%2C3-dioxygenase. assertion.
- assertion asSentence SLAM%2FSLAM+interactions+inhibit+CD40-induced+signal+transduction+in+monocyte-derived+dendritic+cells. assertion.
- assertion asSentence Prmt5+acts+as+a+coactivator+for+the+activation+of+adipogenic+gene+expression+and+promotes+adipogenic+differentiation. assertion.
- assertion asSentence Skp2+plays+an+essential+role+in+adipogenesis+in+mouse+embryonic+fibroblasts+in+a+manner+that+is+at+least+in+part+independent+of+regulation+of+p27%28Kip1%29+expression. assertion.
- assertion asSentence S-phase+kinase-associated+protein-2+%28Skp2%29+promotes+vascular+smooth+muscle+cell+proliferation+and+neointima+formation+in+vivo. assertion.
- assertion asSentence A+previously+unrecognized+role+for+SKP2+in+regulating+HSC+and+progenitor+expansion+and+hematopoietic+regeneration+after+stress. assertion.
- assertion asSentence Deletion+of+AMPKalpha2+through+p52-Skp2-mediated+ubiquitination+%26+degradation+of+p27%28Kip1%29+accentuates+neointimal+hyperplasia+in+response+to+wire+injury. assertion.
- assertion asSentence G5+and+G8+are+sufficient+for+reconstitution+of+sterol+transfer+activity+in+vitro+and+provide+the+first+demonstration+that+sterols+are+direct+transport+substrates+of+the+G5+and+G8+heterodimer. assertion.
- assertion asSentence Hepatic+expression+of+BSEP+mRNA+decreased+after+transplantation. assertion.
- assertion asSentence Homo-oligomerization+of+p80-Amot+and+hetero-oligomerization+of+both+isoforms+are+critical+for+a+switch+between+a+migratory+and+a+non-migratory+cell+phenotype+in+endothelial+cells. assertion.
- assertion asSentence The+genetic+basis+for+resistance+to+anticoagulants+lies+in+mutations+in+Vkorc1. assertion.
- assertion asSentence ILEI+requires+cooperation+with+oncogenic+Ras+to+govern+hepatocellular+EMT+through+mechanisms+involving+PDGF-R%2Fbeta-catenin+and+PDGF-R%2FStat3+signaling. assertion.
- assertion asSentence Glutathione+plays+a+physiologically+relevant+role+in+the+regulation+of+TRPM2+currents+in+hippocampal+pyramidal+neurons. assertion.
- assertion asSentence Iqgap1+modulates+activation+of+B-RAf. assertion.
- assertion asSentence Loss+of+the+melanopsin+gene+causes+significant+attenuation+of+the+diurnal+variation+in+cone+vision. assertion.
- assertion asSentence An+immune+response-suppressing+isoform+of+Ly108+can+regulate+the+pathogenesis+of+lupus. assertion.
- assertion asSentence RP58+controls+cell+division+of+progenitor+cells+and+regulates+the+survival+of+postmitotic+cortical+neurons. assertion.
- assertion asSentence Cerebellothalamocortical+pathway+abnormalities+in+torsinA+DYT1+knock-in+mice. assertion.
- assertion asSentence The+disease+causing+torsinA-DeltaE+mutation+promotes+an+association+between+torA+and+SUN1+that+is+distinct+to+the+interaction+between+LAP1+and+ATP-bound+torA. assertion.
- assertion asSentence Mammary+specific+deletion+of+Bin1+cooperates+with+carcinogen-induced+ras+activation+to+drive+mammary+tumor+progression%2C+establishing+a+role+for+Bin1+as+a+negative+modifier+of+oncogenicity+and+progression+in+breast+cancer. assertion.
- assertion asSentence Once+activated%2C+p110gamma+promotes+inside-out+activation+of+a+single+integrin%2C+alpha4beta1%2C+causing+myeloid+cell+invasion+into+tumors. assertion.
- assertion asSentence Nox4+acts+as+a+switch+between+differentiation+and+proliferation+in+preadipocytes. assertion.
- assertion asSentence Hepatocyte+proliferation+in+vivo+requires+either+glutathione+%28GSH%29+or+at+least+one+functional+allele+of+txnrd1%2C+demonstrating+that+either+the+GSH-+or+the+TrxR1-dependent+redox+pathway+can+independently+support+hepatocyte+proliferation+during+liver+growth. assertion.
- assertion asSentence Attenuated+circadian+rhythms+in+mice+lacking+the+prokineticin+2+gene. assertion.
- assertion asSentence Corin+plays+a+critical+role+in+specifying+coat+color+and+acts+downstream+of+agouti+gene+expression+as+a+suppressor+of+the+agouti+pathway. assertion.
- assertion asSentence Six-bladed+beta+propeller+crystal+structure+of+the+Kelch%2FDGR+and+CTR+domains+of+mouse+Keap1+provides+a+structural+basis+for+the+loss+of+Keap1+function+and+gain+of+Nrf2+function. assertion.
- assertion asSentence Parkin+gene+silencing+alters+behavior+and+dopamine+neurotransmission. assertion.
- assertion asSentence Parkin+regulates+degradation+of+outer+and+inner+mitochondrial+membrane+proteins+differently+through+proteasome-+and+mitophagy-dependent+pathways. assertion.
- assertion asSentence Reduction+of+70%25+of+the+plasma+membrane-associated+sialidase+Neu3+activity+caused+neurite+elongation+in+Neuro2a+murine+neuroblastoma+cells. assertion.
- assertion asSentence Grb14+is+a+normal+physiological+modulator+of+CNG+channel+function+in+vivo. assertion.
- assertion asSentence Memory%2Feffector+%28CD45RB%28lo%29%29+CD4+T+cells+are+controlled+directly+by+IL-10+and+cause+IL-22-dependent+intestinal+pathology. assertion.
- assertion asSentence IL-22+as+a+critical+regulator+of+tissue+sensitivity+to+GVHD+and+a+protective+factor+for+intestinal+stem+cells+during+inflammatory+intestinal+damage. assertion.
- assertion asSentence Knockdown+of+PP2A+inhibits+forskolin-induced+nuclear+translocation+of+HDAC4+and+attenuates+the+ability+of+this+signaling+molecule+to+repress+collagen+X+expression+in+chondrocytes. assertion.
- assertion asSentence The+TLR3-TRIF+mediated+antiviral+response+is+important+for+protection+against+poliovirus+infection+in+poliovirus+receptor+transgenic+mice. assertion.
- assertion asSentence mitoNEET+is+located+in+mitochondrial+fraction+of+adipocytes. assertion.
- assertion asSentence Hap1+interacts+with+Ahi1+to+regulate+cerebellar+and+brainstem+development+in+mice. assertion.
- assertion asSentence The+inhibitory+effect+of+gangliosides+is+mediated+by+at+least+one+mechanism+that+is+distinct+from+any+effect+on+the+binding+of+flagellin+to+TLR5. assertion.
- assertion asSentence DUOX2+plays+pivotal+roles+in+TLR5-dependent+inflammatory+response+of+nasal+airway+epithelium. assertion.
- assertion asSentence Tuba8+is+expressed+at+low+levels+in+the+developing+mouse+brain. assertion.
- assertion asSentence Loss+of+Wip1+sensitizes+cells+to+stress-+and+DNA+damage-induced+apoptosis. assertion.
- assertion asSentence Duodenal+epithelial+and+erythroid+precursor+cells+utilize+an+alternative+upstream+promoter+to+express+a+Ferroportin+transcript+which+lacks+the+Iron-Regulatory+Proteins+and+is+not+repressed+in+iron-deficient+conditions. assertion.
- assertion asSentence Polm+is+required+for+hematopoietic+development+with+an+role+in+maintaining+genetic+stability+in+hematopoietic+and+non-hematopoietic+tissues. assertion.
- assertion asSentence IRF3+plays+an+essential+role+in+allergic+airway+sensitization+to+house+dust+mites. assertion.
- assertion asSentence Plays+a+role+during+the+fusion+events+that+occur+during+development+of+the+lip+and+palate. assertion.
- assertion asSentence ICOS+costimulation+is+crucial+for+protective+immunity+against+oral+infection+with+the+intracellular+bacterium+Listeria+monocytogenes. assertion.
- assertion asSentence ICOS-B7h+pathway+is+critical+in+the+activation+of+effector%2Fmemory+T+cells+that+are+necessary+for+the+progression+of+chronic+rejection. assertion.
- assertion asSentence Important+roles+of+sGC+in+stimulating+platelet+activation+and+in+vivo+thrombosis+and+hemostasis. assertion.
- assertion asSentence HILS1+is+implicated+in+chromatin+remodeling+during+mammalian+spermiogenesis. assertion.
- assertion asSentence Sex-specific+promoters+control+Dnmt3L+expression+in+the+mouse+germ+line%2C+mirroring+the+situation+at+the+Dnmt1+and+Dnmt3A+loci. assertion.
- assertion asSentence NFAT5+is+important+for+cell+growth+in+vivo+and+within+the+context+of+an+isosmotic+environment+plays+a+role+in+optimally+coordinating+transcriptional+programs+in+response+to+osmotic+stresses+to+which+cells+are+normally+exposed+in+vivo+during+cell+growth. assertion.
- assertion asSentence Laminin+alpha4+%28Lama4%29+regulates+tip+cell+numbers+and+vascular+density+by+inducing+endothelial+Dll4%2FNotch+signalling+in+vivo. assertion.
- assertion asSentence Anti-Dll4+treatment+reverses+established+type+1+diabetes+%28T1D%29and+fully+prevents+T1D+via+a+T%28reg%29+cell-mediated+mechanism+and+inhibits+CD8%28%2B%29+T+cell+pancreatic+islet+infiltration. assertion.
- assertion asSentence Syt+VII+regulates+perforin-mediated+cytolytic+CTL+responses. assertion.
- assertion asSentence Synaptotagmin-7+is+a+principal+Ca%282%2B%29+sensor+for+glucagon+secretion+by+pancreatic+alpha+cells. assertion.
- assertion asSentence The+Syt7+C2B+domain+structure+is+very+similar+to+that+of+the+Syt1+C2B+domain+and+contains+three+Ca2%2B-binding+sites. assertion.
- assertion asSentence Role+for+PDGF-C+in+bleomycin-induced+pulmonary+fibrosis. assertion.
- assertion asSentence PDGF-C+is+activated+during+lung+development+and+is+a+potent+growth+factor+for+mesenchymal+cells+in+vivo. assertion.
- assertion asSentence Fezl+functions+in+the+formation+of+subplate+neurons+and+thalamocortical+axons. assertion.
- assertion asSentence Tyk2+is+critical+for+optimal+IL-10-mediated+signaling+and+suppressor+function. assertion.
- assertion asSentence In+muscles+from+wild-type+mice+CaMKKalpha+increased+in+vivo+deoxyglucose+uptake+and+AMPKalpha1+and+-alpha2+activities+2.5-fold. assertion.
- assertion asSentence A+subset+of+dendritic+cells+expressing+CXCR5+migrate+rapidly+into+the+primary+lymphoid+follicles+from+the+marginal+zone+in+response+to+CXC+ligand+13+%28B+lymphocyte+chemoattractant%2C+CXCL13%29+via+a+B+cell-derived%2C+membrane+lymphotoxin-dependent+mechanism. assertion.
- assertion asSentence Pannexin+1+contributes+to+ATP+release+in+airway+epithelia. assertion.
- assertion asSentence Tight+regulation+of+WAP+gene+expression+parallels+variations+in+the+chromatin+structure+and+DNA+methylation+profile+throughout+the+Ramp3-WAP-Tbrg4+locus. assertion.
- assertion asSentence Regulation+of+the+mutually+exclusive+exons+8a+and+8+in+the+CaV1.2+calcium+channel+transcript+by+polypyrimidine+tract-binding+protein. assertion.
- assertion asSentence Autophagy+also+plays+an+essential+role+in+tumorigenesis%2C+as+the+essential+autophagy+regulator+Becn1+is+monoallelically+deleted. assertion.