Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Histopathologic analysis of Casp8 (-/-) embryos revealed marked abdominal hyperemia with erythrocytosis (polycythemia) in the liver" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "In vitro substrates included the translation repressor PHAS-I and the p53 protein. ATM phosphorylated p53 in vitro on a single residue, serine-15, which is phosphorylated in vivo in response to DNA damage" provenance.
- _7 value "we found increased activity of endogenous Rap1 in NIH3T3 cells after stimulation with the neuropeptide growth factor bombesin in a concentration- and time-dependent manner. The activity of endogenous Ras was unaffected However, MAPK/Erk-phosphorylation and the proliferation rate was increased" provenance.
- _4 value "Modified assertion" provenance.
- _6 value "We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12, IFN-gamma and IFN-alpha. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A" provenance.
- _3 value "PGE2, as the main renotubular PG, and PGI2, as the main endothelial prostanoid, both stimulate renin secretion and renin gene expression by activating cAMP formation in JG cells." provenance.
- _4 value "We investigated the role of both cyclic strain and shear stresses in initiating the cellular signaling on cultured VSMCs and found that mechanical forces evoked activation of mitogen-activated protein kinases, followed by enhanced DNA binding activity of transcription factor AP-1. Physical forces rapidly induced phosphorylation of platelet-derived growth factor receptor (PDGFR) alpha, an activated state" provenance.
- _4 value "The PI3K inhibitors wortmannin and LY294002 inhibit the PDGF-induced phosphorylation of IRS-1, whereas the MEK inhibitor PD98059 was without a major effect. PDGF pretreatment for 60-90 min led to a marked 80-90% reduction in insulin stimulatable phosphotyrosine and IRS-1-associated PI3K activity." provenance.
- _5 value "MEF2 and Oct-1 transcription factors bind to the same A/T-rich element. A mutation that blocks this binding markedly reduces gene activation in vivo and in vitro, and overexpression of MEF2A, MEF2C, and MEF2D in noncardiac cells transactivates the cardiac troponin I promoter" provenance.
- _5 value "Overexpression of GATA family members transactivates the cardiac troponin I promoter, and GATA-5 and GATA-6 are stronger transactivators than GATA-4, a property apparently unique to the cardiac troponin I promoter" provenance.
- _5 value "Overexpression of GATA family members transactivates the cardiac troponin I promoter, and GATA-5 and GATA-6 are stronger transactivators than GATA-4, a property apparently unique to the cardiac troponin I promoter" provenance.
- _4 value "Binding of HT29 cells to laminin coated plastic induced tyrosine phosphorylation of FAK." provenance.
- _5 value "Modified assertion" provenance.
- _8 value "PDK1 phosphorylated the activation loop sites of PKCzeta and PKCdelta in vitro and in a phosphoinositide 3-kinase (PI 3-kinase)-dependent manner in vivo in human embryonic kidney (293) cells." provenance.
- _6 value "PDK1 phosphorylated the activation loop sites of PKCzeta and PKCdelta in vitro and in a phosphoinositide 3-kinase (PI 3-kinase)-dependent manner in vivo in human embryonic kidney (293) cells." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _7 value "The homophilic interaction of Cdc42 and Rac2, but not RhoA, in the GTP-bound state, caused a significant stimulation of the intrinsic GTPase activity" provenance.
- _5 value "In vitro, tyrosine phosphorylation of cortactin occurs specifically within the region between the proline-rich sequence and the Src homology 3 domain. Among the nine tyrosine residues in this region, mutations at Tyr421, Tyr466, and Tyr482 significantly reduced Src-meditated tyrosine phosphorylation both in vitro and in vivo." provenance.
- _3 value "Thus, TIEG2, together with TIEG1, defines a new subfamily of TGF-beta-inducible Sp1-like proteins involvedin the regulation of cell growth." provenance.
- _7 value "Recent studies have also suggested a regulatory role for this protein in controlling the activity of cytoplasmic protein complexes, including the proteasome [multicatalytic proteinase (MCP)] and the glucocorticoid and androgen receptors. Binding of IDE to these complexes increases their activity, whereas the addition of substrates for IDE inhibits activity." provenance.
- _7 value "Recent studies have also suggested a regulatory role for this protein in controlling the activity of cytoplasmic protein complexes, including the proteasome [multicatalytic proteinase (MCP)] and the glucocorticoid and androgen receptors. Binding of IDE to these complexes increases their activity, whereas the addition of substrates for IDE inhibits activity." provenance.
- _4 value "The ubiquitous subunits IV, Va, Vb, VIb, VIc, VIIb, VIIc, and VIII (L) are detected in all the tissues, although the mRNA levels for the individual subunits vary in different tissues. transcription activity of the promoter in most of the ubiquitous genes is regulated by factors binding to the 5' upstream Sp1, NRF1, GABP (NRF2), and YY1 sites." provenance.
- _4 value "The ubiquitous subunits IV, Va, Vb, VIb, VIc, VIIb, VIIc, and VIII (L) are detected in all the tissues, although the mRNA levels for the individual subunits vary in different tissues. transcription activity of the promoter in most of the ubiquitous genes is regulated by factors binding to the 5' upstream Sp1, NRF1, GABP (NRF2), and YY1 sites." provenance.
- _5 value "The ubiquitous subunits IV, Va, Vb, VIb, VIc, VIIb, VIIc, and VIII (L) are detected in all the tissues, although the mRNA levels for the individual subunits vary in different tissues. transcription activity of the promoter in most of the ubiquitous genes is regulated by factors binding to the 5' upstream Sp1, NRF1, GABP (NRF2), and YY1 sites." provenance.
- _5 value "The ubiquitous subunits IV, Va, Vb, VIb, VIc, VIIb, VIIc, and VIII (L) are detected in all the tissues, although the mRNA levels for the individual subunits vary in different tissues. transcription activity of the promoter in most of the ubiquitous genes is regulated by factors binding to the 5' upstream Sp1, NRF1, GABP (NRF2), and YY1 sites." provenance.
- _3 value "Smad3 mutant mice are viable and fertile. Between 4 and 6 months of age, the Smad3 mutant mice become moribund with colorectal adenocarcinomas. " provenance.
- _4 value "Moreover, IL-1beta and IFN-gamma synergistically increased the Abeta-induced expression of CD40 and IFN-gammaR." provenance.
- _4 value "Lymph node cells from mice immunized with MOG35-55 were harvested and stimulated in vitro with the peptide for 6 hours. The numbers of cells producing TNF-alpha was very high in IL-10-/- cells 6 h after stimulation with the peptide, whereas fewer Wild type cells secreted TNF. T cells derived from IL-10-/- mice produced a large amount of TNF-alpha. These results show that IL-10 plays a central role in down -regulating TNF-alpha production by autoreactive T cells." provenance.
- _4 value "However, our data further showed that IL-15 or IL-2 significantly increases the expression of CD40 Ag on purified monocytes (Fig. 3 D )." provenance.
- _5 value "We found that TNF-alpha enhances 5-HT uptake, with a doubling of the maximal velocity of uptake." provenance.
- _3 value "Hyperoxia induces a marked increase in RNA or protein levels of p53, bax, bcl-x, and Fas, which are known to be expressed in certain types of apoptosis" provenance.
- _4 value "OA induced downregulation of bcl-2 mRNA and protein prior to the induction of apoptosis OA caused a rapid" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "In this study, we investigated involvement of GRP78 in the mechanism of growth arrest by using human epidermoid carcinoma A431 cells. Under a chemical stress condition with 2-deoxyglucose, GRP78 was induced 3-4-fold." provenance.
- _6 value "Treatment of the GRP78-underglycosylated EGFR complex with ATP resulted in a release of the underglycosylated EGFR from GRP78, indicating that the complex could be formed through the chaperone function of GRP78. In accordance with the complex formation with endoplasmic reticulum-resident GRP78, the underglycosylated EGFR could not be translocated to the cell surface. As a result, EGF could not induce expression of cyclin D3, a G1 cyclin, in the stressed cells, whereas it did in non-stressed cells." provenance.
- _5 value "Within 30 min of treatment, TGF-beta induced translocation of MEF2, but not MyoD, myogenin, or p21, to the cytoplasm of myogenic cells grown to high density. Translocation was reversible on withdrawal of TGF-beta... Myogenic cells expressing the chimerical MEF2C/nlsSV40, but not wild-type MEF2C, retained this transcription factor in the nucleus and were resistant to the inhibitory action of TGF-beta." provenance.
- _2 value "serotonin has also been reported to function as a local antioxidant" provenance.
- _3 value "# Ariadne: There is evidence that glucagon (Torres et al. 1998 ) and glucocorticoids (Lee and Harper 1971 ) are important mediators of Hal gene expression. [Expression]" provenance.
- _6 value "Moreover, the mutationally activated Galpha12 and Galpha13 stimulated the kinase activity of ASK1" provenance.
- _3 value "Taken together, these data indicate that NO suppresses IL-1beta and IGIF processing by inhibiting caspase-1 activity, providing evidence for a unique role for induced NO in regulating IL-1beta and IGIF release." provenance.
- _3 value "IL-1beta rapidly activates the c-Jun NH2-terminal/stress-activated protein kinases (JNK/SAPK) and p38 mitogen-activated protein kinase (MAPK) and also induces Cox-2 expression and prostaglandin E2 (PGE2) production." provenance.
- _5 value "Here we show that EGF is a potent activator of Bmk1. In contrast to Erk1/2, EGF-mediated activation of Bmk1 occurs independently of Ras and requires the MAP-kinase kinase Mek5. Expression of a dominant-negative form of Bmk1 blocks EGF-induced cell proliferation and prevents cells from entering the S phase of the cell cycle." provenance.
- _3 value "phorbol ester, hBub1 expression in this cell line is down-regulated rapidly" provenance.
- _3 value "Modified assertion" provenance.
- _5 value "SPARC thus modulates the mitogenic activity of VEGF through a direct binding interaction and reduces the association of VEGF with its cell-surface receptors" provenance.
- _3 value "The levels of HNF1 and HNF4 mRNA were also decreased following RA treatment." provenance.
- _4 value "OSM induced TIMP-3 mRNA and protein expression in a dose- and time-dependent fashion. Concomitantly, stromelysin-1 and collagenase-1 RNA and activities were also induced" provenance.
- _4 value "OSM induced TIMP-3 mRNA and protein expression in a dose- and time-dependent fashion. Concomitantly, stromelysin-1 and collagenase-1 RNA and activities were also induced" provenance.
- _3 value "Both oxidized LDL and advanced glycation endproduct (AGE) activate endothelial cells with down-regulating thrombomodulin and tissue plasminogen activator(t-PA) expression." provenance.
- _4 value "Granulocyte macrophage colony stimulating factor, Granulocyte colony stimulating factor, Stem cell factor, Macrophage colony stimulating factor and IL11 was upregulated in cells treated with IL13." provenance.
- _5 value "# Ariadne: LyGDI/D4 has been reported to interact with RhoA, Cdc42Hs and Rac1, but not with Ras and Rap (Adra et al. , 1993 ; Scherle et al. , 1993 ). [Binding]" provenance.
- _6 value "Neutrophils contain a soluble guanine-nucleotidebinding protein, made up of two components with molecular masses of 23 and 26 kDa, that mediates stimulation of phospholipase C-beta2 (PLCbeta2). We have identified the two components of the stimulatory heterodimer by amino acid sequencing as a Rho GTPase and the Rho guanine nucleotide dissociation inhibitor LyGDI. Using recombinant Rho GTPases and LyGDI, we demonstrate that PLCbeta2 is stimulated by guanosine 5'-O-(3-thiotriphosphate) (GTP[S])-activated Cdc42HsxLyGDI, but not by RhoAxLyGDI. Stimulation of PLCbeta2, which was also observed for GTP[S]-activated recombinant Rac1, was independent of LyGDI, but required C-terminal processing of Cdc42Hs/Rac1. Cdc42Hs/Rac1 also stimulated PLCbeta2 in a system made up of purified recombinant proteins, suggesting that this function is mediated by direct protein-protein interaction." provenance.
- _4 value "Ectopic cdk3, but not cdk2, enhances Myc-induced proliferation and anchorage-independent growth associated with Myc activation, without effects on cyclin D1, E and A protein expression or kinase activities. " provenance.
- _6 value "Ectopic cdk3, but not cdk2, enhances Myc-induced proliferation and anchorage-independent growth associated with Myc activation, without effects on cyclin D1, E and A protein expression or kinase activities. " provenance.
- _3 value "IL-4 receptor protein expression by bronchial epithelial cells could be increased by stimulation with PMA+calcium ionophore, whereas IL-1beta and IL-6 decreased IL-4 receptor expression" provenance.
- _7 value "Moreover, exogenous BRCA2 expression in cancer cells inhibits p53's transcriptional activity, and RAD51 coexpression enhances BRCA2's inhibitory effects" provenance.
- _5 value "Functional data show that progestin pretreatment of breast cancer cells enhances the ability of prolactin to stimulate the transcriptional activity of Stat5 on a beta-casein promoter." provenance.
- _5 value "Functional data show that progestin pretreatment of breast cancer cells enhances the ability of prolactin to stimulate the transcriptional activity of Stat5 on a beta-casein promoter." provenance.
- _4 value "T47Dco cells were treated for 24 h with 10 nM R5020, then with 10 nM EGF for 5 min. EGF treatment alone promoted nuclear translocation of a portion of Stat5. R5020 not only increased total Stat5 levels but also promoted extensive nuclear translocation of Stat5 independent of EGF treatment." provenance.
- _5 value "We now show that progestin treatment of breast cancer cells regulates Stat5a and 5b, Stat3, and Stat1 protein levels in a PR-dependent manner. In addition, progestin treatment induces translocation of Stat5 into the nucleus, possibly mediated by the association of PR and Stat5." provenance.
- _5 value "We now show that progestin treatment of breast cancer cells regulates Stat5a and 5b, Stat3, and Stat1 protein levels in a PR-dependent manner. In addition, progestin treatment induces translocation of Stat5 into the nucleus, possibly mediated by the association of PR and Stat5." provenance.
- _4 value "We now show that progestin treatment of breast cancer cells regulates Stat5a and 5b, Stat3, and Stat1 protein levels in a PR-dependent manner. In addition, progestin treatment induces translocation of Stat5 into the nucleus, possibly mediated by the association of PR and Stat5." provenance.
- _7 value "MEKK1 interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro" provenance.
- _5 value "MEKK1 interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro" provenance.
- _4 value "MEKK1 is activated by TNF-alpha and in turn potentiate TNF-alpha induced NF-kappaB activation." provenance.
- _5 value "MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory effect of TNF-alpha on IKK and NF-kappaB activation" provenance.
- _6 value "Modified assertion" provenance.
- _4 value "The changes in TTF-1 inversely alter CaSR gene and calcitonin gene expression." provenance.
- _3 value "In non-pituitary cell lines, coexpression of ERF disrupts the cooperative interactions between Pit-1 and ETS-1 and blocks the induction of Pit-1-dependent prolactin promoter activity by cAMP." provenance.
- _5 value "Pak3 phosphorylates Raf-1 on serine 338 in vitro and in vivo. The p21-activated protein kinases are regulated by the Rho-family GTPases Rac and Cdc42." provenance.
- _5 value "JNKs are activated by phosphorylation on two critical residues, the threonine 183 and tyrosine 185, within the TPY motif. The activated JNKs, in turn, phosphorylate the nuclear protein c-Jun, a major component of the transcription factor AP1." provenance.
- _5 value "JNKs are activated by phosphorylation on two critical residues, the threonine 183 and tyrosine 185, within the TPY motif. The activated JNKs, in turn, phosphorylate the nuclear protein c-Jun, a major component of the transcription factor AP1." provenance.
- _5 value "JNKs are activated by phosphorylation on two critical residues, the threonine 183 and tyrosine 185, within the TPY motif. The activated JNKs, in turn, phosphorylate the nuclear protein c-Jun, a major component of the transcription factor AP1." provenance.
- _5 value "JNKs are activated by phosphorylation on two critical residues, the threonine 183 and tyrosine 185, within the TPY motif. The activated JNKs, in turn, phosphorylate the nuclear protein c-Jun, a major component of the transcription factor AP1." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell migration" provenance.
- _6 value "The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell migration" provenance.
- _4 value "In the cultured cells CD40L ligation showed increased expression of MHC class II molecules, costimulatory, and adhesion molecules namely HLA-DR, CD86, CD80, CD40, CD54 and CD14." provenance.
- _5 value "The addition of anti-calmodulin drugs to normal rat kidney cells in early G1 inhibited cyclin-dependent kinase 4 (Cdk4) and Cdk2 activities, as well as retinoblastoma protein phosphorylation." provenance.
- _6 value "The addition of anti-calmodulin drugs to normal rat kidney cells in early G1 inhibited cyclin-dependent kinase 4 (Cdk4) and Cdk2 activities, as well as retinoblastoma protein phosphorylation." provenance.
- _3 value "AA stimulated induction of MKP-1 mRNA and proteins in VSMCs in a time- and dose-dependent manner." provenance.
- _5 value "# Ariadne: Heme can be degraded by xanthine oxidase, hydrogen peroxides, and NADH- cytochrome P-450 reductase" provenance.
- _3 value "Nonetheless, both JNK1 and JNK3 were markedly, but transiently, induced at 48 h post-reoxygenation, when apoptosis-related morphological features became apparent. These data support the hypothesis that transient hypoxia, independently of ischemia, may trigger apoptosis through JNK signaling pathway in developing brain neurons" provenance.
- _4 value "These results indicate that, in the caspase family, the proteases with specificty similar to caspase 3, but not with caspase 1, were activated by X/XO. In addition, we showed that X/XO activated caspase 3 itself by Western blotting analysis (Figure 6b). X/XO induced the release of cytochrome c from mitochondria in a dose dependent fashion." provenance.
- _3 value "In this study, an analysis of mRNA expression showed that Hsp110 and Osp94, like Hsp70, are induced in renal murine inner medullary collecting duct (mIMCD3) epithelial cells by heat shock, hyperosmotic NaCl, and cadmium," provenance.
- _5 value "Additionally, Syk and Vav1 cooperatively induced activation of Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase 2 (ERK2) and the kinase Akt, and phosphorylation of the oncoprotein Cbl in fibrinogen-adherent cells." provenance.
- _6 value "Additionally, Syk and Vav1 cooperatively induced activation of Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase 2 (ERK2) and the kinase Akt, and phosphorylation of the oncoprotein Cbl in fibrinogen-adherent cells." provenance.
- _3 value "Furthermore, NPR-C and osteopontin mRNAs in mouse calvariae were significantly increased by administration of 1,25(OH)2D3, and immunohistological analysis demonstrated that NPR-C is actually and strongly expressed in mouse periosteal fibroblasts." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "We previously have described polyribosomal formation and protein synthesis in response to group I metabotropic glutamate receptor (mGluR) agonist administration to a synaptoneurosome preparation and have shown this to require receptor-coupled phospholipase C activation of protein kinase C (PKC) (23-25). We report here specific mechanisms that appear to link PKC activation to polyribosomal formation and protein synthesis. " provenance.
- _3 value "The production of TNF-alpha was inhibited by calcitriol in a dose-dependent manner [LPS + Vit.D3 100 ng, 2.9 +/- 2.1 in N, 3.7 +/- 1.9 in CRF and 3.4 +/- 1.7 in HD; LPS + Vit.D3 50 ng, 263 +/- 296 (N), 6.73 +/- 11 (CRF), 38 +/- 28 (HD); LPS + Vit.D3 25 ng = 873 +/- 583 (N), 325 +/- 483 (CRF), 588 +/- 507 (HD); LPS + Vit.D3 12.5 ng, 954 +/- 483 (N), 912 +/- 510 (CRF), 875 +/- 527 (HD)]." provenance.
- _3 value "Forskolin treatment induced haptoglobin mRNA levels" provenance.
- _4 value "EGF induced a 25 fold increase in phosphorylation of ERK1/2 at 5 min. The phosphorylation was transient and diminished after 20 min." provenance.
- _3 value "Monocyte CCR2 expression was dramatically increased in hypercholesterolemic patients compared with normocholesterolemic controls." provenance.
- _4 value "When the mice were challenged with a high cholesterol diet, cleavage of SREBP-1 and -2 was reduced in wild-type livers (cleavage increases activity)" provenance.
- _4 value "Consequently, p53CP might also bind to PCNA promoter sequences and thereby account for the greater mobility of complex C2 and repression of PCNA expression at later times postirradiation." provenance.
- _6 value "Following the initial description of p38 (p38a), three additional isoforms of this MAP kinase group have been cloned and characterized: p38b (18), p38g (also termed ERK6 or SAPK3) (22, 24, 30), and p38d (also termed SAPK4) (4, 17, 41). Two MAP kinase kinases (MKK), MKK3 and MKK6, are the upstream activators of the p38 group MAP kinases (6, 12, 14, 37)." provenance.
- _5 value "MEF2C phosphorylation by p38 was shown to play an important role in regulation of c-Jun expression in monocytic cells (10)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.