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- _4 value "Lymph node cells from mice immunized with MOG35-55 were harvested and stimulated in vitro with the peptide for 6 hours. The numbers of cells producing TNF-alpha was very high in IL-10-/- cells 6 h after stimulation with the peptide, whereas fewer Wild type cells secreted TNF. T cells derived from IL-10-/- mice produced a large amount of TNF-alpha. These results show that IL-10 plays a central role in down -regulating TNF-alpha production by autoreactive T cells." provenance.
- _4 wasQuotedFrom 9759845 provenance.