Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Up-regulated+in+pre-osteoclasts+during+cell+differentiation. assertion.
- assertion asSentence p8+negatively+regulates+the+myoblast+cell+cycle. assertion.
- assertion asSentence Txnip+is+a+critical+regulator+of+the+cardiac+response+to+pressure+overload. assertion.
- assertion asSentence Potassium+absorption+in+the+loop+of+Henle+is+reduced+in+Romk-deficient+mice+and+can+account+for+a+significant+fraction+of+renal+potassium+loss. assertion.
- assertion asSentence Microtubules+strongly+inhibit+actin+polymerization+by+mDia2. assertion.
- assertion asSentence BAF53+is+associated+with+mitotic+chromosomes+during+mitosis. assertion.
- assertion asSentence Foxo1+is+a+direct+and+functional+target+for+Sir2+in+mammalian+systems. assertion.
- assertion asSentence In+pancreatic+beta-cells%2C+the+FoxO%2FBcl6%2Fcyclin+D2+pathway+connects+nutrient+and+growth+factor+status+to+cell+cycle+control. assertion.
- assertion asSentence FoxO1+targeted+GRP78+gene+for+trans-activation+via+selective+binding+to+an+insulin+responsive+element+in+the+GRP78+promoter.FOXO1+links+hepatic+insulin+action+to+ER+stress. assertion.
- assertion asSentence Deletion+of+Foxo1+from+LepR-b+neurons+in+Lepr%28DeltaIrs2%29+mice+normalized+energy+balance. assertion.
- assertion asSentence PIAS1+promotes+TGFbeta-induced+activation+of+SM+alpha-actin+gene+expression+at+least+in+part+by+promoting+sumoylation+and+degradation+of+the+TCE+repressor+protein%2C+KLF4. assertion.
- assertion asSentence Mice+lacking+Tbk1+activity+exhibit+immune+cell+infiltrates+in+multiple+tissues+and+increased+susceptibility+to+LPS-induced+lethality. assertion.
- assertion asSentence p38+phosphorylation+of+FOXO3a+on+Ser-7+is+essential+for+its+nuclear+relocalization+in+response+to+doxorubicin. assertion.
- assertion asSentence MSK1+and+MSK2+are+required+for+the+mitogen-+and+stress-induced+phosphorylation+of+CREB+and+ATF1+in+fibroblasts. assertion.
- assertion asSentence GSK-3beta+functions+as+a+multifunctional+signaling+pathway+node. assertion.
- assertion asSentence Liver+ischemia+reperfusion+injury+activated+glycogen+synthase+kinase-3+beta+by+a+significant+decrease+of+its+phosphorylation. assertion.
- assertion asSentence Aldose+reductase+mediates+changes+in+GSK3B+phosphorylation+via+PKC%2FAkt+pathway+during+myocardial+ischemia-reperfusion+injury. assertion.
- assertion asSentence Redundant+functions+of+GSK-3alpha+and+GSK-3beta+through+phosphorylation+of+RelA+at+Thr-254+play+a+crucial+role+in+early+stages+of+chondrocyte+differentiation. assertion.
- assertion asSentence Ankrd2+plays+important+structural+and+gene+regulatory+roles+in+skeletal+muscle. assertion.
- assertion asSentence Dectin-1+signaling+increases+the+phagocytic+activity+of+neutrophils+through+upregulation+of+CD11b+expression. assertion.
- assertion asSentence Examination+of+lipoprotein+profiles+revealed+elevated+levels+of+circulating+high-density+lipoprotein+%28HDL%29+cholesterol+in+G2A-%2F-+LDLR-%2F-+mice+compared+with+their+G2A%2B%2F%2B+LDLR-%2F-+counterparts+after+extended+periods+of+diet+intervention. assertion.
- assertion asSentence The+mTOR-IGF-II+pathway+is+a+major+mediator+of+forkhead+box+protein+O1%27s+inhibitory+function+in+skeletal+myogenesis. assertion.
- assertion asSentence Changes+in+the+insulin%2Fmammalian+target+of+rapamycin+pathway+coincided+with+the+activation+of+autophagy+during+the+period+of+cone+death. assertion.
- assertion asSentence Suppression+of+mTOR+phosphorylation+is+a+necessary+requirement+for+OPG+production+in+bone+marrow+stromal+cells. assertion.
- assertion asSentence Inhibition+of+mTOR+signaling+in+Parkinson%27s+disease+prevents+L-DOPA-induced+dyskinesia. assertion.
- assertion asSentence The+CK2+phospho-dependent+interaction+between+TEL2+and+the+R2TP+complex+affects+phosphatidylinositol+3-kinase-related+kinase+functions+and+is+essential+for+mTOR+and+SMG1+stability+in+vivo. assertion.
- assertion asSentence Platelet+factor+4+regulates+megakaryopoiesis+through+low-density+lipoprotein+receptor-related+protein+1+%28LRP1%29+on+megakaryocytes. assertion.
- assertion asSentence During+the+first+postnatal+week%2C+the+RALDH3-expressing+territory+translocates+in+the+caudal+cortex+from+the+medial+limbic+lobe+to+the+adjacent+neocortex+and+requires+the+neurotrophin+NT-3. assertion.
- assertion asSentence During+development%2C+a+dynamic+pattern+of+GTF2IRD1+expression+is+found+predominantly+in+musculoskeletal+tissues%2C+the+pituitary%2C+craniofacial+tissues%2C+the+eyes+and+tooth+buds. assertion.
- assertion asSentence Hyperexcitability+and+epilepsy+associated+with+disruption+of+the+mouse+neuronal-specific+K-Cl+cotransporter+gene. assertion.
- assertion asSentence Kcc2+developmental+upregulation+is+dependent+on+the+presence+of+repressor+element-1. assertion.
- assertion asSentence Vav+guanine+nucleotide+exchange+factors+and+Rho+GTPases+are+required+in+FcgammaR-+and+complement-mediated+phagocytosis. assertion.
- assertion asSentence Despite+severe+weight+loss+and+significant+falls+in+leptin+expression+and+insulin+concentration%2C+resistin+gene+expression+appears+unchanged+in+white+adipose+tissue+of+mice+with+MAC16+tumour. assertion.
- assertion asSentence Both+DJ-1+protein+and+D2-dopamine+receptor+deletion+induce+a+rearrangement+in+the+high-voltage+activated+calcium+channel+profile%2C+specifically+involving+those+channels+that+are+selectively+modulated+by+D2+receptors. assertion.
- assertion asSentence Abnormal+junctional+membrane+structures+in+cardiac+myocytes+in+transgenic+mice+expressing+junctophilin+type+1. assertion.
- assertion asSentence Order-of-magnitude+higher+levels+of+chromosomal+alterations+are+sustained+in+primary+or+immortal+Xrcc2%28-%2F-%29+embryonic+fibroblasts. assertion.
- assertion asSentence The+mRNA+level+of+alpha%2Fbeta+hydrolase+1+%28ABHD1%29+is+significantly+upregulated+in+D5-%2F-+mice. assertion.
- assertion asSentence Exerts+a+significant+suppressor+function+in+the+development+of+prostatic+metastatic+disease. assertion.
- assertion asSentence ASK1+and+TAK1+function+as+MAP3+kinases+in+Cdo-mediated+p38MAPK+activation+to+promote+myogenic+differentiation. assertion.
- assertion asSentence Hypoxia%2Fischaemia+rapidly+increased+fiaf+mRNA+in+the+injured+cortex+and+hippocampus+at+2+and+7+days+after+hypoxia%2Fischaemia. assertion.
- assertion asSentence Double-positve+thymocyte+survival+by+BCL11B+is+nonredundant+and%2C+at+least+in+part%2C+independent+of+BCL2+prosurvival+factors. assertion.
- assertion asSentence The+Ca%28v%293.2+T-type+Ca%282%2B%29+channel+is+required+for+pressure+overload-induced+cardiac+hypertrophy+in+mice. assertion.
- assertion asSentence The+cytokine+leukemia+inhibitory+factor+%28LIF%29+promotes+the+trafficking+of+T-type+calcium+channels+in+human+HEK293+cells+via+transient+actiation+of+JAK-+and+ERK-kinase+signaling+pathways. assertion.
- assertion asSentence Shank+promotes+the+assembly+of+a+signaling+complex+at+corticostriatal+synapses+that+enables+key+GPCRs+to+regulate+L-type+Ca2%2B+channels+and+the+integration+of+glutamatergic+synaptic+events. assertion.
- assertion asSentence TRPM7+contributes+to+the+mechanism+by+which+hippocampal+neurons+%22detect%22+reductions+in+extracellular+divalents+and+provide+a+means+by+which+TRPM7+contributes+to+neuronal+death+during+transient+brain+ischemia. assertion.
- assertion asSentence Ghrelin+attenuates+glucose-induced+insulin+release+via+pertissigen-sensitive+Galpha%28i2%29-mediated+activation+of+potassium+channels. assertion.
- assertion asSentence Tropomyosin+3+expression+leads+to+hypercontractility+and+attenuates+myofilament+length-dependent+Ca%282%2B%29+activation. assertion.
- assertion asSentence IL-21R+controls+both+antigen+transport+by+DCs+and+the+crucial+beacon+function+of+CD4%28%2B%29+cells+for+autoreactive+CD8%28%2B%29+cells+to+reach+the+islets. assertion.
- assertion asSentence FADS3+does+exist+under+multiple+protein+isoforms+depending+on+the+mammalian+tissues. assertion.
- assertion asSentence Immunomodulatory+molecules+such+as+PD-L1+rather+than+Tregs+play+pivotal+roles+in+the+tissue-specific+regulation+of+alloresponses. assertion.
- assertion asSentence Ataxia+telangiectasia+mutated+and+Fanconi+anemia+genes+function+in+parallel+and+compensatory+roles+to+maintain+genomic+integrity+and+cell+viability. assertion.
- assertion asSentence Modulation+of+the+Ca2+permeable+cation+channel+TRPV4+by+cytochrome+P450+epoxygenases+in+vascular+endothelium. assertion.
- assertion asSentence Even+genetically+complex+leukemias+can+be+reversed+on+inactivation+of+the+initiating+MLL+fusion. assertion.
- assertion asSentence Overexpression+of+mPGES-1+promotes+gastric+carciniogenesis%2C+especially+in+the+fundic+region%2C+in+transgenic+mice+treated+with+methylnitrosourea. assertion.
- assertion asSentence A+tight+cooperation+between+the+EGF%2FEGFR+and+mPGES-1+leads+to+a+significant+tumorigenic+gain+in+epithelial+cells. assertion.
- assertion asSentence Sirt3+modulates+mitochondria+by+promoting+amino+acid+catabolism+and+beta-oxidation. assertion.
- assertion asSentence FGF-23+increases+urinary+and+renal+tubular+PGE2+production+via+the+MAP+kinase+pathway+and+PGE2+inhibits+proximal+tubule+phosphate+transport. assertion.
- assertion asSentence FGFR3+and+4+are+the+receptors+that+regulate+serum+1%2C25%28OH%29%282%29Vitamin+D%283%29+levels+in+response+to+FGF23. assertion.
- assertion asSentence Fibroblast+growth+factor-23-mediated+inhibition+of+renal+phosphate+transport+in+mice+requires+sodium-hydrogen+exchanger+regulatory+factor-1+%28NHERF-1%29+and+synergizes+with+parathyroid+hormone. assertion.
- assertion asSentence The+developmentally+regulated+expression+of+Twisted+gastrulation+reveals+a+role+for+bone+morphogenetic+proteins+in+the+control+of+T+cell+development. assertion.
- assertion asSentence Tbata+modulates+thymus+function+by+regulating+stromal+cell+proliferation+via+the+Nedd8+pathway. assertion.
- assertion asSentence NKG2D%2FRae1+interaction+is+involved+in+the+synergic+effects+of+NK+cells+and+Kupffer+cells+on+acute+liver+injury. assertion.
- assertion asSentence Cells+depleted+of+Arp2%2F3+complex+cannot+respond+to+a+surface-bound+gradient+of+extracellular+matrix+%28haptotaxis%29. assertion.
- assertion asSentence Two+highly+related+subunits+of+the+core+SWI%2FSNF+complex%2C+BAF60c1+and+BAF60c2%2C+interact+physically+with+retinoid+receptors+and+are+coactivators+for+retinoic+acid+receptors. assertion.
- assertion asSentence FANCL+increases+the+activity+and+expression+of+beta-catenin%2C+a+key+pluripotency+factor+in+hematopoietic+stem+cells. assertion.
- assertion asSentence The+presence+of+an+N-terminal+tag+on+dynein+light-chain+Roadblock%2FLC7+affects+its+interaction+with+a+functional+partner. assertion.
- assertion asSentence The+AlkB+domain+of+ALKBH8+specifically+hydroxylates+mcm%285%29U+into+%28S%29-mchm%285%29U+in+tRNA-Gly%28UCC%29. assertion.
- assertion asSentence SOCS+box+acts+as+an+independent+binding+domain+capable+of+recruiting+elonginBC+and+cullin5+to+promote+E3+ligase+formation. assertion.
- assertion asSentence The+murine+PRED28+encodes+two+alternatively+spliced+RNA. assertion.
- assertion asSentence The+RPL4+plays+an+important+role+in+c-myc+expression+by+interacting+with+c-Myb+in+response+to+growth+factor+and+nutritional+signals. assertion.
- assertion asSentence Overexpression+of+Nma%2FBAMBI+in+mouse+odontoblast-like+cell+line+MD10-A2+down-regulated+expression+of+DSPP+by+66%25+and+up-regulated+expression+of+DMP1+four-fold. assertion.
- assertion asSentence Ciz1+promotes+DNA+replication. assertion.
- assertion asSentence Regulation+of+cpg15+expression+during+single+whisker+experience+in+the+barrel+cortex+of+adult+mice. assertion.
- assertion asSentence Cthrc1+selectively+activates+the+planar+cell+polarity+pathway+of+Wnt+signaling+by+stabilizing+the+Wnt-receptor+complex. assertion.
- assertion asSentence MiR-23b+suppresses+IL-17-%2C+tumor+necrosis+factor+alpha+%28TNF-alpha%29-+or+IL-1beta-induced+NF-kappaB+activation+and+inflammatory+cytokine+expression+by+targeting+TAB2%2C+TAB3+and+IKK-alpha. assertion.
- assertion asSentence Hemojuvelin+is+essential+for+transferrin-dependent+and+transferrin-independent+hepcidin+expression+in+conditions+of+iron+overload. assertion.
- assertion asSentence Cellular+activities+of+DAPK+are+critical+for+antagonizing+caspase-dependent+apoptosis+to+promote+cell+survival+under+normal+cell+growth+conditions. assertion.
- assertion asSentence WNK4+reduces+transepithelial+resistance+by+increasing+absolute+chloride+permeability+at+tight+junctions. assertion.
- assertion asSentence KChIP1+is+a+synaptic+protein+that+regulates+behavioral+anxiety+by+modulating+inhibitory+synaptic+transmission. assertion.
- assertion asSentence Mice+deficient+in+LMAN1+exhibit+FV+and+FVIII+deficiencies+and+liver+accumulation+of+alpha1-antitrypsin. assertion.
- assertion asSentence The+C-terminal+domain+of+MUTYH+is+necessary+for+its+ability+to+prevent+OGG1+or+APEX1+from+inappropriately+processing+its+substrate. assertion.
- assertion asSentence Armcx+genes+regulate+mitochondrial+trafficking+in+neurons+and+interact+with+Miro+1%2F2+and+Trak2. assertion.
- assertion asSentence Kinesin+adapter+JLP+links+PIKfyve+to+microtubule-based+endosome-to-trans-Golgi+network+traffic+of+furin. assertion.
- assertion asSentence The+P2Y12+receptor+is+required+for+proinflammatory+actions+of+the+stable+abundant+mediator+LTE4. assertion.
- assertion asSentence Exposure+to+smoke+heightens+platelet+reactivity+and+thrombosis+in+Apoe-%2F-+mice+and+implicate+signaling+through+platelet+P2Y12+receptor+as+a+mediator+of+the+adverse+consequence+of+smoke+exposure. assertion.
- assertion asSentence TIPT%2C+a+male+germ+cell-specific+partner+of+TRF2%2C+is+chromatin-associated+and+interacts+with+HP1. assertion.
- assertion asSentence TIPT2+synergizes+with+geminin+and+TBP+in+the+activation+of+TATA+box-containing+promoters. assertion.
- assertion asSentence Chuzhoi+mutation%2C+that+causes+multiple+abnormalities+maps%2C+to+Chromosome+17+and+carries+a+splice+site+mutation+in+Ptk7+and+causes+disruption+of+Ptk7+protein+expression. assertion.
- assertion asSentence MDA-5+plays+an+important+role+in+the+host+immune+response+to+CVB3+by+preventing+early+virus+replication+and+limiting+tissue+pathology. assertion.
- assertion asSentence The+localisation+of+Syce1+and+Cesc1+%28Syce2%29+to+the+central+element+depends+on+recruitment+by+Sycp1. assertion.
- assertion asSentence The+decreased+inhibition+of+Nanog+expression+in+p53%28S315A%29+ESCs+during+differentiation+is+due+to+an+impaired+recruitment+of+the+co-repressor+mSin3a+to+the+Nanog+promoter. assertion.
- assertion asSentence Nanog+represses+the+pro-differentiation+activities+of+NFkappaB+and+cooperates+with+Stat3+to+maintain+pluripotency. assertion.
- assertion asSentence Reprogramming+capacity+of+Nanog+is+functionally+conserved+in+vertebrates+and+resides+in+a+unique+homeodomain. assertion.
- assertion asSentence Cadherin-23%2C+myosin+VIIa+and+harmonin+form+a+ternary+complex+and+interact+with+phospholipids. assertion.
- assertion asSentence Methylation+of+p53+by+Set7+mediates+p53+acetylation+and+activity+in+vivo. assertion.
- assertion asSentence Adenine+nucleotide+translocase+4+deficiency+leads+to+early+meiotic+arrest+of+murine+male+germ+cells. assertion.
- assertion asSentence Overexpression+of+chemokine-like+factor+2+promotes+the+proliferation+and+survival+of+C2C12+skeletal+muscle+cells. assertion.
- assertion asSentence Null+mutations+in+FAM161A+are+responsible+for+the+RP28-associated+autosomal-recessive+retinitis+pigmentosa. assertion.
- assertion asSentence Sin1-mTORC2+suppresses+rag1%2C2+and+il7r+gene+expression+through+Akt2+in+B+cells. assertion.
- assertion asSentence Expression+of+constitutively+active+Akt2+in+mTORC2-deficient+hepatocytes+restored+both+glucose+flux+and+lipogenesis. assertion.