Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Rho+GDIalpha+and+Rho+GDIbeta+play+synergistic+roles+in+lymphocyte+migration+and+development+by+modulating+activation+cycle+of+the+Rho+proteins+in+a+lymphoid+organ-specific+manner. assertion.
- assertion asSentence Integrin+beta4+signaling+promotes+epidermal+growth+and+wound+healing+through+an+effect+on+nuclear+translocation+of+NF-kappaB+and+mitogen-activated+protein+kinases. assertion.
- assertion asSentence TRPA1+activity+undergoes+pharmacological+desensitization+through+multiple+cellular+pathways+that+are+agonist+dependent+and+modulated+by+TRPV1. assertion.
- assertion asSentence Sensory+neurons+expressing+TRPV1+participate+in+neurogenic+inflammation+during+acute+pancreatitis. assertion.
- assertion asSentence TRPV1+is+essential+for+cystitis-induced+bladder+mechanical+hyperreactivity+and+increased+mechanical+sensitivity+in+peripheral+tissues+associated+with+visceral+inflammation. assertion.
- assertion asSentence MCH%281%29+receptor+KO+mice+are+hypersensitive+to+the+behavioral+and+molecular+effects+of+the+dopaminergic+psychostimulant+d-amphetamine+and+Increased+frontal+cortical+MAPK+phosphorylation+and+c-fos+expression. assertion.
- assertion asSentence Murine+telomere+homeostasis+or+genetic+stability+does+not+depend+on+mPif1. assertion.
- assertion asSentence BTLA-herpesvirus+entry+mediator+%28HVEM%29+interactions+are+functionally+involved+in+T+cell+regulation+during+Plasmodium+berghei+strain+ANKA+blood-stage+malaria+and+regulate+sequestration+of+T+cells+in+brain+capillaries. assertion.
- assertion asSentence BTLA+employs+a+conserved+binding+mode+for+herpesvirus+entry+mediator+recognition. assertion.
- assertion asSentence The+extracellular+domain+of+BTLA+binds+herpesvirus+entry+mediator+%28HVEM%29%2C+blocks+BTLA-HVEM+interactions+and+significantly+improves+antitumor+immunity+in+cervical+cancer+when+combined+with+heat+shock+protein+%28HSP%2970+vaccine. assertion.
- assertion asSentence Presence+of+functional+type+1a+GHSRs+in+the+spinal+cord. assertion.
- assertion asSentence Mutually+opposite+signal+modulation+by+hypothalamic+heterodimerization+of+ghrelin+and+melanocortin-3+receptors. assertion.
- assertion asSentence N-linked+glycosylation+is+required+for+full+activation+of+CREB-H+through+intramembrane+proteolysis. assertion.
- assertion asSentence Metastasis-associated+protein+1%2Fhistone+deacetylase+4-nucleosome+remodeling+and+deacetylase+complex+regulates+phosphatase+and+tensin+homolog+gene+expression+and+function. assertion.
- assertion asSentence Kif15+opposes+the+capacity+of+other+motors+to+generate+independent+microtubule+movements+within+key+regions+of+developing+neurons. assertion.
- assertion asSentence AS160+is+localized+to+GLUT4-containing+vesicles+via+its+interaction+with+IRAP+where+it+inhibits+the+activity+of+Rab+substrates+in+its+vicinity%2C+effectively+tethering+the+vesicles+intracellularly. assertion.
- assertion asSentence Sexually+dimorphic+changes+in+the+exploratory+and+habituation+profiles+of+heterozygous+neuregulin-1+knockout+mice. assertion.
- assertion asSentence Runx2%2C+a+transcription+factor+essential+for+osteoblastogenesis%2C+negatively+regulates+expression+of+the+miR+cluster+23a+approximately+27a+approximately+24-2. assertion.
- assertion asSentence Expressed+in+normal+and+neoplastic+prostate+epithelium+and+is+regulated+by+androgenic+hormones. assertion.
- assertion asSentence When+Dnd1%28Ter%2FTer%29+XX+germ+cells+developed+in+a+testicular+environment+they+gave+rise+to+the+same+neoplastic+clusters+as+mutant+XY+germ+cells+in+a+testis. assertion.
- assertion asSentence MLCK+is+involved+in+egg+polarity+because+inhibitors+prevent+sperm+chromatin-induced+cortical+reorganization. assertion.
- assertion asSentence RNF12+is+essential+for+initiation+of+XCI+and+is+mainly+involved+in+the+regulation+of+Xist. assertion.
- assertion asSentence Expression+restricted+to+the+Sertoli+cells+of+the+developing+testis. assertion.
- assertion asSentence Myocardin+is+differentially+required+for+the+development+of+smooth+muscle+cells+and+cardiomyocytes. assertion.
- assertion asSentence SOCS2+is+a+negative+regulator+of+growth+hormone+signaling. assertion.
- assertion asSentence Over-expression+of+SOCS2+variably+affects+different+cortical+regions+and+neuronal+populations%2C+with+the+predominant+effect+appearing+to+be+on+interneurons+and+neuronal+connectivity+in+the+cortex. assertion.
- assertion asSentence The+inducible+deletion+of+Ccm2+in+adult+mice+recapitulates+the+cerebral+cavernous+malformations-like+brain+lesions+in+humans. assertion.
- assertion asSentence The+Efemp1+knock-in+mice+reconstitute+the+most+important+histopathologic+symptoms+of+both+Malattia+leventinese+and+age-related+macular+degeneration. assertion.
- assertion asSentence CIAS1+mRNA+expression+found+primarily+in+peripheral+blood+leukocytes+consistent+with+the+postulated+inflammatory+function. assertion.
- assertion asSentence Reduced+expression+in+gastrin-cholecystokinin+knockout+mice. assertion.
- assertion asSentence Meiotic+progression+in+female+mice+bearing+mutations+in+genes+of+the+DNA+mismatch+repair+pathway. assertion.
- assertion asSentence FCHO2+regulates+clathrin-mediated+endocytosis+through+its+interactions+with+membranes+and+Eps15. assertion.
- assertion asSentence Aberrant+methylation+of+RAR-beta+is+an+early+and+common+alteration+in+murine+lung+tumors+induced+by+several+environmentally+relevant+exposures. assertion.
- assertion asSentence Modulates+the+responsiveness+of+the+heart+to+stress+signaling+by+functioning+as+a+cytoskeletal+intermediary+between+myocyte+enhancer+factor-2+and+serum+response+factor. assertion.
- assertion asSentence Loss+of+phosphatidylinositol+4-kinase+2alpha+activity+causes+late+onset+degeneration+of+spinal+cord+axons. assertion.
- assertion asSentence TRAF7+negatively+regulates+c-Myb+activity+by+sequestering+c-Myb+to+the+cytosol+via+sumoylation. assertion.
- assertion asSentence LIM1+domain+only+of+either+PINCH1+or+PINCH2+can+prevent+ILK+degradation+despite+their+failure+to+localize+to+focal+adhesions. assertion.
- assertion asSentence Epithelial+cell-mediated+protection+occurred+through+a+TLR3%2FTRIF-dependent+pathway+converging+on+indoleamine+2%2C3-dioxygenase+%28IDO%29+via+non-canonical+nuclear+factor-kappaB+activation. assertion.
- assertion asSentence HNF-6+and+OC-2+play+partially+redundant+roles+in+developing+pancreas%2C+antero-posterior+patterning+of+the+gut+and+in+enteroendocrine+differentiation. assertion.
- assertion asSentence H-rev107+interferes+with+the+biosynthesis+of+ether-type+lipids+and+is+responsible+for+the+dysfunction+of+peroxisomes+in+H-rev107-expressing+cells. assertion.
- assertion asSentence Rin1+links+histone+ubiquitylation+to+gene+silencing+and+X+inactivation. assertion.
- assertion asSentence There+is+a+gender-dependent+regulation+of+Gpbar1+function+in+metabolic+disease. assertion.
- assertion asSentence Artemis%2Fp53-deficient+mouse+tumors+lacked+der%2812%29t%2812%3B15%29+translocations+and+c-myc+amplification. assertion.
- assertion asSentence PIP5KIgamma-mediated+generation+of+phosphatidylinositol+4%2C5-bisphosphate+%28PI%284%2C5%29P2%29+at+sites+of+N-cadherin+contacts+regulates+intercellular+adhesion+strength%2C+an+effect+due+in+part+to+PI%284%2C5%29P2-mediated+regulation+of+gelsolin. assertion.
- assertion asSentence Cardif+regulates+the+initial+type+I+IFN+response+in+lymphoid+tissues. assertion.
- assertion asSentence Spermine+oxidase+mediates+the+gastric+cancer+risk+associated+with+Helicobacter+pylori+CagA. assertion.
- assertion asSentence Deletion+of+Trib3+has+minimal+effect+on+insulin-induced+Akt+activation+in+hepatic+tissue. assertion.
- assertion asSentence DJ-1+enhances+cell+survival+through+the+binding+of+Cezanne%2C+a+negative+regulator+of+NF-kappaB. assertion.
- assertion asSentence RIG-I+and+MDA5+are+responsible+for+triggering+downstream+gene+expression+in+response+to+West+Nile+Virus+infection+by+signaling+through+IPS-1. assertion.
- assertion asSentence Arterivirus+and+nairovirus+deubiquitinases+target+RIG-I+to+control+innate+immune+signaling. assertion.
- assertion asSentence The+coiled-coil+structure+of+LIMP-2+is+required+for+its+interaction+with+beta-glucocerebrosidase. assertion.
- assertion asSentence The+acidic+stretch+of+nardilysin%2C+expressed+as+a+fusion+protein+with+glutathione+S-transferase+and+compared+to+the+native+enzyme+with+respect+to+spermine+binding%2C+functions+as+an+autonomous+domain. assertion.
- assertion asSentence Defective+prelamin+A+processing+and+muscular+and+adipocyte+alterations+in+Zmpste24+metalloproteinase-deficient+mice. assertion.
- assertion asSentence RKTG+has+a+suppressive+activity+in+chemical+carcinogen-induced+mitogenesis+and+tumor+formation+in+mouse+skin. assertion.
- assertion asSentence RNF8+and+Chfr%2C+function+together+to+activate+ATM+and+maintain+genomic+stability+in+vivo. assertion.
- assertion asSentence Ndr2+is+an+interesting+candidate+gene+for+the+regulation+of+structural+processes+in+differentiating+and+mature+neuronal+cells. assertion.
- assertion asSentence Up-regulation+of+beta3Gn-T8+in+differentiated+cells+increases+poly-N-acetyllactosamine+chains+by+activating+intrinsic+beta3Gn-T2. assertion.
- assertion asSentence Dmn+is+expressed+in+reactive+astrocytes+in+neurotrauma+and+interacts+differentially+with+Vim+and+Gfap. assertion.
- assertion asSentence Synemin+isoforms+during+mouse+development. assertion.
- assertion asSentence The+RdCVF+gene+has+an+essential+role+in+photoreceptor+maintenance+and+resistance+to+retinal+oxidative+stress. assertion.
- assertion asSentence Bruton%27s+tyrosine+kinase+and+phospholipase+C+gamma+2+act+both+in+concert+and+independently+throughout+B+cell+development. assertion.
- assertion asSentence Otoferlin-Rab8b+interaction+links+otoferlin+to+the+basolateral+endocytic+and+secretory+trafficking. assertion.
- assertion asSentence Hypb%2FSetd2+is+required+for+embryonic+vascular+remodeling. assertion.
- assertion asSentence Enhanced+flu+susceptibility+of+Ago1%2F3+double-knockout+mice+arises+from+an+intrinsic+impairment+in+the+ability+of+lung+cells+to+tolerate+flu-elicited+inflammation. assertion.
- assertion asSentence Murine+nyctalopin+is+anchored+to+the+plasma+membrane+by+a+single+transmembrane+domain%2C+such+that+the+leucin-rich+repeat+domain+is+located+in+the+extracellular+space. assertion.
- assertion asSentence GNL3L+mediates+the+mitotic+increase+of+TRF1+protein+and+promotes+the+metaphase-to-anaphase+transition. assertion.
- assertion asSentence Mouse+IgA+allotypes+have+major+differences+in+their+hinge+regions. assertion.
- assertion asSentence Deficiency+of+either+MS+or+folate+produces+oxidative+stress+and+endothelial+dysfunction+in+the+cerebral+microcirculation+of+mice. assertion.
- assertion asSentence Slitrk6+gene+expression+profile+in+the+mouse+embryo. assertion.
- assertion asSentence Bcl10+and+Malt1+control+lysophosphatidic+acid-induced+NF-kappaB+activation+and+cytokine+production. assertion.
- assertion asSentence Nn+important+role+of+alpha-gus+is+to+maintain+cAMP+levels+tonically+low+to+ensure+adequate+Ca2%2B+signaling. assertion.
- assertion asSentence The+muscarinic+acetylcholine+receptor+M2+is+a+mediator+of+bradycardia+and+bronchoconstriction+due+to+vagal+innervation. assertion.
- assertion asSentence Substance+P-mediated+sustained+contraction+is+negatively+regulated+by+the+M2+receptor+at+a+presynaptic+level+in+the+ileum. assertion.
- assertion asSentence Siglec-G-dependent+negative+regulation+exists+in+B1+cells. assertion.
- assertion asSentence Monocytic+leukemia+zinc+finger+%28MOZ%29+interacts+with+p53+to+induce+p21+expression+and+cell-cycle+arrest. assertion.
- assertion asSentence CD207+antigens+manifest+a+high+degree+of+colocalization+around+the+nucleus+of+the+Langerhans+cells. assertion.
- assertion asSentence T+cells+lacking+Itk+exhibit+decreased+interleukin-17A+expression+in+vitro+and+in+vivo%2C+despite+relatively+normal+expression+of+retinoic+acid+receptor-related+orphan+receptor-gammaT+and+IL-17F. assertion.
- assertion asSentence DUOX2+and+NOD2+cooperatively+facilitate+antibacterial+action. assertion.
- assertion asSentence %28NOD%292+ligand-mediated+nuclear+factor+%28NF%29-kappa+B+activation+induces+Vibrio+toxin-stimulated+NLRP3+inflammasome+in+bone+marrow+macrophages. assertion.
- assertion asSentence NOD2-driven+activation+of+the+Notch1-PI3K+signaling+axis+contributes+to+its+capacity+to+impart+survival+of+macrophages+against+TNF-alpha+or+IFN-gamma-mediated+apoptosis+and+resolution+of+inflammation. assertion.
- assertion asSentence Nrpn+is+necessary+for+establishment+of+LTP+and+has+a+significant+role+in+memory+acquisition. assertion.
- assertion asSentence FFA+accumulation+and+catabolism+and+oxidative+stress+are+major+consequences+of+Ncb5or+deficiency+in+liver. assertion.
- assertion asSentence Starburst+amacrine+cells+have+large+outward+currents+which+are+mediated+in+part+by+the+Kv3.2+channel. assertion.
- assertion asSentence Immunoelectron+and+confocal+microscopy+reveal+that+postsynaptic+membrane+specializations+can+be+formed+in+the+absence+of+gephyrin. assertion.
- assertion asSentence Lsamp+knockout+mice+have+a+deficit+in+spatial+memory+acquisition+and+poorly+sustained+CA1+long-term+potentiation. assertion.
- assertion asSentence NLRC4-dependent+responses+contribute+to+early+restriction+of+Legionella+pneumophila+replication+in+mouse+macrophages. assertion.
- assertion asSentence AhR+regulates+Ltbp-1+transcription+by+a+mechanism+involving+recruitment+of+co-activators+such+as+CREB1+and+co-repressors+such+as+HDAC2+to+the+Ltbp-1+promoter. assertion.
- assertion asSentence Paskin+gene+expression+is+not+induced+by+glucose+in+pancreatic+beta-cells+and+glucose-stimulated+insulin+production+is+independent+of+PASKIN. assertion.
- assertion asSentence Rtn4r+mutant+mice+exhibited+greater+social+preference+and+a+mild+impairment+in+spatial+cognition. assertion.
- assertion asSentence Loss+of+SLC4A11+leads+to+morphological+changes+in+the+fibrocytes+and+deafness. assertion.
- assertion asSentence Reversible+inhibitor+of+p97%2C+DBeQ%2C+impairs+both+ubiquitin-dependent+and+autophagic+protein+clearance+pathways. assertion.
- assertion asSentence TRPA1+acts+as+a+major+sensor+for+noxious+cold. assertion.
- assertion asSentence The+in+vivo+induction+of+ITGA-11+protein+is+detected+in+spleen+and+lungs+of+type+I+IFN-treated+BALB%2Fc+mice. assertion.
- assertion asSentence The+KASH-domain-containing+proteins+Syne-1+and+Syne-2+play+crucial+roles+in+anchoring+both+synaptic+and+non-synaptic+myonuclei+that+are+important+for+proper+motor+neuron+innervation+and+respiration. assertion.
- assertion asSentence Inhibited+by+lead+which+binds+at+the+active+site+and+my+inhibit+lead+poisoning. assertion.
- assertion asSentence p53%2FTIGAR-mediated+inhibition+of+myocyte+mitophagy+is+responsible+for+impairment+of+mitochondrial+integrity+and+subsequent+apoptosis. assertion.
- assertion asSentence Genetic+ablation+of+Nceh1+promotes+foam+cell+formation+and+the+development+of+atherosclerosis+in+mice. assertion.
- assertion asSentence Gemetic+disturbance+in+CADPS2-mediated+neurotrophin+release+contributes+to+autism+susceptibility. assertion.
- assertion asSentence MYSM1+derepresses+EBF1+transcription+in+B+cell+progenitors+by+orchestrating+histone+modifications+and+transcription+factor+recruitment+to+the+EBF1+locus. assertion.
- assertion asSentence EBI2+provides+a+previously+uncharacterized+dimension+to+B+cell+migration+that+is+crucial+for+coordinating+rapid+versus+long-term+antibody+responses. assertion.