Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Absence+of+IL1RAPL1+causes+a+transient+disinhibition+of+deep+cerebellar+nuclei+neurons+between+postnatal+days+10+and+14. assertion.
- assertion asSentence Frem3+is+a+basement+membrane+protein+that+is+distinct+from+other+12+CSPG+repeats-containing+extracellular+matrix+protein+family+proteins+in+its+tissue+distribution+and+competence+to+assemble+into+the+basement+membrane. assertion.
- assertion asSentence Mice+homozygous+for+Supv3L1+mutation+die+in+utero+before+midgestation. assertion.
- assertion asSentence Correct+spatial+and+inducible+regulation+of+Mafa+involves+cross+talk+between+trans-acting+factors+binding+to+multiple+conserved+cis+elements+located+within+distinct+regions+of+the+promoter. assertion.
- assertion asSentence CED-1%2FSCARF1+and+C03F11.3%2FCD36+are+beta-glucan+binding+receptors+and+define+an+evolutionarily+conserved+pathway+for+the+innate+sensing+of+fungal+pathogens. assertion.
- assertion asSentence Ap2delta+associates+with+ASH2L+and+MLL2+%28ALR%29%2C+forming+a+complex+that+methylates+lysine+4+of+histone+H3. assertion.
- assertion asSentence Adult+GIP+receptor+knock-out+mice+exhibit+a+significantly+lower+number+of+newborn+cells+in+the+hippocampal+dentate+gyrus+compared+with+wild-type+mice. assertion.
- assertion asSentence The+Creb1-Crtc1+pathway+mediates+the+central+effects+of+hormones+and+nutrients+on+energy+balance+and+fertility. assertion.
- assertion asSentence Caspase-10+cleaves+insulin+receptor+substrate. assertion.
- assertion asSentence The+expression+profiles+of+Hoxd4+and+miR-10b+transcripts+during+neural+differentiation+of+mouse+embryonal+carcinoma+%28EC%29+P19+cells+are+co-ordinately+regulated+and+generated+by+Drosha+cleavage. assertion.
- assertion asSentence IGF-1-stimulated+miR-133+in+turn+represses+IGF-1R+expression+to+modulate+the+IGF-1R+signaling+pathway+during+skeletal+myogenesis. assertion.
- assertion asSentence miR-142-3p+regulates+the+production+of+cAMP+by+targeting+adenylyl+cyclase+9+messenger+RNA+in+CD4%28%2B%29CD25%28-%29+T+cells+and+CD4%28%2B%29CD25%28%2B%29+T%28REG%29+cells. assertion.
- assertion asSentence Down-regulation+of+Kruppel-like+factor-4+%28KLF4%29+by+microRNA-143%2F145+is+critical+for+modulation+of+vascular+smooth+muscle+cell+phenotype+by+transforming+growth+factor-beta+and+bone+morphogenetic+protein+4. assertion.
- assertion asSentence TPO+downmodulates+c-Myb+expression+through+induction+of+miR-150. assertion.
- assertion asSentence MiR-18a+and+miR-19b+regulate+connective+tissue+growth+factor+and+thrombospondin-1+expression+in+cardiomyocytes. assertion.
- assertion asSentence MicroRNA-217+promotes+ethanol-induced+fat+accumulation+in+hepatocytes+by+down-regulating+SIRT1. assertion.
- assertion asSentence miR-29+mediates+the+regulation+of+liver+fibrosis+and+is+part+of+a+signaling+nexus+involving+TGF-beta-+and+NF-kappaB-dependent+down-regulation+of+miR-29+family+members+in+hepatic+stellate+cells+with+subsequent+up-regulation+of+extracellular+matrix+genes. assertion.
- assertion asSentence LIN28+alters+cell+fate+succession+and+acts+independently+of+the+let-7+microRNA+during+neurogliogenesis. assertion.
- assertion asSentence Germinal+center+kinase-related+enzyme+%28GCKR%29+facilitates+both+canonical+and+noncanonical+Wnt+signaling+in+B+lymphocytes. assertion.
- assertion asSentence Lacrein+is+highly+restricted+to+lacrimal+gland+and+is+17.4%25+identical+and+32%25+similiar+%28near-optimal+alignment%29+to+human+lacritin. assertion.
- assertion asSentence Regulatory+T+%28Treg%29+cells+overexpand+in+aging+BALB%2Fc+Lyn-deficient+mice+in+an+effort+to+control+overwhelming+autoimmunity%2C+demonstrating+that+Lyn+is+an+important+autoimmune+severity+gene. assertion.
- assertion asSentence V-Src-mediated+down-regulation+of+SSeCKS+metastasis+suppressor+gene+promoter+by+the+recruitment+of+HDAC1+into+a+USF1-Sp1-Sp3+complex. assertion.
- assertion asSentence MuRF1+protein+is+responsible+for+mediating+muscle+atrophy+in+acute+lung+injury. assertion.
- assertion asSentence Development+of+hepatocellular+carcinoma+in+Iqgap2-deficient+mice+is+Iqgap1+dependent. assertion.
- assertion asSentence Mast+cell+chymase+inhibits+the+apolipoprotein-mediated+removal+of+macrophage+cholesterol+in+foam+cells+of+apoA-I+knockout+mice. assertion.
- assertion asSentence Kalirin+regulates+cortical+spine+morphogenesis+and+disease-related+behavioral+phenotypes. assertion.
- assertion asSentence FSCB+contributes+to+spermatozoa+capacitation. assertion.
- assertion asSentence Absence+of+glutathione+peroxidase+4+affects+tumor+angiogenesis+through+increased+12%2F15-lipoxygenase+activity. assertion.
- assertion asSentence Querkopf+%28Qkf%29+protein+is+essential+for+normal+adult+neurogenesis. assertion.
- assertion asSentence miR-370+directly+regulates+BMP-2+and+Ets1+expression%2C+at+the+translational+level%2C+during+BMP-2-stimulated+cell+differentiation. assertion.
- assertion asSentence miR-7a-mediated+fine-tuning+of+Pax6+expression+is+a+mechanism+for+controlling+neuronal+stem+cell+diversity+and%2C+consequently%2C+neuronal+phenotype. assertion.
- assertion asSentence Disruption+of+the+reciprocal+negative+regulatory+loop+between+miR-200+and+Zeb1+under+diabetic+conditions+enhances+proinflammatory+responses+of+vascular+smooth+muscle+cells+implicated+in+vascular+complications. assertion.
- assertion asSentence miR-133+specifically+down-regulates+its+targets+during+myogenesis+in+accordance+with+its+expression. assertion.
- assertion asSentence MiR-9+and+miR-374+transcript+levels+are+regulated+by+extracellular+Ca%28%2B%2B%29+in+a+reciprocal+manner+as+claudin-14. assertion.
- assertion asSentence Immunohistochemical+localization+of+transforming+growth+factor+beta1+and+beta2+in+mouse+testes+during+postnatal+development. assertion.
- assertion asSentence Lack+of+ISG15+conjugation+in+the+absence+of+ISG15-activating+enzyme+UBE1L+%28UBA7%29+does+not+affect+the+level+of+hepatitis+B+virus+%28HBV%29+replication+during+HBV+infection. assertion.
- assertion asSentence Inactivation+of+Nct1%2F2%2C+two+noncoding+RNAs+encoding+piRNAs%2C+leads+to+derepression+of+LINE-1+%28L1%29. assertion.
- assertion asSentence Beclin+1+and+its+binding+proteins+orchestrate+the+precise+function+of+the+class+III+PI%283%29K+in+regulating+autophagy+at+multiple+steps. assertion.
- assertion asSentence miR669a+and+miR669q+are+involved+in+the+upstream+regulation+of+myogenesis. assertion.
- assertion asSentence miR669a+and+miR669q+are+involved+in+the+upstream+regulation+of+myogenesis. assertion.
- assertion asSentence GnRH-stimulated+PACAP+gene+expression+is+mediated+via+multiple+signaling+pathways+acting+on+CRE%2FAP-1+sites+in+the+proximal+gene+promoter. assertion.
- assertion asSentence SHP-2+dysregulation+by+increased+Nox1-derived+ROS+in+spontaneously+hypertensive+rats+is+associated+with+altered+Ang+II-AKT+signaling. assertion.
- assertion asSentence TNF-alpha+increases+mean+arterial+blood+pressure+in+CHF+and+sensitizes+to+pressor+effect+of+centrally+administered+ANGII. assertion.
- assertion asSentence Upregulation+of+the+ligand-RAGE+pathway+via+AT1R+is+an+essential+mechanism+in+diabetic+atherosclerosis. assertion.
- assertion asSentence There+is+AT%281A%29R-+and+insulin-mediated+competitive+signaling+cross+talk+to+regulate+megalin+expression+in+cultured+proximal+tubule+cells. assertion.
- assertion asSentence AT1R%2FB2R+heterodimerization+does+not+occur+as+a+natural+consequence+of+their+simultaneous+expression+in+the+same+cell+nor+does+the+B2R+influence+the+AT1R+signaling. assertion.
- assertion asSentence The+imbalance+in+angiotensin+II+type+1+receptor+and+angiotensin+II+Type+2+receptor+expression+is+associated+with+an+inflammatory+process+that+contributes+to+renal+injury+in+adult+spontaneously+hypertensive+rats+and+to+the+development+of+hypertension. assertion.
- assertion asSentence Expression+of+AT2+receptor+mRNA+and+apoptosis-related+proteins+in+the+rat+urinary+bladder+are+affected+by+the+change+of+androgen+environment. assertion.
- assertion asSentence The+AT2R+constitutively+induced+apoptosis+in+rat+neonatal+cardiac+myocytes+in+dose-dependent+patterns. assertion.
- assertion asSentence Rac-dependent+signaling+is+essential+to+maintain+normal+morphology+and+biological+functions+of+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Akt+phosphorylation+and+activation+is+important+in+the+recovery+of+energy+metabolism+during+ischemia-reperfusion. assertion.
- assertion asSentence The+neuroprotection+of+HGF+depend+on+ERK1%2F2+pathway%2C+and%2C+to+a+lesser+extent%2C+PI-3K%2FAkt+pathway. assertion.
- assertion asSentence Anti-apoptotic+effects+of+1+alpha%2C25%28OH%29%282%29-vitamin+D%283%29+in+osteoblasts+occur+through+nongenomic+activation+of+a+VDR%2FPI3K%2FAkt+survival+pathway. assertion.
- assertion asSentence Age-related+differences+in+insulin-like+growth+factor-1+receptor+signaling+regulates+Akt%2FFOXO3a+and+ERK%2FFos+pathways+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence C-Cbl+tyrosine+phosphorylation+mediates+PI3K%2FAkt%2FmTOR+activation+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Stellate+cells+promotes+their+survival+by+the+JAK%2FSTAT+and+Akt%2FNF-kappaB-dependent+pathways. assertion.
- assertion asSentence RALDH1+mRNA+expression+is+suppressed+by+estrogen. assertion.
- assertion asSentence The+functional+density+of+NKA-alpha2+is+approximately+4.5+times+higher+in+the+T-tubules+vs.+external+sarcolemma+in+ventricular+cardiomyocytes. assertion.
- assertion asSentence Selective+stimulation+of+Y%285%29+receptor+provokes+activation+of+the+HPA+axis+and+its+downstream+pathway+is+chiefly+composed+of+both+CRF+%28primary+regulator%29+and+AVP+%28subordinate+to+the+former%29+with+distinct+relative+contribution. assertion.
- assertion asSentence The+concentrations+of+ACTH+and+corticosterone+in+AA+rats+are+induced+by+hypothalamic+AVP+in+AVP-eGFP+transgenic+rats. assertion.
- assertion asSentence Bcl-2+up-regulation+by+hypoxia+preconditioning+contributes+protection+against+overdistension%2Femptying-induced+oxidative+stress+and+injury+in+the+bladder. assertion.
- assertion asSentence An+increased+release+of+BDNF+is+associated+with+long-term+potentiation+and+spatial+learning. assertion.
- assertion asSentence Activation+of+TrkB%2FPI3-K+and+protein+synthesis+signaling+pathway+by+BDNF+in+the+hippocampus+is+important+for+spatial+memory. assertion.
- assertion asSentence BDNF+is+synthesized+by+a+subpopulation+of+retinal+ganglion+cells+and+axonally+transported+to+visual+centers+where+this+neurotrophin+is+assumed+to+play+important+roles+in+visual+system+maintenance. assertion.
- assertion asSentence Yiqi+Huayu+Decoction+can+inhibit+the+increase+of+BDNF+expression+at+the+early+phase+after+nerve+injury. assertion.
- assertion asSentence Brain+region-specific+changes+in+BDNF+protein+levels+are+correlated+with+exercise-induced+improvements+in+non-spatial+memory%2C+mediated+by+structures+outside+the+hippocampus. assertion.
- assertion asSentence In+CA1+hippocampus%2C+aging+reduced+basal+levels+and+fear-conditioning-induced+expression+of+total+BDNF+mRNA+in+rats. assertion.
- assertion asSentence Stimulation+of+5-HT%282%29+receptors+in+prefrontal+pyramidal+neurons+inhibits+Ca%28v%291.2+L+type+Ca%282%2B%29+currents+via+a+PLCbeta%2FIP3%2Fcalcineurin+signaling+cascade. assertion.
- assertion asSentence cGMP-PKG+regulates+Ca%28v%291.2+phosphorylation+and+function. assertion.
- assertion asSentence Calcitonin%2FCGRP+splice+regulator%28CSR%29+binding+to+the+calcitonin-specific+exonic+splice+enhancer+%28ESE%29+regulates+calcitonin%2FCGRP+pre-mRNA+splicing. assertion.
- assertion asSentence Calmodulin+activity+is+critical+for+activation+of+volume-regulated+anion+channels+in+rat+cerebral+astrocytes. assertion.
- assertion asSentence CaMKIIdelta2+mediates+MEF2-dependent+gene+transcription+in+VSMCs+through+regulation+of+HDAC4+and+HDAC5. assertion.
- assertion asSentence CaR+expressed+in+rat+calvarial+osteoblasts+exerts+a+mitogenic+effect+that+involves+activation+of+the+JNK+pathway+and+up-regulation+of+several+mitogenic+genes. assertion.
- assertion asSentence S100+g+is+a+functional+component+of+E2+genomic+effect+that+accelerates+egg+transport. assertion.
- assertion asSentence Endoplasmic+reticulum+stress+blunts+cytokine-triggered+activation+of+NF-kappaB%2C+in+part+through+PERK-+and+IRE1-mediated+preferential+induction+of+C%2FEBPbeta. assertion.
- assertion asSentence A+small+amount+of+secretogranin+III+is+able+to+sort+chromogranin+A+aggregates+together+with+adrenomedullin+to+secretory+granules. assertion.
- assertion asSentence Chrombacin+is+a+60+residue+anti-microbial+neuroendocrine+peptide+that+includes+an+unusual+sulfotyrosine-%2C+phosphoserine-containing+motif. assertion.
- assertion asSentence In+normal+bladders+both+M%282%29+and+M%283%29+receptors+can+induce+contraction+and+in+the+denervated+bladder%2C+the+M%282%29+and+the+M%283%29+receptors+interact+in+a+facilitatory+manner+to+mediate+contraction. assertion.
- assertion asSentence Interaction+of+the+third+intracellular+loop+of+SET+protein+with+M3+muscarinic+receptor+%28M3-MR%29+leads+to+reduced+M3-MR+signaling+capacity. assertion.
- assertion asSentence Immunoglobulins+from+scleroderma+patients+inhibit+the+muscarinic+receptor+activation+in+internal+anal+sphincter+smooth+muscle+cells. assertion.
- assertion asSentence Taurine+supplementation+of+low-protein+diet+rats+restored+Ach-M3R%2C+Synt1%2C+SNAP-25+protein+levels+and+increased+sarcoendoplasmatic+reticulum+Ca2%2B-ATPase+%28SERCA%29+3+protein+expression+in+rats+on+a+low-protein+diet. assertion.
- assertion asSentence Impairment+of+the+autoregulation+of+renal+hemodynamics+and+the+pressure-natriuresis+relationship+precedes+the+development+of+hypertension+in+Cyp1a1+transgenic+rats. assertion.
- assertion asSentence Activation+of+NAD%28P%29H%3Aquinone+oxidoreductase+1+prevents+arterial+restenosis+by+suppressing+vascular+smooth+muscle+cell+proliferation. assertion.
- assertion asSentence Dopamine+D1+receptor-mediated+effects+in+the+neostriatum+are+complex%2C+with+activation+of+motor+activity+%28projection+spiny+neurons+of+the+direct+pathway%29+and+weak+modulation+of+the+learning+process+%28large+aspiny+cholinergic+interneurons%29. assertion.
- assertion asSentence Drd1+inhibit+insulin-induced+vascular+smooth+muscle+cell+proliferation+via+down-regulation+of+insulin+receptor+expression. assertion.
- assertion asSentence D%281%29-like-Gal%281%29+receptor+heteromers+act+as+processors+that+integrate+signals+of+two+different+neurotransmitters%2C+dopamine+and+galanin%2C+to+modulate+hippocampal+cholinergic+neurotransmission. assertion.
- assertion asSentence No+differences+in+protein+expression+and+cellular+immunolocalization+of+the+D%282%29+receptor+subtypes+between+SHR+and+WKY+rats. assertion.
- assertion asSentence D2+dopamine+receptor+is+found+to+be+expressed+in+the+subcommissural+organ+%28SCO%29%2C+an+ependymal+brain+gland+that+is+located+in+the+roof+of+the+third+ventricle. assertion.
- assertion asSentence Dopamine%2C+via+a+synergistic+activation+of+D1-+%26+D2-like+receptors%2C+depolarizes+layer+I+GABAergic+interneurons+by+enhancing+I%28h%29. assertion.
- assertion asSentence Dopamine+D2+receptors+modulate+nucleus+accumbens+neurons+differentially+in+young+and+old+rats+following+emergence+of+a+D2+dopamine-facilitated+gamma-aminobutyric+acid+%28GABA%29+component+in+synaptic+responses+during+adolescence. assertion.
- assertion asSentence Stretch-induced+growth+signaling+in+vascular+smooth+muscle+depends+on+cholesterol-rich%2C+membrane+microdomains+by+a+mechanism+involving+ET-1+type+A+receptors+that+respond+to+endogenous+ET-1+production. assertion.
- assertion asSentence Demonstration+of+in+vivo+posttraumatic+alterations+of+gene+expression+and+protein+synthesis+of+ET-1+in+single+cells+of+cerebral+cortex+and+hippocampus+supports+metabolic+interaction+with+colocalized+inducible+nitric+oxide+synthase. assertion.
- assertion asSentence Insulin+resistance+in+SHR+is+accompanied+by+endothelial+dysfunction+in+mesenteric+vessels+with+impaired+PI3-kinase-dependent+NO+production+and+enhanced+MAPK-dependent+ET-1+secretion. assertion.
- assertion asSentence Activation+of+peroxisome+proliferator-activated+receptor-alpha+decreases+endothelin-1-induced+p38+mitogen-activated+protein+kinase+activation+in+cardiomyocytes. assertion.
- assertion asSentence Atrial+natriuretic+peptide+suppresses+endothelin+gene+expression+and+proliferation+in+cardiac+fibroblasts+through+a+GATA4-dependent+mechanism. assertion.
- assertion asSentence The+stimulated+exocytotic+release+of+ET-1+is+dramatically+increased+in+aged+endothelium%2C+contributing+to+constriction+of+aged+arteries. assertion.
- assertion asSentence The+local+ET-1+system+and+p38+MAPK+as+key+regulators+of+load-induced+hypertrophic+response+in+isolated+rat+atria. assertion.
- assertion asSentence ET-1+and+VEGF+play+important+roles+in+the+pathogenesis+of+hypoxic+pulmonary+hypertension. assertion.
- assertion asSentence ET%28A%29+receptors+are+expressed+and+functionally+coupled+to+rise+of+%5BCa%282%2B%29%5D%28i%29+in+H9c2+cardiomyoblasts. assertion.
- assertion asSentence Examine+the+role+of+EGF+receptor+transactivation+in+angiotensin+II+and+endothelin+control+of+vascular+protein+synthesis+in+vivo. assertion.