Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence NPAS2+is+also+a+RORalpha+and+REV-ERBalpha+target+gene. assertion.
- assertion asSentence The+SMRT+corepressor+is+directly+involved+in+the+vitamin+D+receptor-mediated+repression+in+vivo+via+an+ID1-specific+interaction+with+the+VDR. assertion.
- assertion asSentence The+ABCG1-mediated+cell+cholesterol+efflux+can+be+efficiently+driven+by+a+small+discoidal+phospholipid-containing+particle+resembling+plasma+pre-beta1+HDL. assertion.
- assertion asSentence Cyclin+D1%2C+a+major+target+of+ERalpha%2C+is+transcriptionally+up-regulated+by+IKKepsilon+in+a+phospho-ERalpha-Ser-167-dependent+manner. assertion.
- assertion asSentence U4+and+U6+small+nuclear+ribonucleoproteins+%28snRNPs%29+accumulate+in+Cajal+bodies+for+the+purpose+of+assembly+into+U4%2FU6+snRNPs+by+SART3%2Fp110. assertion.
- assertion asSentence Mtss1+drives+enhanced+junction+formation+specifically+by+elevating+Rac-GTP. assertion.
- assertion asSentence Keap1+associates+with+the+N-terminal+region+of+Cullin+3+through+the+IVR+domain+and+promotes+the+ubiquitination+of+Nrf2+in+cooperation+with+the+Cullin+3-Roc1+complex. assertion.
- assertion asSentence PSF1+over-expression+is+specifically+involved+in+breast+cancer+cell+growth. assertion.
- assertion asSentence Smad-interacting+protein+1+%28SIP1%29+limits+the+mesendoderm-inducing+effects+of+Activin-Nodal+signaling+without+inhibiting+the+pluripotency-maintaining+effects+exerted+by+SMAD2%2F3. assertion.
- assertion asSentence Endo180+is+a+crucial+link+between+urokinase-type+plasminogen+activator+and+its+receptor+and+setting+of+the+internal+cellular+compass. assertion.
- assertion asSentence KIF14+mRNA+is+an+independent+prognostic+marker+in+serous+ovarian+cancer. assertion.
- assertion asSentence KCNE2+can+functionally+couple+to+KCNQ1+even+in+the+presence+of+KCNE1. assertion.
- assertion asSentence FLASH+functions+in+S+phase+progression+through+interaction+with+ARS2. assertion.
- assertion asSentence WAVE+and+the+Arp2%2F3+complex+jointly+orchestrate+different+types+of+actin-based+plasma+membrane+protrusions+by+promoting+ruffling+and+inhibiting+mDia2-induced+filopodia. assertion.
- assertion asSentence SCP2+is+involved+in+promoter+clearance+during+steroid-activated+transcription. assertion.
- assertion asSentence Visfatin+promotes+angiogenesis+via+activation+of+mitogen-activated+protein+kinase+ERK-dependent+pathway. assertion.
- assertion asSentence Recruitment+of+AKAP450+on+Golgi+membranes+through+GM130+allows+centrosome-associated+nucleating+activity+to+extend+to+the+Golgi%2C+to+control+the+assembly+of+subsets+of+microtubules. assertion.
- assertion asSentence The+transcriptional+corepressor+KAP1+can+inactivate+the+kinetochore. assertion.
- assertion asSentence Topors+enhances+the+conjugation+of+the+small+ubiquitin-like+modifier+1+%28SUMO-1%29+to+p53+in+vivo+and+in+a+reconstituted+in+vitro+system. assertion.
- assertion asSentence HAPO+induces+endothelial+cell+proliferation+through+the+PI-3K%2FAkt+pathway. assertion.
- assertion asSentence TIP47+is+a+cellular+cofactor+that+plays+an+essential+role+in+Env+incorporation%2C+allowing+the+encounter+and+the+physical+association+between+HIV-1+Gag+and+Env+proteins+during+the+viral+assembly+process. assertion.
- assertion asSentence Spry2+can+enhance+the+response+of+colon+cancer+cells+to+gefitinib+by+increasing+the+expression+of+phosphorylated+and+total+EGFR. assertion.
- assertion asSentence The+underlying+pathomechanism+of+CLL+involves+co-regulation+of+miRNA+genes+miR-16-1+and+miR-15a+by+the+two+long+non-coding+RNA+genes+DLEU1+and+DLEU2. assertion.
- assertion asSentence Impaired+recognition+of+intracellular+P.+acnes+through+NOD1+affects+the+susceptibility+to+sarcoidosis+in+the+Japanese+population. assertion.
- assertion asSentence GPNMB+gene+is+a+p53-+and+androgen-dysregulated+gene+and+should+be+regarded+as+an+anti-tumor+gene+for+prostate+cancer. assertion.
- assertion asSentence Knockdown+of+beta-TrCP1+and+beta-TrCP2+markedly+reduced+IL-17-induced%2C+phosphorylation-dependent+ubiquitination+and+degradation+of+Act1. assertion.
- assertion asSentence NMU+plays+a+role+in+feeding+behavior+and+catabolic+functions+via+corticotropin-releasing+hormone. assertion.
- assertion asSentence The+intrahepatic+UII%2FUT+system+has+an+important+pathophysiological+role+in+cirrhosis+and+portal+hypertension. assertion.
- assertion asSentence AF1q+plays+a+critical+role+in+the+regulation+of+apoptosis+and+drug+resistance. assertion.
- assertion asSentence Rab32+facilitates+the+formation+of+autophagic+vacuoles+whose+membranes+are+derived+from+the+ER+and+regulates+the+clearance+of+aggregated+proteins+by+autophagy. assertion.
- assertion asSentence Mda-7%2FIL-24+activation+leads+to+upregulation+of+growth+arrest+and+DNA+damage+inducible+%28GADD%29+45+alpha+and+gamma+and+JNK+activation. assertion.
- assertion asSentence Recombinant+LEDGF+host+cell+factor+efficiently+reconstitutes+the+in+vitro+activity+of+HIV-1+preintegration+complexes. assertion.
- assertion asSentence Nuclear+activation+of+Chk2+by+TRAIL+acts+as+a+positive+feedback+loop+involving+the+mitochondrion-dependent+activation+of+caspases%2C+independently+of+p53. assertion.
- assertion asSentence Glutaredoxin+acts+as+a+reductant+for+methionine+sulfoxide+reductases+A+and+B+%28MsrA+and+MsrB%29+with+or+without+resolving+cysteine. assertion.
- assertion asSentence Epstein-Barr+virus+C+promoter+%28Cp%29+is+a+cell+cycle-regulated+promoter+that+is+under+the+control+of+Rb+and+the+histone+demethylase+LSD1+in+multiple+latency+types. assertion.
- assertion asSentence The+arousal+of+neuronal+LSD1+isoforms+pacemakes+early+neurite+morphogenesis%2C+conferring+a+neurospecific+function+to+LSD1+epigenetic+activity. assertion.
- assertion asSentence Eco1+represses+transcription+by+interacting+with+histone+demethylase%2C+LSD1+to+convert+chromatin+to+inactive+state. assertion.
- assertion asSentence PELP1+is+a+reader+of+H3+methylation+marks+and+has+a+crucial+role+in+modulating+the+histone+code+at+the+ERalpha+target+genes. assertion.
- assertion asSentence Cep68+cooperates+with+rootletin+and+C-Nap1+in+centrosome+cohesion. assertion.
- assertion asSentence hPEM-2+is+a+target+protein+of+Smurf1. assertion.
- assertion asSentence CENP-E-mediated+traction+forces+on+misaligned+chromosomes+are+responsible+for+the+irreversible+loss+of+spindle-pole+integrity+in+CLASP1%2F2-depleted+cells. assertion.
- assertion asSentence ASPP1+enhances+nuclear+accumulation+of+YAP%2FTAZ+and+YAP%2FTAZ-dependent+transcriptional+regulation. assertion.
- assertion asSentence Levels+of+Dicer+and+Drosha+mRNA+in+ovarian-cancer+cells+have+associations+with+outcomes+in+patients+with+ovarian+cancer. assertion.
- assertion asSentence Zn%282%2B%29+plays+a+dual+role+in+SIRT1+activity. assertion.
- assertion asSentence Inhibition+of+the+deacetylase+and+longevity+factor+SIRT1+impairs+global+genome+NER+through+suppressing+the+transcription+of+XPC+in+a+SIRT1+deacetylase-dependent+manner. assertion.
- assertion asSentence PRAME+plays+an+important+role+in+cell+proliferation+and+disease+progression+in+osteosarcoma. assertion.
- assertion asSentence While+excess+Abeta+is+functionally+pathological%2C+BACE1-mediated+processing+of+APP+and+other+substrates+play+a+role+in+%22normal%22+learning%2C+memory+and+sensorimotor+processes. assertion.
- assertion asSentence Compound+59+with+an+IC%2850%29+value+of+11+nM+on+BACE1+and+cellular+activity+of+80+nM. assertion.
- assertion asSentence Increased+expression+of+the+cystine%2Fglutamate+antiporter+system+xCT+in+multiple+sclerosis+provides+a+link+between+inflammation+and+excitotoxicity+in+demyelinating+diseases. assertion.
- assertion asSentence TTP+%28SH3BP4%29%2C+a+SH3-containing+protein%2C+specifically+regulates+the+internalization+of+the+transferrin+receptor+%28TfR%29. assertion.
- assertion asSentence The+genetic+polymorphisms+in+SOSTDC1+have+an+effect+on+attainment+and+maintenance+of+peak+bone+mass+in+Chinese+women. assertion.
- assertion asSentence HD-PTP+contributes+to+the+regulation+of+endothelial+motility+by+modulating+the+tyrosine+phosphorylation+of+FAK. assertion.
- assertion asSentence RFP+is+a+mediator+connecting+several+MBD+proteins+and+allowing+the+formation+of+a+more+potent+transcriptional+repressor+complex. assertion.
- assertion asSentence The+bipartite+mode+of+UPF2+binding+to+UPF1+brings+the+ribosome+and+the+exon+junction+complex+in+close+proximity+by+forming+a+tight+complex+after+an+initial+weak+encounter+with+either+element. assertion.
- assertion asSentence CHD5+is+a+tumor+suppressor+gene+that+is+epigenetically+downregulated+in+laryngeal+squamous+cell+carcinoma. assertion.
- assertion asSentence Bcr-Abl+increases+Emi1+phosphorylation+and+stability+to+prevent+Skp2+protein+degradation+via+APC%2FCdh1-induced+ubiquitination+and+to+enhance+proliferation+of+CML+cells. assertion.
- assertion asSentence PLEK2+is+involved+in+actin+rearrangement+in+a+PI+3-kinase+dependent+manner. assertion.
- assertion asSentence DAZAP1+is+a+component+of+complexes+that+are+crucial+for+the+degradation+and+silencing+of+mRNA. assertion.
- assertion asSentence Natural+killer+cell+immunoreceptor+tyrosine-based+activation+motifs+preferentially+use+a+signaling+cassette+regulated+by+interplay+between+LAT+and+LAB. assertion.
- assertion asSentence In+the+presence+of+a+functional+p53%2FPuma%2FBax-signaling+axis%2C+p14%28ARF%29-triggered+apoptosis+is+enhanced+by+loss+of+p21%28CDKN1%29-mediated+cell+cycle+checkpoint+control. assertion.
- assertion asSentence RBMS3%2C+by+binding+Prx1+mRNA+in+a+sequence-specific+manner%2C+controls+Prx1+expression+and+indirectly+collagen+synthesis. assertion.
- assertion asSentence Hypotonic+low-chloride+conditions+that+activate+the+WNK1-SPAK+and+OSR1+pathway+promote+phosphorylation+of+NKCC2+isoforms. assertion.
- assertion asSentence Chromogranin+A+can+increase+prostatic+cancer+cell+survival+through+AKT+up-regulatoin. assertion.
- assertion asSentence Induction+of+apoptosis+through+the+inhibition+of+Akt+signaling+pathway+is+one+of+the+anti-proliferative+mechanisms+of+DHEA+in+certain+tumors. assertion.
- assertion asSentence PI3-K%2FAkt+pathways+have+a+dual+role+in+both+survival+and+cell+death+processes+depending+on+the+stimulus. assertion.
- assertion asSentence Signal+transduction+pathways+underlying+the+enhanced+cell+migration+reveal+that+the+IGF-I-IGFBP-VN+complex+stimulates+a+transient+activation+of+the+ERK%2FMAPK+signaling+pathway+and+a+sustained+activation+of+the+phosphatidylinositide+3-kinase%2FAKT+pathway. assertion.
- assertion asSentence DEP-1+is+a+positive+regulator+of+VEGF-mediated+Src+and+Akt+activation+and+endothelial+cell+survival. assertion.
- assertion asSentence PTEN+modulated+VEGF-mediated+signaling+and+affected+tumor+angiogenesis+through+PI3K%2FAkt%2FVEGF%2FeNOS+pathway. assertion.
- assertion asSentence Oscillatory+shear+stress+induces+osteoblast-like+cell+proliferation+through+activation+of+alpha%28v%29beta%283%29+and+beta%281%29+integrins+and+synergistic+interactions+of+FAK+and+Shc+with+PI3K%2C+leading+to+the+modulation+of+ERK+and+Akt%2FmTOR%2Fp70S6K+pathways. assertion.
- assertion asSentence Akt1+phosphorylates+palladin%2C+inducing+cytoskeletal+reorganization+and+inhibiting+the+migration+of+breast+cancer+cells. assertion.
- assertion asSentence AKT+activation+controls+cell+survival+to+ionizing+radiation+by+phosphorylating+CLK2%2C+revealing+an+important+regulatory+mechanism+required+for+promoting+cell+survival. assertion.
- assertion asSentence VSV+M+protein+inactivates+the+cellular+Akt+signaling+pathway. assertion.
- assertion asSentence AKT+is+critical+for+transmitting+the+double+strand+break+signal+to+ERK. assertion.
- assertion asSentence Selective+activation+of+Akt1+through+mTORC2+and+P-Rex1+regulates+cancer+cell+migration%2C+invasion+and+metastasis. assertion.
- assertion asSentence For+a+Treg+enhancing+strategy+to+be+successful+in+the+treatment+of+autoimmune+inflammation%2C+resistance+because+of+PKB%2Fc-akt+hyperactivation+should+be+targeted+as+well. assertion.
- assertion asSentence Both+p70S6K+and+Akt+are+activated+in+the+majority+of+human+papillary+cancer+cells. assertion.
- assertion asSentence Akt1+induces+CREB+phosphorylation+at+Ser-133+and+CREB+target+gene+expression. assertion.
- assertion asSentence Angiopoietin-2%2C+an+angiogenic+regulator%2C+promotes+initial+growth+and+survival+of+breast+cancer+metastases+to+the+lung+through+the+integrin-linked+kinase+%28ILK%29-AKT1%2C2-B+cell+lymphoma+2+%28Bcl-2%29+pathway. assertion.
- assertion asSentence Multi-organ+iron+overload+in+an+African-American+man+with+ALAS2+R452S+and+SLC40A1+R561G. assertion.
- assertion asSentence The+developed+immunoassay+system+using+fluorescence+dye+and+lateral-flow+chromatography+is+a+simple%2C+fast+and+reliable+method+for+quantifying+the+albumin+concentration+in+whole+blood. assertion.
- assertion asSentence Albumin+colocalized+together+with+its+transcription+factor+PCD%2FDCoH%2FHNF-1alpha+in+suprabasal+keratinocytes+in+human+full-thickness+skin+sections+and+in+keratinocytes+cultured+in+serum-free+medium. assertion.
- assertion asSentence The+unfolding+of+domain+II+precedes+that+of+domain+I+and+the+unfolding+of+domain+III+follows+that+of+domain+I. assertion.
- assertion asSentence Ischemia-modified+albumin+is+a+good+alternative+to+D-dimer+in+pulmonary+embolism+diagnosis+in+terms+of+both+cost+and+efficiency. assertion.
- assertion asSentence Decreased%2Flost+ALCAM+membrane+expression+is+a+marker+of+poorer+outcome+in+epithelial+ovarian+cancer. assertion.
- assertion asSentence High+ALCAM+expression+is+associated+with+malignant+mesothelioma. assertion.
- assertion asSentence ALDH2+mutation+is+a+genetic+risk+marker+for+acute+coronary+syndrome. assertion.
- assertion asSentence Antihypertensives%2C+nonopioid+analgesics+and+hormonal+contraceptives+significantly+affect+the+salivary+ALDH3A1+activity. assertion.
- assertion asSentence Exposure+to+high+glucose+and+overexpression+AR+increase+the+expression+of+fibronectin. assertion.
- assertion asSentence The+expression+of+the+dual+specificity+phosphatase+CDC25A%2C+is+deregulated+in+Ba%2FF3+cells+expressing+the+oncogenic+protein+NPM%2FALK+and+in+human+cell+lines+derived+from+NPM%2FALK-positive+anaplastic+large+cell+lymphomas. assertion.
- assertion asSentence MiR-29a+down-regulation+in+ALK-positive+anaplastic+large+cell+lymphomas+contributes+to+apoptosis+blockade+through+MCL-1+overexpression. assertion.
- assertion asSentence The+shorter+repeat+alleles+of+the+5-LO+promoter+lead+to+higher+gene+expression. assertion.
- assertion asSentence The+polymorphism+of+SG13S114A%2FT+in+ALOX5AP+is+not+related+with+atherosclerotic+cerebral+infarction. assertion.
- assertion asSentence Lipoxygenase-3+%28ALOXE3%29+and+12%28R%29-lipoxygenase+%28ALOX12B%29+are+mutated+in+non-bullous+congenital+ichthyosiform+erythroderma+%28NCIE%29+linked+to+chromosome+17p13.1. assertion.
- assertion asSentence Overexpression+of+human+15%28S%29-lipoxygenase-1+in+RAW+macrophages+leads+to+increased+cholesterol+mobilization+and+reverse+cholesterol+transport. assertion.
- assertion asSentence Layer+5+has+a+distinctive+role+in+cortical+computation+and+neurological+disorders+caused+by+TNAP+dysfunctions+in+human+brain. assertion.
- assertion asSentence Processing+of+the+lipocalin+alpha%281%29-microglobulin+by+hemoglobin+induces+heme-binding+and+heme-degradation+properties. assertion.
- assertion asSentence Mullerian+inhibiting+substance+regulates+androgen-induced+gene+expression+and+growth+in+prostate+cancer+cells+through+a+nuclear+factor-kappaB-dependent+Smad-independent+mechanism. assertion.
- assertion asSentence AMH+levels+are+inversely+associated+with+age+and+differed+significantly+between+oral+contraceptive+pill+users+and+nonusers. assertion.
- assertion asSentence N-terminal+extensions+of+the+AMPD2+polypeptide+influence+ATP+regulation+of+isoform+L. assertion.
- assertion asSentence ANG1+attenuates+hydrogen+peroxide-induced+stress-activated+protein+kinase+%28SEK%291%2FJNK+phosphorylation+via+the+phosphoinositide+3-kinase%2FAkt+kinase+pathway+and+inhibits+apoptosis+of+vascular+endothelial+cells+induced+by+oxidative+stress. assertion.