Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mdetabolic+inhibition+of+cardiomyocytes+induces+a+parallel+release+of+intact+Tnnt3+and+its+degradation+products%2C+starting+only+after+onset+of+irreversible+cardiomyocyte+damage. assertion.
- assertion asSentence The+TSC2+modulates+actin+dynamics+and+cell+adhesion+and+the+TSC1-binding+domain+%28TSC2-HBD%29+is+essential+for+this+function+of+TSC2. assertion.
- assertion asSentence Expression+of+the+classic+vitamin+D3+receptor+in+osteoblasts+is+required+to+generate+a+rapid+1alpha%2C25-dihydroxy+vitamin+D3-mediated+increase+in+the+intracellular+Ca%282%2B%29+concentration. assertion.
- assertion asSentence Wt1+modulates+renin+gene+transcription. assertion.
- assertion asSentence Significant+decline+%28P+%3C+0.01%29+in+the+levels+of+the+ERalpha+and+ERbeta+proteins+in+the+aged+hippocampus. assertion.
- assertion asSentence Estrogen+receptor+alpha+is+the+predominant+mediator+of+estradiol-mediated+dopamine+efflux+from+the+plasma+membrane. assertion.
- assertion asSentence Changes+in+oxytocin+receptor%2C+ERalpha+and+ERbeta+mRNA+levels+during+proestrus+and+estrus+following+pseudopregnancy+are+similar+to+those+during+the+normal+estrous+cycle. assertion.
- assertion asSentence Activation+of+ERalpha+is+necessary+for+the+anorexigenic+effects+of+exogenous+and+endogenous+estradiol+in+female+rats. assertion.
- assertion asSentence 25+HC+exhibits+the+ERalpha-dependent+ability+like+17+beta-estradiol+%28E2%29+to+inhibit+the+up-regulation+of+HIF-1alpha+and+connective+tissue+growth+factor+by+hypoxic+conditions+in+cardiomyocytes+and+rat+heart+preparations+and+to+prevent+the+hypoxia-induced+apoptosis. assertion.
- assertion asSentence High-molecular-weight+kininogen+and+its+peptide+fragments+modulate+arterial+thrombosis+after+arterial+injury. assertion.
- assertion asSentence During+endotoxemia+NO%2C+produced+by+iNOS%2C+is+responsible+for+a+down-regulation+of+the+renal+influx+carriers%2C+Oct1+and+Oct2. assertion.
- assertion asSentence Five+amino+acids+in+the+innermost+cavity+of+the+substrate+binding+cleft+of+Roct1+interact+with+extracellular+and+intracellular+corticosterone. assertion.
- assertion asSentence Low+pH+enhances+Gaba+A+beta+3+receptor+steady-state+currents+by+modifying+GABA%28A%29+receptor+gating+properties. assertion.
- assertion asSentence Tonic+activation+of+GABA-A+receptors+in+developing+hippocampus+enhances+glutamergic+cell+excitability+and+synaptic+activity. assertion.
- assertion asSentence Beta1-adrenoceptor+expression+in+rat+anterior+pituitary+gonadotrophs. assertion.
- assertion asSentence SNAP-25+in+the+hippocampal+CA3+region+is+required+for+long-term+memory+formation%2C+consistent+with+its+role+in+learning%2Fmemory+function+in+area+CA1. assertion.
- assertion asSentence Calmodulin+bound+to+the+first+IQ+motif+is+responsible+for+calcium-dependent+regulation+of+myosin+5a. assertion.
- assertion asSentence The+expression+of+CD11b+in+retinal+microglia+fluctuated+with+chronic+ocular+hypertension. assertion.
- assertion asSentence PKC+is+involved+in+ethanol-induced+MAPK+expression+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence EGFR-PLCgamma1+signaling+mediates+high+glucose-induced+PKCbeta1-Akt+activation+and+collagen+I+upregulation+in+mesangial+cells. assertion.
- assertion asSentence Endogenous+adrenomedullin+plays+a+physiological+role+in+cultured+rat+ZG+cells%2C+by+exerting+a+buffering+action+on+their+acute+secretory+response+to+Ang-II+and+K%2B+and+by+maintaining+basal+proliferative+and+apoptotic+activities. assertion.
- assertion asSentence The+loop+between+helix+4+and+helix+5+in+MCT1+is+important+for+transport+activity. assertion.
- assertion asSentence Abnormal+regulation+of+CaMKIV+is+a+component+of+beta-cell+dysfunction+caused+by+high+glucose. assertion.
- assertion asSentence Endogenous+GLP-1+receptor+signaling+is+necessary+for+the+reduction+in+food+intake+produced+by+jejunal+linoleic+acid+infusions. assertion.
- assertion asSentence Nicotine+impairs+secretion+rather+than+production+of+pancreatic+trypsinogen+2. assertion.
- assertion asSentence NGF+administration+reverses+the+neuro-glial+morphomolecular+changes+occurring+in+neuropathic+animals+paralleled+by+alterations+in+neurotrophin+receptors+ratio. assertion.
- assertion asSentence The+release+of+5-HT+after+subarachnoid+hemorrhage+activates+5-HT1B+receptors+and+the+synthesis+of+20-HETE+contributing+to+the+acute+fall+in+rCBF+by+potentiating+the+vasoconstrictor+response+of+cerebral+vessels+to+5-HT. assertion.
- assertion asSentence Alpha%282A%29-+and+alpha%282C%29-adrenoceptors+play+predominant+roles+in+the+regulation+of+cervical+resistance+on+days+18-21. assertion.
- assertion asSentence alpha2-Adrenoceptors+do+not+play+a+substantial+role+in+regulating+the+tyrosine+hydroxylase+phenotype+of+hypothalamic+magnocellular+neurons+during+osmotic+challenge+induced+by+vasopressin+deficiency. assertion.
- assertion asSentence PC12+cells+require+PLD2+to+attentuate+glutamate-induced+cell+death. assertion.
- assertion asSentence YY1+activates+hBNP+transcription+through+interaction+with+histone+deacetylase+2+in+cardiac+myocytes. assertion.
- assertion asSentence Increased+amounts+of+renal+cortex+V1A+receptors+in+spontaneously+hypertensive+rats+play+an+important+role+in+the+pathophysiology+of+hypertension. assertion.
- assertion asSentence Inflammation+upregulates+the+expression+of+11HSD1+in+mobile+lymphoid+cells+similar+to+the+intraepithelial+and+lamina+propria+leukocytes+isolated+from+the+colon. assertion.
- assertion asSentence Intact+JAK%2FSTAT1+signaling+is+important+in+the+regulation+of+inducible+nitric+oxide+synthase+expression+in+intestinal+epithelial+cells. assertion.
- assertion asSentence Both+embryonic+and+adult+hippocampal+neurons+express+leptin+receptors+coupled+to+activation+of+STAT3+and+phosphatidylinositol+3-kinase-Akt+signaling+pathways. assertion.
- assertion asSentence In+the+Leydig+cells+of+sexually+mature+male+rats%2C+eNOS+and+P450+are+differently+expressed+in+different+stages+of+sexual+maturation. assertion.
- assertion asSentence Regulates+levels+of+GABA-A+receptors+in+response+to+brain-derived+neurotrophic+factor. assertion.
- assertion asSentence PELP1+functionally+interacts+with+both+ERalpha+and+ERbeta+and+enhances+their+transcriptional+responses. assertion.
- assertion asSentence DYX1C1+comlexes+with+ERalpha+or+ERbeta+at+endogenous+levels+along+neurites+of+primary+rat+hippocampal+neurons. assertion.
- assertion asSentence Ang-%281-7%29+stimulates+mesangial+cells+proliferation+via+Mas+receptor. assertion.
- assertion asSentence An+interaction+of+protein+kinase+C+signaling+pathway+with+estrogen-dependent+progesterone+receptor+in+ligand-independent+activation+manner+in+gonadotrope. assertion.
- assertion asSentence Ephrin-B1+and+ephrin-B2+mediate+EphB-dependent+presynaptic+development+via+syntenin-1. assertion.
- assertion asSentence Akt+inhibits+BID-mediated+apoptosis+downstream+of+BID+cleavage+via+promotion+of+mitochondrial+hexokinase+association+and+antagonism+of+tBID-mediated+BAX+and+BAK+activation+at+the+mitochondria. assertion.
- assertion asSentence GRK2+expression+is+downregulated+after+cerebral+hypoxia%2Fischemia. assertion.
- assertion asSentence GRK2+is+involved+in+corticotropin+releasing+factor-induced+desensitization+by+CRF+receptor+type+1+%28CRFR1+in+a+cell+line. assertion.
- assertion asSentence Ischemic+acute+renal+failure+leads+to+down+regulation+of+pulmonary+ENaC%2C+Na%2CK-ATPase+and+aquaporin-5. assertion.
- assertion asSentence NEEP21-GRIP1+binding+is+crucial+for+GluR2-AMPAR+sorting+through+endosomes+and+their+recruitment+to+the+plasma+membrane%2C+providing+a+mechanism+to+differentially+regulate+AMPAR+subunit+cycling+in+internal+compartments. assertion.
- assertion asSentence N-terminal+splicing+of+SAP97+controls+synaptic+strength+by+regulating+distribution+of+alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic+acid+%28AMPA%29+receptors. assertion.
- assertion asSentence As+monitored+by+circular+dichroism+and+differential+scanning+calorimetry%2C+SAP97+%28T%28m%29%3D64+degrees+C%29+is+significantly+more+thermal+stable+than+SAP90%2FPSD-95+%28T%28m%29%3D52+degrees+C%29+and+follows+a+bimodal+phase+transition. assertion.
- assertion asSentence Cdc2%2Fcyclin+B1+interacts+with+and+modulates+inositol+1%2C4%2C5-trisphosphate+receptor+%28type+1%29+functions. assertion.
- assertion asSentence Enzyme+is+down-regulated+and+leukotriene+production+reduced+by+prolonged+exposure+to+lipopolysaccharide. assertion.
- assertion asSentence Multiple+pools+of+AQP4+are+expressed+in+the+plasma+membrane+and+are+associated+with+the+dystrophin+complex. assertion.
- assertion asSentence TFIIA+gamma+together+with+ATF4+and+Runx2+stimulates+osteocalcin+promoter+activity+and+endogenous+mRNA+expression. assertion.
- assertion asSentence RANKL+increases+vascular+smooth+muscle+cell+calcification+through+a+RANK-BMP4-dependent+pathway. assertion.
- assertion asSentence beta3+can+have+a+profound+negative+regulatory+effect+on+N-type+%28and+also+R-type%29+calcium+channels+by+causing+a+hyperpolarizing+shift+of+the+inactivation+without+affecting+%22ultra-slow%22+and+%22closed-state%22+inactivation+properties. assertion.
- assertion asSentence CaR+is+the+beta+51-63+peptide+sensor+responsible+for+the+stimulation+of+CCK+secretion+in+enteroendocrine+STC-1+cells. assertion.
- assertion asSentence Expression+of+Mrp2+in+decreased+in+jejunum+of+long-evans+cinnamon+rats. assertion.
- assertion asSentence Sustained+delivery+of+Fgf1+increases+vascular+density+in+comparison+to+bolus+administration. assertion.
- assertion asSentence IL-6+and+IL-10+are+important+physiological+contributors+to+the+central+insulin+and+leptin+action+mediated+by+physical+activity%2C+linking+it+to+hypothalamic+ER+stress+and+inflammation. assertion.
- assertion asSentence Glutamate+substantially+increases+the+release+of+anti-inflammatory+cytokine+IL-10+%28but+not+IL-1beta+release%29+activated+by+a+high+concentration+of+lipopolysaccharide. assertion.
- assertion asSentence JNK+regulates+both+LHbeta+and+FSHbeta+transcription+in+a+differential+manner. assertion.
- assertion asSentence Selective+stimulation+of+Y%285%29+receptor+provokes+activation+of+the+HPA+axis+and+its+downstream+pathway+is+chiefly+composed+of+both+CRF+%28primary+regulator%29+and+AVP+%28subordinate+to+the+former%29+with+distinct+relative+contribution. assertion.
- assertion asSentence Different+values+of+traction+force+cause+a+variation+of+the+RANKL%2FOPG+ratio+through+the+expression+of+RANKL+protein%2C+modulating+the+activities+of+bone+remodeling+in+the+subchondral+bone+of+condyle. assertion.
- assertion asSentence Marked+hypertension-induced+reduction+in+oxytocin+receptor+mRNA+expression%2C+not+altered+by+training. assertion.
- assertion asSentence Adenosine+A2A+receptors+through+activation+of+the+adenylate+cyclase%2FcAMP%2FPKA+pathway+facilitate+GAT-1+mediated+GABA+transport+into+nerve+endings. assertion.
- assertion asSentence Adenosine+acting+via+A%282A%29-receptors+plays+a+role+in+the+hyperaemia+associated+with+tetanic+skeletal+muscle+contraction. assertion.
- assertion asSentence Inhibition+of+adenosine+A2A+receptors+prevents+the+lipopolysaccharide-induced+depression+of+synaptic+plasticity. assertion.
- assertion asSentence Replacement+of+intracellular+loop+3+and+the+COOH+tail+of+the+NK1R+with+comparable+domains+of+the+NK3R+diminished+colocalization+of+the+NK1R+with+beta-arrestin+1+and+accelerated+resensitization+to+that+of+the+NK3R. assertion.
- assertion asSentence Independent+beta-arrestin2+and+Gq%2Fprotein+kinase+Czeta+pathways+for+ERK+stimulated+by+angiotensin+type+1A+receptors+in+vascular+smooth+muscle+cells+converge+on+transactivation+of+the+epidermal+growth+factor+receptor. assertion.
- assertion asSentence ATF3deltaZip2+counteracts+anti-apoptotic+activity+of+NF-kappaB. assertion.
- assertion asSentence ATF3+plays+an+important+role+in+caspase-dependent+neuronal+apoptotic+signal+transduction+pathways+caused+by+focal+cerebral+ischemia+and+reperfusion+injury. assertion.
- assertion asSentence Thermal+instability+of+rat+muscle+sarcoplasmic+reticulum+Ca%282%2B%29-ATPase+function. assertion.
- assertion asSentence CaMKIIalpha+is+preferentially+targeted+to+glutamatergic+or+GABAergic+synapses+providing+neurons+with+a+mechanism+whereby+activity+can+selectively+potentiate+excitation+or+inhibition+through+a+single+kinase+mediator. assertion.
- assertion asSentence GABA+receptor+co-activation+inhibits+Fas%2FFasL+apoptosis%2C+kainic-acid-induced+thioredoxin+reductase+activity%2C+%26+procaspase-3+activation+by+diminishing+the+denitrosylation+of+its+active-site+thiol+%26+decreasing+cleavage+to+its+active+subunits. assertion.
- assertion asSentence The+expression+of+caveolin-1+and+-2+is+increased+in+EAM+lesions+and+the+increased+expression+of+caveolin-1+stimulates+second+signals+in+affected+cells%2C+such+as+macrophages+and+some+cardiomyocytes%2C+in+EAM+rats. assertion.
- assertion asSentence CAV1-mediated+ERalpha+trafficking+to+the+cell+membrane+is+required+for+estradiol+activation+of+circuits+underlying+female+sexual+receptivity. assertion.
- assertion asSentence CD44+is+a+specific+marker+of+small+hepatocytes. assertion.
- assertion asSentence Cas+plays+pivotal+roles+in+liver+development+through+the+reorganization+of+the+actin+cytoskeleton+and+formation+of+fenestrae+in+sinusoidal+endothelial+cells. assertion.
- assertion asSentence Individual+neuerons+in+the+prefrontal+cortex+that+receive+a+functional+input+from+the+basolater+amygdala+actively+encode+emotional+learning+and+thts+process+depends+on+dopamine+D4+receptor+stimulation. assertion.
- assertion asSentence FSH+up+%281.8-fold%29+regulates+its+receptor+level+only+in+the+immature+Sertoli+cells+and+not+in+the+adult. assertion.
- assertion asSentence Overexpression+of+GDNF+induces+genes+regulating+migration+and+differentiation+of+neuronal+progenitor+cells. assertion.
- assertion asSentence GFRalpha-1+displays+a+widespread+distribution+in+the+CNS+and+in+neurons+with+different+phenotypes. assertion.
- assertion asSentence RT-PCR+and+in+situ+hybridization+revealed+high-level+testicular+expression+of+HMGB1+mRNA+and+localization+of+this+expression+to+the+Sertoli+cells+and+germ+cells+of+the+human+and+rat+testis. assertion.
- assertion asSentence Both+the+repair+of+cisplatin-damaged+nucleosomes+and+its+inhibition+by+HMGB1+are+nucleosome+position-dependent+events+which+are+accomplished+via+the+acidic+tail+and+modulated+by+acetylation. assertion.
- assertion asSentence Cardiomyocyte+ICAM-1+binding%2C+by+polymorphonuclear+leukocytes+or+other+ligands%2C+induces+decreased+cardiomyocyte+contractility+via+this+pathway. assertion.
- assertion asSentence ICAM-1+activates+caveolin-1+signaling+responsible+for+caveolae-mediated+endothelial+hyperpermeability+in+rat+lung+cells. assertion.
- assertion asSentence Early+induction+of+moderate+hypothermia+suppresses+systemic+inflammatory+cytokines+and+intracellular+adhesion+molecule-1+in+rats+with+caerulein-induced+pancreatitis+and+endotoxemia. assertion.
- assertion asSentence The+freezing%2Fthawing+of+vascular+endothelial+cells+can+elicit+an+increase+in+ICAM-1+expression+on+the+cell+surface. assertion.
- assertion asSentence Exercise+reverses+insulin+sensitivity+in+diet-induced+obese+rats+by+improving+the+insulin+signalling+pathway%2C+in+parallel+with+a+decrease+in+iNOS+expression+and+in+the+S-nitrosation+of+IR%2FIRS1%2FAkt. assertion.
- assertion asSentence In+rat+bronchial+smooth+muscle+cells+PKC+activation+inhibits+K%28V%29+currents+and+down-regulates+the+expression+of+K%28V%291.5. assertion.
- assertion asSentence Kv1.5+and+Kv2.1+account+for+virtually+all+the+O2-sensitive+current+in+resistance+pulmonary+arteries. assertion.
- assertion asSentence Vasopressin+and+oxytocin+release+as+influenced+by+thyrotropin-releasing+hormone+in+euhydrated+and+dehydrated+rats. assertion.
- assertion asSentence The+role+of+OT+in+the+control+of+suckling+and+steroid-induced+PRL+secretion. assertion.
- assertion asSentence CypA+is+associated+with+the+inflammatory+infiltration+and+alveolar+bone+destruction+of+periodontitis. assertion.
- assertion asSentence Independent+beta-arrestin2+and+Gq%2Fprotein+kinase+Czeta+pathways+for+ERK+stimulated+by+angiotensin+type+1A+receptors+in+vascular+smooth+muscle+cells+converge+on+transactivation+of+the+epidermal+growth+factor+receptor. assertion.
- assertion asSentence Protein+kinase+G+regulation+of+interleukin+6+promoter+signaling+pathway+largely+prevented+fluid+shear+stress-induced+increases+of+IL-6+mRNA+in+osteosarcoma+cells. assertion.
- assertion asSentence Repeated+gene+transfer+of+PGIS+into+skeletal+muscle+attenuates+monocrotaline-induced+pulmonary+hypertension+and+prolongs+survival. assertion.
- assertion asSentence In+neurons+GTP+hydrolysis+and+rabphilin+are+involved+in+Rab3A+dissociation+from+the+vesicles+and+the+occurrence+of+exocytosis. assertion.
- assertion asSentence RhoA%2FROCK+play+a+critical+role+in+maintenance+of+spontaneous+tone+in+the+internal+anal+sphincter+smooth+muscle+via+inhibition+of+myosin+light+chain+phosphatase. assertion.
- assertion asSentence Regulation+of+the+neuronal+glutamate+transporter+excitatory+amino+acid+carrier-1+%28EAAC1%29+by+different+protein+kinase+C+subtypes. assertion.