Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "The insulin receptor, a ligand-stimulated tyrosine kinase, mediates the first steps in insulin action (White and Yenush, 1998). The activated receptor phosphorylates multiple proteins-e.g., insulin receptor substrates (IRS)-1, -2, -3, and -4. Phosphorylation of tyrosine residues in these substrates leads to activation of multiple downstream signaling pathways." provenance.
- _5 value "The insulin receptor, a ligand-stimulated tyrosine kinase, mediates the first steps in insulin action (White and Yenush, 1998). The activated receptor phosphorylates multiple proteins-e.g., insulin receptor substrates (IRS)-1, -2, -3, and -4. Phosphorylation of tyrosine residues in these substrates leads to activation of multiple downstream signaling pathways." provenance.
- _4 value "hepatocyte nuclear factor (HNF)-4a, HNF-1a, insulin promoter factor-1, and HNF-1b in MODY1, -3, -4, and -5, respectively (Yamagata et al., 1996a, 1996b; Stoffers et al., 1997; Horikawa et al., 1997). These transcription factors are expressed in pancreatic b cells, and the mutations are believed to cause insulin deficiency by impairing b cell function." provenance.
- _3 value "when the p85a subunit of PI 3-kinase was knocked out, the mice developed increased insulin sensitivity and hypoglyce- mia rather than diabetes" provenance.
- _3 value "when the p85a subunit of PI 3-kinase was knocked out, the mice developed increased insulin sensitivity and hypoglyce- mia rather than diabetes" provenance.
- _2 value "Glucose transport in beta-cells of type 2 diabetes patients appears to be greatly reduced" provenance.
- _2 value "Other defects in beta-cell function in type 2 diabetes mellitus include... decreased conversion of proinsulin to insulin hyperinsulinemia inhibits both insulin secretion (39) and action (40), and hyperglycemia can impair both the insulin secretory response to glucose (41) as well as cellular insulin sensitivity (42, 43)," provenance.
- _5 value "Furthermore, baseline and HA fragment-induced MME gene expression in alveolar Mphi from bleomycin-treated rats was inhibited by IFN-gamma. These data suggest that HA fragments may be an important mechanism for the expression of MME by Mphi in inflammatory lung disorders." provenance.
- _3 value "We have observed that NGF at doses as low as 10 ng/ml will induce IL-6 production and inhibit TNF-alpha release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor. NGF synergizes with LPS treatment of peritoneal mast cells (PMC) for the induction of IL-6. Examination of the mechanism of this phenomenon has revealed that NGF can induce both rat PMC and mouse bone marrow-derived cultured mast cells to produce substantial levels of PGE2." provenance.
- _5 value "In FDCP2 myeloid cells, IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4, whereas IL-3, granulocyte-macrophage CSF (GM-CSF), and phorbol ester (PMA) selectively activated PDE4." provenance.
- _4 value "PMA activated only MAP kinase" provenance.
- _6 value "TNF-alpha, AG-490 (Janus kinase inhibitor), and wortmannin (PI3-K inhibitor) inhibited activation of PDE3 and PDE4 by IL-4. TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6. AG-490 and wortmannin, not TNF-alpha, inhibited activation of PDE4 by IL-3" provenance.
- _4 value "We report here that oncogenic Ras (H-Ras) downregulates Fas expression and renders cells of fibroblastic and epitheloid origin resistant to Fas ligand-induced apoptosis.H-Ras signals via the PI 3-kinase pathway to downregulate Fas, suggesting that the known anti-apoptotic effect of the downstream PKB/Akt kinase may be mediated, at least in part, by the repression of Fas expression." provenance.
- _3 value "the oncogenic potential of H-ras may reside on its capacity not only to promote cellular proliferation, but also to simultaneously inhibit Fas-triggered apoptosis." provenance.
- _4 value "Mkk3(-/-) mice were viable and fertile; however, they were defective in interleukin-12 (IL-12) production by macrophages and dendritic cells." provenance.
- _4 value "Mkk3(-/-) mice were viable and fertile; however, they were defective in interleukin-12 (IL-12) production by macrophages and dendritic cells." provenance.
- _3 value "Haloperidol (0.1-8 mg/kg) and (-)-sulpiride (10-100 mg/kg), induced NGF mRNA in a dose-dependent fashion haloperidol and (-)-sulpiride induce the expression of c-fos and c-jun mRNAs and increase their AP-1 DNA binding activities. Thus, the data suggest that neuroleptics induce NGF gene expression by increasing AP-1 DNA binding activity." provenance.
- _3 value "Haloperidol (0.1-8 mg/kg) and (-)-sulpiride (10-100 mg/kg), induced NGF mRNA in a dose-dependent fashion haloperidol and (-)-sulpiride induce the expression of c-fos and c-jun mRNAs and increase their AP-1 DNA binding activities. Thus, the data suggest that neuroleptics induce NGF gene expression by increasing AP-1 DNA binding activity." provenance.
- _4 value "Haloperidol (0.1-8 mg/kg) and (-)-sulpiride (10-100 mg/kg), induced NGF mRNA in a dose-dependent fashion haloperidol and (-)-sulpiride induce the expression of c-fos and c-jun mRNAs and increase their AP-1 DNA binding activities. Thus, the data suggest that neuroleptics induce NGF gene expression by increasing AP-1 DNA binding activity." provenance.
- _5 value "Incubation of medium conditioned by human smooth muscle cells that contained pro-MMP-2, with plasma membrane extracts prepared from EC treated with TNF-a, interleukin-1b, or OxLDL, increased the proteolytic conversion of 72-kDa proMMP-2 to new gelatinolytic bands of 70- and 68-kDa corresponding to the processed active MMP-2 (Fig. 7A). Proteolytic processing of pro-MMP-2 was reduced in membrane extracts incubated with anti-MT1-MMP antibody (Fig. 7A and B)." provenance.
- _4 value "GPX is induced by etoposide, a topoisomerase II inhibitor and a p53 activator" provenance.
- _3 value "The c-Myc oncoprotein induces cell proliferation" provenance.
- _5 value "STATs (mainly STAT5A and STAT5B, but also STAT1 and STAT3) are also activated in hematopoietic cell lines expressing BCR/ABL (24) and in CML cells" provenance.
- _4 value "Both GH-dosage, the increase in IGF-II, and body mass index correlated with the decrease in IGFBP-2. Furthermore, the increase in serum IGF-I, IGF-II, and triiodothyronine correlated with the increase in IGFBP-3. Moreover, GH-dosage correlated with the increase in serum IGFBP-4." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "As shown in Fig. 1B, the levels of IL-6 protein were similarly increased in a concentration-dependent manner as compared with controls. Unstimulated quiescent human lung fibroblasts secreted 260 6 13 pg/ml of IL-6 protein within 12 h." provenance.
- _4 value "We show that, in vitro, interferon-gamma (IFN-gamma) together with interleukin-1beta (Il-1beta) and tumor necrosis factor-alpha (TNF-alpha) can induce the expression of CD23 in glial cells." provenance.
- _2 value "when the supply of glucose to muscle is increased, malonyl CoA levels increase in keeping with a decreased need for fatty acid oxidation, and fatty acids are preferentially esterified to form diaglycerol and triglycerides" provenance.
- _4 value "The chymotrypsin-like and peptidylglutamyl peptide bond hydrolyzing activities of the proteasome increased five weeks after retinoic acid," provenance.
- _7 value "Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM)." provenance.
- _7 value "Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM)." provenance.
- _9 value "Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM)." provenance.
- _4 value "Modified assertion" provenance.
- _3 value "Estradiol interacting with its cognate receptor reduces the accumulation of Nos2 in rat smooth muscle cell. This effect might be due to the activation of either estrogen receptor alpha or estrogen receptor beta. Treating the cell with Tamoxifen and ICI182,780 (antagonist of estrogen receptor) blocks the estradiol induced decrease of Nos2 protein content." provenance.
- _3 value "Such conditional mutant mice (knockout of wild type IL6ST under the Cre-Lox system) have normal cardiac structure and function, but during aortic pressure overload, these mice display rapid onset of dilated cardiomyopathy and massive induction of myocyte apoptosis versus the control mice that exhibit compensatory hypertrophy. " provenance.
- _6 value "stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase" provenance.
- _6 value "stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase" provenance.
- _9 value "stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase" provenance.
- _6 value "stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase" provenance.
- _6 value "stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase" provenance.
- _3 value "The administration of LPS, zymosan, BCG, or L. monocytogenes to mice resulted in ... the upregulation of MSR-A expression in the liver and spleen" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Ras-3T3 tumor cells produced increased amounts of vascular endothelial growth factor (VEGF) and lovastatin effectively suppressed VEGF production by these cells." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (Jak PTKs); Jak1/Tyk2 and Jak1/Jak2 for IFN-alpha/beta and IFN-gamma, respectively." provenance.
- _3 value "Modified assertion" provenance.
- _4 value "Nonetheless, a functional link between TRAF2 and IKK activity in B cells is demonstrated by the fact that overexpression of TRAF2 constitutively induces IKK activity, NF-kappaB luciferase and Fas expression" provenance.
- _5 value "cellular treatment with H2O2 negatively modulates GR function and decreases glucocorticoid-inducible gene expression. Impaired cellular response to glucocorticoids is rescued by overexpression of TRX, most probably through the functional replenishment of the GR. Moreover, not only the ligand binding domain but the DNA binding domain of the GR is also suggested to be a direct target of TRX." provenance.
- _5 value "Cross-linking of CD43 induced tyrosine phosphorylation of several intracellular molecules including the protein tyrosine kinase Syk, the proto-oncogene product Cbl, and phospholipase C (PLC)-gamma2 in MO7e cells." provenance.
- _5 value "Cross-linking of CD43 induced tyrosine phosphorylation of several intracellular molecules including the protein tyrosine kinase Syk, the proto-oncogene product Cbl, and phospholipase C (PLC)-gamma2 in MO7e cells." provenance.
- _5 value "# Ariadne: Small amounts of TIMP-2 added to cells expressing MT1-MMP can enhance pro-MMP-2 activation, because this increases the concentration of the MT1-MMP/TIMP-2 receptor for pro-MMP-2 on the cell surface. [Regulation] # Ariadne: In this study, we demonstrated that all of the growth factors and cytokines tested, namely G-CSF, GM-CSF, SCF, IL-3, IL-6, M-CSF, IL-8, and TNF-alpha, were able to induce the secretion of MMP-9 and MMP-2 by bone marrow CD34 + cells. [Regulation]" provenance.
- _5 value "# Ariadne: Small amounts of TIMP-2 added to cells expressing MT1-MMP can enhance pro-MMP-2 activation, because this increases the concentration of the MT1-MMP/TIMP-2 receptor for pro-MMP-2 on the cell surface. [Regulation] # Ariadne: In this study, we demonstrated that all of the growth factors and cytokines tested, namely G-CSF, GM-CSF, SCF, IL-3, IL-6, M-CSF, IL-8, and TNF-alpha, were able to induce the secretion of MMP-9 and MMP-2 by bone marrow CD34 + cells. [Regulation]" provenance.
- _4 value "arachidonic acid liberated by phospholipase A2 can act as an additional trigger for PLC-gamma activation" provenance.
- _5 value "Finally, we report that several different cardiac transcription factors trans-activate the 1.9HSCAT construct... Adss1 appears to be one of the first target genes identified for the bHLH factors Hand1 and Hand2. the combinations utilizing all of the transcription factors, Nkx 2.5, GATA 4, MEF2C, E12, and Hand1 or Hand2, result in a substantial 35-65-fold enhancement of reporter expression" provenance.
- _5 value "Finally, we report that several different cardiac transcription factors trans-activate the 1.9HSCAT construct... Adss1 appears to be one of the first target genes identified for the bHLH factors Hand1 and Hand2. the combinations utilizing all of the transcription factors, Nkx 2.5, GATA 4, MEF2C, E12, and Hand1 or Hand2, result in a substantial 35-65-fold enhancement of reporter expression" provenance.
- _5 value "Within the proximal A1AR promoter, putative binding sites for cardiac transcription factors GATA and Nkx2.5 were identified. Co-expression studies revealed that GATA-4 and Nkx2.5 could individually drive A1AR promoter activity and act synergistically to activate A1AR expression" provenance.
- _7 value "LAR over-expression eliminated p130Cas from focal adhesions without affecting focal adhesion assembly. Restoring the level of p130Cas alleviated LAR-induced apoptosis. " provenance.
- _4 value "The over-expression of LAR in mammalian tissue culture cells does not affect cell adhesion but induces caspase-dependent apoptosis." provenance.
- _4 value "Background Skeletal muscle differentiation (myogenesis) involves a cascade of muscle-specific gene expression that is coordinated with permanent withdrawal from the cell cycle. The commitment of cells to the myogenic lineage requires either of two members of the myogenic basic helix-loop-helix (bHLH) transcription-factor family, MyoD or Myf-5, which are expressed in proliferating myoblasts prior to the onset of muscle differentiation (reviewed in [1-3])." provenance.
- _4 value "In monocytic cells, mutation of these residues to alanine prevents MEF2C activation in response to either lipopolysaccharide stimulation or constitutive activation of the p38 kinase pathway [25]." provenance.
- _5 value "In monocytic cells, mutation of these residues to alanine prevents MEF2C activation in response to either lipopolysaccharide stimulation or constitutive activation of the p38 kinase pathway [25]." provenance.
- _5 value "To better understand the mechanism(s) through which pRb positively affects myogenesis and to ascertain why the later steps of myogenesis are specifically altered in the absence of pRb, we have further characterized the differentiation defects that are seen in pRb-deficient muscle cells. We demonstrate that the failure to activate late muscle-gene expression in pRbdeficient myocytes is due to a requirement for both MyoD and pRb in the activation of MEF2 transactivation-domain (TAD) function." provenance.
- _7 value "To test whether pRb is required for MyoD to activate the MEF2C TAD, we transfected Rb-/- fibroblasts with the Gal4-MEF2C fusion protein either alone or with MyoD and E12, in either the absence or the presence of exogenous pRb. When expressed alone, MyoD+E12 did not significantly stimulate Gal4-MEF2C function in these cells (Figure 3c, column 4). Similarly, the expression of pRb alone did not affect the activity of Gal4-MEF2C (Figure 3c, column 5); but, the combined expression of MyoD+E12 and pRb led to a 45-fold increase in the activity of Gal4-MEF2C (Figure 3c, column 6). These findings indicate that MyoDmediated activation of the MEF2C TAD requires pRb." provenance.
- _4 value "even though this fusion protein efficiently prevented BrdU uptake in MCK-CAT-positive cells (Figure 4h-j). As E2F1-pRb(SP) retained the anti-proliferative property of pRb but did not fully activate myogenesis on its own, we tested whether it could cooperate with MEF2C-VP16 in our myogenesis assays. The combination of MyoD+E12, MEF2C-VP16, and E2F1-pRb(SP) activated MCK-luciferase expression to a level equal to or greater than that achieved following co-transfection of MyoD+E12 with pRb (Figure 4a, compare columns 3 and 7), and led to the appearance of numerous cells in the culture that displayed very high levels of CAT staining and no BrdU incorporation (Figure 4k-m), very similar to what was observed following transfection of MyoD with pRb (Figure 4b-d). Cotransfection of E2F1-pRb(SP) and MEF2C-VP16 in the absence of MyoD did not induce the expression of MCK-CAT (data not shown). Thus, we were able to fully substitute for the loss of pRb by cotransfecting MyoD with an activated form of MEF2 and the cell-cycle-arresting molecule E2F1-pRb(SP)." provenance.
- _5 value "These findings demonstrate that sensitization of human ovarian carcinoma cell lines to Fas-mediated apoptosis by IFN-gamma can be due, in part, to the induction of iNOS and the subsequent upregulation of Fas gene expression by reactive nitrogen intermediates" provenance.
- _2 value "Troponin T (TnT) is an essential protein in the transduction of the Ca2+-binding signal that triggers striated muscle contraction" provenance.
- _5 value "Here we demonstrate that the expression of the human MMP-2 gene is enhanced by a synergistic action of retinoic acid (RA) and dibutyryl cyclic AMP" provenance.
- _7 value "Binding of vascular endothelial growth factor (VEGF) to its receptor, VEGFR-2 (Flk-1/KDR), induces dimerization and activation of the tyrosine kinase domain of the receptor," provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Pyk2-induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades. Expression of a Grb2 mutant with a deletion of the amino-terminal Src homology 3 domain or the carboxyl-terminal tail of Sos strongly reduced Pyk2-induced ERK activation, with no apparent effect on JNK activity." provenance.
- _5 value "expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2" provenance.
- _6 value "the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway." provenance.
- _5 value "In this study we show that K protein is phosphorylated in vitro by PKCdelta and by other PKCs. Deletion analysis and site-directed mutagenesis revealed that Ser302 is a major K protein site phosphorylated by PKCdelta in vitro." provenance.
- _4 value "NE also upregulated MUC5AC in A549 cells in a time-dependent manner (Fig. 2A)" provenance.
- _6 value "Modified assertion" provenance.
- _6 value "# Ariadne: The transactivation domains of MEF2A and MEF2C are activated by m1 G protein-coupled receptors. [Regulation]" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "FOG-2 resulted in a nearly 10-fold reduction in activity of the BNP promoter in the absence of added GATA-4, and it inhibited activity in the presence of GATA-4." provenance.
- _6 value "Following the expression of ASK1, activated forms of JNK and p38 were observed in apoptotic cells detected by the TUNEL method" provenance.
- _5 value "TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin." provenance.
- _2 value "LPS treatment increased vascular O2- (from 35+/-2 cpm/ring at baseline to 166+/-21 cpm/ring at 12 hours and 225+/-16 cpm/ring at 30 hours) and H2O2 formation" provenance.
- _4 value "physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid and deoxycholic acid activated Fxr, an orphan nuclear receptor as ligands, these bile acids and their conjugates modulated interaction of Fxr with a peptide derived from steroid receptor coactivator 1 these results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis" provenance.
- _4 value "293T cells were cotransfected with empty vector, or plasmids expressing wild type RIPK3 or RIPK3 (1-436), together with pGDB, and treated with 10 nanogram/ml of TNF and 10 microgram/ml cycloheximide. Lysates analysed by immunoblotting after 24 hours with anti-GFP monoclonal antibodies showed that RIPK3 (1-436) significantly decreases TNF-induced CASP activity." provenance.
- _5 value "HsCdc6 is an excellent substrate for Cdk2 in vitro and is phosphorylated in vivo at three sites (Ser-54, Ser-74, and Ser-106) that are phosphorylated by Cdk2 in vitro, strongly suggesting that HsCdc6 is an in vivo Cdk substrate . . . It is thought that Cdk phosphorylation of Cdc6p and Cdc18 triggers their degradation through a ubiquitination-mediated protein-degradation pathway (11?13)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA)" provenance.
- _3 value "In rat endometrium, expression of gap junction connexin-26 (cx26) in the epithelium and cx43 in the uterine stroma is suppressed by progesterone before implantation. A hormonal ratio of E2 to P that mimics conditions during pregnancy (0.1 microg E2 and 4 mg P) suppressed expression of cx26 and cx43. By changing the ratio to higher E2 levels (1 microg E2), cx26, in contrast to cx43, was not suppressed even by application of a high P concentration (10 mg)" provenance.
- _3 value "Modified assertion" provenance.
- _3 value "cx26 gene expression is induced earlier by E2 and is likely to be more sensitive to a shift in the E2 to P ratio than cx43." provenance.
- _4 value "Levels of bcl-xl, bcl-xs, and caspase-3 mRNAs were increased by NGF treatment." provenance.
- _4 value "Levels of bcl-xl, bcl-xs, and caspase-3 mRNAs were increased by NGF treatment." provenance.
- _4 value "NGF withdrawal resulted in abrupt down-regulation of bcl-xl and up-regulation of bax, favoring apoptosis." provenance.
- _5 value "We now show that in osteoblast-like cells, rhBMP-2 inhibits NCAM expression, while HOXC6 increases its expression, both acting via the same region of the promoter." provenance.
- _4 value "Antigen-evoked secretion of interferon-gamma (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA/2 mouse I-Ed-restricted clones, that express EP3Rs and EP4Rs, was enhanced a maximum of 3-fold by 10(-10) to 10(-8) M PGE2 and 2.5-fold each for the EP1R/EP3R-directed agonist sulprostone (10(-8) and 10(-7) M) and for the EP4R/EP3R/EP2R agonist misoprostol (10(-9) M). " provenance.
- _4 value "Antigen-evoked secretion of interferon-gamma (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA/2 mouse I-Ed-restricted clones, that express EP3Rs and EP4Rs, was enhanced a maximum of 3-fold by 10(-10) to 10(-8) M PGE2 and 2.5-fold each for the EP1R/EP3R-directed agonist sulprostone (10(-8) and 10(-7) M) and for the EP4R/EP3R/EP2R agonist misoprostol (10(-9) M). " provenance.
- _4 value "Antigen-evoked secretion of interferon-gamma (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA/2 mouse I-Ed-restricted clones, that express EP3Rs and EP4Rs, was enhanced a maximum of 3-fold by 10(-10) to 10(-8) M PGE2 and 2.5-fold each for the EP1R/EP3R-directed agonist sulprostone (10(-8) and 10(-7) M) and for the EP4R/EP3R/EP2R agonist misoprostol (10(-9) M). " provenance.
- _3 value "The expression of p18 and p21, regulated at the level of protein and mRNA accumulation, was directly coupled to differentiation." provenance.
- _3 value "The expression of p18 and p21, regulated at the level of protein and mRNA accumulation, was directly coupled to differentiation." provenance.
- _5 value "Reporter gene studies in HepG2 hepatoma cells show that FKHR stimulates insulin-like growth factor-binding protein-1 promoter activity through an IRS, and introduction of IRSs confers this effect on a heterologous promoter." provenance.
- _5 value "Modified assertion" provenance.