Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "In vitro kinase assay... As demonstrated in Fig. 4b, PMA induced rapid activation of MAPKerk1/2 at 15 min, consistent with the Western blot information. TNF-a-induced activation of MAPKerk1/2 was detected by 60 min." provenance.
- _4 value "TNF-a induced minimal activation of MAPKerk after brief periods of exposure (5?15 min); however, phosphoactivation of MAPKerk was observed by 60 min." provenance.
- _4 value "TNF-a induced minimal activation of MAPKerk after brief periods of exposure (5?15 min); however, phosphoactivation of MAPKerk was observed by 60 min." provenance.
- _3 value "Recombinant TMEFF2 also promoted survival of mesencephalic dopaminergic neurons." provenance.
- _4 value "An increase in fatty acyl CoAs can lead to increased diacylglycerol (DAG) concentrations. DAG, in turn, activates many isoforms of protein kinase C (PKC), including PKCepsilon and PKCtheta." provenance.
- _3 value "increasing plasma FFA concentrations during an insulin infusion inhibits insulin -stimulated glucose uptake," provenance.
- _2 value "increasing plasma FFA concentrations during an insulin infusion inhibits insulin -stimulated glucose uptake," provenance.
- _2 value "infusion of lipid concomitantly reduces glucose uptake and insulin-stimulated glycogen synthesis." provenance.
- _2 value "Thiazolidinediones (TZDs) reduce insulin resistance in type 2 diabetes by increasing peripheral uptake of glucose, and they bind to and activate the transcriptional factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma)." provenance.
- _6 value "we have demonstrated that PP1, a pharmacological inhibitor of Src kinases, blocked SCF-mediated activation of mitogen-activated protein (MAP) kinase, but it also inhibited Kit activation." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "These findings indicate that TNF-induced MT stabilization is mediated by hyperphosphorylation of Op18 and that this promotes cell death." provenance.
- _4 value "These findings indicate that TNF-induced MT stabilization is mediated by hyperphosphorylation of Op18 and that this promotes cell death." provenance.
- _5 value "# Ariadne: RhoB also has cell cycle inhibitory roles and is upregulated during stress responses ( 14 , 15 ) and by the inhibitory growth factor transforming growth factor beta ( 12 ). [Regulation]" provenance.
- _5 value "Increased protein tyrosine phosphatase activity as well as mRNA levels of PTPbeta2 and PTPepsilon could be observed by wildtype p53 overexpression." provenance.
- _5 value "Increased protein tyrosine phosphatase activity as well as mRNA levels of PTPbeta2 and PTPepsilon could be observed by wildtype p53 overexpression." provenance.
- _3 value "The intestinal Gpx2 mRNA levels of Gpx1-KO and wild-type mice increased up to 14- and 7-fold after radiation, respectively" provenance.
- _6 value "Mutation of serine 117 to alanine abolished Erk2-mediated phosphorylation in vitro and the MAP kinase-related transcriptional activation of SREBP-1a by insulin and platelet-derived growth factor in vivo." provenance.
- _6 value "Mutation of Lys650-->Glu in the activation loop of the FGFR3 kinase domain causes the lethal human skeletal disorder thanatophoric dysplasia type II (TDII) and is also found in patients with multiple myeloma, bladder and cervical carcinomas. This mutation leads to constitutive activation of FGFR3. We show that the kinase domains of FGFR1, FGFR3, and FGFR4 containing the activation loop mutation, when targeted to the plasma membrane by a myristylation signal, can transform NIH3T3 cells and induce neurite outgrowth in PC12 cells. Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated by all three 'TDII-like' FGFR derivatives. Additionally, activation of Stat1 and Stat3 was observed in cells expressing the activated FGFR derivatives. Finally, we demonstrate that FGFR1, FGFR3, and FGFR4 derivatives can stimulate PI-3 kinase activity. " provenance.
- _5 value "IFN-alpha and IFN-beta demonstrated that the two IFNs were similarly effective in inducing tyrosine phosphorylation of the Jak-1 and Tyk-2 kinases and the transcription factors Stat-1 and Stat-2" provenance.
- _5 value "The myrAkt-expressing cells continued to proliferate, even in the absence of hormones, and they were resistant to programmed cell death induced by starvation. These effects were paralleled by the induction of the G1 cyclins D3 and E and by the inhibition of induction of the proapoptotic Fas, Fas ligand, and BAD genes in starved cells." provenance.
- _5 value "Apoptosis signal-regulating kinase 1 (ASK 1) is a mitogen-activated protein (MAP) kinase kinase kinase (MAPKKK) that is activated by TNF and IL-1" provenance.
- _3 value "FER overexpression caused cortactin phosphorylation that was further enhanced by hypertonicity. Exchange of tyrosine residues 421, 466, and 482 for phenylalanine prevented cortactin phosphorylation by hypertonicity and strongly decreased it upon FER overexpression," provenance.
- _3 value "Hypertonicity provoked Fyn-dependent tyrosine phosphorylation in beta-catenin, alpha-catenin, and p120(Cas) and caused the dissociation of beta-catenin from the contacts." provenance.
- _3 value "Hypertonicity provoked Fyn-dependent tyrosine phosphorylation in beta-catenin, alpha-catenin, and p120(Cas) and caused the dissociation of beta-catenin from the contacts." provenance.
- _6 value "In response to Wnt, beta-catenin is stabilized and translocated into the nucleus where it stimulates gene expression through Tcf/Lef." provenance.
- _4 value "LPS (10-100 microgram) treatment induced a dose-dependent increase in expression of E-selectin in the high probability (HP) for atherosclerotic lesion development region, whereas in the LP region, low expression levels were found even at the 100 microgram dose via p65." provenance.
- _2 value "In perfused fast-twitch muscles, contractions induced significant increases in AMPK activity and glucose transport" provenance.
- _5 value "Thus, we postulate that the decreased tyrosine kinase activity of the insulin receptor may be caused by serine/threonine phosphorylation by PKC." provenance.
- _4 value "inhibition of CLN3 protein synthesis by antisense approach acidifies lysosomal compartments. These changes in lysosomal pH are sufficient to exert a significant biological effect and modify intracellular processing of amyloid-beta protein precursor and cathepsin D, model proteins whose metabolism is influenced by the pH of acidic organelles." provenance.
- _3 value "We demonstrate that ACS4 expression in steroidogenic tissues in vivo is induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin." provenance.
- _3 value "We demonstrate that ACS4 expression in steroidogenic tissues in vivo is induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin." provenance.
- _3 value "We demonstrate that ACS4 expression in steroidogenic tissues in vivo is induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin." provenance.
- _4 value "Na+-salicylate and cyclopentenone PGs, direct inhibitors of IKK beta, interfered in the activation of the Bcl-xL promoter and induced apoptosis in CD28-costimulated CD4+ T cells." provenance.
- _4 value "Na+-salicylate and cyclopentenone PGs, direct inhibitors of IKK beta, interfered in the activation of the Bcl-xL promoter and induced apoptosis in CD28-costimulated CD4+ T cells." provenance.
- _4 value "Also, EGTA and NAC regulated H2O2- or ionomycininduced AP-1 binding activity in the same pattern (Fig. 6B)." provenance.
- _4 value "Also, stimulation with TGF-b1 (1 ng/ml) caused a time-dependent increase in IL-6 protein accumulation in the culture supernatants (Fig. 2C)." provenance.
- _3 value "Furthermore, direct addition of exogenous H2O2 also increased IL-6 mRNA expression in a dose-dependent manner (Fig. 3B)." provenance.
- _2 value "In addition, when HLF cells were treated with H2O2, [Ca21] was elevated ;3-fold (Fig. 6C)" provenance.
- _3 value "In the same line, H2O2 treatment also activated AP-1 activation" provenance.
- _4 value "Similar results were also observed in AP-1 EMSA (Fig. 7B). (EMSA of AP-1 site in H202, TGFB1 and Ionomycin treated cells +/- PD compound)" provenance.
- _3 value "Angiotensin II (Ang II), a proinflammatory mediator implicated in atherosclerosis, restenosis, and hypertension,13 leads to the hypertrophic response in SMCs via the production of both superoxide and H2O2 and activation of p38 MAPK.14,15" provenance.
- _4 value "Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis." provenance.
- _2 value "Generation of reactive oxygen intermediates, activation of NF-kB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?" provenance.
- _2 value "Generation of reactive oxygen intermediates, activation of NF-kB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?" provenance.
- _3 value "Similarly, thrombin stimulates H2O2 and superoxide production in SMCs.7" provenance.
- _3 value "Suppression of endogenous intracellular H2O2, through overexpression of catalase or treatment with membrane-permeable antioxidants, not only inhibits proliferation but also promotes apoptosis in SMCs.11,12" provenance.
- _4 value "c-Jun triggers apoptosis in human vascular endothelial cells" provenance.
- _4 value "p38 Mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells" provenance.
- _4 value "Furthermore, CD40 and IL-4 synergistically increased IL-6 but decreased IL-8 production by HUVEC." provenance.
- _4 value "Furthermore, CD40 and IL-4 synergistically increased IL-6 but decreased IL-8 production by HUVEC." provenance.
- _3 value "XS mRNA expression and the transcription activity of 5'FL-TXS were inhibited by PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ(2)), and the thiazolidinedione troglitazone (TRO) in a dose-dependent manner." provenance.
- _3 value "Furthermore, antisense c-jun oligonucleotides decreased the stretch-induced stimulation of the fibronectin promoter activity and the mRNA expression. These results suggest that cyclic stretch stimulates vascular fibronectin gene expression mainly via the activation of AP-1 through the angiotensin II type 1 receptor." provenance.
- _4 value "Insulin increased the phosphorylation of the GGTase I alpha subunit without affecting the total amount of GGTase I protein." provenance.
- _4 value "XIAP had no detectable effect on ara-C-induced release of mitochondrial cytochrome c and attenuated cleavage of procaspase-9." provenance.
- _3 value "Muscle-G4KO mice showed insulin resistance" provenance.
- _3 value "homozygous or heterozygous disruption of the gene for GLUT4 in muscle increases the risk of hyperglycemia and hyperinsulinemia, with some knockout and heterozygous knockout mice showing glucose levels in the diabetic range and insulin levels indicative of severe insulin resistance" provenance.
- _6 value "Furthermore, Iba1 colocalized with a small GTPase Rac in the membrane ruffles and the phagocytic cups. The Iba1 mutants also suppressed membrane ruffling induced by dominant active Rac1V12" provenance.
- _4 value "Furthermore, Iba1 colocalized with a small GTPase Rac in the membrane ruffles and the phagocytic cups. The Iba1 mutants also suppressed membrane ruffling induced by dominant active Rac1V12" provenance.
- _4 value "Furthermore, Iba1 colocalized with a small GTPase Rac in the membrane ruffles and the phagocytic cups. The Iba1 mutants also suppressed membrane ruffling induced by dominant active Rac1V12" provenance.
- _3 value "JunB, c-Jun, c-Fos, and Fra2 were rapidly but transiently induced by FSH in immature granulosa cells." provenance.
- _6 value "Moreover, purified recombinant PP2C alpha and PP2C beta 2 proteins efficiently dephosphorylated monomeric Cdk2/Cdk6 in vitro." provenance.
- _5 value "Thus, the GnRH proximal promoter is regulated by the Otx2 homeoprotein." provenance.
- _6 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Our results indicate that autocrine secretion of PRL stimulates tyrosine phosphorylation of ErbB-2 by Jak2, provides docking sites for Grb2 and stimulates Ras-MAP kinase cascade, thereby causing unrestricted cellular proliferation." provenance.
- _5 value "Our results indicate that autocrine secretion of PRL stimulates tyrosine phosphorylation of ErbB-2 by Jak2, provides docking sites for Grb2 and stimulates Ras-MAP kinase cascade, thereby causing unrestricted cellular proliferation." provenance.
- _3 value "Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin. " provenance.
- _3 value "The serum G-CSF concentration and the increased total leukocyte count were markedly decreased by the presence of the NO scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazole-1-oxyl 3-oxide sodium salt (carboxy-PTIO), in combination with rhG-CSF and SNAP" provenance.
- _4 value "expression of CDK4/cyclin D1, which stimulated RB phosphorylation" provenance.
- _4 value "though V12Ras was able to stimulate ERK phosphorylation and induce cyclin D1 expression in the absence of androgen" provenance.
- _4 value "though V12Ras was able to stimulate ERK phosphorylation and induce cyclin D1 expression in the absence of androgen" provenance.
- _4 value "GRP Increases FAK Expression." provenance.
- _4 value "Phosphorylation of Epor, Stat5 and Gab1 induced by Epo was inhibited by Jak2 inhibitor AG490." provenance.
- _4 value "Phosphorylation of Epor, Stat5 and Gab1 induced by Epo was inhibited by Jak2 inhibitor AG490." provenance.
- _4 value "Jubilant: Following the treatment with IL-18 plus IL-12, IFNgamma and TNFalpha levels rose rapidly, GM-CSF modestly elevated, Il-1beta, IL-6 and IL-10 were markedly elevated in SCID mice. IL-18 alone did not stimulate significant endogenous production of IFNgamma, TNFalpha and GM-CSF, whereas modest serum level of IFNgamma were observed in mice receiving injections of IL-12 alone." provenance.
- _6 value "Jubilant: Following the treatment with IL-18 plus IL-12, IFNgamma and TNFalpha levels rose rapidly, GM-CSF modestly elevated, Il-1beta, IL-6 and IL-10 were markedly elevated in SCID mice. IL-18 alone did not stimulate significant endogenous production of IFNgamma, TNFalpha and GM-CSF, whereas modest serum level of IFNgamma were observed in mice receiving injections of IL-12 alone." provenance.
- _3 value "p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression. " provenance.
- _2 value "p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression. " provenance.
- _6 value "In this paper, we demonstrate that TTF-2 is able to inhibit the activity of the thyroid-specific transcription factors TTF-1 and Pax-8 only on certain promoters." provenance.
- _2 value "T18A/S19A RLC overexpression resulted in the production of multinucleated cells, suggesting the failure of proper cell division in these cells. Video microscopic observation revealed that cells expressing T18A/S19A RLC showed abnormalities during mitosis in two respects." provenance.
- _4 value "FGF-2 stimulated DNA synthesis and induced a sustained phosphorylation of p42/44(MAPK) and of its downstream target, p90(RSK)." provenance.
- _7 value "Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress GSK-3beta-dependent phosphorylation of Axin." provenance.
- _4 value "Forced expression of JNKAPF, a dominant negative form of JNK, caused a minimal increase (5%) in the level of cell death in untreated cells, in a manner that was not affected by GSTp expression (Fig. 4a ? ). The level of H2O2-induced cell death was reduced upon expression of GSTp (from 36% to 22%) and upon coexpression of JNKAPF and GSTp (from 17% to 8%; Fig. 4a ? ). " provenance.
- _4 value "Treatment with 50 ?m H2O2 in the absence of GSTp expression led to the death of 35% of the cells after 24 h; this was reduced to 20% upon GSTp expression (Fig. 3 ? )." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _4 value "The TNF-ainduced COX-2 promoter activity was blocked by genistein, herbimycin, U73122, or staurosporine, while the TPA-induced activity was inhibited by genistein or herbimycin (Fig. 12A)." provenance.
- _4 value "The endogenous IKK complex was isolated by immunoprecipitation with anti-IKKb Ab and tested for in vitro kinase activity. As shown in Fig. 13, both TNF-a and TPA induced IKK activation, and these effects were inhibited by staurosporine and herbimycin." provenance.
- _4 value "When cells were pretreated with 10?100 mM genistein or 1 mM herbimycin, TPA-induced COX-2 expression was inhibited" provenance.
- _4 value "AxCAIL-13 reduced the secreted quantity of ENA-78 by 85 and 94% at 24 and 48hours, respectively (p<0.05; n=6). ENA-78 levels were decreased by 92% after 72hours." provenance.
- _6 value "COUP-TFII has been demonstrated to negatively regulate the transcriptional activity of adrenal 4-binding protein" provenance.
- _6 value "In contrast, in the presence of mutant TSHRs or Gsalpha, total PDE activity was higher. This increase was primarily due to PDE4 induction (917 +/- 116% over NTs), ...In particular, increases in cAMP levels in FRTL-5 cells after TSH treatment result in short-term activation of cAMP-specific PDEs (such as PDE4) via protein kinase A-induced phosphorylation and in long-term activation via gene expression and protein synthesis regulation (9, 10, 11)." provenance.
- _6 value "Semiquantitative RT-PCR experiments suggest that the stimulation of cAMPspecific PDE4 is the consequence of an increased mRNA steady state and protein synthesis, at least in the case of PDE isoforms encoded by the 4C and 4D genes" provenance.
- _6 value "beta- and alpha 2-adrenergic receptors (ARs) couple positively and negatively, respectively, to adenylyl cyclase" provenance.
- _4 value "beta- and alpha 2-adrenergic receptors (ARs) couple positively and negatively, respectively, to adenylyl cyclase" provenance.
- _4 value "beta- and alpha 2-adrenergic receptors (ARs) couple positively and negatively, respectively, to adenylyl cyclase" provenance.
- _4 value "beta- and alpha 2-adrenergic receptors (ARs) couple positively and negatively, respectively, to adenylyl cyclase" provenance.
- _4 value "increased alpha 2/beta-AR balance in adipocytes promotes obesity by stimulating adipocyte hyperplasia" provenance.