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- _6 value "In contrast, in the presence of mutant TSHRs or Gsalpha, total PDE activity was higher. This increase was primarily due to PDE4 induction (917 +/- 116% over NTs), ...In particular, increases in cAMP levels in FRTL-5 cells after TSH treatment result in short-term activation of cAMP-specific PDEs (such as PDE4) via protein kinase A-induced phosphorylation and in long-term activation via gene expression and protein synthesis regulation (9, 10, 11)." provenance.
- _6 wasQuotedFrom 10946896 provenance.