Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "Modified assertion" provenance.
- _4 value "Mutations in hepatocyte nuclear factor 1 alpha (HNF-1A) lead to maturity-onset diabetes of the young type 3 as a result of impaired insulin secretory response in pancreatic Beta-cells. Furthermore the expression of steady-state mRNA levels of gene encoding glucose transporter 2 (Glut2) was found to be decreased in Hnf-1-/- adult and new born mice, suggesting that HNF-1 alpha leads to the expression of GLUT-2 in pancreatic islets of mice." provenance.
- _5 value "Rolipram had little effect on the increases of IL-1 beta concentrations in lung and serum, whereas treatment with anti-TNF-alpha markedly increased the concentration of this cytokine. Concentrations of IL-10 rose significantly in the lung and serum and these increases were blocked by rolipram or anti-TNF-alpha." provenance.
- _3 value "PKCzeta down-regulation is shown to be a critical determinant of cell migration. Transfection of high-motility cells with either wild-type PKCzeta or its regulatory domain suppresses migration." provenance.
- _6 value "However, using an antibody that recognizes the tyrosine-phosphorylated forms of both Stat5a and Stat5b (Y694/Y699), it was found that AG490 could inhibit PRL-induced Stat5a phosphorylation only and had little or no effect on Stat5b phosphorylation." provenance.
- _3 value "their expression is up-regulated by the activation of leukemia inhibitory factor receptor (LIF-R) and prostacyclin receptor (IP-R) via the extracellular signal-regulated kinase (ERK) pathway and cAMP production, respectively." provenance.
- _6 value "their expression is up-regulated by the activation of leukemia inhibitory factor receptor (LIF-R) and prostacyclin receptor (IP-R) via the extracellular signal-regulated kinase (ERK) pathway and cAMP production, respectively." provenance.
- _5 value "Nrf2 contains two transcription activation domains, Neh4 and Neh5, which act synergistically to attain maximum a activation of reporter gene expression. Neh4 and Neh5 both individually and cooperatively bind to CBP" provenance.
- _7 value "C/EBPbeta-PThr(217) and the phosphorylation mimic C/EBPbeta-Glu(217), but not C/EBPbeta-Ala(217), were associated with procaspases 1 and 8 in vivo and in vitro and inhibited their activation." provenance.
- _4 value "C/EBPalpha directly interacts with cdk2 and cdk4 and arrests cell proliferation by inhibiting these kinases" provenance.
- _4 value "C/EBPalpha directly interacts with cdk2 and cdk4 and arrests cell proliferation by inhibiting these kinases" provenance.
- _6 value "C/EBPalpha directly interacts with cdk2 and cdk4 and arrests cell proliferation by inhibiting these kinases" provenance.
- _4 value "The transcription factor CCAAT/enhancer binding protein alpha (C/EBPalpha) is a strong inhibitor of cell proliferation" provenance.
- _3 value "Overall, DM subjects had significantly higher values for hormone levels of TSH, FSH, LH, progesterone, testosterone, cortisol, prolactin, GH, and ferritin." provenance.
- _6 value "We also showed that overexpressed NH2 termini of K18 and K8/18 were associated with endogenous TRADD in SW13 cells, resulting in the inhibition of caspase-8 activation." provenance.
- _6 value "EGF-R causes disassembly of hemidesmosomes by activating Fyn, which in turn phosphorylates the beta4 cytoplasmic domain. Neoplastic cells expressing dominant negative Fyn display increased hemidesmosomes and migrate poorly in vitro in response to EGF." provenance.
- _5 value "In Hoxa9HF1 cells, Meis1a prevented G-CSF-induced transcriptional up-regulation of the genes encoding gp91phox (subunit of the respiratory burst oxidase), lactoferrin, Egr-1, neutrophil gelatinase B, and the lipopolysaccharide receptor (CD14), each of which is normally activated coincident with neutrophil differentiation (Fig. 1 J)" provenance.
- _3 value "hexokinase II and DEC1/Stra13, genes known to be hypoxia inducible in other systems, were found to be hypoxia inducible in our pancreatic cancer system." provenance.
- _5 value "A yeast two-hybrid screening identified a serine/threonine protein phosphatase 5 (PP5) as a binding partner of ASK1. PP5 directly dephosphorylated an essential phospho-threonine residue within the kinase domain of ASK1 and thereby inactivated ASK1 activity in vitro and in vivo" provenance.
- _3 value "Smad3 and E2F-4 directly bound to the element (TIE/E2F) in the myc promoter" provenance.
- _5 value "identification of an acidic domain of gp130 as a binding region for Hck, which mediates proliferative signaling the deletion of this region of gp130 resulted in a significant reduction of Hck kinase activity and cell proliferation upon stimulation of gp130 compared to wild-type gp130" provenance.
- _5 value "this acidic domain of gp130 is responsible for the activation of Hck, Erk, Pyk2 and signals cell proliferation upon growth factor stimulation" provenance.
- _6 value "transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580" provenance.
- _3 value "Treatment of breast cancer MCF7 cells with 5'azacytidine and Trichostatin A resulted in expression of hSRBC, confirming DNA methylation as the mode of inactivation." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "In addition, preincubation of the cells with an MEK inhibitor, PD98059 (10 ?mol/L), diminished the activation of ERK1/2 in PBECs, and preincubation with 0.1% DMSO did not affect the phosphorylation of ERK1/2 (Fig 2, B)." provenance.
- _4 value "untreated or IL- 17?stimulated cells were lysed at various time points... Western blot analysis revealed the phosphorylation of ERK1/2 to reach a maximum at approximately 20 minutes and to return to baseline levels by 60 minutes (Fig 2, A)." provenance.
- _8 value "caspase-3 prevented the inhibition of DNAS1L3 endonuclease activity by wild-type PARP-1" provenance.
- _4 value "Incubation of cells with TNF-alpha for various lengths of time up to 6 hours showed a maximum activation of p42/44 between 10 and 30 minutes after TNF-alpha treatment." provenance.
- _3 value "Ep300; subsetOf; HAT" provenance.
- _4 value "VEGF increased the focal adhesion localization of FAK phosphorylated at Tyr-397 (Y397) and Y861 but stimulated a marked increase in phosphorylation at Y861 without significantly affecting the total level of phospho-Y397 FAK. Inhibition of Src with the specific inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) completely blocked VEGF-induced Y861 phosphorylation without decreasing the level of phospho-Y397 FAK." provenance.
- _3 value "RT-PCR analysis and nuclear run-on assays provided evidence for upregulation of the transporter gene. This study provides the first evidence of an increase in taurine transporter gene expression in human RPE cells cultured under conditions of elevated levels of NO" provenance.
- _4 value "Stimulation of macrophages with SDF-1alpha led to JNK/SAPK MAPK phosphorylation." provenance.
- _4 value "Stimulation of macrophages with SDF-1alpha led to p38 MAPK phosphorylation." provenance.
- _10 value "It hasrecently been reported that a cytosolic isoform of PTPepsilon (PTPepsilonC) whenover-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)- and leukemia inhibitory factor-induced activation of Janus kinases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signaling." provenance.
- _10 value "over-expressedPTPepsilonC also inhibits IL-10-induced tyrosine phosphorylation of STAT3 in M1cells, whereas PTPepsilonC does not affect either interferon-beta- and interferon-gamma-induced tyrosine phosphorylation of STATs or expression of STATtranscriptional targets." provenance.
- _6 value "To address this, 293T cells were transfected with constructs for beta2AR, HA-tagged hSpry2, and FLAG-tagged ERK2....The data shown in Fig. 5 demonstrate that ERK2 phosphorylation was elevated 5 min after isoprenaline addition and that this level was sustained for the next 25 min at least. hSpry2 substantially inhibited ERK2 phosphorylation to the degree that any level of phosphorylation in the data shown was only evident at 5 min." provenance.
- _3 value "apM1 gene expression was also negatively regulated byglucocorticoids and positively by insulin and IGF-1." provenance.
- _3 value "The treatment of primary cultures of rat hepatocytes with Wy14,643 or clofibrate increased mRNA steady state levels of both PPARalpha and acyl coenzyme A oxidase (ACOX)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _8 value "Instead, the collagen receptor glycoprotein VI seems to mediate FAK phosphorylation by a protein kinase C-dependent pathway. In many different cell lines, alpha1beta1 stimulation induces collagen type I synthesis [86]. Expression of GPVI is only found in platelets and their precursor cells." provenance.
- _8 value "Major functions of the alpha2beta1 receptor include the induction of MMP1, % MMP13 and MT1-MMP, as well as activation of proMMP2" provenance.
- _6 value "Only 4 of them have been shown to bind collagens. These integrin collagen-receptors have the beta1 subunit in common which can pair up with one of the following alpha subunits: alpha1, alpha2, alpha10 and alpha11. The 4 integrins are not only receptors for collagens but at least alpha1, alpha2 also bind laminins, albeit with much lower affinity. Whereas the alpha1beta1 receptor preferably binds to basement membrane (type IV) and type XIII collagens, alpha2beta1 and alpha11beta1 have a preference for fibrillar collagens and alpha10beta1 integrin for type II collagen [4-11]." provenance.
- _3 value "Parathyroid hormone, vitamin D(3), calcium, phosphate and some cytokines increase OPN expression in vitro or in vivo, whereas female sex hormones and angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists decrease OPN expression in some renal damage states." provenance.
- _5 value "Id2 enhancement of SMC growth and inhibition of p21 expression were dependent on phosphorylation of Id2 by cyclin E/cdk2, as an Id2 cDNA containing a mutation in the cdk2 phosphorylation site (serine 5) failed to regulate SMC cell cycle progression or p21 promoter activity." provenance.
- _3 value "The results demonstrated that overexpression of Id2 resulted in a significant enhancement of SMC growth via increased S-phase entry. " provenance.
- _3 value "1,25-dihydroxyvitamin D(3) and transforming growth factor-beta (TGFbeta), potent inducers of the 5-LO pathway in myeloid cell lines, increased 5-LO RNA expression in HL-60TB and U937 cells," provenance.
- _7 value "Ectopically expressed ik3-1 potentiates p53-induced cell death but not p73-induced cell death" provenance.
- _5 value "This stimulation of reporter gene activity was accompanied by a PGE(2)-dependent increase in the phosphorylation of both glycogen synthase kinase-3 (GSK-3) and Akt kinase." provenance.
- _3 value "ErbB2 overexpression confers chemoresistance to certain chemotherapeutic agents such as paclitaxel. trastuzumab can effectively sensitize ErbB2-overexpressing breast cancer cells to paclitaxel" provenance.
- _4 value "Moreover, Jab1-enhanced transcriptional activity of HIF-1 under hypoxia led to increase the expression of VEGF, a major HIF-1 target gene. Furthermore, Jab1 increased HIF-1alpha protein levels, which was due to the enhanced HIF-1alpha stability" provenance.
- _6 value "Modified assertion" provenance.
- _7 value "The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity in contrast to Akt1 and Akt2, which bind to all members of the TCL1 family," provenance.
- _7 value "The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity in contrast to Akt1 and Akt2, which bind to all members of the TCL1 family," provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Thus enforced expression of c-myc in SW480 and SW620 lines sensitizes cells to cisplatin-induced apoptosis, whereas the down-regulation of c-myc in SW480DDP and SW620DDP increases cisplatin resistance when using antisense strategy. " provenance.
- _4 value "PDGF (20 ng/ml) stimulated an Ets-1 protein expression (14-fold at 60 min) in VSMC, which was inhibited by PD98059 (-72% at 30 microM), troglitazone (-69% at 20 microM), and rosiglitazone (-54% at 10 microM) (all p < 0.05)." provenance.
- _5 value "PDGF (20 ng/ml) stimulated an Ets-1 protein expression (14-fold at 60 min) in VSMC, which was inhibited by PD98059 (-72% at 30 microM), troglitazone (-69% at 20 microM), and rosiglitazone (-54% at 10 microM) (all p < 0.05)." provenance.
- _3 value "Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas" provenance.
- _3 value "Recent work has also revealed that diverse agonists and stresses (cytokines, UV light, glucocorticoids, heat shock and toxic compounds) modulate SPT activity by induction of SPTLC2 gene transcription" provenance.
- _6 value "High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases" provenance.
- _4 value "Whereas IP-10, MIP1a, MIP1b, MCP1, and IL8 mRNA levels are induced upon PMA treatment of the ?-gal antisense-ribozyme stable U937 cell line, there was a complete failure in the TIF1? antisense-ribozyme stable U937 cell lines to induce these cytokines." provenance.
- _5 value "Furthermore, collagen-bound OSM is biologically active and able to inhibit proliferation of A375 melanoma cells." provenance.
- _5 value "The functional insulin receptor is a heterotetrameric protein composed of two alpha and two beta subunits. The alpha subunits contain the insulin binding site and the binding causes conformational changes in the receptor molecule. The quaternary structure of the beta subunit then changes to allow for stimulating autophosphorylation of its tyrosine residues. Those in the catalytic domain(tyrosines 1146, 1150, 1151) are essential to promote the kinase activity of the receptor" provenance.
- _7 value "SOCS-2 can play a more important potentiator role on PRL signaling, resulting in a restoration of 50% of transcriptional inhibition induced by SOCS-3 and a restoration of 100% of transcriptional inhibition induced by CIS. SOCS-2 was able to block the inhibitory effect of SOCS-1" provenance.
- _7 value "We demonstrate that CIS produces a 70% inhibition of PRL signaling by a mechanism distinct from, and downstream of, the effect of SOCS-1 on JAK2. This inhibition involves association with the PRL receptor (PRLR), resulting in the inhibition of signal transducer and activator of transcription 5 (STAT5) activation. CIS binds the PRLR but inhibits signal transducer and activator of transcription 5 rather than JAK2." provenance.
- _5 value "Whereas TIP49a activated beta-catenin transcriptional activities, TIP49b repressed them" provenance.
- _5 value "Etk/Bmx activation requires FAK and Src and is critical for neurotrophic factor-induced growth, as LNCaP cells transfected with a dominant-negative Etk/BMX fail to respond to bombesin." provenance.
- _5 value " These findings suggest that the association of TIP49b with ATF2 serves to limit basal and inducible transcriptional activities of ATF2." provenance.
- _6 value "Modified assertion" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "colonic epithelia, these mutations produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that initiates polyp formation and eventually malignant growth" provenance.
- _5 value "JNK activation is transient in wildtype and Ikka -/- fibroblasts but sustained in RelA -/- and Ikkb -/- cells" provenance.
- _3 value "In an animal model of atherosclerosis, estradiol restores FasL expression, which is suppressed by atherogenic levels of serum cholesterol." provenance.
- _6 value "Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses." provenance.
- _4 value "We show here that like p53, the p63alpha and p63gamma isoforms are able to associate with human MDM2 (HDM2). Overexpression of HDM2 increased the steady-state level of intracellular p63 and enhanced its transcriptional activity. Both effects appeared to be counteracted by ARF coexpression. These data indicate that p63 can be activated by HDM2 under conditions in which p53 is inhibited." provenance.
- _7 value "3 independent signaling pathways, STAT3, MEK1-ERK1/2, and AKT activation, that are coinduced by Lif stimulation were completely suppressed by SOCS3 overexpression" provenance.
- _4 value "Ariadne: However, IL-18 can also induce IL-4 and IL-13 production in T cells, NK cells, mast cells, and basophils. [Regulation]" provenance.
- _5 value "HER-2/neu-mediated resistance to DNA-damaging agents requires the activation of Akt, which enhances MDM2-mediated ubiquitination and degradation of p53." provenance.
- _5 value "Wortmannin and LY294002, PI3-kinase inhibitors, as well as lovastatin and PD152440, Ras farnesylation inhibitors, and MEK inhibitor PD98059 abolished the insulin repression of ALAS transcription." provenance.
- _5 value "A truncated version of RGS3 (RGS3T = RGS3 314-519) inhibited gonadotropin releasing hormone-stimulated inositol trisphosphate production more potently than did RSG3 in gonadotropin releasing hormone receptor-bearing COS cells." provenance.
- _5 value "A truncated version of RGS3 (RGS3T = RGS3 314-519) inhibited gonadotropin releasing hormone-stimulated inositol trisphosphate production more potently than did RSG3 in gonadotropin releasing hormone receptor-bearing COS cells." provenance.
- _4 value "BACKGROUND: The proper balance between epithelial cell proliferation, quiescence, and apoptosis during development is mediated by the specific temporal and spatial appearance of transcription factors, growth factors, cytokines, caspases, etc. Since our prior studies suggest the importance of transcription factor NF-kappaB during embryonic submandibular salivary gland (SMG) development, we attempted to delineate the emergent dynamics of a cognate signaling network by studying the molecular patterns and phenotypic outcomes of interrupted NF-kappaB signaling in embryonic SMG explants. RESULTS: SN50-mediated inhibition of NF-kappaB nuclear translocation in E15 SMG explants cultured for 2 days results in a highly significant increase in apoptosis and decrease in cell proliferation. Probabilistic Neural Network (PNN) analyses of transcriptomic and proteomic assays identify specific transcripts and proteins with altered expression that best discriminate control from SN50-treated SMGs. These include PCNA, GR, BMP1, BMP3b, Chk1, Caspase 6, E2F1, c-Raf, ERK1/2 and JNK-1, as well as several others of lesser importance. Increased expression of signaling pathway components is not necessarily probative of pathway activity; however, as confirmation we found a significant increase in activated (phosphorylated/cleaved) ERK 1/2, Caspase 3, and PARP in SN50-treated explants. This increased activity of proapoptotic (caspase3/PARP) and compensatory antiapoptotic (ERK1/2) pathways is consistent with the dramatic cell death seen in SN50-treated SMGs. CONCLUSIONS: Our morphological and functional genomic analyses indicate that the primary and secondary effects of NF-kappaB-mediated transcription are critical to embryonic SMG developmental homeostasis. Relative to understanding complex genetic networks and organogenesis, our results illustrate the importance of evaluating the gene, protein, and activated protein expression of multiple components from multiple pathways within broad functional categories." provenance.
- _4 value "SN50-mediated inhibition of NF-kappaB nuclear translocation in E15 SMG explants cultured for 2 days results in a highly significant increase in apoptosis and decrease in cell proliferation. Probabilistic Neural Network (PNN) analyses of transcriptomic and proteomic assays identify specific transcripts and proteins with altered expression that best discriminate control from SN50-treated SMGs. These include PCNA, GR, BMP1, BMP3b, Chk1, Caspase 6, E2F1, c-Raf, ERK1/2 and JNK-1, as well as several others of lesser importance." provenance.
- _4 value "SN50-mediated inhibition of NF-kappaB nuclear translocation in E15 SMG explants cultured for 2 days results in a highly significant increase in apoptosis and decrease in cell proliferation. Probabilistic Neural Network (PNN) analyses of transcriptomic and proteomic assays identify specific transcripts and proteins with altered expression that best discriminate control from SN50-treated SMGs. These include PCNA, GR, BMP1, BMP3b, Chk1, Caspase 6, E2F1, c-Raf, ERK1/2 and JNK-1, as well as several others of lesser importance." provenance.
- _4 value "SN50-mediated inhibition of NF-kappaB nuclear translocation in E15 SMG explants cultured for 2 days results in a highly significant increase in apoptosis and decrease in cell proliferation. Probabilistic Neural Network (PNN) analyses of transcriptomic and proteomic assays identify specific transcripts and proteins with altered expression that best discriminate control from SN50-treated SMGs. These include PCNA, GR, BMP1, BMP3b, Chk1, Caspase 6, E2F1, c-Raf, ERK1/2 and JNK-1, as well as several others of lesser importance." provenance.
- _4 value "SN50-mediated inhibition of NF-kappaB nuclear translocation in E15 SMG explants cultured for 2 days results in a highly significant increase in apoptosis and decrease in cell proliferation. Probabilistic Neural Network (PNN) analyses of transcriptomic and proteomic assays identify specific transcripts and proteins with altered expression that best discriminate control from SN50-treated SMGs. These include PCNA, GR, BMP1, BMP3b, Chk1, Caspase 6, E2F1, c-Raf, ERK1/2 and JNK-1, as well as several others of lesser importance." provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.
- _5 value "Table I: Genes regulated by progesterone" provenance.