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- _7 value "We demonstrate that CIS produces a 70% inhibition of PRL signaling by a mechanism distinct from, and downstream of, the effect of SOCS-1 on JAK2. This inhibition involves association with the PRL receptor (PRLR), resulting in the inhibition of signal transducer and activator of transcription 5 (STAT5) activation. CIS binds the PRLR but inhibits signal transducer and activator of transcription 5 rather than JAK2." provenance.
- _7 wasQuotedFrom 11713228 provenance.