Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence HPV16+E7-dependent+transformation+activates+NHE1+through+a+PKA-RhoA-induced+inhibition+of+p38alpha. assertion.
- assertion asSentence IL-8-Rac1%2FRhoA-p38MAPK+signaling+pathway+plays+a+vital+role+in+the+IL-8-induced+endothelial+cell+migration. assertion.
- assertion asSentence RHOB+activation+is+required+for+mannose+receptor-mediated+phagocytosis+by+alveolar+macrophages. assertion.
- assertion asSentence Suppressed+RhoB+is+implicated+as+a+molecular+target+for+therapy+against+anaplastic+thyroid+carcinoma+cells+because+RhoB+is+regulated+and+growth+inhibited. assertion.
- assertion asSentence Overexpression+of+D4-GDI+is+associated+with+breast+cancer. assertion.
- assertion asSentence Phosphorylation+by+Src+enhances+RhoGDI2+metastasis+suppression+and+loss+of+Src+relieves+metastasis+suppression+in+tumor+cells+that+maintain+RhoGDI2+expression. assertion.
- assertion asSentence PLCgamma+plays+a+key+role+in+RhoGDI2-mediated+cisplatin+resistance+and+cell+invasion+in+gastric+cancer+cells. assertion.
- assertion asSentence RHOH+deficiency+leads+to+T+cell+defects+and+persistent+epidermodysplasia+verruciformis-HPV+infections. assertion.
- assertion asSentence %2Aata+demonstrate+that+PGE%282%29+partially+stimulates+hMSCs+migration+and+proliferation+by+interaction+of+Pfn-1+and+F-actin+via+EP2+receptor-dependent+beta-arrestin-1%2FJNK+signaling+pathways. assertion.
- assertion asSentence ARRB1+and+ARRB2+play+an+important+role+in+biological+processes+involved+in+the+regulation+of+smoking+urgency+%28that+is+time+to+smoke+first+cigarette%29. assertion.
- assertion asSentence betaarr2+is+localized+to+the+centrosome+in+cycling+cells+and+to+the+primary+cilium+in+quiescent+cells. assertion.
- assertion asSentence Arrestin-2+via+its+interaction+with+STAM-1+modulates+CXCR4+sorting+by+regulating+the+ubiquitination+status+of+HRS. assertion.
- assertion asSentence Arylsulfatase+B+regulates+colonic+epithelial+cell+migration+by+effects+on+MMP9+expression+and+RhoA+activation. assertion.
- assertion asSentence Steroid+sulfatase+increases+steroid+acute+regulatory+protein+expression+level+and+stimulates+steroid+production. assertion.
- assertion asSentence Acid+ceramidase%2C+through+sphingosine+1-phosphate%2C+promotes+an+invasive+phenotype+in+prostate+cancer+by+causing+overexpression+and+secretion+of+cathepsin+B+through+activation+and+nuclear+expression+of+Ets1. assertion.
- assertion asSentence ASAH1+inhibition+synergistically+sensitizes+lung+cancer+cells+resistant+to+the+antiproliferative+effect+of+choline+kinase+alpha+inhibitors. assertion.
- assertion asSentence These+support+the+role+of+the+polyglutamine+length+variants+in+the+MASH1+gene+in+Parkinson%27s+disease+susceptibility. assertion.
- assertion asSentence ATBF1+plays+a+role+in+breast+cancer+through+transcriptional+downregulation+rather+than+mutations. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+ESR2+and+ATF3+are+borderline+associated+with+hypospadias+%5Bodds+ratios+0.9+%2895%25+confidence+interval+0.7-1.0%29+and+1.2+%2895%25+confidence+interval. assertion.
- assertion asSentence Common+variants+in+the+ATM+and+CHEK2+genes%2C+in+interaction+with+oestrogen-related+exposures%2C+are+involved+in+endometrial+cancer+aetiology. assertion.
- assertion asSentence Smad7+plays+a+crucial+role+upstream+of+ATM+and+p53+to+protect+the+genome+from+insults+evoked+by+extracellular+stress. assertion.
- assertion asSentence ATM+and+DNA+cross-link+repair+1C+%28PSO2+homolog+S.+cerevisiae%29+are+required+for+efficient+formation+of+single-stranded+DNA+and+Rad51+foci+at+radiation-induced+double-strand+breaks+in+G2+phase. assertion.
- assertion asSentence HATH1+is+an+important+factor+in+the+up-regulation+of+MUC2+expression+that+occurs+in+mucinous+cancers+and+signet+ring+carcinomas. assertion.
- assertion asSentence Atonal+homolog+1+is+required+for+growth+and+differentiation+effects+of+notch%2Fgamma-secretase+inhibitors+on+normal+and+cancerous+intestinal+epithelial+cells. assertion.
- assertion asSentence The+entire+carboxy-terminus+of+HKalpha2+is+required+for+stable+assembly+with+beta1-Na%2B%2CK%2B-ATPase+and+functionality. assertion.
- assertion asSentence Deletion+of+two+tyrosines+at+the+carboxy+terminus+of+the+human+Na%28%2B%29%2FK%28%2B%29-ATPase+alpha%282%29+subunit+decreases+the+affinity+for+extracellular+and+intracellular+Na%28%2B%29. assertion.
- assertion asSentence Aggregation+of+SERCA2+mutant+protein+is+associated+with+Darier+disease+elicits+endoplasmic+reticulum+stress+and+apoptosis+in+keratinocytes. assertion.
- assertion asSentence Monoclonal+antibody+PL%2FIM430+inhibits+SERCA3+activity+by+sterically+preventing+movement+of+the+actuator+domain+into+a+catalytically+critical+position+in+the+E2+conformation+of+the+enzyme. assertion.
- assertion asSentence Alterations+in+the+region+of+the+alternative+splicing+site+A+change+the+sensitivity+to+Ca%282%2B%29+of+the+human+isoform+4+of+the+PMCA. assertion.
- assertion asSentence Disturbed+flow+and+hypercholesterolemia+synergistically+promote+gamma%2Fdelta+T-lymphocyte+activation+by+the+membrane+translocation+of+ATPSbeta+in+endothelial+cells. assertion.
- assertion asSentence Coupling+factor+6+enhances+Src-mediated+responsiveness+to+angiotensin+II+in+resistance+arterioles+and+cells. assertion.
- assertion asSentence Mutated+in+Menkes+syndrome. assertion.
- assertion asSentence Effect+of+copper+perfusion+of+an+isolated+segment+of+the+jejunum+of+ATP7A+transgenic+mice+on+the+intracellular+distribution+of+ATP7A+by+immunofluorescence+of+frozen+sections. assertion.
- assertion asSentence The+functional+effect+of+a+large+frameshift+deletion+in+ATP7A+%28including+exons+3+and+4%29+is+investigated+in+a+patient+with+Menkes+disease+with+unexpectedly+mild+symptoms+and+long+survival. assertion.
- assertion asSentence ATP7A+expression+is+regulated+by+retinoic+acid+receptor+beta+and+it+has+effects+on+intracellular+copper+levels%2C+revealing+a+link+between+the+anticancer+action+of+retinoids+and+copper+metabolism. assertion.
- assertion asSentence Mutated+in+Wilson+disease. assertion.
- assertion asSentence Higher+ATP7B+expression+is+associated+with+platinum+drug+resistance+in+human+non-small+cell+lung+cancer+xenografts. assertion.
- assertion asSentence ATP7B+mutation+is+associated+with+increased+ceruloplasmin+and+Wilson+disease. assertion.
- assertion asSentence The+G2%2FM+checkpoint-mediated+arrest+of+the+cell+cycle+is+critical+for+the+prevention+of+both+apoptosis+and+the+accumulation+of+cells+with+rereplicated+DNA%2C+because+the+loss+of+ATR%2C+BRCA1%2C+or+FANCA+promotes+apoptosis+and+suppresses+the+accumulation. assertion.
- assertion asSentence ATR+is+activated+by+mild+hypothermia+in+mammalian+cells+and+subsequently+activates+p53. assertion.
- assertion asSentence WRN+is+involved+in+the+generation+of+ssDNA+and+ATR+activation+in+response+to+camptothecin. assertion.
- assertion asSentence Disruption+of+the+MeCP2-ATRX+interaction+leads+to+pathological+changes+that+contribute+to+mental+retardation. assertion.
- assertion asSentence Mutations+in+the+AUH+gene+are+linked+to+metabolic+disease+3-methylglutaconic+aciduria+type+I+%28MGA1%29. assertion.
- assertion asSentence GAS6%2FAxl+signaling+is+involved+in+human+renal+disease. assertion.
- assertion asSentence Axl+and+Gas6+are+frequently+overexpressed+in+both+glioma+and+vascular+cells+and+predict+poor+prognosis+in+GBM+patients. assertion.
- assertion asSentence Effects+of+guanidine+hydrochloride+on+the+amyloid+fibrils+of+beta2-m+reveal+a+cooperative+unfolding+transition+similar+to+that+of+the+native+state. assertion.
- assertion asSentence Significant+association+between+urinary+beta2-microglobulin+excretion+and+cancer+mortality+in+cadmium+polluted+area. assertion.
- assertion asSentence beta2-microglobulin+levels+are+positively+associated+with+insulin+resistance+in+chronic+kidney+disease+patients+receiving+dialysis. assertion.
- assertion asSentence BAD+overexpression+significantly+inhibited+A549+cell+proliferation+and+induced+apoptosis. assertion.
- assertion asSentence Mycobacterium+leprae+inhibits+apoptosis+in+THP-1+cells+by+downregulation+of+Bak+and+upregulation+of+Mcl-1+gene+expression. assertion.
- assertion asSentence Galpha%28s%29+protects+neuroblastoma+cells+from+hydrogen+peroxide-induced+apoptosis+by+repressing+Bak+induction. assertion.
- assertion asSentence DPV022+encoded+an+inhibitor+of+apoptosis+and+interacted+with+cellular+Bak+and+Bax. assertion.
- assertion asSentence BRCA1+and+BARD1+are+associated+with+the+RNA+polymerase+II+holoenzyme. assertion.
- assertion asSentence BARD1+phosphorylation%2C+expression+and+localisation+patterns+are+regulated+in+the+nucleus+and+at+mitochondria+in+response+to+different+forms+of+DNA+damage. assertion.
- assertion asSentence Curcumin+induces+apoptosis+in+human+breast+cancer+cells+through+p53-dependent+Bax+induction. assertion.
- assertion asSentence Bax+over-expression+restored+back+theaflavin-induced+apoptosis+in+pifithrin-alpha-inhibited%2Fdominant-negative+p53-expressing+cells. assertion.
- assertion asSentence Ku70+is+a+regulator+of+Bax-mediated+pathogenesis+in+laminin-alpha2-deficiency+muscle+cells. assertion.
- assertion asSentence Bcl-x%28L%29+inhibits+and+maintains+Bax+in+the+cytosol+by+constant+retrotranslocation+of+mitochondrial+Bax. assertion.
- assertion asSentence Melatonin+inhibited+Bax+expression+and+the+release+of+the+omi%2FHtrA2+into+the+cytoplasm+induced+by+1+muM+rotenone. assertion.
- assertion asSentence EBP50+gene+transfection+promotes+5-fluorouracil-induced+apoptosis+in+gastric+cancer+cells+through+Bax-+and+Bcl-2-triggered+mitochondrial+pathways. assertion.
- assertion asSentence The+affinity+of+the+Bax+C-domain+for+its+binding+groove+is+decreased+due+to+the+Arg94-mediated+abrogation+of+the+Ser184-Asp98+interaction. assertion.
- assertion asSentence When+genetically+transferred+into+rats%2C+accelerated+cocaine+metabolism. assertion.
- assertion asSentence The+PKCalpha-ERK1%2F2+cascade+is+involved+in+PMA+induced+up-regulation+of+cyclin+D1+and+P21%28cip1%29+and+proliferation+in+human+airway+smooth+muscle+cells. assertion.
- assertion asSentence 59%25+of+Paget%27s+disease+of+the+vulva+cases+examined+overexpressed+cyclin+D1+compared+with+8%25+of+Paget%27s+disease+of+the+breast+cases. assertion.
- assertion asSentence Increased+protein+expression+of+p16+and+cyclin+D1+in+squamous+cell+carcinoma+tissues. assertion.
- assertion asSentence Prediction+of+CCND1+amplification+using+plasma+DNA+is+thought+to+be+a+promising+prognostic+biomarker+in+esophageal+squamous+cell+carcinoma+patients. assertion.
- assertion asSentence Cyclin+D1+G870A+polymorphism+is+associated+with+breast+cancer. assertion.
- assertion asSentence Bcl-2+overexpression+prevents+apoptosis+induced+by+ceramidase+inhibitors+in+malignant+melanoma+and+HaCaT+keratinocytes. assertion.
- assertion asSentence Over-expression+of+BCL2+is+associated+with+muscle+invasive+transitional+cell+carcinoma+of+the+bladder. assertion.
- assertion asSentence Impaifred+kinetics+of+Bax-GFP+and+Smac%2FDIABLO-GFP+in+caspase+8+and+bid-silenced+and+Bcl-2-overexpressed+breast+cancer+cells+exposed+to+camptothecin. assertion.
- assertion asSentence EBV+is+not+related+to+the+overexpression+of+Bcl-2+and+c-Myc+%28nuclear%29+in+gastric+carcinomas. assertion.
- assertion asSentence Bcl-2+is+a+key+regulator+in+TRAIL-Daidzein+mediated+cell+death+in+malignant+glioma. assertion.
- assertion asSentence High+Bcl-2+in+combination+with+CD13+antigen+expression+is+associated+with+adult+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence NAF-1+is+a+BCL-2-associated+co-factor+that+targets+BCL-2+for+antagonism+of+the+autophagy+pathway+at+the+endoplasmic+reticulum. assertion.
- assertion asSentence In+quiescent+human+fibroblasts+cytomegalovirus+regulates+mitochondrial+apoptosis+at+the+level+of+bcl-2+gene+transcription%2C+exerting+both+pro-+and+anti-apoptotic+effects. assertion.
- assertion asSentence Phosphorylated+alphaB-crystallin+interacts+with+Bcl-2+and+prevents+the+translocation+of+Bcl-2+to+mitochondria. assertion.
- assertion asSentence VAV1+protects+Jurkat+cells+from+apoptosis+by+promoting+Bcl-2+transcription+through+its+guanine+nucleotide+exchange+factor+activity. assertion.
- assertion asSentence Estrogen+receptor-regulated+microRNAs+contribute+to+the+BCL2%2FBAX+imbalance+in+endometrial+adenocarcinoma+and+precancerous+lesions. assertion.
- assertion asSentence EZH2+mutations+constitute+an+additional+genetic+%22hit%22+in+many+BCL2-rearranged+germinal+center+B+cell+lymphomas. assertion.
- assertion asSentence EBP50+gene+transfection+promotes+5-fluorouracil-induced+apoptosis+in+gastric+cancer+cells+through+Bax-+and+Bcl-2-triggered+mitochondrial+pathways. assertion.
- assertion asSentence Bcl-xl+over-expression+does+not+confer+protection+against+cell+death+in+U937+cells. assertion.
- assertion asSentence Bcl-xL+gene+overexpression+is+linked+to+short+overall+survival+times+in+follicular+lymphoma. assertion.
- assertion asSentence Transgenic+mice+crrossed+with+c-MYC+transgenic+mice+develop+multiple+myeloma. assertion.
- assertion asSentence Downregulation+of+Bcl-xL+%28but+not+Bcl-2%2C+Bax%2C+or+Bid%29+connects+cathepsin+D+and+the+mitochondrial+pathway+during+glucosamine+sulfate-induced+apoptosis. assertion.
- assertion asSentence Antiapoptotic+proteins+Bcl-2+and+Bcl-X%28L%29+bind+and+suppress+NALP1%2C+reducing+caspase-1+activation+and+interleukin-1beta+%28IL-1beta%29+production. assertion.
- assertion asSentence Bcl-x%28L%29+and%2C+to+a+lower+extent%2C+Mcl-1%2C+are+important+anti-apoptotic+factors+in+colorectal+carcinoma. assertion.
- assertion asSentence Bcl-xl+expression%28along+with+GLUT1+and+EPO%29plays+a+role+in+promoting+self+survival+of+malignant+cells+under+hypoxic+conditions+of+colorectal+cancer. assertion.
- assertion asSentence In+EBV-negative+diffuse+large+B-cell+lymphoma+and+Burkitt+lymphoma-derived+cell+lines+infected+in+vitro+with+a+recombinant+EBV%2C+high+expression+of+EBNA2+inversely+correlated+with+expression+of+germinal+center-associated+genes%2C+BCL6+and+TCL1. assertion.
- assertion asSentence IFNalpha+rapidly+down-regulates+BCL-6+mRNA+in+purified+mouse+normal+germinal+center+B+cells. assertion.
- assertion asSentence Detection+BCR-ABL+fusion+signal+in+both+metaphase+spreads+and+interphase+cells+of+patients+with+chronic+myeloid+leukemia. assertion.
- assertion asSentence Susceptibility+to+develop+cough+is+associated+with+a+genetic+variant+of+the+bradykinin+B2+receptor+promoter. assertion.
- assertion asSentence RT-PCR+demonstrates+the+presence+of+mRNAs+for+brradykinin+B2+receptors+in+a+human+embryo+kidney+cell+line. assertion.
- assertion asSentence BDNF+Val66Met+allele+increases+risk+for+bipolar+I+disorder+in+patients+of+European+descent. assertion.
- assertion asSentence The+BDNF-linked+complex+polymorphic+region+is+a+functional+variation+that+confers+susceptibility+to+bipolar+disorder+and+affects+transcriptional+activity+of+the+BDNF+gene. assertion.
- assertion asSentence The+combination+of+5-HT1A+GG+and+BDNF+GA+%2B+AA+genotypes+is+associated+with+an+increased+risk+of+depression. assertion.
- assertion asSentence A+single+exercise+session+for+elderly+women+with+relapsed+major+depression+leads+to+a+significant+up-regulation+of+BDNF+serum+levels. assertion.
- assertion asSentence A+significant+association+is+found+between+the+presence+of+one+or+two+Met+alleles+and+the+major+role+of+BDNF+in+energy+metabolism%2C+food+regulation+and+body+mass+index. assertion.
- assertion asSentence A+role+for+fragment+Bb+in+the+host+immune+response+against+intra-amniotic+infection%2Finflammation. assertion.
- assertion asSentence Low+serum+level+in+osteochondrodysplasia. assertion.
- assertion asSentence The+Ad-leptin+up-regulated+osteocalcin+expression. assertion.