Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 2. Genes other than HSPs whose expression is affected by heat stress [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)] down" provenance.
- _3 value "Table 3. Genes whose expression is affected by cold stress. [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)]" provenance.
- _3 value "Table 3. Genes whose expression is affected by cold stress. [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)]" provenance.
- _3 value "Table 3. Genes whose expression is affected by cold stress. [table excludes genes whose change in expression has only been observed by genomic or proteomic technologies (i.e., not yet confirmed by other techniques)]" provenance.
- _3 value "up" provenance.
- _3 value "up" provenance.
- _3 value "up" provenance.
- _3 value "up" provenance.
- _3 value "up" provenance.
- _4 value "EGF stimulation induces the tyrosine phosphorylation of Gab1 and a further increase in the phosphorylation was observed on concomitant inhibition of ERK activity." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Transient expression of mCLCA4 in 293T cells resulted in the appearance of a prominent calcium-activated chloride current." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _5 value "Bad was known to be phosphorylated by Akt at Ser136 (Vanhaesebroeck and Alessi, 2000)....As shown in Figure 1d, UCN-01 decreased the phospho-Bad (Ser136) level in a dose-dependent manner. We also found that UCN-01 could inhibit the phosphorylation of glycogen synthase kinase-3a (GSK-3a) at Ser21 residue (data not shown). These results suggest that UCN-01 suppressed Akt kinase activity in vivo." provenance.
- _4 value "% However, estrogen also triggers rapid activation of classical second messengers (cAMP, calcium, and inositol triphosphate) and stimulation of intracellular signaling cascades mitogen-activated protein kinase (MAP K), PI3K and eNOS." provenance.
- _7 value "Ariadne: Moreover, PSF recruits the corepressor mSin3A to the hCYP17 promoter, resulting in repression, which is then alleviated upon cAMP stimulation and subsequent activation of SF-1" provenance.
- _10 value "Ariadne: Moreover, PSF recruits the corepressor mSin3A to the hCYP17 promoter, resulting in repression, which is then alleviated upon cAMP stimulation and subsequent activation of SF-1" provenance.
- _7 value "Histamine and H1R and H2R agonists downregulated IL-12p70 production of prestimulated MoDCs." provenance.
- _4 value "Interleukin-1beta stimulated the 24 hr nitric oxide production and WAY 121509 decreased it under both low and high glucose culture conditions. The interleukin-1beta stimulation was continued for 72 hrs We conclude that high glucose enhances the interleukin-1beta-induced nitric oxide synthesis and the cytokine-induced nitric oxide production was inhibited by aldose reductase inhibition" provenance.
- _3 value "Insulin-induced VEGF expression requires p38 MAPK and PI 3-kinase, whereas hyperglycemia-induced VEGF expression is HIF-1alpha-independent and requires PKC and p42/p44 MAPK." provenance.
- _4 value "Insulin-induced VEGF expression requires p38 MAPK and PI 3-kinase, whereas hyperglycemia-induced VEGF expression is HIF-1alpha-independent and requires PKC and p42/p44 MAPK." provenance.
- _3 value "Ariadne: Epidermal growth factor and retinol have been shown to induce the hnRNP A1 gene (Planck et al., 1988 ; An and Wu, 1993 )" provenance.
- _5 value "CDK2 is sequentially activated by the E-type cyclins cyclin E1 and E2 during the G1/S transition, and the A-type cyclins cyclin A1 and A2 during S phase" provenance.
- _5 value "Mitogen-activated protein kinases such as ERK phosphorylate and activate MNK1, which in turn is able to phosphorylate eIF4E" provenance.
- _3 value "RB can be dephosphorylated by the PP1 phosphatase, which restores RB growth-suppressing function after mitosis" provenance.
- _3 value "HIF1A activates expression of 2 pro-apoptotic proteins, NIX and NIP3 the mechanism by which NIP3 causes cell death seems to be a combination of both necrosis and apoptosis" provenance.
- _4 value "HIF1A also activates transcription of NOS, which promotes angiogenesis and vasodilation" provenance.
- _3 value "angiogenesis: adrenomedullin, angiopoietin-2, cyclooxygenase-2, endothelin-1 and -2, fibroblast growth factor-3, hepatocyte growth factor, histone deacetylase, monocyte chemotactic protein-1, nitric oxide synthase, osteopontin, placental growth factor, Tie-2, transforming growth factor alpha, beta1 and beta3" provenance.
- _3 value "angiogenesis: adrenomedullin, angiopoietin-2, cyclooxygenase-2, endothelin-1 and -2, fibroblast growth factor-3, hepatocyte growth factor, histone deacetylase, monocyte chemotactic protein-1, nitric oxide synthase, osteopontin, placental growth factor, Tie-2, transforming growth factor alpha, beta1 and beta3" provenance.
- _3 value "angiogenesis: adrenomedullin, angiopoietin-2, cyclooxygenase-2, endothelin-1 and -2, fibroblast growth factor-3, hepatocyte growth factor, histone deacetylase, monocyte chemotactic protein-1, nitric oxide synthase, osteopontin, placental growth factor, Tie-2, transforming growth factor alpha, beta1 and beta3" provenance.
- _3 value "angiogenesis: adrenomedullin, angiopoietin-2, cyclooxygenase-2, endothelin-1 and -2, fibroblast growth factor-3, hepatocyte growth factor, histone deacetylase, monocyte chemotactic protein-1, nitric oxide synthase, osteopontin, placental growth factor, Tie-2, transforming growth factor alpha, beta1 and beta3" provenance.
- _3 value "cell adhesion, extracellular matrix, cytoskeleton and proteases/coagulation: cd99, collagen-5alpha, Ku70, Ku80, matrix metalloproteinase-13, L1CAM, plasminogen activator inhibitor-1, proline-4 hydroxylase, tissue factor (tf), urokinase receptor, vimentin" provenance.
- _7 value "during hypoxia-induced apoptosis, only the phosphorylated HIF1A binds ARNT the dephosphorylated form of HIF1A binds p53 and induces apoptosis" provenance.
- _3 value "glycolysis and glucose uptake: aldolase-A, enolase-1, glucose transporter-1, -3, glyceraldehyde-3-phosphate dehydrogenase, hexokinase-1, hexokinase-2, lactate dehydrogenase-A, phosfructokinase-C, phosfructokinase-L, phosphoglycerate kinase-1, pyruvate kinase-M" provenance.
- _3 value "glycolysis and glucose uptake: aldolase-A, enolase-1, glucose transporter-1, -3, glyceraldehyde-3-phosphate dehydrogenase, hexokinase-1, hexokinase-2, lactate dehydrogenase-A, phosfructokinase-C, phosfructokinase-L, phosphoglycerate kinase-1, pyruvate kinase-M" provenance.
- _3 value "glycolysis and glucose uptake: aldolase-A, enolase-1, glucose transporter-1, -3, glyceraldehyde-3-phosphate dehydrogenase, hexokinase-1, hexokinase-2, lactate dehydrogenase-A, phosfructokinase-C, phosfructokinase-L, phosphoglycerate kinase-1, pyruvate kinase-M" provenance.
- _3 value "glycolysis and glucose uptake: aldolase-A, enolase-1, glucose transporter-1, -3, glyceraldehyde-3-phosphate dehydrogenase, hexokinase-1, hexokinase-2, lactate dehydrogenase-A, phosfructokinase-C, phosfructokinase-L, phosphoglycerate kinase-1, pyruvate kinase-M" provenance.
- _3 value "glycolysis and glucose uptake: aldolase-A, enolase-1, glucose transporter-1, -3, glyceraldehyde-3-phosphate dehydrogenase, hexokinase-1, hexokinase-2, lactate dehydrogenase-A, phosfructokinase-C, phosfructokinase-L, phosphoglycerate kinase-1, pyruvate kinase-M" provenance.
- _3 value "growth factors/cytokines: igf2, il6, il8, intestinal trefoil factor, macrophage inhibitory factor, platelet-derived growth factor-B" provenance.
- _2 value "hypoxia induces expression of various growth factors that are known to promote cell proliferation" provenance.
- _6 value "in the nucleus, HIF1A can also interact with transcription factors such as AP1, ETS and CREB to activate transcription" provenance.
- _3 value "increases expression - ligands of tyrosine kinase receptors (EGF, IGF1 and IGF2, insulin, PDGF)" provenance.
- _2 value "low oxygen tension in tumors was associated with increased metastasis and poor survival in patients suffering from squamous tumors of the head and neck, cervical or breast cancers" provenance.
- _3 value "metabolism/pH/neurotransmitters: acetoacetyl CoA thiolase, adenylate kinase-3, aminopeptidase-A, carbonic anhydrase-9,-12, phosphoribosyl pyrophosphate synthetase, spermidine N1-acetyltransferase, tyrosine hydroxylase, alpha-adrenergic receptor" provenance.
- _3 value "metabolism/pH/neurotransmitters: acetoacetyl CoA thiolase, adenylate kinase-3, aminopeptidase-A, carbonic anhydrase-9,-12, phosphoribosyl pyrophosphate synthetase, spermidine N1-acetyltransferase, tyrosine hydroxylase, alpha-adrenergic receptor" provenance.
- _3 value "metabolism/pH/neurotransmitters: acetoacetyl CoA thiolase, adenylate kinase-3, aminopeptidase-A, carbonic anhydrase-9,-12, phosphoribosyl pyrophosphate synthetase, spermidine N1-acetyltransferase, tyrosine hydroxylase, alpha-adrenergic receptor" provenance.
- _3 value "metabolism/pH/neurotransmitters: acetoacetyl CoA thiolase, adenylate kinase-3, aminopeptidase-A, carbonic anhydrase-9,-12, phosphoribosyl pyrophosphate synthetase, spermidine N1-acetyltransferase, tyrosine hydroxylase, alpha-adrenergic receptor" provenance.
- _4 value "several other transcription factors are activated by hypoxia, CREB and NFKB" provenance.
- _4 value "stabilized HIF1A is translocated to the nucleus, where it interacts with cofactors such as ARNT, CBP/p300 and the DNA polymerase II complex to bind to hypoxia-responsive elements and activate transcription of target genes" provenance.
- _3 value "stress-response pathways: 150kDa oxygen-reglated protein, growth arrest-and DNA damage-induced gene (GADD153), hap1, thioredoxin" provenance.
- _5 value "the p42/p44 MAPK have been shown to phosphorylate HIF1A and activate transcription of HIF1 target genes" provenance.
- _6 value "the redox active apurinic/apyrimidinic endonuclease-1 has been shown to keep HIF1A in a reduced state that is necessary for its transcriptional function" provenance.
- _3 value "transcription factors: annexin V, BCL-interacting killer, cyclin G2, differentiated embryo-chondrocyte expressed gene 1, FOS, HIF1A, insulin-like growth factor binding protein-1,-2,-3, JUN, KIP1, lipocortin, NFKB, NIP3, NIX, transgelin, transglutaminase-2, WAF1" provenance.
- _3 value "transcription factors: annexin V, BCL-interacting killer, cyclin G2, differentiated embryo-chondrocyte expressed gene 1, FOS, HIF1A, insulin-like growth factor binding protein-1,-2,-3, JUN, KIP1, lipocortin, NFKB, NIP3, NIX, transgelin, transglutaminase-2, WAF1" provenance.
- _4 value "H ferritin promoter transcription is tightly dependent on nuclear factor Y (NFY). Ferritin transcription is activated by c-Jun, although the promoter does not contain a canonical binding site" provenance.
- _6 value "c-Jun, when activated or overexpressed, is recruited to the H ferritin promoter by p300, which links NFY, bound to DNA, to the complex." provenance.
- _6 value "..supporting the finding that NcoR interacted with LBDs of the Ppars." provenance.
- _6 value "The PPAR delta-RXR alpha heterodimer bound to an acyl-CoA oxidase (ACO)-type peroxisome-proliferator response element recruited a glutathione S-transferase-NCoR fusion protein in a ligand-independent manner" provenance.
- _4 value "The fluorescein derivative phloxine B is a potent modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). Low micromolar concentrations of phloxine B stimulate CFTR Cl(-) currents, whereas higher concentrations of the drug inhibit CFTR. In this study, we investigated the mechanism of action of phloxine B. Phloxine B (1 microm) stimulated wild-type CFTR and the most common cystic fibrosis mutation, DeltaF508, by increasing the open probability of phosphorylated CFTR Cl(-) channels. At each concentration of ATP tested, the drug slowed the rate of channel closure without altering the opening rate. Based on the effects of fluorescein derivatives on transport ATPases, these data suggest that phloxine B might stimulate CFTR by binding to the ATP-binding site of the second nucleotide-binding domain (NBD2) to slow the dissociation of ATP from NBD1. Channel block by phloxine B (40 microm) was voltage-dependent, enhanced when external Cl(-) concentration was reduced and unaffected by ATP (5 mm), suggesting that phloxine B inhibits CFTR by occluding the pore. We conclude that phloxine B interacts directly with CFTR at multiple sites to modulate channel activity. It or related agents might be of value in the development of new treatments for diseases caused by the malfunction of CFTR." provenance.
- _6 value "We now report that excitotoxic (N-methyl-D-aspartate) insults to mature cerebrocortical neurons activate caspase-3, -7, in turn cleaving MEF2A, C, and D isoforms. MEF2 cleavage fragments containing a truncated transactivation domain but preserved DNA-binding domain block MEF2 transcriptional activity via dominant interference." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "clusterin does have a slight protective effect against apoptosis under some conditions." provenance.
- _5 value "BLT1 protein expression on neutrophils exposed to DEX for 24 h was also up-regulated 2- to 3-fold, and DEX-treated as well as LTB(4)-treated cells showed enhanced responsiveness to LTB(4) in terms of intracellular Ca(2+) mobilization and chemotaxis." provenance.
- _3 value "Moreover, LTB(4) itself up-regulated the expression of BLT1 mRNA." provenance.
- _4 value "# GeneRif: When expressed in respiratory epithelial cells and cell lines, protease-activated receptor 1 (PAR1)induces the release of IL-6, IL-8, and PGE2. Agonist peptides corresponding to the nascent N termini of PAR-1, PAR-2, and PAR-4 induced the release of cytokines from A549, BEAS-2B, and HBECs with a rank order of potency of PAR-2 > PAR-4 > PAR-1 at 400 microM. PAR-1, PAR-2, and PAR-4 also caused the release of PGE(2) from A549 and HBECs." provenance.
- _5 value "Basal and LIT induced IL-1beta and TNF-alpha production were inhibited by Bay-x-1005 in a dose dependent manner, while the addition of NS-398 caused a potent stimulatory effect. lit from nci meta A potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). It also acts as a non-phorbol-ester-type tumor promoter which discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca(2+)-ATPase. (Biochem Pharmacol 1987;36(5):621-6; Proc Natl Acad Sci USA 1991;88(16):7096-100)" provenance.
- _5 value "Basal and LIT induced IL-1beta and TNF-alpha production were inhibited by Bay-x-1005 in a dose dependent manner, while the addition of NS-398 caused a potent stimulatory effect. lit from nci meta A potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). It also acts as a non-phorbol-ester-type tumor promoter which discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca(2+)-ATPase. (Biochem Pharmacol 1987;36(5):621-6; Proc Natl Acad Sci USA 1991;88(16):7096-100)" provenance.
- _6 value "COX-2-specific inhibitor, NS-398," provenance.
- _3 value "Endogenous and locally produced eicosanoids regulate proinflammatory cytokine and MMP-1 synthesis under basal and stimulated conditions in vitro, with leukotrienes and prostaglandins having opposite effects in general." provenance.
- _4 value "LTB4 stimulated IL-1beta and TNF-alpha synthesis" provenance.
- _4 value "LTB4 stimulated IL-1beta and TNF-alpha synthesis" provenance.
- _3 value "Synovial explant culture spontaneously released small quantities (15 pg/g tissue wet weight) of Leukotriene B4 (LTB4) and when activated with LIT (Lipopolysaccharide (LPS) and calcium flux stimulators ionomycin and thapsigargin) produced larger amounts of LTB4 (120-150 pg/g tissue wet weight). The 5-LO activating protein (FLAP) inhibitor Bay-x-1005 blocked LIT-induced LTB4 release." provenance.
- _3 value "Microinjection of antibodies against Nir2 into neuronal cells markedly attenuates neurite extension, whereas overexpression of Nir2 in these cells attenuates Rho-mediated neurite retraction. These results implicate Nir2 as a novel regulator of the small GTPase Rho in actin cytoskeleton reorganization and cell morphogenesis." provenance.
- _4 value "from the paper:" provenance.
- _5 value "Using mouse knockouts for mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 and a double knockout of both MSK1 and MSK2, we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts. In contrast mitogen-induced phosphorylation of CREB and ATF1 is greatly reduced but not totally abolished. The mitogen- and stress-induced phosphorylation of CREB at Ser133 has been linked to the transcription of several immediate early genes, including c-fos, junB, and egr1. The knockout of both MSK1 and MSK2 resulted in a 50% reduction in c-fos and junB gene transcription in response to anisomycin or UV-C radiation but only a small reduction in response to tetradecanoyl phorbol acetate or epidermal growth factor in fibroblasts. The transcription of egr1 in response to both mitogenic and stress stimuli, as well as stress-induced apoptosis, was unaffected in the MSK1/MSK2 double knockout." provenance.
- _5 value "Primary human hepatocytes respond very well to IFN-alpha stimulation as shown by activation of multiple signal transducer and activator of transcription factor (STAT) 1, 2, 3, 5, and multiple genes." provenance.
- _2 value "We demonstrated a down-regulation of vimentin after ATRA treatment of NB4 cells by immunoblotting and immunofluorescence" provenance.
- _6 value ". This leucine-zipper protein interacts with a zinc finger motif in the regulatory domain of atypical PKCs, which dramatically inhibits their kinase activity" provenance.
- _4 value "Enforced expression of Par-4 induces apoptosis, which is abrogated by cotransfection of PKC{zeta} but not its kinase-inactive mutant (39)" provenance.
- _3 value "HSP25 was induced and phosphorylated by heat shock (at 43 degrees C for 3 h). HSP25, which was located in the cytoplasm in the normal condition, translocated into the nucleus after the heat shock" provenance.
- _5 value "In this study, we have analyzed the consequences of Gp96 interaction with cells expressing different Toll-like receptors (TLRs) and with bone marrow-derived dendritic cells from mice lacking functional TLR2 and/or TLR4 molecules. We find that the Gp96-TLR2/4 interaction results in activation of nuclear factor kappaB-driven reporter genes and mitogen- and stress-activated protein kinases and induces IkappaBalpha degradation." provenance.
- _5 value "PIMT (PRIP-interacting protein with methyltransferase domain), an RNA-binding protein with a methyltransferase domain capable of binding S-adenosylmethionine, has been shown previously to interact with nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR)-interacting protein) and enhance its coactivator function. We now report that PIMT strongly interacts with transcriptional coactivators, CBP, p300, and PBP but not with SRC-1 and PGC-1alpha under in vitro and in vivo conditions. The PIMT binding sites on CBP and p300 are located in the cysteine-histidine-rich C/H1 and C/H3 domains, and the PIMT binding site on PBP is in the region encompassing amino acids 1101-1560. The N-terminal of PIMT (residues 1-369) containing the RNA binding domain interacts with both C/H1 and C/H3 domains of CBP and p300 and with the C-terminal portion of PBP that encompasses amino acids 1371-1560. The C-terminal of PIMT (residues 611-852), which binds S-adenosyl-l-methionine, interacts respectively with the C/H3 domain of CBP/p300 and with a region encompassing amino acids 1101-1370 of PBP. Immunoprecipitation data showed that PIMT forms a complex in vivo with CBP, p300, PBP, and PRIP. PIMT appeared to be co-localized in the nucleus with CBP, p300, and PBP. PIMT enhanced PBP-mediated transcriptional activity of the PPARgamma, as it did for PRIP, indicating synergism between PIMT and PBP. In contrast, PIMT functioned as a repressor of CBP/p300-mediated transactivation of PPARgamma. Based on these observations, we suggest that PIMT bridges the CBP/p300-anchored coactivator complex with the PBP-anchored coactivator complex but differentially modulates coactivator function such that inhibition of the CBP/p300 effect may be designed to enhance the activity of PBP and PRIP." provenance.
- _7 value "PIMT enhanced PBP-mediated transcriptional activity of the PPARgamma, as it did for PRIP, indicating synergism between PIMT and PBP." provenance.
- _4 value "BCL6 overrides the senescence response downstream of p53 through a process that requires induction of cyclin D1 expression" provenance.
- _4 value "BCL6 overrides the senescence response downstream of p53 through a process that requires induction of cyclin D1 expression" provenance.
- _5 value "Effect of Ser371 on S6K1 Activation-- As shown previously (13), substitution of an alanine or an aspartate for Ser371 blocks serum- or insulin-induced Thr389 phosphorylation and S6K1 activation (Fig. 6A). However, substitution of an acidic residue at Thr389 in the S6K1-E389D3E background fails to rescue kinase activity (13), suggesting that Ser371 phosphorylation contributes directly to S6K1 activation independent of its role in regulating Thr389 phosphorylation. To test this possibility in vitro, either S6K1 or S6K1-S371A, from 293 cells pretreated with rapamycin, were incubated with either HA-mTOR-WT or HA-mTOR-KI. Both S6K1 variants displayed basal levels of phosphorylated Thr229, which were not altered by incubation with either mTOR variant (Fig. 6B). However, incubation of either S6 kinase variant with wild type, but not kinase-inactive, mTOR led to increased Thr389 phosphorylation, with the extent of Thr389 phosphorylation much higher in S6K1-S371A than in wild type S6K1 (Fig. 6B). However, to achieve the same level of activity as S6K1-WT, S6K1-S371A apparently requires much higher levels of Thr389 phosphorylation (Fig. 6B), consistent with detailed titration studies (data not shown). Although unexpected, these findings are compatible with Ser371 phosphorylation regulating Thr389 phosphorylation and with its ability to directly affect S6K1 activity. (From full text)" provenance.
- _5 value "Recently, it has been demonstrated that Thr229 phosphorylation is mediated by PDK1 (15, 16), whereas Thr389 as well as Ser411, Thr421, and Ser424 phosphorylation have been shown to be regulated by mTOR (17)." provenance.
- _4 value "Similar results have been obtained with ZD1839 (\"Iressa\"), an epidermal growth factor receptor (HER1) tyrosine kinase inhibitor." provenance.
- _5 value "Small molecule inhibitors of the HER2 kinase or MAP extracellular signal-regulated kinase 1/2 or dominant-negative MAP extracellular signal-regulated kinase 1/2 constructs restored the inhibitory effect of tamoxifen on both ER-mediated transcription and tumor cell proliferation." provenance.
- _10 value "Small molecule inhibitors of the HER2 kinase or MAP extracellular signal-regulated kinase 1/2 or dominant-negative MAP extracellular signal-regulated kinase 1/2 constructs restored the inhibitory effect of tamoxifen on both ER-mediated transcription and tumor cell proliferation." provenance.
- _2 value "the basal glucose uptake as well as insulin-stimulated GS activity is reduced in satellite cell cultures established from patients with type 2 diabetes" provenance.
- _3 value "Ariadne: However, palmitate also increased expression of calcyclin and 25-kDa synaptosomal-associated protein (SNAP25), which control distal secretory processes." provenance.
- _3 value "Increases in transcriptional modulators such as ATF3, CCAAT/enhancer binding protein-beta (C/EBPbeta), C/EBPdelta, and c-fos were also seen." provenance.
- _3 value "Oleate and palmitate also induced expression of chemokines (MCP-1 and GRO1 oncogene) and genes of the acute phase response (serum amyloid A3)." provenance.