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- _5 value "Bad was known to be phosphorylated by Akt at Ser136 (Vanhaesebroeck and Alessi, 2000)....As shown in Figure 1d, UCN-01 decreased the phospho-Bad (Ser136) level in a dose-dependent manner. We also found that UCN-01 could inhibit the phosphorylation of glycogen synthase kinase-3a (GSK-3a) at Ser21 residue (data not shown). These results suggest that UCN-01 suppressed Akt kinase activity in vivo." provenance.
- _5 wasQuotedFrom 11896604 provenance.