Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "Stimulation of T47D cells with epidermal growth factor (EGF) results in the activation of the intrinsic tyrosine kinases of the receptor and the phosphorylation of multiple cellular proteins including the receptor, scaffold molecules such as c-Cbl, adapter molecules such as Shc, and the serine/threonine protein kinase Akt. " provenance.
- _5 value "T cell?enriched LPMCs from T-bet knockout mice secreted lower levels of IFN-{gamma} than cells from wild-type littermates in the absence of colitogenic stimuli. In contrast, production of the Th2 type cytokines IL-4, IL-6, and IL-10 by T cell?enriched LPMCs was augmented in T-bet?deficient animals compared with wild-type mice." provenance.
- _2 value "...agents such as leptin, isoproterenol and dibutyryl cyclic AMP decrease glucose uptake, whereas cycloheximide and adenosine increase glucose uptake without affecting the amount of GLUT4 at the plasma membrane." provenance.
- _3 value "Table 2. List of shear stress-upregulated genes identified in the S4R subtracted cDNA library. non-uniform shear stress = turbulent shear stress" provenance.
- _3 value "Table 2. List of shear stress-upregulated genes identified in the S4R subtracted cDNA library. non-uniform shear stress = turbulent shear stress" provenance.
- _3 value "Table 2. List of shear stress-upregulated genes identified in the S4R subtracted cDNA library. non-uniform shear stress = turbulent shear stress" provenance.
- _3 value "Table 2. List of shear stress-upregulated genes identified in the S4R subtracted cDNA library. non-uniform shear stress = turbulent shear stress" provenance.
- _5 value "APS-facilitated phosphorylation occurred on tyrosines 371, 700, and 774 in the Cbl protein." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "Death associated protein kinase (DAP-kinase) is a pro-apoptotic calcium/calmodulin-regulated serine/threonine kinase with a multidomain structure that participates in a wide array of apoptotic systems initiated by IFN-gamma, TNF-alpha, activated Fas, and detachment from extracellular matrix." provenance.
- _5 value "Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression." provenance.
- _5 value "TBX2 and TBX3 bind to a variant T-site present in the p14ARF promoter. A, EMSA with probe -14/+35 and extracts of COS-7 cells overexpressing TBX2, TBX2RD, TBX2TB(R122E, R123E), TBX2TB(A272E), TBX3, TBX3 L143P, or TBX3 Y149S. Competitor oligos and antibodies as indicated. Note that TBX2, TBX2RD, and TBX3 can bind probe in both the absence and presence of anti-TBX2 antibody as opposed to the DNA binding inability of T-box mutants of TBX2 and TBX3.The Variant T-site of p14ARF Is Required for p14ARF Promoter Repression. To prove that the variant T-site is the relevant site via which TBX2 and TBX3 mediate repression we mutated the site in p14ARF promoter-reporter constructs at exactly the same positions as those used in EMSAs. Because these mutations reside in the core promoter region, it was not surprising that substantial and progressive activity loss was observed. However, in agreement with the binding data obtained in EMSA, T-half-site mutants could still be repressed by TBX2, whereas mutants in which both T-half-sites were disrupted were insensitive to TBX2 even at a very high dose in MEFs (Fig. 3A)." provenance.
- _3 value "RA treatment activates the PI3K/Akt signaling pathway, resulting in increased PI3K activity in extracts from RA-treated cells and a rapid increase in phosphorylation of Akt in Ser-473. Inhibition of PI3K by LY294002 impaired RA-induced differentiation, as assessed by morphological and biochemical criteria" provenance.
- _5 value "eNOS-derived NO and its biological effects are determined by the levels of eNOS protein and by eNOS catalytic activity; the latter is regulated partly through the dynamic interaction with an inhibitory protein (caveolin) and a stimulatory protein (calmodulin)." provenance.
- _7 value "eNOS-derived NO and its biological effects are determined by the levels of eNOS protein and by eNOS catalytic activity; the latter is regulated partly through the dynamic interaction with an inhibitory protein (caveolin) and a stimulatory protein (calmodulin)." provenance.
- _3 value "The in vitro model also demonstrates reactive oxygen species-dependent activation of nuclear factor-kappaB and activator protein-1 and that 24 hrs of ischemia results in increased cell division. These results indicate a novel cell-signaling pathway in response to loss of shear stress." provenance.
- _5 value "ST3 gene promoter that is accessible to nuclear factors such as C/EBP and retinoic acid receptors" provenance.
- _2 value "increased fatty acid flux to the liver increases apoB secretion in VLDL hyperinsulinemia can acutely inhibit VLDL apoB secretion in normal subjects but not in insulin-resistant subjects" provenance.
- _4 value "increased fatty acid flux to the liver increases apoB secretion in VLDL hyperinsulinemia can acutely inhibit VLDL apoB secretion in normal subjects but not in insulin-resistant subjects" provenance.
- _4 value "proteasomal inhibitors do not affect apoB degradation stimulated by either fish oils or insulin a variety of experimental data indicate that these stimuli induce the degradation of apoB after translocation, assembly with lipids, and exit from the ER interestingly, inhibition of phosphatidylinositol 3-kinase reduces the degradation stimulated by either fish oils or insulin" provenance.
- _5 value "After refolding, the purified recombinant protein (restin) specifically inhibits bovine aortic endothelial (BAE) cell proliferation stimulated by basic fibroblast growth factor (bFGF) in a dose-dependent manner, but the activity of restin was weaker than that of endostatin. Treatment of BAE cell with recombinant restin caused G(1) arrest and apoptosis in BAE cells" provenance.
- _3 value "After refolding, the purified recombinant protein (restin) specifically inhibits bovine aortic endothelial (BAE) cell proliferation stimulated by basic fibroblast growth factor (bFGF) in a dose-dependent manner, but the activity of restin was weaker than that of endostatin. Treatment of BAE cell with recombinant restin caused G(1) arrest and apoptosis in BAE cells" provenance.
- _3 value "Twenty-eight genes were found to be induced or upregulated by heat-shock in IMC-3 cells. These included genes involved in the apoptosis (e.g., CC3, caspase10), tumor invasion (e.g., CC3, TIMP-3), cell cycle checkpoint control (e.g., DP-1, CDC25A), signal transduction (e.g., MEK1) as well as genes associated with heat stress (e.g., Hsp70B', Hsp40)" provenance.
- _3 value "Twenty-eight genes were found to be induced or upregulated by heat-shock in IMC-3 cells. These included genes involved in the apoptosis (e.g., CC3, caspase10), tumor invasion (e.g., CC3, TIMP-3), cell cycle checkpoint control (e.g., DP-1, CDC25A), signal transduction (e.g., MEK1) as well as genes associated with heat stress (e.g., Hsp70B', Hsp40)" provenance.
- _3 value "Twenty-eight genes were found to be induced or upregulated by heat-shock in IMC-3 cells. These included genes involved in the apoptosis (e.g., CC3, caspase10), tumor invasion (e.g., CC3, TIMP-3), cell cycle checkpoint control (e.g., DP-1, CDC25A), signal transduction (e.g., MEK1) as well as genes associated with heat stress (e.g., Hsp70B', Hsp40)" provenance.
- _3 value "Twenty-eight genes were found to be induced or upregulated by heat-shock in IMC-3 cells. These included genes involved in the apoptosis (e.g., CC3, caspase10), tumor invasion (e.g., CC3, TIMP-3), cell cycle checkpoint control (e.g., DP-1, CDC25A), signal transduction (e.g., MEK1) as well as genes associated with heat stress (e.g., Hsp70B', Hsp40)" provenance.
- _4 value "The levels of IL-1Ra were undetectable in culture supernatants of untreated cells, but were significantly increased by IL-1beta." provenance.
- _4 value "The levels of IL-1Ra were undetectable in culture supernatants of untreated cells, but were significantly increased by IL-1beta." provenance.
- _4 value "Rheumatoid arthritic fibroblasts were treated with EP2 receptor agonist ONO-AE1-259 in the presence of NS-398 (COX-2 inhibitor 1 microM) and IL-1beta (1 ng/ml). EP2 receptor agonist at a dose of 2 nM enhanced the production of VEGF." provenance.
- _4 value "Rheumatoid arthritic fibroblasts were treated with EP4 receptor agonist ONO-AE1-329 in the presence of NS-398 (COX-2 inhibitor 1 microM) and IL-1beta (1 ng/ml). EP4 receptor agonist at a dose of 2 nM enhanced IL-1 beta stimulated production of IL-6." provenance.
- _3 value "Ariadne: Exposure of cardiomyocytes to hydrogen peroxide (100 ..mol/liter) also suppressed expression of VDUP1 mRNA (mean decrease 2.6 .. 0.2-fold at 8 h , Fig. 1 B , upper panel ) and protein (average decrease 1.4 .. 0.1-fold at 24 h). [Expression]" provenance.
- _5 value "Furthermore, physical association is mediated by the C-terminal zinc finger of GATA factors and the homeodomain of HNF-1alpha. Deletion of HNF-1alpha activation domains or interruption of HNF-1-binding sites in the lactase-phlorizin hydrolase promoter resulted in a complete loss of cooperativity, whereas deletion of GATA-5 activation domains or interruption of GATA-binding sites resulted in a reduction, but not an elimination, of cooperativity. " provenance.
- _3 value "Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet." provenance.
- _3 value "Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet." provenance.
- _4 value "CDCA and DCA both inhibited 11 beta HSD2 with IC(50) values of 22 and 38 microm, respectively and caused cortisol-dependent nuclear translocation and increased transcriptional activity of MR. LCA, the bile acid that most efficiently inhibited 11 beta HSD2" provenance.
- _6 value "CDCA and DCA both inhibited 11 beta HSD2 with IC(50) values of 22 and 38 microm, respectively and caused cortisol-dependent nuclear translocation and increased transcriptional activity of MR. LCA, the bile acid that most efficiently inhibited 11 beta HSD2" provenance.
- _4 value "Inappropriate activation of the mineralocorticoid receptor (MR) results in renal sodium retention and potassium loss" provenance.
- _3 value "tumor progression and DNA damage were shown to correlate with the decrease in MnSOD and GPX activities in murine fibrosarcoma cells" provenance.
- _4 value "p16INK4a was much lower or undetectable in all the Id-1 expressing clones of LNCaP cells, while approximately 2 to 3 fold increases in p16INK4a levels was observed in the controls and in the Id-1 negative clones, suggesting that expression of Id-1 reduced the p16INK4a protein levels in LNCaP cells." provenance.
- _5 value "Multiple transcription factors including AP-1 and C/EBP are also implicated in the fine-tuned up regulation of other oxidative stress-related target genes which become significantly expressed in CS-treated cells, i.e. mt1/2 (35), hsp105 and hsp90" provenance.
- _5 value "Multiple transcription factors including AP-1 and C/EBP are also implicated in the fine-tuned up regulation of other oxidative stress-related target genes which become significantly expressed in CS-treated cells, i.e. mt1/2 (35), hsp105 and hsp90" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Finally, leptin activates phospholipase C and voltage-dependent Ca2 + channels, most likely L-type and N-type Ca2 + channels, an effect that might underlie leptin-induced catecholamine secretion [121]." provenance.
- _3 value "Leptin expression can be induced by obesity, insulin, TNF-a and glucocorticoids and is negatively regulated by fasting, b-adrenergic agonists and thiazolidinediones" provenance.
- _3 value "Leptin expression can be induced by obesity, insulin, TNF-a and glucocorticoids and is negatively regulated by fasting, b-adrenergic agonists and thiazolidinediones" provenance.
- _5 value "Leptin expression can be induced by obesity, insulin, TNF-a and glucocorticoids and is negatively regulated by fasting, b-adrenergic agonists and thiazolidinediones" provenance.
- _2 value "Normal leptin receptor, but not the mutated form present in fa/fa rats, has been shown to lead to changes in PDE2 expression and activity in brown fat [99]. Therefore, regulation of PDE isoforms by leptin is apparent in various tissues and further work will help understand the mechanism and consequences of this action. There are several other signalling proteins regulated by leptin that should be mentioned here. Two studies have demonstrated an ability of leptin to increase production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVEC) or bovine aortic endothelial cells (BAEC) [65,119]." provenance.
- _5 value "SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus." provenance.
- _6 value "SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus." provenance.
- _2 value "The functional significance of increased SOCS-3 expression on leptin signalling was demonstrated by a 75% reduction in the lipopenic effect of leptin upon transgenic overexpression of SOCS-3 in islets" provenance.
- _2 value "These may be relevant in the pathogenesis of cardiovascular complications associated with obesity, such as atherosclerosis, and demand further investigation. Leptin stimulates prostaglandin E2 and prostaglandin F2a production in rat hypothalamic cells [111]." provenance.
- _2 value "These may be relevant in the pathogenesis of cardiovascular complications associated with obesity, such as atherosclerosis, and demand further investigation. Leptin stimulates prostaglandin E2 and prostaglandin F2a production in rat hypothalamic cells [111]." provenance.
- _4 value "Yeast two hybrid and protein precipitation experiments identified binding of diacylglycerol kinase-z interacts via ankyrin repeats with the cytoplasmic domain of obRb (not obRa) [120]. The p90 ribosomal protein S6 and p70S6K are activated by leptin in human mononuclear cells [62]." provenance.
- _4 value "Yeast two hybrid and protein precipitation experiments identified binding of diacylglycerol kinase-z interacts via ankyrin repeats with the cytoplasmic domain of obRb (not obRa) [120]. The p90 ribosomal protein S6 and p70S6K are activated by leptin in human mononuclear cells [62]." provenance.
- _5 value "ligand-receptor binding activated STAT3, STAT5 and STAT6" provenance.
- _6 value "ligand-receptor binding activated STAT3, STAT5 and STAT6" provenance.
- _6 value "ligand-receptor binding activated STAT3, STAT5 and STAT6" provenance.
- _6 value "ligand-receptor binding activated STAT3, STAT5 and STAT6" provenance.
- _3 value "treatment of human mononuclear cells with leptin increased p38 MAP kinase phosphorylation Another study in L6 muscle cells suggested that leptin did not itself alter p38 MAP kinase phosphorylation but reduced insulin-stimulated p38 MAP kinase phosphorylation" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _3 value "induction of S phase by E2F1 overexpression is accompanied by p53-dependent induction of apoptosis and overexpression of E2F1 induces the accumulation of p53 protein" provenance.
- _3 value "overexpression of E2F1 drives quiescent cells into S phase" provenance.
- _3 value "The information below is from table 3 [SH]" provenance.
- _3 value "The information below is from table 3 [SH]" provenance.
- _3 value "The information below is from table 3 [SH]" provenance.
- _4 value "Furthermore, the presence of an intact AP1 element in the pS2 promoter sustained suppression of pS2 promoter activity by an LXXLL peptide." provenance.
- _5 value "Fibroblast growth factor (Yoshida et al., 1997), insulin-like growth factor-1 (Rhoads et al., 1997), epidermal growth factor (Heinrich and Kraiem, 1997), endothelin-1 (Salamonsen et al., 1997), oncostatin M (Isozaki et al., 1997), nerve growth factor (Courtney et al., 1997), tumor necrosis factor alpha (Yoshida et al., 1997), and interleukin-1alpha and beta (Lu et al., 1997) activate Jun kinase and increase c-jun gene expression." provenance.
- _5 value "Ref-1 is an important redox regulator of a number of transcription factors, including NF-kappaB and AP-1" provenance.
- _3 value "We found that incubation with low concentrations of crocidolite asbestos (0.5-1.25 microg/cm(2)) resulted in an increase in nuclear Ref-1 protein after 5 min, with a persistent elevation in protein up to 24 h. Additionally, an increase in nuclear Ref-1 could be induced by treating the cells with an oxidant-generating stimulus (iron loading plus PMA) and inhibited by diphenyleneiodonium chloride, an inhibitor of NADPH oxidase" provenance.
- _4 value "Vegf (10ng/ml) treatment induced the Tyrosine phosphorylation of FAK in Raw cells. Tyrosine phosphorylation was observed at Y397 and Y925 in FAK." provenance.
- _4 value "We found that LPS treatment increased caspase-3 and caspase-1 activities and induced the cleavage of focal adhesion kinase. " provenance.
- _5 value "Overexpression of either p47phox or full-length TRAF4 alone in Fx cells did not appreciably affect JNK activity. In contrast, overexpression of both p47phox and TRAF4 increased JNK activity greater than 4-fold over control, suggesting a functional as well as physical interaction between the two proteins. Overexpression of truncated TRAF4 consistently decreased activation of both HA-JNK1 and HA-JNK2 by HIV-1 Tat in HUVEC. Whereas full-length TRAF4 did not affect JNK activation." provenance.
- _7 value "Following exposure to ionizing radiation (IR), the BRCA1-c-Abl complex is disrupted in an ATM-dependent manner, which correlates temporally with ATM-dependent phosphorylation of BRCA1 and ATM-dependent enhancement of the tyrosine kinase activity of c-Abl. In vivo, BRCA1 is phosphorylated at tyrosine residues in an ATM-dependent, radiation-dependent manner" provenance.
- _6 value "Tiam1 and Ras-GRF1 are guanine nucleotide exchange factors (GEFs) that activate the Rac GTPase." provenance.
- _4 value "RNA interference-mediated downregulation of endogenous RASSF1A expression in human epithelial cells results in abnormal accumulation of cyclin D1 protein" provenance.
- _5 value "FKHRL1, a member of the forkhead in rhabdosarcoma (FKHR) subclass of the Fox family of transcription factors, stimulates transcription from transfected 3-hydroxy-3-methylglutaryl-CoA synthase promoter-luciferase reporter constructs, and that this stimulation is repressed by insulin." provenance.
- _3 value "IL-6 increased Cp mRNA expression in HepG2 cells by approximately 5-fold. Simultaneous treatment with insulin reduced this stimulation by half. Surprisingly, insulin by itself caused a 2-4-fold induction in Cp mRNA expression. The role of hypoxia-inducible factor-1 in the induction of Cp by insulin was shown by electrophoretic mobility shift assays and by the absence of insulin-stimulated Cp promoter activation in mouse Hepa c4 cells deficient in hypoxia-inducible factor-1 activity." provenance.
- _4 value "growth inhibitors such as transforming growth factor TGF beta block Mat2a up-regulation while increasing Mat1a mRNA levels" provenance.
- _4 value "Both PMA and cAMP decreased CYP7B1 activity by 60% and 34%, respectively, in a time-dependent fashion." provenance.
- _7 value "EGR2 recessive mutation (I268N) is known to affect the inhibitory domain that binds the NAB transcriptional corepressors, NAB1 and NAB2. This mutation abolishes the interaction of EGR2 with the NAB corepressors and thereby increases transcriptional activity" provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _5 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _5 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _5 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _5 value "HNF-1 is known to activate the transcription of the IGF-1 gene ( 23 , 24 )." provenance.
- _3 value "Below are the contents of a table from the paper" provenance.