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- _2 value "Normal leptin receptor, but not the mutated form present in fa/fa rats, has been shown to lead to changes in PDE2 expression and activity in brown fat [99]. Therefore, regulation of PDE isoforms by leptin is apparent in various tissues and further work will help understand the mechanism and consequences of this action. There are several other signalling proteins regulated by leptin that should be mentioned here. Two studies have demonstrated an ability of leptin to increase production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVEC) or bovine aortic endothelial cells (BAEC) [65,119]." provenance.
- _2 wasQuotedFrom 12020765 provenance.