Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "increased expression of p21 by skeletal muscle satellite cells would be expected to result in irreversible cell cycle exit, such that removal of ATP would not rescue cells" provenance.
- _4 value "title := \"ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.\" Using immunocytochemistry, RT-PCR, and electrophysiology, we demonstrate that the ionotropic P2X5 receptor is present on satellite cells and that activation of a P2X receptor inhibits proliferation, stimulates expression of markers of muscle cell differentiation, including myogenin, p21, and myosin heavy chain, and increases the rate of myotube formation." provenance.
- _4 value "EGF and/or insulin increased protein kinase B/Akt serine phosphorylation" provenance.
- _3 value "EGF increased the tyrosine phosphorylation of several proteins (the EGF receptor,insulin receptor substrate (IRS)-1, IRS-2, and Grb2-associated binder 1)" provenance.
- _4 value "Like insulin, glucose transport in response to EGF was inhibited by both wortmannin and ML-9" provenance.
- _5 value "Like insulin, glucose transport in response to EGF was inhibited by both wortmannin and ML-9" provenance.
- _6 value "Modified assertion" provenance.
- _6 value "TGF-, which also binds to EGFR, also increased glucose transport to the same extent as insulin and with a similar affinity" provenance.
- _3 value "The ability of the growth factors epidermal growth factor (EGF), transforming growth factor alpha, and platelet-derived growth factor to exert insulin-like effects on glucose transport and lipolysis were examined in human and rat fat cells. High concentrations of EGF/TGF-, but not PDGF, increased glucose transport to same extent as insulin, and no additive effect was seen when both EGF and insulin were present" provenance.
- _3 value "The activation of PI 3-kinase lipid kinase and the downstream serine/threonine kinase, PKB/Akt, by insulin is critical for the translocation of GLUT4 to the plasma membrane and the increased glucose transport" provenance.
- _5 value "insulin activates the p21ras/MAP kinase pathway through the phosphorylation and activation of Shc" provenance.
- _6 value "Here, we investigated the signaling cascade required for Ark inhibition of the GnRH promoter in GT1-7 GnRH neuronal cells. Ark repression was blocked by the MEK/ERK pathway inhibitor, PD98059, and dominant negative MEK1 but was unaffected by dominant negative Ras." provenance.
- _6 value "Here, we investigated the signaling cascade required for Ark inhibition of the GnRH promoter in GT1-7 GnRH neuronal cells. Ark repression was blocked by the MEK/ERK pathway inhibitor, PD98059, and dominant negative MEK1 but was unaffected by dominant negative Ras." provenance.
- _4 value "In CHO-K1 cells, GIP induced phosphorylation of Raf-1 (Ser-259), Mek1/2 (Ser-217/Ser-221), ERK1/2 (Thr-202 and Tyr-204), and p90 RSK (Ser-380) in a concentration-dependent manner." provenance.
- _4 value "In CHO-K1 cells, GIP induced phosphorylation of Raf-1 (Ser-259), Mek1/2 (Ser-217/Ser-221), ERK1/2 (Thr-202 and Tyr-204), and p90 RSK (Ser-380) in a concentration-dependent manner." provenance.
- _3 value "In addition to HSP70, other heat shock proteins have been examined for their induction by hypertonicity. A small heat shock protein (B-crystallin [4]), a HSP40 called HLJ1 (34), and a couple of the HSP110 members (Osp94 [16] and HSP105B [42]) are induced by hypertonicity" provenance.
- _3 value "In addition to HSP70, other heat shock proteins have been examined for their induction by hypertonicity. A small heat shock protein (B-crystallin [4]), a HSP40 called HLJ1 (34), and a couple of the HSP110 members (Osp94 [16] and HSP105B [42]) are induced by hypertonicity" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "However, LXR alpha has several important roles in adipocyte function. Our studies show that this nuclear receptor increases basal glucose uptake and glycogen synthesis in 3T3-L1 adipocytes. In addition, LXR alpha increases cholesterol synthesis and release of nonesterified fatty acids. F" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Integrin-linked kinase (ILK) has been implicated in Ca(2+)- independent contraction of smooth muscle via its ability to phosphorylate myosin." provenance.
- _5 value "The (PPARG) agonists appeared to potentiate Akt1 phosphorylation in muscle and liver and both Akt1 and Akt2 in adipose" provenance.
- _6 value "The (PPARG) agonists appeared to potentiate Akt1 phosphorylation in muscle and liver and both Akt1 and Akt2 in adipose" provenance.
- _5 value "Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase activity in vitro, in intact cells, and in vivo." provenance.
- _5 value "Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle." provenance.
- _5 value "we demonstrate that the E3 ligase activity of Mdm2 and phosphorylation of Mdm2 by Akt are essential for Mdm2 to affect AR ubiquitylation and degradation." provenance.
- _4 value "Furthermore, AP-1 cooperates with NF-kappaB and stimulates expression of the cell-cycle regulator cyclin D2, proto-oncogene c-met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells." provenance.
- _7 value "Furthermore, AP-1 cooperates with NF-kappa B and stimulates expression of the cell-cycle regulator cyclin D2, proto-oncogene c-met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells." provenance.
- _7 value "Furthermore, AP-1 cooperates with NF-kappa B and stimulates expression of the cell-cycle regulator cyclin D2, proto-oncogene c-met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells." provenance.
- _7 value "Furthermore, AP-1 cooperates with NF-kappa B and stimulates expression of the cell-cycle regulator cyclin D2, proto-oncogene c-met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells." provenance.
- _4 value "We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and p110 beta, and 1 mm for p110 gamma), and theophylline has similar effects (IC(50) = 75 microm for p110 delta, 300 microm for p110 alpha, and 800 microm for p110 beta and p110 gamma) and also inhibits the alpha isoform of class II PI3K (PI3K-C2 alpha) (IC(50) approximately 400 microm). Surprisingly the triazoloquinazoline CGS15943 (9-chloro-2-(2-furyl)(1,2,d)triazolo(1,5-c)quinazolin-5-amine) also selectively inhibits p110 delta (IC(50) < 10 microm)." provenance.
- _4 value "We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and p110 beta, and 1 mm for p110 gamma), and theophylline has similar effects (IC(50) = 75 microm for p110 delta, 300 microm for p110 alpha, and 800 microm for p110 beta and p110 gamma) and also inhibits the alpha isoform of class II PI3K (PI3K-C2 alpha) (IC(50) approximately 400 microm). Surprisingly the triazoloquinazoline CGS15943 (9-chloro-2-(2-furyl)(1,2,d)triazolo(1,5-c)quinazolin-5-amine) also selectively inhibits p110 delta (IC(50) < 10 microm)." provenance.
- _3 value "TABLE III Genes up-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE III Genes up-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE III Genes up-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE V Genes down-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE V Genes down-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE V Genes down-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _3 value "TABLE V Genes down-regulated by 3 h of hypoxia (8% O2) followed by re-oxygenation (R) in neonatal rat brain" provenance.
- _5 value "Activation is abolished when either CRE or SRE are removed/mutated. Furthermore, mutation of CRE abolishes SREBP-dependent activation after overexpression of SREBP-1a and CRE binding protein (CREB). This shows that CRE is essential, and that under ex vivo conditions CREB and SREBP cooperate in transactivating CYP51. Interestingly, protein kinase A shows a marked stimulation of the CYP51 promoter activity when overexpressed together with SREBP-1a but not when overexpressed with CREB, suggesting phosphorylation of SREBP-1a. Using a DNA probe containing all three regulatory elements, it is found that SREBP-1a, a CREB-like factor, and specificity protein (Sp1) all probably bind the CYP51 promoter. While SREBP-1a and the CRE-bound proteins are essential for the SREBP-dependent response, Sp1 apparently functions only to maximize sterol regulation of CYP51." provenance.
- _4 value "Lanosterol 14alpha-demethylase (CYP51) is involved in the cholesterol biosynthesis pathway, producing follicular fluid meiosis-activating sterol." provenance.
- _3 value "Finally, PDK-1CAAX expression inhibited insulin-induced ERK1/2 phosphorylation in a dose-dependent manner." provenance.
- _3 value "oncostatin M down-regulated the expression of cyclin D1 and D2 in a primary culture of fetal hepatocytes in which OSM induces hepatic differentiation" provenance.
- _6 value "We demonstrate that RanBPM can interact with MET in vitro and in vivo, and the interaction can be strengthened by HGF stimulation." provenance.
- _3 value "The two hybrid system identified the S100A4 (mts1) calcium binding protein as a partner of CCN3 and the use of the GST fusion proteins showed that the addition of CCN3 and CCN2 to G59 glioblastoma and SK-N-SH neuroblastoma cells caused a pronounced but transient increase of intracellular calcium, originating from both the entry of extracellular calcium and the mobilisation" provenance.
- _4 value "Furthermore, epiregulin up-regulated the mRNAs of TGF-alpha and HB-EGF, and in turn, these growth factors enhanced the expression of epiregulin mRNA." provenance.
- _3 value "activin A is induced by inflammation and exerts anti-inflammatory effects" provenance.
- _3 value "The mRNA for beta-ketoacyl thiolase, which catalyzes the last step, was also increased. The expression of electron transfer flavoprotein-beta (ETF) was increased in the STZ-diabetic mouse." provenance.
- _3 value "The mRNA for beta-ketoacyl thiolase, which catalyzes the last step, was also increased. The expression of electron transfer flavoprotein-beta (ETF) was increased in the STZ-diabetic mouse." provenance.
- _3 value "The mRNAs for two enzymes specifically required for beta-oxidation of unsaturated fatty acids,namely 2,3-enoyl-CoA isomerase and dodecenoyl-CoA delta- isomerase, were also increased" provenance.
- _3 value "The transcripts for alpha-SNAP, syntaxin-4 (a t-SNARE), and VAMP-5 (a v-SNARE) were all increased in diabetes." provenance.
- _3 value "the mRNA for GTP dissociation inhibitor-1 (RhoGDI-1) was decreased." provenance.
- _3 value "Overexpression of cyclin D1 altered sensitivity to taxol by modulating exit from mitosis, which is controlled by p21. These results indicate that overexpression of cyclin D1 sensitizes MCF7 cells to treatment with taxol." provenance.
- _5 value "Supplemental Table S1. Transcripts found in Class I [activated by FKHR]" provenance.
- _5 value "Supplemental Table S1. Transcripts found in Class I [activated by FKHR]" provenance.
- _5 value "Supplemental Table S1. Transcripts found in Class I [activated by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]" provenance.
- _5 value "Supplemental Table S4. Transcripts found in Class III [transcriptional downregulation]" provenance.
- _5 value "Supplemental Table S4. Transcripts found in Class III [transcriptional downregulation]" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Elevated chk1 phosphorylation at Ser(345) following DNA damage induced by BNP1350 was accompanied by G(2) accumulation" provenance.
- _8 value "interleukin-1beta (IL-1beta) causes nuclear export of a specific N-CoR corepressor complex, resulting in derepression of a specific subset of NF-kappaB-regulated genes, exemplified by the tetraspanin KAI1 that regulates membrane receptor function" provenance.
- _3 value "the mRNA and protein profiles for BMP ligands were significantly altered during airway inflammation with induction of BMP2, BMP4, and BMP6, and downregulation of BMP5 and BMP7." provenance.
- _3 value "the mRNA and protein profiles for BMP ligands were significantly altered during airway inflammation with induction of BMP2, BMP4, and BMP6, and downregulation of BMP5 and BMP7." provenance.
- _4 value "p21WAF1 deletion resulted in an increase in Bax protein expression. Quantitative analysis of the intensity of the bands revealed that the apparent Bax/Bcl2 ratio was 4-fold higher in the absence of p21WAF1." provenance.
- _3 value "Here we provide evidence that both the mitogenic effect of bFGF and the differentiation-promoting effect of NT3 are linked with modifications of cell cycle kinetics in mouse cortical precursor cells" provenance.
- _3 value "Down-regulation of drs mRNA was also observed in human lung adenocarcinoma down-regulation of drs mRNA is correlated with a poor degree of differentiation and progression of lung adenocarcinoma." provenance.
- _5 value "Apo2L/TRAIL-induced apoptosis involves caspase-8-mediated cleavage of BID." provenance.
- _4 value "We find that CK2 inhibits Apo2L/TRAIL-induced caspase-8-mediated cleavage of BID, thereby reducing the formation of tBID. In addition, CK2 promotes nuclear factor kappa B (NF-kappa B)-mediated expression of Bcl-x(L), which sequesters tBID and curtails its ability to activate BAX." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Like VEGF, VEGFC stimulates the migration of endothelial cells and induces vascular permeability and endothelial-cell proliferation, but at higher concentrations than are required for VEGF 22,24. These signals for endothelial cells are probably mediated by means of VEGFR2 in blood-vascular-endothelial cells and generally by VEGFR3 (also known as FLT4) in lymphatic endothelial cells," provenance.
- _4 value "Overexpression of VEGFC in skin keratinocytes leads to dermal lymphatic-vessel hyperplasia 16. Signalling by means of VEGFR3 alone was shown to be sufficient for the hyperplasia, as transgenic mice that overexpress a mutant form of VEGFC, which has lost its capacity to bind VEGFR2 and only binds and activates VEGFR3 (VEGFC156S), was able to induce a similar phenotype 20." provenance.
- _4 value "Stimulation of VEGFR3 alone protected these cells from serum-deprivation-induced apoptosis and induced cell growth and migration.At least some of these signals were transduced via a protein- kinase-C-dependent activation of the p42/p44 mitogen-activated protein kinase (MAPK) signalling cascade and via AKT phosphorylation40." provenance.
- _3 value "VEGFD was also shown to promote the metastatic spread of tumour cells via the lymphatics in a mouse tumour model21 (FIG. 3). In addition to lymphangiogenesis and increased metastasis, the tumours that secrete VEGFD also showed an increase of both growth rate and angiogenesis." provenance.
- _3 value "VEGFD was also shown to promote the metastatic spread of tumour cells via the lymphatics in a mouse tumour model21 (FIG. 3). In addition to lymphangiogenesis and increased metastasis, the tumours that secrete VEGFD also showed an increase of both growth rate and angiogenesis." provenance.
- _5 value "In the presence of C/ EBPalpha, Nkx2.1 stimulated the CCSP promoter already at 50 ng of Nkx2.1 expression plasmid (Fig. 2 B )." provenance.
- _3 value "data indicate that the transcript levels of interleukin 1 receptor antagonist (IL-1ra), beta 2-microglobulin, annexin XI and the LXR(alpha) receptor significantly increased and that Ly-GDI transcript levels significantly decreased after estrogen withdrawal;" provenance.
- _3 value "mature liver expresses Mat1a, whereas Mat2a is expressed in extrahepatic tissues and induced during liver growth and dedifferentiation by using the Mat1a knockout mouse model in which hepatic AdoMet and GSH levels decrease, the liver becomes larger and more susceptible to injury, and steatohepatitis develops spontaneously" provenance.
- _4 value "The expression of the GATA5 antisense cDNA had no effect on the morphology or proliferation of undifferentiated cells (Fig. 5D and data not shown). However, in the absence of GATA5 protein, treatment with RA did not lead to the appearance of endothelial-like morphological and biochemical changes nor to a decrease in cell proliferation as in control cells, even with increasing concentration (10?4 M) and time (5 days) of RA treatment (Fig. 5D). Furthermore, unlike control cells, endothelial markers like ET-1, Flt1, and EPAS1 were not induced in cell lines lacking GATA5 indicating that GATA5 expression is required for endocardial differentiation (Fig. 5E). In order to molecularly define the stage at which differentiation was arrested, RT-PCR analyses were carried out. As shown in Fig. 5E, early endothelial markers like Msx1 and Cx37 were induced, albeit at a relatively lower level than in control cells." provenance.
- _5 value "We therefore tested whether GATA5 and NF-ATc collaborate in regulating endocardial transcription thereby affecting cell differentiation. For this, we used the GATA-dependent ET-1 promoter, which is preferentially regulated by GATA5 (Nemer et al., 1999Go). As shown in Fig. 6B, the ET-1 promoter is synergistically activated in TC13 cells by co-expression of GATA5 and NF-ATc suggesting that these two transcription factors act cooperatively to induce endocardial gene expression." provenance.
- _4 value "Androgen and IL-6 stimulated the MAPK pathway." provenance.
- _5 value "Phosphorylation of SRC-1 by MAPK was required for optimal ligand-independent activation of the AR by IL-6." provenance.
- _4 value "Both GDNF and NGF were able to partially reverse the axotomy-induced increase in Na(v)1.3 mRNA, with GDNF plus NGF producing the largest effect." provenance.
- _4 value "both high glucose and exogenous TGF-beta1 increased alpha3 collagen IV and VEGF, with TGF-beta1 having the greater effect high glucose and TGF-beta1 coordinately induce the production of alpha3[IV] collagen and VEGF in the podocyte the high glucose-induced increases in alpha3[IV] collagen and VEGF proteins are mediated by the TGF-beta system" provenance.
- _3 value "both high glucose and exogenous TGF-beta1 increased alpha3 collagen IV and VEGF, with TGF-beta1 having the greater effect high glucose and TGF-beta1 coordinately induce the production of alpha3[IV] collagen and VEGF in the podocyte the high glucose-induced increases in alpha3[IV] collagen and VEGF proteins are mediated by the TGF-beta system" provenance.
- _5 value "Repression of AP-1 function by BCL-6 may be a key mechanism for how BCL-6 regulates gene expression to control inflammation, lymphocyte differentiation, and lymphomagenesis." provenance.
- _2 value "Because reactive oxygen species (ROS) generated from mitochondria are one of the signaling molecules induced by hypoxia, the role of ROS in hypoxia-induced TLR4 down-regulation was evaluated. Our data showed that hypoxia increased ROS generation and that hypoxia-induced TLR4 down-regulation was inhibited by myxothiazol, a mitochondrial site III electron transport inhibitor. Hypoxia also inhibited AP-1 translocation. Since the TLR4 promoter has a binding site for AP-1, hypoxia-induced TLR4 down-regulation may be due to an ROS-mediated decrease in AP-1-binding activity." provenance.
- _2 value "Because reactive oxygen species (ROS) generated from mitochondria are one of the signaling molecules induced by hypoxia, the role of ROS in hypoxia-induced TLR4 down-regulation was evaluated. Our data showed that hypoxia increased ROS generation and that hypoxia-induced TLR4 down-regulation was inhibited by myxothiazol, a mitochondrial site III electron transport inhibitor. Hypoxia also inhibited AP-1 translocation. Since the TLR4 promoter has a binding site for AP-1, hypoxia-induced TLR4 down-regulation may be due to an ROS-mediated decrease in AP-1-binding activity." provenance.
- _3 value "Hypoxia decreased TLR4 expression on cultured endothelial cells." provenance.
- _6 value "The response to C5a was blocked by inhibitors of phosphatidylinositol-3-kinase, src kinase, and of the epidermal growth factor (EGF) receptor (EGFR) as well as by neutralizing Abs against the EGFR and heparin-binding EGF-like factor. Furthermore, immune precipitations showed that the EGFR was phosphorylated following stimulation with C5a. The C5aR in endothelial cells thus uses a signaling cascade-transactivation of the EGFR-that does not exist in leukocytes" provenance.
- _7 value "Since p53 activation requires recruitment of CREB binding protein (CBP) as a coactivator, we also examined the effect of CBP on TNFalpha-induced attenuation of p53 promoter activation. Overexpression of CBP induced p53 transcriptional activity and recovery of TNFalpha-induced inhibition." provenance.