Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence A+decrease+of+osteopontin+and+osteocalcin+in+bone+is+important+for+promoting+vulnerability+to+hip+fracture. assertion.
- assertion asSentence CEACAM-1+and+CXCL-14+are+involved+in+the+occurrence+and+development+of+infantile+hemangioma. assertion.
- assertion asSentence Association+between+the+homozygous+mutant+form+of+BHMT+%28742G--%3EA%29+polymorphism+and+increased+risk+for+placental+abruption. assertion.
- assertion asSentence Bid+both+exhibits+S+phase+checkpoint+activation+and+plays+a+pro-apoptotic+role+in+response+to+different+degrees+of+etoposide-induced+DNA+damage+in+HCC+cells. assertion.
- assertion asSentence BLM-defective+cells+display+a+higher+frequency+of+anaphase+bridges+and+lagging+chromatin+than+do+isogenic+corrected+derivatives+that+eptopically+express+the+BLM+protein. assertion.
- assertion asSentence Human+SUV3+protein+interacts+with+human+BLM+helicase. assertion.
- assertion asSentence BMI-1+is+transiently+localized+with+the+centromeric+region+in+interphase. assertion.
- assertion asSentence BMP1+processes+PRL+to+a+17-kDa+anti-angiogenic+factor. assertion.
- assertion asSentence Inactivating+BMPR-IA+and+causing+a+loss+of+the+BMP-2+tumor+suppressor+function+in+colon+epithelial+cells. assertion.
- assertion asSentence In+MSI+CRC+this+is+associated+predominantly+with+impaired+BMPR2+expression+and+in+MSS+CRC+with+impaired+SMAD4+expression. assertion.
- assertion asSentence High+BMP2+is+associated+with+gastric+cancer+progression. assertion.
- assertion asSentence Agrin+binds+BMP2%2C+BMP4+and+TGFbeta1+with+relatively+high+affinity. assertion.
- assertion asSentence Runx2+plus+BMP2+mediated+efficient+conversion+of+fibroblast-like+ligamentum+flavum+cells+into+osteoblast-+like+cells. assertion.
- assertion asSentence The+numbers+of+tyrosine+hydroxylase-+and+calcitonin+gene-related+peptide+%28TrkC%29-expressing+neurons+are+increased+by+overexpression+of+transgenic+BMP4. assertion.
- assertion asSentence Smad4+is+dispensable+for+enhanced+invasiveness+of+human+colorectal+cancer+cells+due+to+BMP-4+overexpression. assertion.
- assertion asSentence LL-37+inhibits+gastric+cancer+cell+proliferation+through+activation+of+BMP4+signaling+via+a+proteasome-dependent+mechanism. assertion.
- assertion asSentence BMP-2+and+BMP-6+are+expressed+in+arthritic+synovium+and+are+strongly+up-regulated+by+proinflammatory+cytokines. assertion.
- assertion asSentence BMP-7+does+not+inhibit+mesenchymal-to-epithelial+transition+in+either+primary+or+immortalized+human+proximal+tubule+cells. assertion.
- assertion asSentence OP-1+combined+with+locally+obtained+autograft+is+a+safe+and+effective+alternative+for+iliac+crest+autograft+in+instrumented+single-level+posterolateral+fusions+of+the+lumbar+spine. assertion.
- assertion asSentence BMP-7+modulates+the+profibrotic+effects+of+TGF-beta1+on+normal+lung+fibroblasts. assertion.
- assertion asSentence Bmx+is+a+downstream+Rap1+effector+in+VEGF-induced+endothelial+cell+activation. assertion.
- assertion asSentence BNIP3+is+involved+in+SYUIQ-5+induced+autophagy+in+nasopharyngeal+cancer+cells. assertion.
- assertion asSentence BNIP3+expression+and+TGM2+expression+are+independent+prognostic+factors+in+laryngeal+SCC+patients+receiving+postoperative+radiotherapy. assertion.
- assertion asSentence Deletion+of+the+conserved+non-coding+sequences+upstream+of+FOXL2+is+associated+with+blepharophimosis+syndrome. assertion.
- assertion asSentence BRCA1+function+contributes+to+maintenance+of+the+proper+heterochromatin+superstructure+on+inactivated+X+chromosomes. assertion.
- assertion asSentence Role+of+BRCA1+and+BRCA2+mutation+in+pre-disposition+to+ovarian+cancer. assertion.
- assertion asSentence Weight+loss+in+early+adult+life+%28age+18+to+30%29+protects+against+early-onset+BRCA1+associated+breast+cancers. assertion.
- assertion asSentence Regulates+Akt+signaling+and+the+PI3K%2FAkt+pathway+modulates+the+ability+of+BRCA1+to+repress+estrogen+receptor-alpha. assertion.
- assertion asSentence AhR%2C+a+transcription+factor%2C+can+bind+specifically+to+AD1+in+the+C-terminal+region+of+BRCA1+and+affect+BRCA1%27s+ability+to+regulate+transcription+activity. assertion.
- assertion asSentence An+important+interaction+between+BRCA1+and+ERK1%2F2+in+the+regulation+of+cellular+response+after+IR-induced+DNA+damage+in+MCF-7+cells. assertion.
- assertion asSentence The+interaction+between+BRCA1+and+acetyl-CoA-carboxylase+is+regulated+during+cell+cycle+progression. assertion.
- assertion asSentence A+stable+complex+containing+MERIT40+acts+early+in+DNA+damage+response+and+regulates+damage-dependent+BRCA1+localization. assertion.
- assertion asSentence BRCA1+promoter+methylation+is+associated+with+sporadic+breast+cancer. assertion.
- assertion asSentence BRCA1+mutation+is+associated+with+breast+and+ovarian+Neoplasms. assertion.
- assertion asSentence In+sporadic+breast+carcinoma%2C+a+negative+expression+of+BRCA1+is+selectively+associated+with+a+higher+expression+rate+of+progesterone+receptor+A+rather+than+progesterone+receptor+B. assertion.
- assertion asSentence Following+a+diagnosis+of+breast+cancer%2C+the+annual+risk+of+ipsilateral+breast+cancer+risk+in+BRCA+mutation+carriers+is+1.2%25+per+year. assertion.
- assertion asSentence BRCA1+is+involved+in+transcription-coupled+repair+and+a+BRCA1-dependent+polyubiquitination+pathway+for+Cockayne+syndrome+B+protein+exists+alongside+the+CSA-dependent+pathway+to+yield+more+efficient+excision+repair+of+lesions+on+the+transcribed+DNA+strand. assertion.
- assertion asSentence The+rate+of+phenocopy+breast+cancer+in+non-carriers+from+Israeli+BRCA1+BRCA2+mutation+carrier+families+is+2.26%25+with+no+increased+breast+cancer+risk+over+the+average-risk+population. assertion.
- assertion asSentence Mutated+in+childhood+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Develompment+of+malignant+strumo+ovarii+with+papillary+thyroid+carcinoma+features+is+associated+with+BRAF+mutations. assertion.
- assertion asSentence Both+BRAF+and+RKIP+expression+levels+exhibit+a+decrease+from+normal+skin+tissue+and+actinic+keratosis%2C+going+to+squamous+cell+carcinoma. assertion.
- assertion asSentence Beta-catenin+nuclear+labeling+is+a+common+feature+of+sessile+serrated+adenomas+and+correlates+with+early+neoplastic+progression+after+BRAF+activation. assertion.
- assertion asSentence BRAF+V600E+detection+in+the+tumor+does+not+induce+a+higher+expression+of+the+B-raf+protein+or+the+preferential+activation+of+the+p42%2F44+mitogen-activated+protein+kinase+%28MAPK%29+signaling+pathway+compared+with+GISTs+without+the+BRAF+mutation. assertion.
- assertion asSentence Traditional+DNA+sequencing+and+the+somewhat+more-sensitive+pyrosequencing+method+can+detect+multiple+alternative+BRAF+mutations. assertion.
- assertion asSentence BRAF+mutations+activate+the+mitogen-activated+protein+kinase+pathway+and+confer+an+aggressive+thyroid+cancer+phenotype. assertion.
- assertion asSentence Effective+use+of+PDT+in+the+treatment+of+BRAF+inhibitor-associated+KAs+and+SCCs. assertion.
- assertion asSentence Cardio-facio-cutaneous+syndrome+is+caused+by+heterogeneous+mutations+in+BRAF+gene. assertion.
- assertion asSentence BRCA1%2F2+mutation+screening+should+be+considered+for+all+women+diagnosed+before+age+41. assertion.
- assertion asSentence No+BRCA1%2F2+genomic+rearrangements+found+in+high-risk+French-Canadian+breast%2Fovarian+cancer+families. assertion.
- assertion asSentence The+researchers+found+17+pathogenic+changes+in+the+BRCA2+genes+in+64+families+with+a+pedigree+of+male+breast+neoplasms. assertion.
- assertion asSentence MDM2+SNP309+accelerates+breast+and+ovarian+carcinogenesis+in+BRCA1+and+BRCA2+carriers+of+Jewish-Ashkenazi+descent. assertion.
- assertion asSentence Germline+mutations+in+the+BRCA1+or+BRCA2+tumour-suppressor+genes+are+strong+predictors+of+breast+and%2For+ovarian+cancer+development. assertion.
- assertion asSentence Role+of+MCPH1+in+the+DNA+damage+response+is+in+part+associated+with+the+ability+to+localize+BRCA2+to+sites+of+DNA+double-stand+breaks. assertion.
- assertion asSentence BRCA1+mutations+are+associated+with+breast+carcinoma+In+Situ. assertion.
- assertion asSentence BRCA2+helps+restore+and+maintain+integrity+of+the+genome. assertion.
- assertion asSentence Mutations+in+the+BRCA2+gene+is+associated+low+with+sporadic+breast+cancer+of+Spanish+population. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+correlate+with+TP53+abnormalities+and+presence+of+immune+cell+infiltrates+in+ovarian+high-grade+serous+carcinoma. assertion.
- assertion asSentence Cardiac-restricted+overexpression+of+EMMPRIN+causes+myocardial+remodeling+and+dysfunction+in+aging+mice. assertion.
- assertion asSentence Tetherin+inhibits+the+release+of+Lassa+and+Marburg+virus+from+host+cells. assertion.
- assertion asSentence Tetherin+is+the+physical+tether+linking+HIV-1+virions+and+the+plasma+membrane. assertion.
- assertion asSentence In+hydrogen+peroxide-stimulated+DT40+cells%2C+BLNK+is+phosphorylated+by+Syk+and+not+by+Btk. assertion.
- assertion asSentence CD40+is+a+surface+receptor+through+which+the+activity+of+Btk+can+be+stimulated+in+human+B+cells. assertion.
- assertion asSentence Btk+is+essential+in+regulating+thresholds+for+human+B+cell+tolerance. assertion.
- assertion asSentence Phosphorylation+of+Bub1+at+T609+by+Cdk1+creates+a+docking+site+for+the+PBD+of+Plk1+and+facilitates+the+kinetochore+recruitment+of+Plk1. assertion.
- assertion asSentence %2818%29F-PBR06+is+a+longer-lived+and+promising+alternative+to+%2811%29C-labeled+radioligands+to+measure+TSPOs+as+a+biomarker+of+inflammation+in+the+brain. assertion.
- assertion asSentence An+18-kDa+Translocator+Protein+polymorphism+explains+differences+in+binding+affinity+of+the+PET+radioligand+PBR28. assertion.
- assertion asSentence Human+pasteurized+C1-inhibitor+concentrate+for+the+treatment+of+hereditary+angioedema+due+to+C1-inhibitor+deficiency. assertion.
- assertion asSentence The+C1QA+gene+is+associated+with+subphenotypes+of+lupus+in+the+African-American+and+Hispanic+subjects. assertion.
- assertion asSentence Non-small+cell+lung+cancer+%28NSCLC%29+cells+produce+soluble+complement+inhibitors+factor+I+%28FI%29+and+C4b-binding+protein+%28C4BP%29. assertion.
- assertion asSentence Binding+of+the+classical+pathway+inhibitor%2C+C4b-binding+protein+%28C4bp%29%2C+to+three+genospecies+of+B.+burgdorferi+sensu+lato%2C+is+demonstrated. assertion.
- assertion asSentence In+mesenchymal+stem+cells+both+C3a+and+C5a+cause+prolonged+and+robust+extracellular+signal-regulated+kinase+%28ERK%291%2F2+and+proto-oncogene+protein+c-akt+%28Akt%29+kinase+phosphorylation. assertion.
- assertion asSentence Arboxyl-terminal+tail+acts+together+with+the+intracellular+loops+to+generate+a+specificity+filter+for+ths+and+other+receptor-G+protein+interactions+that+functions+primarily+to+restrict+access+of+incorrect+G+proteins+to+the+receptor. assertion.
- assertion asSentence C5a%2C+a+complement+activation+product%2C+is+a+useful+marker+in+predicting+the+severity+of+necrotizing+enterocolitis. assertion.
- assertion asSentence Low+expression+of+CAIX+and+high+expression+of+VEGF+is+associated+with+metastasis+in+clear+cell+renal+cell+carcinoma. assertion.
- assertion asSentence Genetic+variation+in+the+pleiotropic+psychiatric+disease+gene+CACNA1C+is+associated+with+brainstem+volume. assertion.
- assertion asSentence CaV1.3+channels+and+intracellular+calcium+mediate+osmotic+stress-induced+N-terminal+c-Jun+kinase+activation+and+disruption+of+tight+junctions+in+Caco-2+CELL+MONOLAYERS. assertion.
- assertion asSentence Ion+channel+gating+is+regulated+by+calcium+and+calmodulin+binding. assertion.
- assertion asSentence No+significant+differences+in+cerebellar+Purkinje+cells+in+levels+of+CALB+in+autism+or+in+the+normal+cerebellum. assertion.
- assertion asSentence Procalcitonin+measurement+is+a+helpful+marker+in+bacterial+infection+and+sepsis. assertion.
- assertion asSentence More+CGRP-immunoreactive+sensory+nerve+fibers+and+dorsal+root+ganglia+neurons+are+found+innervating+muscle+in+the+midline+approach+area+than+in+the+Wiltse+paraspinal+approach+area. assertion.
- assertion asSentence Procalcitonin+cannot+be+considered+as+a+good+marker+of+joint+prosthesis+infection. assertion.
- assertion asSentence Motifs+of+the+caldesmon+family. assertion.
- assertion asSentence Membrane+trafficking+at+early+steps+of+the+basolateral+endocytic+pathway+in+HepG2+cells+is+regulated+by+an+intricate+interplay+between+calmodulin+and+PKC. assertion.
- assertion asSentence CALR+and+Hsp90+stabilize+INSR. assertion.
- assertion asSentence Transgenic+CaMKIV+plays+a+modulatory+role+in+the+nucleus+accumbens+in+anxiety-like+behavior+of+adult+CaMKIV+variant+mice. assertion.
- assertion asSentence Ca%282%2B%29%2Fcalmodulin-dependent+kinase+II+participate+in+control+of+cell+cycle+progression+and+survival+of+irradiated+CML+cells. assertion.
- assertion asSentence The+ability+of+LL-37+to+enhance+delivery+of+CpG-rich+islands+to+stimulate+immune+cells+is+independent+of+its+amphipathic+structure+and+its+bactericidal+property. assertion.
- assertion asSentence Polypeptide+substrate+recognition+by+CANX+requires+specific+conformations+of+the+CANX+protein. assertion.
- assertion asSentence Both+calpain+1+and+calpain+2+are+essential+for+the+replication+of+EV1+RNA. assertion.
- assertion asSentence Subtype-selective+induction+of+m-calpain+in+aorta+during+atherosclerotic+progression+is+associated+with+proteolytic+disorganization+of+VE-cadherin+and+proatherogenic+hyperpermeability+in+cells. assertion.
- assertion asSentence RasGAP+and+Capns1+interaction+in+oncogenic+Ras+cells+is+involved+in+regulating+migration+and+cell+survival. assertion.
- assertion asSentence Calpastatin+overexpression+reduces+calpain-mediated+proteolysis+and+behavioral+impairment+after+traumatic+brain+injury. assertion.
- assertion asSentence Pannexin-1+is+required+for+processing+of+caspase-1+and+release+of+mature+IL-1beta+induced+by+P2X%287%29+receptor+activation. assertion.
- assertion asSentence Caspase-1+is+upregulated+in+human+heart+failure+and+acts+as+a+potent+proapoptotic+caspase+both+in+isolated+human+cardiomyocytes+and+in+vivo. assertion.
- assertion asSentence Inhibitory+effects+of+chelidonic+acid+on+IL-6+production+by+blocking+NF-kappaB+and+caspase-1+in+HMC-1+cells. assertion.
- assertion asSentence CASP3+is+activated+in+the+oxidative+stress-induced+apoptosis+in+tendon+fibroblasts+in+vitro. assertion.
- assertion asSentence IGF-I+activates+specific+apoptotic+pathways+%28Caspase-3+activation%2C+Annexin-V+binding+and+DNA+degradation+in+an+osteosarcoma+cell+line. assertion.
- assertion asSentence Akt1+is+cleaved+in+vitro+at+the+caspase-3+consensus+site+DQDD%28456%29. assertion.
- assertion asSentence Specific+cleavage+by+caspase-7+relies+on+excluding+recognition+by+caspase-3+and+not+on+increasing+binding+for+caspase-7. assertion.
- assertion asSentence Resveratrol+significantly+enhanced+cigarette+smoke-stimulated+caspase+3+and+caspase+9+activity+in+human+bronchial+epithelial+cells. assertion.