Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "Here we demonstrate that Brn-3a is able to stimulate p53 expression." provenance.
- _5 value "Enforced MTA1 expression in HT1080 cells reduced basal and 12-myristate 13-acetate-induced 92-kDa type IV collagenase (MMP-9) protein/mRNA levels." provenance.
- _5 value "Three additional factors regulate the transription of Srebp1c; liver X-activated receptors (LXR's), insulin, and glucagon...Unsaturated fatty acids competitively block LXR activation of Srebp1c expression by antagonizing the activation of LXR by its endogenous ligands in vitro." provenance.
- _5 value "Three additional factors regulate the transription of Srebp1c; liver X-activated receptors (LXR's), insulin, and glucagon...Unsaturated fatty acids competitively block LXR activation of Srebp1c expression by antagonizing the activation of LXR by its endogenous ligands in vitro." provenance.
- _3 value "Chronic leptin treatment resulted in an approximately 2- to 3-fold greater protein expression of AMPK catalytic (alpha(2)) and regulatory (beta(2)) units as well as a 1.5- to 2-fold increase in Thr(172) phosphorylation of AMPK in both soleus and white gastrocnemius muscles." provenance.
- _4 value "however, after stimulation with interleukin-1beta or tumor necrosis factor-alpha, levels of ESE-3 mRNA and protein increase dramatically by 24 h. ESE-3 mRNA and Protein Are Inducibly Expressed in Human Bronchial Smooth Muscle Cells after Treatment with TNF-{alpha} or IL-1beta To test the hypothesis that ESE-3 may be induced in other cells of the airways in response to inflammatory cytokines of relevance to asthma, we exposed HBSMC to TNF-{alpha} and IL-1beta. ESE-3 mRNA was induced 6 to 24 h after treatment with both cytokines, each at a concentration of 5 ng/ml, and detected by RT-PCR" provenance.
- _4 value "once cAMP is generated, the only way to inactivate it is to degrade it to 5'-AMP, through PDE action" provenance.
- _6 value "there is beta-arrestin1 and beta-arrestin2 beta2-adrenoceptor, upon agonist occupancy, couples to Gs to effect activation of adenylate cyclase and the concomitant generation of cAMP" provenance.
- _5 value "The aim of this study was to determine whether aminoguanidine (AG), an inhibitor of advanced glycation, prevents expression of the profibrotic cytokine, connective tissue growth factor (CTGF), as well as accumulation of the previously reported CTGF-dependent matrix protein, fibronectin, in a model of experimental diabetic nephropathy." provenance.
- _6 value "To further explore the relationship between AGEs and mesangial CTGF and fibronectin production, cultured human mesangial cells were exposed in vitro to soluble AGE-BSA and carboxymethyl lysine-BSA, and this led to induction of both CTGF and fibronectin." provenance.
- _3 value "Ectopic expression of three such genes, TEAP, GP49B, and Lipin1 was found to have an anti-proliferative effect on pro-B cells" provenance.
- _2 value "We have previously shown that the neurotoxic compounds colchicine, methylmercury (MeHg) and hydrogen peroxide (H2O2) cause apoptosis in primary cultures of cerebellar granule cells (CGC), characterized by nuclear condensation and high-molecular weight DNA fragmentation." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "patients considered to be malnourished with albumin below 35g/l significant decrease in all classically lipid parameters, total cholesterol, HDL cholesterol, apoproteins A1 and B in the malnourished group" provenance.
- _3 value "The most strongly induced genes included genes coding for endoplasmic reticulum proteins (Ero1L/Giig11, Sac1p, Ddit3/Gadd153), proteins involved in ubiquitination (Arih2, P4hb), proteins induced by hypoxia in non-neuronal systems (Gpi1, Aldo1, Anxa2, Hig1), and proteins that might promote cell death (Gas5, Egr1, Ndr1, Vdac2)." provenance.
- _7 value "A CD44 isoform containing variant exon v6 sequences is strictly required for c-Met activation by HGF/SF in rat and human carcinoma cells, in established cell lines as well as in primary keratinocytes. " provenance.
- _4 value "Mutation of Sp1 sites 1, 3 and 4 abolished most of the promoter activity of TP in TNFalpha-treated WiDr cells." provenance.
- _3 value "Adaptive response of mitochondrial enzymes and GLUT4 to the swimming program To determine whether the swimming program provides an adequate stimulus for inducing an increase in mitochondrial biogenesis, we measured the concentrations of mitochondrial marker enzymes and GLUT4 in triceps muscle. As shown in Fig. 1, 5 days of the exercise program induced significant increases in ALA synthase, citrate synthase, cytochrome oxidase subunit I, cytochrome c, and GLUT4 protein concentrations." provenance.
- _3 value "Adaptive response of mitochondrial enzymes and GLUT4 to the swimming program To determine whether the swimming program provides an adequate stimulus for inducing an increase in mitochondrial biogenesis, we measured the concentrations of mitochondrial marker enzymes and GLUT4 in triceps muscle. As shown in Fig. 1, 5 days of the exercise program induced significant increases in ALA synthase, citrate synthase, cytochrome oxidase subunit I, cytochrome c, and GLUT4 protein concentrations." provenance.
- _2 value "This adaptation includes increases in components of the mitochondrial respiratory chain (2), ATP synthase (3), enzymes of the citrate cycle (4, 5), and enzymes involved in fatty acid (6, 7) and ketone oxidation (5, 8)." provenance.
- _4 value "Table 3. Genes differentially expressed in LGMD2B muscles (DYSF mutant) upregulated" provenance.
- _4 value "Table 3. Genes differentially expressed in LGMD2B muscles (DYSF mutant) upregulated" provenance.
- _4 value "Table 3. Genes differentially expressed in LGMD2B muscles (DYSF mutant) upregulated" provenance.
- _3 value "IGFs also cooperate with EGF to increase mammary epithelial cell proliferation" provenance.
- _5 value "activation of the IGF1R occurs following IGF1 binding to the alpha-subunit of the IGF1R on epithelial cells, leading to autophosphorylation of the beta-subunit by an intrinsic tyrosine kinase" provenance.
- _3 value "in breast cancer cells, oestrogens enhance the mitogenic effect of IGFs by inducing expression of several members of the IGF family, including IGF1, IGF2, IGF1R, IRS1 and insulin-receptor substrate-2" provenance.
- _3 value "The molecular mechanism by which PKCh induces G1 arrest was demonstrated in our recent study. PKCh associates with the cyclin E/cdk2/p21 complex in the cytoplasm of normal human keratinocytes. This association results in the inhibition of cdk2 kinase activity, leading to the dephosphorylation of Rb proteins and thereby G1 arrest" provenance.
- _8 value "Also, inhibition of the cAMP-dependent PKA signal pathway is involved in an IL-1beta-stimulated increase in G6PD activity." provenance.
- _3 value "TFF1 and TFF3 mRNA are coinduced by X-irradiation" provenance.
- _3 value "Lipogenesis is hormonally regulated by insulin, and the ability of this hormone to stimulate lipogenesis is mediated by SREPBP-1c. Only the initial condensation reaction catalyzed by LCE is regulated by insulin The mRNA levels of the identified genes responsible for these reactions follow a similar pattern of regulation. The condensing enzyme, LCE, is suppressed in livers of fasted mice and increased in livers from mice that were fasted (low insulin) and refed a high carbohydrate diet(high insulin)." provenance.
- _3 value "Further analysis demonstrated that the activated androgen receptor blocked FKHR's DNA binding activity and impaired its ability to induce Fas ligand expression and prostate cancer cell apoptosis and cell cycle arrest" provenance.
- _3 value "Modified assertion" provenance.
- _3 value "On treatment of LNCaP cells with R1881 (synthetic androgen), it was observed that the expression levels of adenosylmethionine decarboxylase 1 (AMD1) was high when compared with untreated cells. Androgen up-regulates AMD1, indicating that AMD1 is an androgen-regulated gene (ARG) in polyamine biosynthesis pathway." provenance.
- _3 value "This study focuses on our new observations of the coordinated androgen induction of genes (NDRG1, PDIR, HERPUD1, ORP150) involved in the endoplasmic reticulum (ER) stress response pathway." provenance.
- _6 value "the central module is the interplay between p53 and the Mdm2 protein, which inactivates p53 and targets it for rapid proteolysis." provenance.
- _5 value "reducing endogenous levels of ASC using siRNA enhanced TNF- and LPS-induced degradation of the IKK substrate, IkappaBalpha." provenance.
- _4 value "Proinflammatory and type 1 cytokines including TNF-alpha, IL-1beta, IFN-gamma, IL-2, RANTES, and IP-10 were elevated in CNS tissues from mice with PREMO." provenance.
- _5 value "Proinflammatory and type 1 cytokines including TNF-alpha, IL-1beta, IFN-gamma, IL-2, RANTES, and IP-10 were elevated in CNS tissues from mice with PREMO." provenance.
- _3 value "Following exposure to 50-150 microM H2O2 levels of mRNA and protein for Fas and, to a lesser degree, Fas-L were increased and intestinal epithelial cells underwent apoptosis" provenance.
- _4 value "NMuMg mammary epithelial cells exposed to hyperosmotic stress induced by the organic osmolyte sorbitol, heat shock, ultraviolet irradiation, oxidative stress induced by hydrogen peroxide... The environmental stresses, but not dexamethasone, stimulatedSgk expression through a p38/MAPK-dependent pathway." provenance.
- _3 value "TABLE 3. Genes Repressed in RAW 264.7 Macrophages by CpG-DNA or LPS" provenance.
- _3 value "TABLE 3. Genes Repressed in RAW 264.7 Macrophages by CpG-DNA or LPS" provenance.
- _3 value "The expression of IL-18 mRNA in FRTL-5 cells was enhanced by thryoid-stimulating hormone (TSH) in a dose-dependent manner. 8-Bromo-cyclic adenosine monophosphate (cAMP) also increased in IL-18 mRNA levels." provenance.
- _5 value "Herein we report that inhibition of the polyol pathway enzyme aldose reductase (AR) by two structurally unrelated inhibitors - sorbinil and tolrestat - prevents, in the human lens epithelial cell line B-3, the apoptosis and activation of caspase-3 caused by exposure to high glucose levels or TNF-alpha" provenance.
- _4 value "Inhibition of AR attenuated TNF-alpha and hyperglycemia-induced activation of protein kinase C (PKC), phosphorylation of the inhibitory subunit of nuclear factor-kappaB (NF-kappaB), and stimulation of NF-kappaB" provenance.
- _5 value "hGrb10gamma inhibited insulin-stimulated IRS-1 tyrosine phosphorylation in a dose-dependent manner, but did not affect IR catalytic activity toward Tyr(972) in the juxtamembrane region and Tyr(1158/1162/1163) in the regulatory domain" provenance.
- _3 value "Treatment of vascular smooth muscle cells with angiotensin II as well as overexpression of the constitutively active mutant RacL61 increased ROS release as assessed by" provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Overexpressed IRS-3 as well as IRS-1 enhanced phosphoinositide (PI) 3-kinase activity in response to insulin and increased phosphorylation of protein kinase B (PKB) at S473 and phosphorylation of one of the members of the forkhead transcription factor FKHRL1 on T32 in both insulin-untreated and -treated states." provenance.
- _4 value "gp130-dependent pathways control Stat3 activation in liver regeneration after partial hepatectomy" provenance.
- _4 value "Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells." provenance.
- _5 value "Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _4 value "We tested the hypothesis that contractile activity in vivo induces NRG/ErbB activation" provenance.
- _5 value "In spreading platelets, most endogenous ASAP1 is localized at peripheral focal adhesions. Unlike endogenous ASAP1 in platelets, overexpressed ASAP1 showed diffuse cytoplasmic distribution. However, when co-expressed with wild-type CrkL, both endogenous and expressed ASAP1 accumulated at CrkL-induced focal adhesions. An SH2-mutated CrkL, which cannot localize at focal adhesions, failed to recruit ASAP1 into focal adhesions. Thus, CrkL appears to be a lynchpin between ASAP1 and peripheral focal adhesions." provenance.
- _6 value "the initial factor Xa produced when bound to a membrane activates tiny amounts of prothrombin to thrombin, albeit rather inefficiently; this initial thrombin is essential to the acceleration of the process by serving as the activator for platelets, factor V and factor VIII" provenance.
- _4 value "HGF induced activation of ERK1 and ERK2 was shown to be dependent on the presence of HS moieties." provenance.
- _4 value "From text: Like glucocorticoids, application of thyroid hormones exerts short and long-term effects. Isolated mitochondria as well as rat cells in in vivo, quickly respond to T3 with increased oxidative phosphorylation, oxygen consumption and mitochondrial translocator activity (Sterling, 1977), and a change in adenine nucleotide pool ratios (Palacios-Romero and Mowbray, 1979)." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "These results show a coordinated and long-lasting upregulation of gp130 mRNA and STAT3 activation in reactive astrocytes of the postischemic hippocampus, indicating that they may be involved in the astrocytic response to an ischemic insult." provenance.
- _5 value "estrogen receptor alpha (ERalpha)-driven transcription is also enhanced by SUMO-1" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "PTP activity participates in StAR protein induction and led us to attribute to the PKA-mediated PTP activation in steroidogenic systems a functional role, as mediator of StAR protein induction" provenance.
- _3 value "In the control subjects the decrease in PP2A-Calpha... correlated significantly with the decrease in total glucose disposal, glucose oxidation, nonoxidative glucose metabolism and the decrease in lipid oxidation (Table 3). The cor- relations... were absent in the type II diabetic subjects. insulin downregulates PP2A-Calpha expression in skeletal muscle of control subjects, but not in patients with Type II diabetes" provenance.
- _4 value "PP2A has been shown to inhibit PKB activity[11,12,14] and to prevent insulin- mediated inhibition of GSK-3[11,15]." provenance.
- _6 value "p73-mediated induction of Bax expression following DNA damage requires YAP function and is attenuated by Akt phosphorylation of YAP." provenance.
- _4 value "Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine" provenance.
- _3 value "24 h of insulin stimulation induced the expression of both uncoupling protein-1 and CCAAT/enhancer-binding protein alpha (C/EBPalpha) in wild-type brown adipocytes;" provenance.
- _5 value "2 of the most potent cyokines that regulate anterior pituitary cell function are Lif and Il6 these and others like Il11 and Cntf are referred to as the gp130 cytokines because they share the gp130 glycoprotein as a common receptor initial signal transducer" provenance.
- _4 value "Furthermore, expression of GEFT in NIH3T3 cells promotes foci formation, cell proliferation, and cell migration, possibly through the activation of transcriptional factors involved in cell growth and proliferation. " provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _8 value "Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153). RKIP Ser-153 phosphorylation by PKC either in vitro or in response to 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor causes release of RKIP from Raf-1" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Egr1 overexpressing in C2 TRAMP cells upregulated the expression of G-alpha12. When transfected with antisense oligonucleotide of Egr1, the antisense oligonucleotide drastically inhibited the mRNA expression G-alpha12 compared to control cells." provenance.
- _3 value "Furthermore we also showed that Egr1 is responsible for cyclin D2overexpression in tumorigenic DU145 human prostate cells. The regulation ofthese genes by Egr1 was demonstrated using Egr1 antisense oligonucleotides thatfurther implicated Egr1 in resistance to apoptotic signals" provenance.
- _4 value "Modified assertion" provenance.
- _3 value "The levels of Nurr1, NGFI-B and NOR-1 mRNA were elevated markedly in NTera2 teratocarcinoma-derived neurons (NTera2-N), a model of differentiated human neurons, following a 1.5 or 3 h-exposure to 1 mM dibutyryl cyclic AMP or 100 nm phorbol 12-myristate 13-acetate" provenance.
- _5 value "The levels of Nurr1, NGFI-B and NOR-1 mRNA were elevated markedly in NTera2 teratocarcinoma-derived neurons (NTera2-N), a model of differentiated human neurons, following a 1.5 or 3 h-exposure to 1 mM dibutyryl cyclic AMP or 100 nm phorbol 12-myristate 13-acetate" provenance.
- _5 value "Moreover, ASK1 phosphorylates and activates MKK3 and MKK6" provenance.
- _3 value "Immunoprecipitation experiments revealed that beta-catenin is one of the main binding partners and a substrate for SHP-1. Taken together, our results indicate that SHP-1 may be involved in the regulation of beta-catenin transcriptional function and in the negative control of intestinal epithelial cell proliferation." provenance.
- _5 value "Overexpression of M-type sPLA(2)R enhanced group IIA PLA(2)-induced promoter activity and iNOS protein expression, and these effects were abolished by LY294002." provenance.
- _4 value "Upon treating with group IIA PLA(2), Akt is phosphorylated in a PI3K-dependent manner." provenance.
- _3 value "Table for global DNA methylation inhibition using 5-aza-CdR." provenance.
- _3 value "Table for global DNA methylation inhibition using 5-aza-CdR." provenance.
- _3 value "Ten other transcripts elevated in both mouse models are associated with macrophage functions, including complement C4, the three subunits of complement C1q, lysozyme M, cathepsins S and Z, cytochrome b558 small subunit, macrophage-specific protein 1, and DAP12. Cathepsin Z has been found in phagosomes of macrophages" provenance.
- _2 value "reatment with Fas siRNA 2 days before ConA challenge abrogated hepatocyte necrosis and inflammatory infiltration and markedly reduced serum concentrations of transaminases. Administering Fas siRNA beginning one week after initiating weekly ConA injections protected mice from liver fibrosis. In a more fulminant hepatitis induced by injecting agonistic Fas-specific antibody, 82% of mice treated with siRNA that effectively silenced Fas survived for 10 days of observation, whereas all control mice died within 3 days. " provenance.
- _4 value "Angiotensin converting enzyme inhibitor benazepril showed some renal protective effect on diabetic nephropathy, partly through inhibiting apoptosis by down-regulating Fas and Fas-L expression." provenance.
- _5 value "Akt is a serine/threonine kinase that is activated by phosphatidylinositol 3-kinase (PI3K) signaling and phosphorylates GSK3 on Ser9, thereby inactivating it" provenance.
- _4 value "15d-PGJ(2) and rosiglitazone rapidly induce the transcription of suppressor of cytokine signaling (SOCS) 1 and 3, which in turn inhibit JAK activity in activated glial cells." provenance.
- _3 value "Table 2 Genes with altered expression in response to ischemia/reperfusion when compared to non-ischemic hearts" provenance.
- _3 value "Table 2 Genes with altered expression in response to ischemia/reperfusion when compared to non-ischemic hearts" provenance.
- _3 value "Table 2 Genes with altered expression in response to ischemia/reperfusion when compared to non-ischemic hearts" provenance.
- _6 value "( ) and selective activation of ATF4 transcription that up-regulates CHOP gene expression," provenance.
- _3 value "Real time RT-PCR experiments were performed as described under \"Materials and Methods.\" Matrin3 (mRNA) and Contactin 1 (mRNA) samples represent reactions performed using the same samples that were used in the microarray hybridizations. All of the other results are from a replicate experiment wherein total RNA was isolated and used as the template for the RT reactions. Column labels are as follows: Nicotine, samples treated with 1 mM nicotine for 1 h; d-TC, samples treated with 100 �M d-tubocurarine for 1 h. " provenance.
- _3 value "activation of JAK1, JAK2 and STAT3 is necessary for leptin-induced transactivation of NPY gene through the leptin-response element in these neural cells." provenance.
- _3 value "TABLE 2 Genes that change in transition from non-tumor tissue in non-smokers (Nns) to tumor tissue in non-smokers (Tns). All fold changes are greater than or equal to 1.3. NOTE: THIS TABLE WAS PUT IN AS CAUSAL FOR THE PURPOSES OF THE INDICATED PROJECT ONLY. IT IS CLEARLY NOT CAUSAL BUT CORRELATIVE [BCD]." provenance.
- _3 value "TABLE 2 Genes that change in transition from non-tumor tissue in non-smokers (Nns) to tumor tissue in non-smokers (Tns). All fold changes are greater than or equal to 1.3. NOTE: THIS TABLE WAS PUT IN AS CAUSAL FOR THE PURPOSES OF THE INDICATED PROJECT ONLY. IT IS CLEARLY NOT CAUSAL BUT CORRELATIVE [BCD]." provenance.
- _3 value "TABLE 2 Genes that change in transition from non-tumor tissue in non-smokers (Nns) to tumor tissue in non-smokers (Tns). All fold changes are greater than or equal to 1.3. NOTE: THIS TABLE WAS PUT IN AS CAUSAL FOR THE PURPOSES OF THE INDICATED PROJECT ONLY. IT IS CLEARLY NOT CAUSAL BUT CORRELATIVE [BCD]." provenance.
- _3 value "TABLE 2 Genes that change in transition from non-tumor tissue in non-smokers (Nns) to tumor tissue in non-smokers (Tns). All fold changes are greater than or equal to 1.3. NOTE: THIS TABLE WAS PUT IN AS CAUSAL FOR THE PURPOSES OF THE INDICATED PROJECT ONLY. IT IS CLEARLY NOT CAUSAL BUT CORRELATIVE [BCD]." provenance.