Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Leptin, secreted from adipose tissue, regulates body weight by acting directly in the CNS to inhibit feeding behavior." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "DHPG activates CK1(epsilon) via Ca(2+)-dependent stimulation of calcineurin and subsequent dephosphorylation of inhibitory C-terminal autophosphorylation sites." provenance.
- _3 value "In mouse neostriatal slices, the effect of DHPG on phosphorylation of Ser-137 or Thr-75 of DARPP-32 was blocked by the phospholipase Cbeta inhibitor, the Ca(2+) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA/AM), and the calcineurin inhibitor cyclosporin A." provenance.
- _3 value "We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2)." provenance.
- _4 value "TABLE 2 Endogenous Chemicals Affecting Energy Intake and Expenditure: Appetite Stimulants" provenance.
- _3 value "TABLE 3 Endogenous Chemicals Affecting Energy Intake and Expenditure: Appetite Suppressants" provenance.
- _4 value "TABLE 3 Endogenous Chemicals Affecting Energy Intake and Expenditure: Appetite Suppressants" provenance.
- _3 value "AE2 {SLC4a2} protein expression in vivo after exposure to hyperoxia {in the lung}. Rats were exposed to 70% O2 for 0, 1, 3, and 7 days. {1 Day exposure led to increased Slca2 levels which was increased over control through the time course}" provenance.
- _3 value "Transcriptional regulation of AE2 {SLC4A2} was also evaluated in differentiated HBE cells stimulated with H2O2. AE2 mRNA expression was analyzed by RT-PCR. A single band corresponding to the 411-base pair product of the AE2 primers was obtained. The relative quantity of the AE2 mRNA was normalized against that of GAPDH (Fig. 5). Minimal AE2 mRNA expression was seen at baseline in the unstimulated cells, despite amplification to 36 cycles. This expression significantly increased within 4 h of exposure to H2O2. This increase persisted 12 h after exposure with return to near baseline by 24 h. " provenance.
- _4 value "Mobility shift assays revealed that HSP60 induced NF-kappaB and CRE binding activity, while CCAAT/enhancer binding protein (C/EBP), which binds to NF-IL-6, was constitutively active in the cells. CREB and c-Jun bind CRE regulatory regions in responsive gene promoters. HSP60, like LPS, readily activated CRE in macrophages. Both c-Jun and CRE binding protein (CREB) bound to the CRE, while C/EBP-beta bound to NF-IL-6. These data indicate that NF-kappaB, C/EBP-beta, c-Jun, and CREB are important in HSP60-induced expression of COX-2." provenance.
- _5 value "PD-98059, an inhibitor of phosphorylation of ERK1/2, caused a marked inhibition of HSP60-induced COX-2 and NOS-2 expression." provenance.
- _5 value "Unexpectedly, SB-203580, a p38 kinase antagonist, was found to block HSP60-induced expression of COX-2, but not NOS-2." provenance.
- _5 value "Interestingly, in the prostate PC3 and LNCaP cells, addition of Smad3 can enhance AR transactivation, and co-transfection of Smad3 and Smad4 can then repress AR" provenance.
- _5 value "Interestingly, in the prostate PC3 and LNCaP cells, addition of Smad3 can enhance AR transactivation, and co-transfection of Smad3 and Smad4 can then repress AR" provenance.
- _5 value "A modest overexpression of RALT (about threefold over endogenous levels) is sufficient to inhibit EGF- dependent proliferation of NIH-EGFR/ErbB-2 trans- fectants as well as focus formation induced by ErbB-2 in NIH3T3 cells (Fiorentino et al., 2000)." provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "In burned skin, 85 genes showed above threefold or greater increases and 54 genes showed threefold or greater decreases in expression compared with normal skin. up" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _4 value "We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated degradation." provenance.
- _5 value "DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells. In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1, glucose-6 phosphatase, and PEPCK. In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27Kip, Rb2, and GADD45, and proteins that promote cells death, including Bim and Fas ligand." provenance.
- _5 value "DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells. In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1, glucose-6 phosphatase, and PEPCK. In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27Kip, Rb2, and GADD45, and proteins that promote cells death, including Bim and Fas ligand." provenance.
- _4 value "The serine protease tissue-type plasminogen activator (t-PA) initiates the fibrinolytic protease cascade and plays a significant role in motor learning, memory, and neuronal cell death induced by excitotoxin and ischemia." provenance.
- _5 value "The serine protease tissue-type plasminogen activator (t-PA) initiates the fibrinolytic protease cascade and plays a significant role in motor learning, memory, and neuronal cell death induced by excitotoxin and ischemia." provenance.
- _6 value "Essentially, they inhibit angiotensin-converting enzyme (ACE), thereby blocking the generation of angiotensin II (Ang II); at the same time they prevent the breakdown of natriuretic peptides by the enzyme neutral endopeptidase." provenance.
- _3 value "exposure of SNB19 cells to HOCl, a generator of reactive oxygen species (ROS), results in elevated Ape1/Ref-1 protein and Ap endo activity" provenance.
- _2 value "adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA) significantly reduces the isoproterenol-induced increase in left ventricular developed pressure of isolated hearts, and this effect is blocked by pretreatment of hearts with the PP2a inhibitor cantharidin" provenance.
- _5 value "adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA) significantly reduces the isoproterenol-induced increase in left ventricular developed pressure of isolated hearts, and this effect is blocked by pretreatment of hearts with the PP2a inhibitor cantharidin" provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _4 value "Overexpression of Mad1 in primary thymocytes alters the expression of predominantly genes involved in controlling cellular growth. DN thymocytes from 6- to 9-week-old Mad1+/RAG2?/? or RAG2?/? mice. In an effort to minimize experimental variation, pairwise comparisons were made using Mad1/RAG-2?/? and RAG-2?/? sample pairs that were prepared and processed in parallel. For each of three comparison sets, data from Mu11Ksub A & B arrays were combined and an expression ratio (R) was calculated for individual genes/ESTs, where R = AveDiffMadRag/AveDiffRag. Data filtering and normalization were similar to those used by Coller et al. (2000). Genes/ESTs that the AMS algorithm called ?absent? in both MadRag and Rag sample pairs, or where |AveDiffMadRag ? AveDiffRag| ? 100, were filtered from further analysis. An exception was made for mad, where in two of three comparisons the high level of mad expression in the MadRag samples produced extensive saturation of the array probe signals, which resulted in an erroneous ?absent? call when the AMS gene-call algorithm was applied. Ratio values for each filtered data set were log2 transformed and normalized using mean = 0 and SD = 1. Genes/ESTs were considered significantly overexpressed in MadRag if R? 2 for each of the three pairwise comparisons. Likewise, genes/ESTs were considered underexpressed in MadRag if R? 0.5 for each of the three pairwise comparisons." provenance.
- _5 value "we demonstrated that the ShcY317F mutant exerts an inhibitory effect on TRK-T3 transforming activity." provenance.
- _3 value "Enhanced expression of dimethylarginine dimethylaminohydrolase I increased nitric oxide synthesis (as indicated by a two-fold increase in the production of cGMP), expression and secretion of vascular endothelial cell growth factor, and induced angiogenesis in vitro." provenance.
- _5 value "These data suggest that IDBP-1 is capable of controlling 1,25-(OH)2D production by modulating the delivery of 1) substrate 25-OHD to in the mitochondrial CYP1alpha gene product and 2) CYP1alpha product 1,25-(OH)2D to the vitamin D receptor for upregulation of expression of the catabolic CYP24 gene." provenance.
- _6 value "Modified assertion" provenance.
- _5 value "CTGF stimulates HMC to actively enter the G(1) phase from G(0), but they do not then progress further through the cell cycle. Using CTGF antisense oligonucleotides, the results also indicate that the previously identified transforming growth factor-beta (TGF-beta)-induced hypertrophy in mesangial cells is CTGF-dependent." provenance.
- _3 value "Myostatin appears to function by controlling myoblast cell cycle progression (35). Recombinant myostatin, when added to actively growing myoblasts, inhibited the progression of G1 myoblasts into S phase." provenance.
- _5 value "The results show that MEF2C enhanced the myostatin promoter activity by threefold (Fig. 5A, panel i) indicating that MEF2C can transactivate the myostatin promoter in C2C12 cells." provenance.
- _4 value "To investigate the role of PLZF in megakaryopoiesis, we transduced the PLZF gene into the erythro-megakaryocytic TF1 cell line. PLZF overexpression upmodulates the megakaryocytic specific markers (CD42a, CD42b, CD61, PF4) and induces the thrombopoietin receptor (TpoR). The proximal promoter of the TpoR gene is activated in PLZF-expressing TF1 cells: in this promoter region, a PLZF DNA-binding site was identified by deletion constructs studies." provenance.
- _3 value "Inhibition of RAR function by the DNRAR in HMECs resulted in retinoid- resistance, increased proliferation, and dysregulated growth when cells were cultured in reconstituted extracellular matrix (rECM)." provenance.
- _6 value "However, the molecular mechanism by which KDR mediates EC migration is not clear yet. Here we show for the first time that activation of RhoA and Rac1 is fully and partially required for KDR-mediated human umbilical vein endothelial cell (HUVEC) migration, respectively, and that CDC42, however, is not involved." provenance.
- _4 value "Interestingly, the RhoA activation can be partially inhibited by overexpression of Rac1-17N, but overexpression of RhoA-19N has no effect on Rac1 activation. Finally, Gq/11 and Gbetagamma subunits are also required for VPF/VEGF-stimulated HUVEC migration." provenance.
- _5 value "A thiol antioxidant, N-acetyl-l-cysteine, or overexpression of an H(2)O(2) scavenger, catalase, inhibited glucose deprivation-induced dissociation of GRX from ASK1" provenance.
- _4 value "A thiol antioxidant, N-acetyl-l-cysteine, or overexpression of an H(2)O(2) scavenger, catalase, inhibited glucose deprivation-induced dissociation of GRX from ASK1" provenance.
- _7 value "GRX is a negative regulator of ASK1 and dissociation of GRX from ASK1 activates ASK1-SEK1-JNK1 signaling leading to cytotoxicity during glucose deprivation. These results support the hypothesis that the GRX-ASK1 interaction is redox sensitive and regulated in a glutathione-dependent fashion by H(2)O(2)." provenance.
- _6 value "GRX is a negative regulator of ASK1 and dissociation of GRX from ASK1 activates ASK1-SEK1-JNK1 signaling leading to cytotoxicity during glucose deprivation. These results support the hypothesis that the GRX-ASK1 interaction is redox sensitive and regulated in a glutathione-dependent fashion by H(2)O(2)." provenance.
- _5 value "Phosphorylation by CK2 of the TATA-binding protein (TBP), a subunit of TFIIIB (the core component of the PolIII transcriptional machinery), promotes a remarkable increase in PolIII activity" provenance.
- _5 value "Increases in caspase-8 and caspase-3 cleavage induced by CH11 and in consequent apoptotic killing were observed in these cells." provenance.
- _5 value "Prolonged (2-h) stimulation with TNF and LPS induces resynthesis of IkappaBalpha that is again translocated to the nucleus in human neutrophils," provenance.
- _3 value "Moreover, the RGPR-p117 mRNA expression in H4-II-E cells was stimulated in the presence of dibutyryl cAMP, PMA, insulin, 17beta-estradiol, or serum in culture medium" provenance.
- _3 value "Moreover, the RGPR-p117 mRNA expression in H4-II-E cells was stimulated in the presence of dibutyryl cAMP, PMA, insulin, 17beta-estradiol, or serum in culture medium" provenance.
- _5 value "Moreover, the RGPR-p117 mRNA expression in H4-II-E cells was stimulated in the presence of dibutyryl cAMP, PMA, insulin, 17beta-estradiol, or serum in culture medium" provenance.
- _3 value "Smad7 is known to block both TGFbeta and bone morphogenetic protein (BMP) signaling," provenance.
- _4 value "TIEG specifically enhances only the TGFbeta pathway" provenance.
- _3 value "guanylyl cyclase A, GCA, lowers blood pressure and inhibits the growth of cardiac myocytes and fibroblasts" provenance.
- _6 value "SHP-2 and Stat1 nuclear localization and their association in response to either epidermal growth factor or interferon-gamma (IFNgamma) were confirmed by immunofluorescent staining and affinity precipitation assays. " provenance.
- _3 value "Epinephrine-stimulated P-selectin expression was inhibited by aspirin at 6 h, and after 2 and 6 h by aspirin plus cocoa." provenance.
- _5 value "Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase (FAK), which then associated with phosphatidylinositol 3-kinase (PI3K) and activated mitogen-activated protein kinase at its downstream." provenance.
- _4 value "GKLF may function as a G(1)/S checkpoint regulator and exert its growth arrest effect through down-regulation of ODC gene expression" provenance.
- _5 value "We assumed them to be regulated by the proinflammatory cytokines interleukin-1beta (IL1beta) and interleukin-6 (IL6), which trigger the transcriptional factors NF-kappaB and C/EBPbeta." provenance.
- _4 value "We have functionally identified transcription factors NF-kappaB and C/EBPbeta to inhibit transcription of human TFF genes." provenance.
- _3 value "CD200 is up-regulated in rodent transplantation models where successful inhibition of rejection is accomplished, and is believed to signal immunosuppression following engagement of a receptor, CD200R, on macrophages and/or gammadelta T-cell receptor (gammadelta TCR+ cells)." provenance.
- _4 value "Recently, it was found that human cells overexpressing MnSOD resulted in cell cycle arrest, decrease in mitochondrial mass, accumulation of intracellular hydrogen peroxide, and induction of mRNA levels of matrix-degrading metalloprotease-1, which plays a major role in the process of carcinogenesis and aging" provenance.
- _3 value "RDA was used to study differential gene expression in macrophage-like cells (PMA-stimulated THP-1 cells) and foam-cell-like cells (PMA-stimulated and oxLDL-exposed THP-1 cells). A modified solid-phase representational difference analysis (RDA) protocol was used [7] in combination with DNA microarray analysis and reverse transcriptase PCR (RT-PCR) for evaluation. Array analysis was performed using a scanner (GMS418 Array Scanner, Genetic MicroSystems, USA) and the GenePixPro 3.0 software (Axon Instruments, USA). For data the level of significance was set to a 2-fold relative difference between samples after background subtraction. " provenance.
- _3 value "RDA was used to study differential gene expression in macrophage-like cells (PMA-stimulated THP-1 cells) and foam-cell-like cells (PMA-stimulated and oxLDL-exposed THP-1 cells). A modified solid-phase representational difference analysis (RDA) protocol was used [7] in combination with DNA microarray analysis and reverse transcriptase PCR (RT-PCR) for evaluation. Array analysis was performed using a scanner (GMS418 Array Scanner, Genetic MicroSystems, USA) and the GenePixPro 3.0 software (Axon Instruments, USA). For data the level of significance was set to a 2-fold relative difference between samples after background subtraction. " provenance.
- _3 value "RDA was used to study differential gene expression in macrophage-like cells (PMA-stimulated THP-1 cells) and foam-cell-like cells (PMA-stimulated and oxLDL-exposed THP-1 cells). A modified solid-phase representational difference analysis (RDA) protocol was used [7] in combination with DNA microarray analysis and reverse transcriptase PCR (RT-PCR) for evaluation. Array analysis was performed using a scanner (GMS418 Array Scanner, Genetic MicroSystems, USA) and the GenePixPro 3.0 software (Axon Instruments, USA). For data the level of significance was set to a 2-fold relative difference between samples after background subtraction. " provenance.
- _3 value "RDA was used to study differential gene expression in macrophage-like cells (PMA-stimulated THP-1 cells) and foam-cell-like cells (PMA-stimulated and oxLDL-exposed THP-1 cells). A modified solid-phase representational difference analysis (RDA) protocol was used [7] in combination with DNA microarray analysis and reverse transcriptase PCR (RT-PCR) for evaluation. Array analysis was performed using a scanner (GMS418 Array Scanner, Genetic MicroSystems, USA) and the GenePixPro 3.0 software (Axon Instruments, USA). For data the level of significance was set to a 2-fold relative difference between samples after background subtraction. " provenance.
- _2 value "Fasting insulin for the entire group was significantly lower than baseline (P = 0.02) after treatment (with TZD)" provenance.
- _4 value "AT, NADPH oxidase inhibitors (apocynin and diphenyleneiodonium chloride [DPI]), and an inhibitor to PKC-alpha and other isoforms (2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether [HBDDE]) but not PKC-beta II (LY379196) decreased O(2)(-) release and p47phox translocation." provenance.
- _4 value "Antisense oligodeoxynucleotides to PKC-alpha and p47phox but not to PKC-betaII inhibited HG-induced O(2)(-) release and p47phox translocation in THP-1 cells." provenance.