Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "from full text - Table 3. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Mitochondrial/energy metabolism and Oxidative stress" provenance.
- _3 value "from full text - Table 3. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Mitochondrial/energy metabolism and Oxidative stress" provenance.
- _3 value "from full text - Table 4. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Protein synthesis, sorting, and degradation" provenance.
- _3 value "from full text - Table 4. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Protein synthesis, sorting, and degradation" provenance.
- _3 value "from full text - Table 4. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Protein synthesis, sorting, and degradation" provenance.
- _3 value "from full text - Table 5. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Signal transduction and Transcription" provenance.
- _3 value "from full text - Table 5. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Signal transduction and Transcription" provenance.
- _3 value "from full text - Table 5. Large functional clusters of genes that exhibited differential expression in rat mesangial cells in response to high glucose: Signal transduction and Transcription" provenance.
- _3 value "Fig. 3. Representative list of the effects of DF, CR, and DF and CR (DFCR) together on hepatic gene expression. upregulated" provenance.
- _3 value "downregulated" provenance.
- _3 value "downregulated" provenance.
- _4 value "The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced caspase 3 activation as well as ERK activation." provenance.
- _2 value "This study show for the first time that calbindin-D28k can prevent glucocorticoid-induced bone cell death." provenance.
- _2 value "This study show for the first time that calbindin-D28k can prevent glucocorticoid-induced bone cell death." provenance.
- _3 value "In the LNCaP cell model, OPN stimulates cell proliferation in serum-free medium and colony growth at high dilution but this effect is visible only in presence of epidermal growth factor (EGF). Proliferation induced by OPN is accompanied by a sustained activation of EGF receptor (EGFR)" provenance.
- _5 value "In the LNCaP cell model, OPN stimulates cell proliferation in serum-free medium and colony growth at high dilution but this effect is visible only in presence of epidermal growth factor (EGF). Proliferation induced by OPN is accompanied by a sustained activation of EGF receptor (EGFR)" provenance.
- _5 value "Hearts of transgenic embryos that expressed Tbx2 in the prechamber myocardium completely failed to form chambers and to express the chamber myocardium-specific genes Nppa, Cx40, and Chisel, whereas other cardiac genes were normally expressed." provenance.
- _5 value "Hearts of transgenic embryos that expressed Tbx2 in the prechamber myocardium completely failed to form chambers and to express the chamber myocardium-specific genes Nppa, Cx40, and Chisel, whereas other cardiac genes were normally expressed." provenance.
- _6 value "In vitro, Tbx2 repressed the activity of regulatory fragments of Cx40, Cx43, and Nppa." provenance.
- _5 value "TGFbeta-mediated phosphorylation of Akt at Ser-473 was inhibited by dominant-negative ILK and PI3K inhibitors, LY294002 and wortmannin. Treatment with TGFbeta stimulated induction of Akt and ILK kinase activity in HaCat control cells." provenance.
- _3 value "OPN stimulates T cell proliferation and induces T cells and macrophages to express other Th1 cytokines...it is involved in macrophage recruitment during inflammation" provenance.
- _3 value "estrogen stimulates the expression of ezrin and the LDLR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "Conversely, TNF-alpha, IL-6, and IL-8 increased reactive oxygen species production and the expression of CD11b and CD15 on both neutrophils and monocytes and decreased the expression of CD62L." provenance.
- _5 value "Recombinant human (rh) CyPA activated ERK1/2, p38MAPK, SAPKs, and Akt in cultured cardiac myocytes. Furthermore, CyPA significantly increased Bcl-2 in cardiac myocytes." provenance.
- _5 value "Recombinant human (rh) CyPA activated ERK1/2, p38MAPK, SAPKs, and Akt in cultured cardiac myocytes. Furthermore, CyPA significantly increased Bcl-2 in cardiac myocytes." provenance.
- _4 value "To investigate the humoral factors which mediate cardiac response to hypoxia/reoxygenation, we analyzed the conditioned media from cardiac myocytes subjected to hypoxia/reoxygenation by two-dimensional electrophoresis and mass spectrometry. We identified cyclophilin A (CyPA) as one of the proteins secreted from cardiac myocytes in response to hypoxia/reoxygenation." provenance.
- _5 value "Modified assertion" provenance.
- _7 value "CEACAM6 cross-linking increased c-Src activation and induced tyrosine phosphorylation of p125(FAK) focal adhesion kinase.Focal adhesion kinase phosphorylation was dependent on c-Src kinase activation, for which caveolin-1 was required.CEACAM6 cross-linking induced a significant increase in cellular resistance to anoikis. These observations represent the first characterization of the mechanism through which this important cell surface oncoprotein influences intracellular signaling events and hence malignant cellular behavior." provenance.
- _2 value "Here, we report that bile acids inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase, and fructose 1,6-bis phosphatase in an SHP-dependent fashion. Cholic acid diet decreased the mRNA levels of these gluconeogenic enzymes, whereas those of SHP were increased." provenance.
- _3 value "Ariadne: In particular, extracellular S100A4 down-regulates the pro-apoptotic bax and the angiogenesis inhibitor thrombospondin-1 genes." provenance.
- _4 value "Akt/phosphoinositide 3-kinase (PI3-kinase) pathway with LY294002 and wortmannin prevents the ability of ET-1 to induce alpha-SMA, ezrin, paxillin, and moesin and to promote matrix contraction." provenance.
- _4 value "Figure 8. Endothelin induces {alpha}-SMA, paxillin, moesin, and ezrin expression; SSc fibroblasts overexpress {alpha}-SMA, paxillin, moesin, and ezrin in a manner that is dependent on endogenous ET-1 signaling. Normal and SSc fibroblasts were treated with and without 100 nM ET-1 (24 h) as indicated in the presence or absence of bosentan or wortmannin. Cell layers were harvested, and equal amounts of protein were subjected to SDS-PAGE and Western blot analysis with anti-{alpha}-SMA, anti-paxillin, anti-moesin, and anti-ezrin antibodies, as indicated. As a loading control, Western analysis with an anti-GAPDH antibody also was performed." provenance.
- _3 value "steady-state levels of mRNA for vitamin D3 upregulated protein 1 (Vdup1) were significantly higher." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Down-regulation of the transcriptional repressor E2F6 by TGFbeta1" provenance.
- _3 value "In contrast, addition of ascorbic acid to KCL22/SR cells resulted in a decrease in Nrf2-DNA binding and decreases in levels of gamma-GCSl mRNA and GSH." provenance.
- _5 value "Such activation of p70 S6 kinase is blocked by pharmacological inhibitors of the PI 3' kinase and mTOR," provenance.
- _4 value "Relative to the control stably transfected or CITED2-cells, CITED2+ cells had an increased rate of cell proliferation" provenance.
- _6 value "On exposure of the cells to TGFbeta1, S100C/A11 was phosphorylated, bound to nucleolin, and transferred to the nucleus, resulting in induction of p21WAF1/CIP1 and p15INK4B through activation of Sp1. Protein kinase C alpha (PKCalpha) was shown to phosphorylate 10Thr of S100C/A11, which is a critical event for the signal transduction. The TGFbeta1-induced growth inhibition was almost completely mitigated when PKCalpha activity was blocked or when S100C/A11 was functionally sequestered." provenance.
- _6 value "On exposure of the cells to TGFbeta1, S100C/A11 was phosphorylated, bound to nucleolin, and transferred to the nucleus, resulting in induction of p21WAF1/CIP1 and p15INK4B through activation of Sp1. Protein kinase C alpha (PKCalpha) was shown to phosphorylate 10Thr of S100C/A11, which is a critical event for the signal transduction. The TGFbeta1-induced growth inhibition was almost completely mitigated when PKCalpha activity was blocked or when S100C/A11 was functionally sequestered." provenance.
- _3 value "Fibroblasts growing under stressed conditions within a three-dimensional collagen gel showed at least a 15 times higher level of Cyr61 mRNA than cells growing under relaxed conditions. Upon relaxation, the decline of the Cyr61 mRNA to a lower level occurred within 2 h, and was thus quicker than the response of CTGF. The regulation was fully reversible when stress was reapplied. Thus, Cyr61 represents another typical example of a stress-responsive gene. The level of the Nov mRNA was low in the stressed state, but increased in the relaxed state." provenance.
- _8 value "The mechanism by which CCL19 activates ERK1/2 was determined to be beta-arrestin-dependent, because it is reduced both by depletion of beta-arrestin-2 with small interfering RNA and by elimination of the phosphorylation sites in the tail of the receptor" provenance.
- _6 value "The mechanism by which CCL19 activates ERK1/2 was determined to be beta-arrestin-dependent, because it is reduced both by depletion of beta-arrestin-2 with small interfering RNA and by elimination of the phosphorylation sites in the tail of the receptor" provenance.
- _3 value "This is the first identification of specific factors involved in regulating differentiation-associated gene changes in urothelium and the first unambiguous evidence of a role for PPARgamma signalling in the terminal differentiation programme of a normal epithelium." provenance.
- _3 value "Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb " provenance.
- _3 value "Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb " provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "MLK2 is an upstream activator of JNKs and activation of MLK2-mediated signaling cascades play roles in neurodegenerative and apoptotic mechanisms in the central nervous system." provenance.
- _2 value "The aging process is accompanied by significant changes in body composition characterized by decreased fat free mass and increased and redistributed fat mass. Muscle loss results from the atrophy of muscle fibers and decreased synthesis of muscle proteins. Increased number of adipocytes and fat accumulation in non-adipose tissue leads to adiposity. These changes can impose functional limitations and increase morbidity. In men, declining testosterone levels that occur with aging can be a contributing factor to these changes. Studies in hypogonadal men have shown that testosterone replacement is effective in increasing muscle mass and strength and decreasing fat mass. The molecular mechanisms of testosterone's influence on muscle and adipose are not fully elucidated. However, testosterone appears to stimulate IGF-1 expression directly and indirectly leading to increased muscle protein synthesis and growth. It may also counter the inhibitory effects of myostatin, cytokines, and glucocorticoids. The predominant effects of testosterone on fat mass are increased lipolysis and decreased adipogenesis. Current evidence suggests that testosterone replacement may be effective in reversing age-dependent body composition changes and associated morbidity. However, hypogonadism must be diagnosed carefully, and therapy should be monitored regularly in order to avoid the adverse effects associated with testosterone supplementation." provenance.
- _4 value "TNF alpha and other inflammatory mediators can down-regulate EPCR and TM and IL-6 can depress levels of protein S in experimental animals." provenance.
- _7 value "Nur77 is essential for POMC stimulation by IL-1 in corticotrophs" provenance.
- _8 value "MRN stimulates the kinase activity of ATM in vitro toward its substrates p53, Chk2, and histone H2AX. MRN makes multiple contacts with ATM and appears to stimulate ATM activity by facilitating the stable binding of substrates .. phospho-sites from Figs 1-2" provenance.
- _4 value "Additionally, KLF6 inhibits cellular transformation induced by several oncogenes (c-sis/PDGF-B, v-src, H-Ras, and EGFR) that are components of signaling cascades implicated in GBM." provenance.
- _4 value "Additionally, KLF6 inhibits cellular transformation induced by several oncogenes (c-sis/PDGF-B, v-src, H-Ras, and EGFR) that are components of signaling cascades implicated in GBM." provenance.
- _4 value "Additionally, KLF6 inhibits cellular transformation induced by several oncogenes (c-sis/PDGF-B, v-src, H-Ras, and EGFR) that are components of signaling cascades implicated in GBM." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "IFN-gamma induces the serine/threonine phosphorylation of PU.1 in cultured monocytes ... This phosphorylation, as well as the IFN-gamma-induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976" provenance.
- _3 value "Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells. Inhibition of Akt phosphorylation with specific PI 3-K inhibitors and down-regulation of COX-2 increased apoptosis in human endometrial cancer cells." provenance.
- _4 value "Gene transcripts for oncogenes and tumor markers such as pleiomorphic adenoma gene-like 1 (Plagl1) tumor antigen (L6) and claudin 3 were markedly elevated following LH and FSH stimulation." provenance.
- _4 value "In contrast, increase in tumor rejection antigen (gp96) 1 and decrease in connective tissue growth factor (CTGF), transforming growth factor-beta 1 induced transcript 1 (TGFB1Il), pim-1 oncogene (PIM1), v-maf musculoaponeurotic fibrosarcoma oncogene homologue (MAF) and CD24 antigen" provenance.
- _4 value "stimulation of cells with saturating doses of gonadotropins gives rise to the expression of genes coding for presenilin 1 and 2, along with the up-regulation of genes involved in steroidogenesis such as StAR, cytochrome P450scc enzyme system and aromatase." provenance.
- _4 value "stimulation of cells with saturating doses of gonadotropins gives rise to the expression of genes coding for presenilin 1 and 2, along with the up-regulation of genes involved in steroidogenesis such as StAR, cytochrome P450scc enzyme system and aromatase." provenance.
- _3 value "In addition, fucose induced the accumulation of TNF-alpha mRNA in a time-dependent manner with a peak at 8 h and a return to baseline values at 20 h after stimulation." provenance.
- _5 value "Notch signaling, which promotes keratinocyte differentiation, is upregulated in embryonic keratinocyte and epidermis, and elevated caspase 3 expression, which we identify as a transcriptional Notch1 target, accounts in part for the high commitment of embryonic keratinocytes to terminal differentiation. Table 1. Genes Concomitantly Upregulated in Embryonic Keratinocytes and in Response to Increased Notch1 Activity Figure 3. Elevated caspase 3 Expression in Embryonic Keratinocytes and Skin and in Response to Notch1 Activation." provenance.
- _3 value "Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes" provenance.
- _5 value "From Full Text: We have recently demonstrated that 11 other poorly studied protein kinases that belong to the AMPK subfamily (NUAK1, NUAK2, BRSK1, BRSK2, QSK, SIK, QIK, MARK1, MARK2, MARK3, MARK4), are activated in vitro following phosphorylation of their T-loop threonine residues by LKB1 (16). We have also developed assays to measure the activities of the endogenous AMPK-related kinases and found that the activities of these enzymes are markedly reduced in LKB1-deficient fibroblasts or HeLa cells (16). These results imply that LKB1 functions as a master \"upstream\" protein kinase, regulating the activities of AMPK and the AMPK-related kinases. LKB1 and AMPK-related kinase activities have thus far been studied only in cultured cell lines and not in tissues of relevance to diabetes. Because the beneficial effects of exercise and metformin for type 2 diabetes are thought to be at least partly mediated through activation of AMPK, we sought to determine whether LKB1 and AMPK-related kinases are also regulated by muscle contraction and/or phenformin in rat skeletal muscles." provenance.
- _6 value "From Full Text: We have recently demonstrated that 11 other poorly studied protein kinases that belong to the AMPK subfamily (NUAK1, NUAK2, BRSK1, BRSK2, QSK, SIK, QIK, MARK1, MARK2, MARK3, MARK4), are activated in vitro following phosphorylation of their T-loop threonine residues by LKB1 (16). We have also developed assays to measure the activities of the endogenous AMPK-related kinases and found that the activities of these enzymes are markedly reduced in LKB1-deficient fibroblasts or HeLa cells (16). These results imply that LKB1 functions as a master \"upstream\" protein kinase, regulating the activities of AMPK and the AMPK-related kinases. LKB1 and AMPK-related kinase activities have thus far been studied only in cultured cell lines and not in tissues of relevance to diabetes. Because the beneficial effects of exercise and metformin for type 2 diabetes are thought to be at least partly mediated through activation of AMPK, we sought to determine whether LKB1 and AMPK-related kinases are also regulated by muscle contraction and/or phenformin in rat skeletal muscles." provenance.
- _4 value "Insulin action on Na+, K+-ATPase was dependent on ERK1/2 in HSMCs. Insulin also increased phosphorylation and plasma membrane content of the Na+,K+-ATPase alpha1- and alpha2-subunits. The insulin induced phosphorylation at threonine and proline motif of alpha subunits inhibited by ERK1/2 inhibitors and its upstream kinase inhibitors. Results of in-vitro assay showed that ERK1/2 phosphorylated alpha subunits of Na+, K+-ATPase." provenance.
- _5 value "Insulin-stimulated Na(+),K(+)-ATPase activation, phosphorylation, and translocation of alpha-subunits to the plasma membrane were abolished by 20 microm PD98059, which is an inhibitor of MEK1/2, an upstream kinase of ERK1/2. Furthermore, inhibitors of phosphatidylinositol 3-kinase (100 nm wortmannin) and protein kinase C (10 microm GF109203X) had similar effects." provenance.
- _4 value "Insulin-stimulated Na(+),K(+)-ATPase activation, phosphorylation, and translocation of alpha-subunits to the plasma membrane were abolished by 20 microm PD98059, which is an inhibitor of MEK1/2, an upstream kinase of ERK1/2. Furthermore, inhibitors of phosphatidylinositol 3-kinase (100 nm wortmannin) and protein kinase C (10 microm GF109203X) had similar effects." provenance.
- _4 value " We show here that neither BAFF nor APRIL was able to induce STAT3 phosphorylation but did activate ERK1/2 and PI3K/Akt pathways." provenance.
- _5 value "The protein encoded by this gene (TNFRSF13B) is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17." provenance.
- _4 value "The protein encoded by this gene (TNFRSF17)is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation." provenance.
- _5 value "The protein encoded by this gene (TNFRSF17)is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation." provenance.
- _3 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _3 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _3 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _5 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _4 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _4 value "we found that annexin II expression was regulated by IL-3 mainly by Ras pathways, including Ras/phosphatidylinositol 3-kinase pathways." provenance.
- _5 value "IL-1beta increased HK activity in both a time- and concentration-dependent manner: activity increased maximally by approximately 50% between 12 and 24 h with an apparent EC(50) of 3 pM. IL-1alpha mimicked, but did not augment, the effects of IL-1beta. Changes in HK activity were associated with both increased Glc metabolism and selective increases in HKII isoform abundance # Pubmed:gene: Proinflammatory interleukin-1 cytokines increase mesangial cell hexokinase activity and hexokinase II isoform abundance." provenance.
- _4 value "Other thrombin inhibitors include melagatran, ximelagatran, napsagatran, inogatran, and efegatra.49" provenance.
- _4 value "The DTI include Hirudin, Bivalirudin, and a second generation of agents, called active site inhibitors. Melagatran, together with its oral prodrug (Ximelagatran) is the most extensively investigated of this last group of drugs." provenance.
- _4 value "The DTI include Hirudin, Bivalirudin, and a second generation of agents, called active site inhibitors. Melagatran, together with its oral prodrug (Ximelagatran) is the most extensively investigated of this last group of drugs." provenance.
- _5 value "Besides classical interaction with the ERE, ligandactivated ERs also regulate gene expression by interacting directly with the AP-1 protein complex (Webb et al. 1999), the Sp1 protein (Safe 2001) or the nerve factor-kB (NF-kB) protein" provenance.
- _3 value "Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines" provenance.
- _4 value "Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2." provenance.
- _3 value "Figure 2 Gene expression variations measured by cDNA arrays in independent E2 (E2), OH-Tam, ICI 182,780 (ICI) and E2+OH-Tam experiments." provenance.
- _5 value "Importantly, mACTN2 not only served as a primary coactivator for androgen receptor, estrogen receptor and thyroid receptor activities, but also acted synergistically with GRIP1 to enhance these nuclear receptor (NR) functions." provenance.
- _5 value "Importantly, mACTN2 not only served as a primary coactivator for androgen receptor, estrogen receptor and thyroid receptor activities, but also acted synergistically with GRIP1 to enhance these nuclear receptor (NR) functions." provenance.