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- _7 value "CEACAM6 cross-linking increased c-Src activation and induced tyrosine phosphorylation of p125(FAK) focal adhesion kinase.Focal adhesion kinase phosphorylation was dependent on c-Src kinase activation, for which caveolin-1 was required.CEACAM6 cross-linking induced a significant increase in cellular resistance to anoikis. These observations represent the first characterization of the mechanism through which this important cell surface oncoprotein influences intracellular signaling events and hence malignant cellular behavior." provenance.
- _7 wasQuotedFrom 15047698 provenance.