Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Insulin-induced gene 1 (INSIG-1)" provenance.
- _3 value "Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis." provenance.
- _5 value "Expression of tight junction proteins, including claudin-1, occludin and ZO-1, was downregulated in MDCK cells exogenously expressing Snail protein." provenance.
- _5 value "Map3k2 is localized mainly in the cytosol of resting cells, and translocates into the nucleus upon EGF stimulation" provenance.
- _5 value "# Ariadne: TopBP1 recruits Brg1/Brm, a central component of the SWI/SNF chromatin-remodeling complex, to E2F1-responsive promoters and represses the activities of E2F1, but not E2F2 or E2F3. [Binding]" provenance.
- _5 value "In contrast, co-transfection of p300 and CBP with ESE-1 enhances the transcriptional activity of ESE-1." provenance.
- _5 value "Interestingly, Ku70 and Ku 86 negatively regulate the transcriptional activity of ESE-1." provenance.
- _2 value "Estradiol promoted the proliferation of prostatic stromal cells by 10% to 20%. Estradiol and TGF-beta1 enhanced SMA expression." provenance.
- _4 value "Signal transduction and activator of transcription 3 (STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis." provenance.
- _4 value "We hypothesized that Rituximab may inhibit p38 MAPK activity that regulates IL-10 expression via Sp1. Treatment of 2F7 cells with Rituximab or the p38 inhibitor SB203580 inhibited the constitutive p38 MAPK activity and resulted in the inhibition of Sp1, IL-10, STAT3, and Bcl-2." provenance.
- _5 value "Figure 4 shows the inhibitory effect of gefitinib on EGFinduced autophosphorylation of EGFR, and phophorylation of Akt and ERK1/2 in three of the NSCLC cell lines. EGF stimulated EGFR autophosphorylation and activation of Akt and ERK1/2 in PC9 (A), A549 (B), and QG56 (C) cells, and activation was blocked to different extents by gefitinib." provenance.
- _3 value "We have used in vitro oligodendrocyte differentiation and the in vivo remyelination model, the cuprizone model, to identify genes regulating oligodendrocyte function and remyelination. One of the genes we identified, osteopontin (opn), is a secreted glycoprotein with cytokine-like, chemotactic, and anti-apoptotic properties that contains an Arg-Gly-Asp (RGD) cell adhesion motif-mediating interactions with several integrins." provenance.
- _5 value "Based on our observations we speculate that PGE1 exerts its effect on VEGF-1 via interaction via EP2 and_or EP4 PG receptors both of which increase intracellular cAMP levels, whereas we hypothesize that neither EP1 nor EP3 receptors play a role in this effect since they lead to a rise in intracellular calcium or to a decrease in intracellular cAMP, respectively" provenance.
- _3 value "We recently reported that fibroblast growth factor 1 (FGF-1) upregulates apolipoprotein E (apoE) synthesis and its secretion as high density lipoprotein (HDL)" provenance.
- _5 value "We recently reported that fibroblast growth factor 1 (FGF-1) upregulates apolipoprotein E (apoE) synthesis and its secretion as high density lipoprotein (HDL)" provenance.
- _5 value "Figure 5. Regulation of the core cell-death machinery by E2F-1 and the p53 family. E2F-1 can regulate apoptosis in many ways. It can induce cell death by stabilizing the levels of p53 through activating the ARF tumor suppressor, which suppresses Mdm2, a negative regulator of p53. The p53 protein regulates the transcription of several celldeath genes including BH3-only proteins, proapoptotic Bcl-2 protein Bax and the caspase-9 adaptor Apaf-1. In cells lacking p53, E2F-1 can act through p73, a member of p53 family that activates some of the same target genes as p53. E2F-1 can also directly regulate the transcription of several different caspases and suppress cell survival pathways by suppressing Mcl-1 expression or by inhibiting NFkB-mediated antiapoptotic signaling." provenance.
- _3 value "Profiling the effect of this compound on various cytokines in the signaling cascade attenuated by cAMP elevation demonstrates that L-826,141 is also a potent inhibitor of IL-12, GM-CSF, and IFNgamma(IC50's of 0.3-0.9 micro M) as well as TNFalpha formation." provenance.
- _4 value "Subsequent Akt activation by S473 phosphorylation was PI 3-kinase dependent and specific for Akt2 rather than Akt1" provenance.
- _5 value "cross-talk and activation between the PI 3-kinase/Akt and p38 MAPK pathways that is essential for efficient myoblast differentiation. During myoblast differentiation, Akt kinase activity correlated with S473 but not T308 phosphorylation and occurred 24 h after p38 activation Akt2 promoter activity and protein levels were regulated by p38 activation, thus providing a mechanism for communication." provenance.
- _5 value "cross-talk and activation between the PI 3-kinase/Akt and p38 MAPK pathways that is essential for efficient myoblast differentiation. During myoblast differentiation, Akt kinase activity correlated with S473 but not T308 phosphorylation and occurred 24 h after p38 activation Akt2 promoter activity and protein levels were regulated by p38 activation, thus providing a mechanism for communication." provenance.
- _6 value "cross-talk and activation between the PI 3-kinase/Akt and p38 MAPK pathways that is essential for efficient myoblast differentiation. During myoblast differentiation, Akt kinase activity correlated with S473 but not T308 phosphorylation and occurred 24 h after p38 activation Akt2 promoter activity and protein levels were regulated by p38 activation, thus providing a mechanism for communication." provenance.
- _3 value "The maximum level of VEGF mRNA was observed at 1 h after raloxifene and 6 h after tamoxifen or ospemifene treatment. Maximum levels of the c-fos and VEGF mRNA after raloxifene treatment were higher than those seen after treatments with E2 or a corresponding dose of tamoxifen or ospemifene." provenance.
- _6 value "The co-transcription factor and DNA repair enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilitates DNA binding and transcriptional activity of a number of transactivating factors, including those governing hypoxia-induced gene expression HIF-1" provenance.
- _3 value "24 h after the first bout of exercise, calpain 1, calpain 2, and calpastatin expression were markedly increased compared with basal and post-immobilization values" provenance.
- _6 value "CK1-a, which has been shown to rephosphorylate and deactivate NFAT4 transcription factor (18, 19), and p38 MAPK." provenance.
- _3 value "Twenty four hours after limb cast removal and the first bout of exercise training, IKKb expression was up-regulated by 37% (P < 0.05) compared with postimmobilization and by 83% (P < 0.001), compared with basal" provenance.
- _3 value "Twenty fours hours after cast removal and the first bout of exercise training, MAFbx and MuRF1 were down-regulated by 39% (P < 0.01) and 33% (P < 0.05)," provenance.
- _8 value "Co-transfection of Smad3, JunB, and Cbfa1/Runx2 constructs along with a constitutively active TGF-beta type I receptor construct identified functional interaction of these proteins and transcriptional activation of the collagenase-3 gene by TGF-beta1." provenance.
- _4 value "Gel shift, real time reverse transcriptase-PCR, and Western blot analyses showed increased levels of c-Jun, JunB, and Cbfa1/Runx2 upon TGF-beta1 treatment in MDA-MB231 cells." provenance.
- _5 value "Insig-1 and Insig-2 have been shown to block lipid synthesis in a cholesterol-dependent fashion by inhibiting proteolytic processing of sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors that activate lipid synthesis Insig's exert this action in the ER by binding SREBP cleavage-activating protein (SCAP) and preventing it from escorting SREBPs to the Golgi apparatus where the SREBPs are processed to their active forms" provenance.
- _5 value "Elevated mRNA levels in sham-operated NOS-3 KO mice compared with sham-operated WT mice were demonstrated for CB-1, NOS-1 and the adrenomedullin receptor" provenance.
- _2 value "# Ariadne: The present data demonstrate that high glucose increases cellular ROS in HPMC through activation of PKC, NADPH oxidase, and mitochondrial metabolism and that ROS, thus generated, up-regulate fibronectin expression by HPMC. [Expression]" provenance.
- _4 value "# Ariadne: The present data demonstrate that high glucose increases cellular ROS in HPMC through activation of PKC, NADPH oxidase, and mitochondrial metabolism and that ROS, thus generated, up-regulate fibronectin expression by HPMC. [Expression]" provenance.
- _3 value "A single dose of H(2)O(2) or H(2)O(2) continuously generated by glucose oxidase up-regulated fibronectin expression [corrected]. Antioxidants trolox and catalase inhibited high glucose- and PMA-induced fibronectin mRNA and protein expression." provenance.
- _3 value "A single dose of H(2)O(2) or H(2)O(2) continuously generated by glucose oxidase up-regulated fibronectin expression [corrected]. Antioxidants trolox and catalase inhibited high glucose- and PMA-induced fibronectin mRNA and protein expression." provenance.
- _6 value "We previously reported that c-Jun binds directly to the N-terminal 163 amino acids of Homo sapiens TATA-binding protein-associated factor-1 (hsTAF1), causing a derepression of transcription factor IID (TFIID)-driven transcription" provenance.
- _3 value "Using colon carcinoma cells that express a temperature-sensitive variant of p53 and undergo p53-dependent apoptosis after UV irradiation, we found that the number of p53-induced genes Table 3. The size of genes induced at the permissive temperature" provenance.
- _6 value "A constitutively active form of ERRalpha is sufficient to elicit both responses." provenance.
- _4 value "Male Swiss Webster mice were subjected to a 40% hemorrhage without resuscitation. Western blot analysis indicated that c-Jun (an AP-1 protein), Kruppel-like factor 6 (KFL6), and inducible nitric oxide synthase (iNOS) were upregulated sequentially in that order." provenance.
- _4 value "Male Swiss Webster mice were subjected to a 40% hemorrhage without resuscitation. Western blot analysis indicated that c-Jun (an AP-1 protein), Kruppel-like factor 6 (KFL6), and inducible nitric oxide synthase (iNOS) were upregulated sequentially in that order." provenance.
- _2 value "BACKGROUND: We have shown that both intraischemic hypothermia and hypertonic saline resuscitation provide dramatic protection against gut ischemia/reperfusion (I/R) injury that is in part mediated by heme oxygenase-1 (HO-1). We therefore hypothesized that induction of HO-1 by hemin would lessen damage and improve function after gut I/R. MATERIALS AND METHODS: Male Sprague-Dawley rats were treated with 50 micromol/kg hemin (HO-1 inducer ferric protoporphyrin IX chloride) sq or vehicle 2 h before superior mesenteric artery occlusion for 60 min or sham laparotomy. After 6 h of reperfusion, transit was determined by quantitation of percentage of tracer in 10 equal segments of small intestine 30 min following injection into the duodenum (expressed as mean geometric center). Ileum was harvested for assessment of mucosal histologic injury (Chiu score 0-5 by blinded observer), myeloperoxidase activity (MPO, index of inflammation), and HO-1 protein expression. RESULTS: Hemin treatment was associated with increased HO-1 protein expression, lessened mucosal injury, decreased MPO activity, and improved intestinal transit following gut I/R. CONCLUSION: These data corroborate that HO-1 plays an important role in protecting the gut against I/R-induced injury." provenance.
- _4 value "Leptin stimulates MAPK 1 and MAPK 2 phosphorylation in a time dependent manner with a maximal activation detected at 5 min, then this activation greatly diminishes. PD98059, an inhibitor of MAPK1 and MAPK2 totally inhibits the leptin induced cell proliferation." provenance.
- _6 value "Immunoblotting following transfection of RFL6 fibroblasts with Thy-1 demonstrates that Thy-1 expression inhibits src-family protein tyrosine kinase (SFK) activation, resulting in decreased phosphorylation of p190 Rho GTPase-activating protein (GAP)." provenance.
- _3 value "Using differential display reverse transcription-polymerase chain reaction (DDRT-PCR), seven upregulated genes including S100 calcium binding protein A9 (S100A9) mRNA and antigenic determinant for rec-A protein mRNA and five downregulated genes including caseinolytic protease X (ClpX) mRNA and ceruloplasmin (CP) mRNA by cisplatin were identified. A" provenance.
- _5 value "we have demonstrated that Brn-3a is involved in the regulation of Dpl in vivo in E13.5 mice, and that both Brn-3a and Brn-3b are able to strongly stimulate the expression of Dpl in vitro when over-expressed in two different neuroblastoma cell lines." provenance.
- _3 value " TGF-{beta} suppressed the proliferation of these cells (Fig. 2C)." provenance.
- _3 value "In the present work, we demonstrate that TGF-beta is able to induce Foxp3 expression and subsequently a regulatory phenotype in CD4(+)CD25(-) peripheral murine T cells. " provenance.
- _4 value "Similarly, TGF-{beta} stimulation regulated Foxp3 expression in anti-CD3/CD28-stimulated human CD4+ T lymphocytes at the mRNA and protein level, suggesting that TGF-{beta} controls expression of this key regulatory protein both in human and murine T cells (Fig. 1, B and C)." provenance.
- _3 value "Gene expression changes in other functional groups. Hypoxia also resulted in an increase in the expression of vascular endothelial growth factor C (VEGFC), although this was not statistically significant. Additionally, we observed a significant increase in the expression of plasminogen activator inhibitor type 1 (SERPINE1). This increase was confirmed by real-time RT-PCR (Fig. 1). We also found that a number of genes encoding proteins involved in mediating a cytoprotective response to oxidant stress were reduced by hypoxia, including metallothionein 2A (MT2A), biliverdin reductase A (BLVRA), and GABAB-related G-protein coupled receptor (GABABL)." provenance.
- _3 value "Gene expression changes in other functional groups. Hypoxia also resulted in an increase in the expression of vascular endothelial growth factor C (VEGFC), although this was not statistically significant. Additionally, we observed a significant increase in the expression of plasminogen activator inhibitor type 1 (SERPINE1). This increase was confirmed by real-time RT-PCR (Fig. 1). We also found that a number of genes encoding proteins involved in mediating a cytoprotective response to oxidant stress were reduced by hypoxia, including metallothionein 2A (MT2A), biliverdin reductase A (BLVRA), and GABAB-related G-protein coupled receptor (GABABL)." provenance.
- _3 value "calmodulin 1 (CALM1), which is involved in driving cell cycle progression, is reduced by hypoxia." provenance.
- _5 value "A G protein-coupled chemoattractant receptor (R) activates PI3K isoforms, which converts PtdIns(4,5)P2 to PtdIns(3,4,5)P3. PI3K activation itself would lead only to a transient increase in PtdIns(3,4,5)P3 followed by a decrease in this lipid product as a result of depletion of the upstream phosphoinositide substrates, such as PtdIns(4,5)P2. Hence, PtdIns(3,4,5)P3 at the leading edge or front of the cell stimulates its own accumulation through the activation of one or more Rho GTPases (Rac, cdc42 and/or Rho), which in turn activate PI3K and increase PtdIns(3,4,5)P3 formation. " provenance.
- _5 value "Table 1. Lymphoid chemokine receptors" provenance.
- _5 value "Table 1. Lymphoid chemokine receptors" provenance.
- _3 value "transcription from the human C/EBPbeta gene is induced in response to endoplasmic reticulum stress, such as glucose deprivation, or treatment of cells with tunicamycin or thapsigargin." provenance.
- _4 value "expression of a dominant negative IkappaBalpha (IkappaBalphaM) inhibited NF-kappaB-dependent p53 activation and apoptosis" provenance.
- _3 value "A dose-dependent inhibition of MMP-2 mRNA level was demonstrated in ECs treated with NO." provenance.
- _4 value "PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death." provenance.
- _3 value "Through isolation and analysis of the SIVA promoter, we have identified response elements for both p53 and E2F1. Like p53, E2F1 is another tumor suppressor gene involved in the regulation of apoptosis, including neuronal injury models. We have identified E2F consensus sites in the promoter region, whereas p53 recognition sequences were found in intron1. Sequence analysis has shown that these consensus sites are also conserved between mouse and human SIVA genes. Electrophoretic mobility shift assays reveal that both transcription factors are capable of binding to putative consensus sites, and luciferase reporter assays reveal that E2F1 and p53 can activate transcription from the SIVA promoter. " provenance.
- _5 value "JNK, which phosphorylates ATF2 in Thr-69 and Thr-71," provenance.
- _3 value "Exposure of human smooth muscle cells with LDL (100 micro g cholesterol/mL) caused a 4-8 fold increase in PDGF-A levels. The maximal level was found after 8 hour of LDL-incubation. However, addition of BHT, an antioxidant, caused no significant increase in PDGFA mRNA, indicating that oxidative modification of LDL is required for modulating PDGFA transcript levels." provenance.
- _4 value "Fig. 6B shows a Western blot measuring the amount of phosphorylated c-Jun, the active form of the transcription factor, induced by LPS in both control and OxLDL pre-treated whole cell lysates." provenance.
- _5 value "MAP kinase phosphatase-1 (MKP-1) is an immediate-early gene with a dual-specificity phosphatase properties that dephosphorylates ERK1/2 [19-22], as well as SAPK and p38 MAP kinase" provenance.
- _5 value "MAP kinase phosphatase-1 (MKP-1) is an immediate-early gene with a dual-specificity phosphatase properties that dephosphorylates ERK1/2 [19-22], as well as SAPK and p38 MAP kinase" provenance.
- _8 value "Moreover, Chk1 phosphorylated by PKB fails to undergo activating phosphorylation on serine 345 by ATM/ATR." provenance.
- _7 value "We have shown recently that DNA damage effector kinase Chk1 is phosphorylated in vitro by protein kinase B/Akt (PKB/Akt) on serine 280. Activation of Chk1 by DNA damage in vivo is suppressed in presence of activated PKB. In this study we show that Chk1 is phosphorylated by PKB in vivo, and that increased phosphorylation by PKB on serine 280 correlates with impairment of Chk1 activation by DNA damage." provenance.
- _3 value "12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth." provenance.
- _4 value "p18(INK4c), a member of INK4 family of cyclin-dependent kinase inhibitors, negatively regulates the cyclin D-cyclin-dependent kinase 4/6 complexes which promote G1/S transition by phosphorylating the retinoblastoma" provenance.
- _3 value "Stable expression of a DEGA/AMIGO-2 antisense construct in the gastric adenocarcinoma cell line, AGS, led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration" provenance.
- _5 value "We identified an interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifier enzyme. Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes.... Biochemical studies in mammalian cells demonstrated that Smad5 binds to both known mammalian isoforms of Suv39h proteins, and that Smad proteins activated by the TGF-beta signaling pathway, Smad2 and Smad3, do not bind with significant affinity." provenance.
- _5 value "phenotypes of Cnot7(-/-) mice are similar to those of mice deficient in retinoid X receptor beta (Rxrb). We further show that Cnot7 binds the AF-1 domain of Rxrb and that Rxrb malfunctions in the absence of Cnot7. Therefore, Cnot7 seems to function as a coregulator of Rxrb" provenance.
- _5 value "Similarly, the SH3-mediated binding of Trio to a proline-rich motif following the FERM domain promotes increased FAK catalytic activity [13]." provenance.
- _4 value "We identify the transcription factor ATF4 as a critical substrate of RSK2 that is required for the timely onset of osteoblast differentiation" provenance.
- _4 value "we show that RSK2 is required for osteoblast differentiation" provenance.
- _4 value "In atrophying muscles, the ubiquitin ligase, atrogin-1 (MAFbx), is dramatically induced, and this response is necessary for rapid atrophy." provenance.
- _4 value "When Foxo activation is blocked by a dominant-negative construct in myotubes or by RNAi in mouse muscles in vivo, atrogin-1 induction during starvation and atrophy of myotubes induced by glucocorticoids are prevented." provenance.
- _5 value "When Foxo activation is blocked by a dominant-negative construct in myotubes or by RNAi in mouse muscles in vivo, atrogin-1 induction during starvation and atrophy of myotubes induced by glucocorticoids are prevented." provenance.
- _3 value "# Ariadne: Cyclosporine (but not tacrolimus) increased the expression of (alpha2)IV collagen and TIMP2 in isolated glomeruli. [Expression]" provenance.
- _6 value "We report here that the transcriptional activity of NF-kappaB is negatively regulated by protein disulfide isomerase (PDI). Over-expression of PDI in RAW 264.7 cells strongly suppressed the LPS-induced production of inflammatory cytokines as well as NF-kappaB-dependent luciferase activity." provenance.
- _6 value "We report here that the transcriptional activity of NF-kappaB is negatively regulated by protein disulfide isomerase (PDI). Over-expression of PDI in RAW 264.7 cells strongly suppressed the LPS-induced production of inflammatory cytokines as well as NF-kappaB-dependent luciferase activity." provenance.
- _4 value "The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7" provenance.
- _4 value "The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7" provenance.
- _4 value "The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7" provenance.
- _4 value "The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7" provenance.
- _6 value "At a given concentration of intracellular Ca(2+), rSlo/rbeta4 channels were more sensitive to transmembrane voltage changes. The channel activation by Ca(2+) became more cooperative by the coexpression of rbeta4." provenance.
- _4 value "At a given concentration of intracellular Ca(2+), rSlo/rbeta4 channels were more sensitive to transmembrane voltage changes. The channel activation by Ca(2+) became more cooperative by the coexpression of rbeta4." provenance.
- _5 value "EDF-1, but not phosphorylated EDF-1, inhibits the activity of NOS." provenance.
- _5 value "Gel shift assays showed that the Sox1 and Sox2 proteins preferentially bound to E2 and E4. Moreover, disruption of E2 and E4 abolished the reporter gene expression in the lens. These results indicate that the newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens," provenance.
- _5 value "Caspase-8 and caspase-9 activation, as shown by their cleavages appeared as early as 24 h after treatment, whereas caspase-3 and caspase-7 activation, as shown by their cleavages occurred after 72 h of LIGHT treatment" provenance.
- _6 value "In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo" provenance.
- _6 value "In Rat1/vector cells, PDGF-induced phosphorylation of ERK was completely inhibited by pretreatment with PD98059, a MEK inhibitor." provenance.
- _6 value "Platelet-derived growth factor (PDGF) has multiple functions including inhibition of apoptosis and promotion of cell proliferation. In this study, we show that Na(+)/H(+) exchanger regulatory factor 2 (NHERF2) binds to the carboxyl-terminal PDZ domain-binding motif of the PDGF receptor through a PDZ domain-mediated interaction, and evaluate the consequence on PDGF-induced proliferation. Stable transfection with NHERF2 increased the PDGF-induced phosphorylation of ERK and Akt in Rat1 embryonic fibroblasts." provenance.
- _6 value "Platelet-derived growth factor (PDGF) has multiple functions including inhibition of apoptosis and promotion of cell proliferation. In this study, we show that Na(+)/H(+) exchanger regulatory factor 2 (NHERF2) binds to the carboxyl-terminal PDZ domain-binding motif of the PDGF receptor through a PDZ domain-mediated interaction, and evaluate the consequence on PDGF-induced proliferation. Stable transfection with NHERF2 increased the PDGF-induced phosphorylation of ERK and Akt in Rat1 embryonic fibroblasts." provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.