Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Ataxin+2+intermediate-length+polyQ+expansions+contribute+to+amyotrophic+lateral+sclerosis+by+enhancing+stress-induced+TAR+DNA-binding+protein+%28TDP%29-43+pathological+modifications+via+CASP3+activation. assertion.
- assertion asSentence CASP8+activity+is+triggered+by+TRAIL-R1+and+TRAIL-R2+and+continues+to+apoptosis. assertion.
- assertion asSentence Src+activation+triggers+Caspase-8+phosphorylation+on+Tyr380+and+impairs+Fas-induced+apoptosis. assertion.
- assertion asSentence HIPK2-induced+p53Ser46+phosphorylation+activates+the+KILLER%2FDR5-mediated+caspase-8+extrinsic+apoptotic+pathway. assertion.
- assertion asSentence Cells+stabilize+active+caspase-8+on+the+mitochondria+in+order+to+specifically+target+mitochondria-associated+BID. assertion.
- assertion asSentence Thrombin+is+able+to+induce+activation+of+caspases+3+and+9+in+human+platelets+and+significantly+increases+the+amount+in+the+cytoskeleton+of+the+active+forms+of+both+caspases+and+the+procaspases+3+and+9. assertion.
- assertion asSentence In+the+human+gastric+parietal+cell+the+CaSR+is+coupled+to+pertussis+toxin+sensitive+heterotrimeric+G-Proteins+and+requires+calcium+to+enhance+the+activity+of+the+proton-pump. assertion.
- assertion asSentence The+increase+in+oxidative+stress+induced+by+various+fatty+acids+in+Jurkat+and+Raji+cells+partially+occurs+due+to+a+reduction+in+catalase+activity. assertion.
- assertion asSentence PCB77+induces+eNOS+phosphorylation+in+endothelial+cells+through+a+Src%2FPI3K%2FAkt-dependent+mechanism%2C+regulated+by+functional+caveolin-1. assertion.
- assertion asSentence The+mechanisms+of+drug+sensitivity+and+resistance+differs+between+TELAML1-positive+ALL+and+other+precursor+B-lineage+ALL+patients. assertion.
- assertion asSentence Conditional+expression+of+AML1-ETO+by+the+ecdysone-inducible+system+dramatically+increases+the+expression+of+connexin+43+together+with+growth+arrest+at+G1+phase+in+leukemic+U937+cells. assertion.
- assertion asSentence Existence+of+an+essential+structural+motif+%28hot+spot%29+at+the+NHR2+dimer-tetramer+interface%2C+suitable+for+a+molecular+intervention+in+t%288%3B21%29+leukemias. assertion.
- assertion asSentence AML1-ETO+promotes+leukemogenesis+by+blocking+cell+differentiation+through+inhibition+of+Sp1+transactivity. assertion.
- assertion asSentence Genetic+variants+in+the+Runt-related+transcription+factor+3+gene+contribute+to+gastric+cancer. assertion.
- assertion asSentence The+pattern+of+Runx3+gene+methylation+is+related+to+the+tumorigenesis+of+salivary+gland+adenoid+cystic+carcinoma. assertion.
- assertion asSentence Plasma+cortisol+responses+attenuated+more+rapidly+in+the+able-bodied+men%2C+compared+to+spinal+cord-injured+subjects%2C+due+to+significant+rise+in+circulating+corticosteroid-binding+globulin. assertion.
- assertion asSentence An+obligatory%2C+intrapeptidyl+H-bond+between+the+phosphotyrosine+and+the+conserved+asparagine+or+adjacent+arginine+is+essential+for+binding+and+orientates+peptides+into+a+positively+charged+pocket+on+c-Cbl. assertion.
- assertion asSentence The+expression+of+c-Cbl+blocks+the+ability+of+mixed+lineage+kinases+to+signal+to+downstream+components+of+the+kinase+cascade+leading+to+JNK+activation+and+protects+neuronal+cells+from+death+induced+by+mixed+lineage+kinases. assertion.
- assertion asSentence Methylation+of+TET2%2C+CBL+and+CEBPA+is+infrequent+in+myeloproliferative+neoplasms+at+diagnosis. assertion.
- assertion asSentence CBR1+polymorphisms+have+a+significant+influence+on+the+pharmacokinetics+of+doxorubicin+in+Asian+breast+cancer+patients. assertion.
- assertion asSentence Autoinhibition+of+CBS+is+associated+with+changes+in+conformational+stability+and+with+sterical+hindrance+of+the+catalytic+core. assertion.
- assertion asSentence Acid+stable+fat+emulsions+increased+postprandial+CCK+levels. assertion.
- assertion asSentence Activation+of+splice+variant+of+the+CCK-2R+retaining+intron+4+by+gastrin+transactivates+the+COX-2+promoter+in+human+colon+cancer+cells. assertion.
- assertion asSentence B-Myb+repressor+function+is+regulated+by+cyclin+A+phosphorylation+and+sequences+within+the+C-terminal+domain. assertion.
- assertion asSentence Over-expression+of+cyclin+A+is+associated+with+poor+prognosis+in+breast+cancer+patients. assertion.
- assertion asSentence Aberrant+expression+of+cyclin+a+correlates+with+morphogenesis+of+reed-sternberg+cells+in+Hodgkin+lymphoma. assertion.
- assertion asSentence Estrogen+receptor+beta+causes+a+G2+cell+cycle+arrest+by+inactivating+CDK1+through+the+repression+of+cyclin+B1+and+stimulation+of+GADD45A+and+BTG2+expression. assertion.
- assertion asSentence Cdk1%2Fcyclin+B1-dependent+hyper-phosphorylation+of+Bim+during+prolonged+mitotic+arrest+is+an+important+cell+death+signal. assertion.
- assertion asSentence The+knockdown+of+cyclin+D1+is+compensated+by+the+upregulation+of+cyclin+D2%2C+a+more+powerful+strategy+would+be+to+inhibit+both+cyclin+D1+and+cyclin+D2. assertion.
- assertion asSentence Cyclin+E+deregulation+impairs+mitotic+progression+through+premature+activation+of+Cdc25C+in+breast+cancer. assertion.
- assertion asSentence The+antiproliferative+effect+of+Nodal%2FALK7+on+ovarian+cancer+cells+is+in+part+mediated+by+cyclin+G2. assertion.
- assertion asSentence P-TEFb+containing+cyclin+K+and+Cdk9+can+activate+transcription+via+RNA. assertion.
- assertion asSentence A+cognate+mechanism+whereby+CD1b-glycolipid+complexes+bind+to+TCRs. assertion.
- assertion asSentence CD1d+proteins+sre+strong+binders+of+small+hydrophobic+probes+such+as+1-anilinonaphthalene-8-sulfonic+acid+and+4%2C4%27-dianilino-1%2C1%27-naphthyl-5%2C5%27-disulfonic+acid. assertion.
- assertion asSentence Investigation+of+the+5%27+upstream+region+of+human+CD1D+reveals+multiple+transcription+initiation+sites+and+TATA+boxless+dual+promoters+located+within+700+base+pairs+5%27+upstream+of+the+coding+region. assertion.
- assertion asSentence CD1d+gene+polymorphisms+are+associated+with+breast%2C+colorectal+and+lung+cancers. assertion.
- assertion asSentence A+transgenic+T+cell+receptor+gammadelta-low+expressing+subset+of+T+cells+accumulates+in+mouse+ear+keratinocytes+after+IL-23+injections. assertion.
- assertion asSentence Recruitment+of+Nck+by+CD3+epsilon+reveals+a+ligand-induced+conformational+change+essential+for+T+cell+receptor+signaling+and+synapse+formation. assertion.
- assertion asSentence A+transgenic+T+cell+receptor+gammadelta-low+expressing+subset+of+T+cells+accumulates+in+mouse+epidermis+after+IL-23+injections. assertion.
- assertion asSentence TCRzeta%28dim%29+T+cells+accumulate+in+inflamed+tissues+in+vivo+and+have+intrinsic+migratory+activity+in+vitro. assertion.
- assertion asSentence The+CD4+mRNA+expression+level+strongly+correlated+with+the+CD4%28%2B%29+infiltration+score+in+the+cancer+epithelium+%28r%28s%29+%3D+0.858%2C+P+%3C+0.001%29+and+in+the+cancer+stroma+%28r%28s%29+%3D+0.797%2C+P+%3C+0.001%29. assertion.
- assertion asSentence Circulating+CD4%2BCD25hiCD127lo+Treg-cell+levels+are+not+significantly+associated+with+the+extent+of+severity+of+carotid%2Fcoronary+atherosclerosis. assertion.
- assertion asSentence CD7+expression+in+hematopoitic+cells+denotes+commitment+to+B-cell+and+natural+killer+cells+lineages. assertion.
- assertion asSentence The+epigenetic+control+of+gene+transcription+by+histone+acetylation+is+important+for+1%2C25D3-regulated+cathelicidin+and+CD14+expression. assertion.
- assertion asSentence Significan+reduction+in+expression+of+CD14+in+human+adrernal+cortex+tumors. assertion.
- assertion asSentence Soluble+CD14+correlates+with+the+severity+of+liver+disease+and+predicts+early+response+to+peg-INF-alpha%2Fribavirin. assertion.
- assertion asSentence Mutation+of+the+CD19+gene+causes+a+type+of+hypogammaglobulinemia+in+which+the+response+of+mature+B+cells+to+antigenic+stimulation+is+defective. assertion.
- assertion asSentence Chimeric+2H7+%28C2H7%29+can+mediate+complement+dependent+cytotoxicity+and+antibody-dependent+cellular+cytotoxicity+effects+on+CD20+positive+human+Burkitt+lymphoma+cells. assertion.
- assertion asSentence A+functional+role+for+sCD27+in+WM%28Waldenstrom+macroglobulinemia%29+pathogenesis%2C+along+with+its+utility+as+a+surrogate+marker+of+disease+and+a+target+in+the+treatment+of+WM. assertion.
- assertion asSentence Lack+of+CD27+expression+on+natural+killer+%28NK%29+cells+is+associated+with+high+cytolytic+function+and%2C+in+combination+with+CD56%2C+allows+a+better+definition+of+cytotoxic+effector+cells. assertion.
- assertion asSentence CD30+activation+plays+a+role+in+eosinophil+apoptosis. assertion.
- assertion asSentence Presence+of+CD30+T+cells+correlated+with+preservation+of+graft+function+following+lung+transplantation. assertion.
- assertion asSentence CD30+is+a+costimulatory+molecule+and+marker+of+a+regulatory+subpopulation+of+DCs+which+induces+and+modulates+immune+cells+involved+in+the+maintenance+of+the+balance+between+TH1%2FTH2+immune+responses+and+tolerance. assertion.
- assertion asSentence Increased+CD34+expression+is+associated+with+pediatric+T-cell+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Patients+with+refractory+angina+who+received+intramyocardial+injections+of+autologous+CD34%2B+cells+experienced+significant+improvements+in+angina+frequency+and+exercise+tolerance. assertion.
- assertion asSentence Silencing+of+liver+SR-BI+expression+in+mice+and+inhibition+of+SR-BI+activity+in+human+hepatocytes+reduced+infection+by+Plasmodium. assertion.
- assertion asSentence SR-BI-mediated+selective+uptake+of+HDL+cholesteryl+ester+is+essential+for+the+remodeling+of+large+alpha-migrating+HDL+particles+by+EL. assertion.
- assertion asSentence Scavenger+receptor+B2+is+a+cellular+receptor+for+enterovirus+71. assertion.
- assertion asSentence Thrombin-induced+deactivation+of+CD39+in+endothelial+cells+is+reversed+by+HMG-CoA+reductase+inhibitors+and+preservation+of+ATP+and+ADP+metabolism. assertion.
- assertion asSentence Ectonucleotide+triphosphate+diphosphohydrolase-1+%28CD39%29+mediates+resistance+to+occlusive+arterial+thrombus+formation+after+vascular+injury. assertion.
- assertion asSentence CD40+stimulation+can+transiently+induce+RANTES+and+MCP-1+expression+in+LMP1-negative+epithelial+cells. assertion.
- assertion asSentence Serum+levels+in+type+1+diabetes+are+not+different+from+normal+values. assertion.
- assertion asSentence Extracellular+HSP70+blocks+CD40L-induced+apoptosis+and+tubular+formation+in+endothelial+cells. assertion.
- assertion asSentence CD40%2FCD40L+interaction+induces+E-selectin+dependent+adhesion+of+leukocytes+to+human+endothelial+cells+and+reduces+endothelial+cell+migration+by+inhibiting+the+Akt%2FeNOS+signaling+pathway. assertion.
- assertion asSentence Initial+steps+of+Shigella+binding+and+cell+entry+depend+on+the+cholesterol%2Fsphingolipid+raft-mediated+CD44-IpaB+interaction. assertion.
- assertion asSentence Post-translational+modification+of+CD44s+represents+the+principal+regulatory+mechanism+of+CD44s-mediated+functions+in+melanoma. assertion.
- assertion asSentence Fuzheng+Yiliu+granules+enhance+the+immune+adhesion+function+of+RBCs+and+reduce+the+number+of+CD44%28%2B%29-cells+in+esophageal+carcinoma+patients. assertion.
- assertion asSentence E-cad%2C+CD44v6+and+PCNA+play+important+roles+in+invasion+and+metastasis+of+non-small+cell+lung+cancer+%28NSCLC%29. assertion.
- assertion asSentence Expression+of+both+OPN+and+CD44s+in+hepatocellular+carcinoma+is+associated+with+advanced+tumor+stage+and+contributes+to+prognosis+information. assertion.
- assertion asSentence High+CD44+expression+is+associated+with+tumor+progression+of+follicular+lymphoma. assertion.
- assertion asSentence Knockdown+of+CD44+is+an+effective+strategy+for+attacking+the+stemness+of+breast+cancer+stem+cells. assertion.
- assertion asSentence The+epithelial-mesenchymal+transition+%28EMT%29+correlated+with+CD24%2BCD44%2B+and+CD133%2B+cells+in+pancreatic+cancer. assertion.
- assertion asSentence Inhibition+of+T+cell+receptor+signaling+by+thrombospondin-1+is+mediated+by+CD47+and+requires+its+modification+at+Ser%2864%29. assertion.
- assertion asSentence The+expression+of+CD59+is+up-regulated+after+atorvastatin+treatment+independently+of+blood+lipids. assertion.
- assertion asSentence Complement+regulator+CD59+protects+against+atherosclerosis+by+restricting+the+formation+of+complement+membrane+attack+complex. assertion.
- assertion asSentence CD151+promotes+cell+migration+by+regulating+integrin+trafficking. assertion.
- assertion asSentence CD151+importantly+modulates+podocyte+function. assertion.
- assertion asSentence The+reduced+CDK7+kinase+activity+is+responsible+for+the+inactivation+of+CDC2%2Fp34+kinase+and+the+irreversible+G%282%29%2FM+phase+cell-cycle+arrest+of+a+human+gastric+carcinoma+cell+line. assertion.
- assertion asSentence Both+Cdk1+and+-2+require+cyclin+binding+and+T+loop+phosphorylation+for+full+activity. assertion.
- assertion asSentence FoxM1+is+transcriptionally+active+during+a+DNA-damage-induced+G2+arrest+and+is+essential+for+checkpoint+recovery. assertion.
- assertion asSentence Phosphorylation+of+NuSAP+by+Cdk1+is+an+important+mechanism+to+regulate+microtubule+dynamics+during+cell+cycle+progression. assertion.
- assertion asSentence SEPT7+gene+can+inhibit+the+invasion+and+migration+ability+of+U251+glioma+cells+by+reversing+imbalanced+state+of+MMPs%2FTIMPs%2C+downregulating+expression+of+integrin+alpha%28v%29beta%283%29+and+altering+structure+of+tubulin-alpha. assertion.
- assertion asSentence Cdc6+plays+a+key+role+in+the+sequential+molecular+events+leading+to+repression+of+origin+licensing+and+loss+of+proliferative+capacity+during+execution+of+the+differentiation+programme. assertion.
- assertion asSentence The+sequential+actions+of+the+APC-c%28Cdc20%29+and+APC-c%28Cdh1%29+ubiquitin+ligases+regulate+the+clearance+of+Mps1+levels+and+are+critical+for+Mps1+functions+during+the+cell+cycle+in+human+cells. assertion.
- assertion asSentence Caulibugulone+inhibition+of+cellular+Cdc25A+and+B+phosphatases+occurred+through+at+least+two+different+mechanisms%2C+leading+to+pronounced+cell+cycle+arrest. assertion.
- assertion asSentence Instead+of+inducing+neurite+formation%2C+a+constitutively+active+form+of+human+Cdc42+stimulates+the+proliferation+of+rat+PC12+cells+in+the+presence+of+nerve+growth+factor. assertion.
- assertion asSentence In+neutrophils%2C+Rac2+and+Cdc42+are+involved+in+FcR-+and+CR3-induced+activation+and+for+properly+functioning+signal+transduction+involved+in+the+generation+of+oxygen+radicals. assertion.
- assertion asSentence Both+expression+of+E-cadherin+and+its+membranous+localization+are+required+for+well-differentiated-type+morphogenesis+in+gallbladder+cancer+cells. assertion.
- assertion asSentence E-cadherin+expression+is+frequently+reduced+in+laryngeal+squamous+epithelium+of+patients+with+laryngopharyneal+reflux. assertion.
- assertion asSentence Short-term+preoperative+treatment+of+celecoxib+up-regulates+the+expression+of+E-cadherin+in+gastric+carcinomas. assertion.
- assertion asSentence High+E-cadherin+is+associated+with+metastatic+lymph+nodes+of+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence CDH1+polymorphisms+are+associated+with+epithelial+E-cadherin+expression+contributor+to+airway+remodelling+and+lung+function+in+asthma. assertion.
- assertion asSentence Differential+expression+of+E-cadherin+has+an+important+role+in+pathogenesis+of+endometriosis. assertion.
- assertion asSentence CDH1+promoter+methylation+is+associated+with+triple-negative+breast+cancer. assertion.
- assertion asSentence In+ductal+carcinomas%2C+decreased+levels+of+N-cadherin+in+primary+tumors+correlate+with+local+recurrence+and+death+in+long-term+followup+of+patients. assertion.
- assertion asSentence High+N-cadherin+expression+is+associated+with+metastatic+spread+to+the+brain+in+primary+non-small+cell+lung+cancer. assertion.
- assertion asSentence Levels+of+N-cadherin+are+decreased+at+synaptic+sites+following+impairment+of+ADAM10+activity. assertion.
- assertion asSentence The+intracellular+association+of+VE-cadherin+with+beta-catenin-linked+cytoskeleton+is+essential+to+the+maintenance+of+endothelial+junctional+integrity+and+microvascular+permeability. assertion.
- assertion asSentence Cadherin-7+interacts+with+melanoma+inhibitory+activity+protein+and+negatively+modulates+melanoma+cell+migration. assertion.
- assertion asSentence The+functional+T-G+haplotype+of+CDH17+%28651+C%3ET+and+IVS6%2B35A%3EG%29+is+a+genetic+susceptibility+factor+for+the+development+of+Hepatocellular+carcinoma+%28HCC%29+in+a+Chinese+population. assertion.