Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Transient+binding+of+a+second+catalytic+magnesium+activates+the+structure+and+dynamics+of+CDK2+kinase+for+catalysis. assertion.
- assertion asSentence Cyclin+D2+and+the+CDK+substrate+p220%28NPAT%29+are+required+for+self-renewal+of+human+embryonic+stem+cells. assertion.
- assertion asSentence A+direct+impact+of+CDK9-cyclin+T1+on+the+nuclear+localization+and+activity+of+the+viral+regulator+pUL69. assertion.
- assertion asSentence Flavopiridol+abrogates+depsipeptide+mediated+induction+of+p21+expression+via+inhibition+of+protein+kinase+C+signaling+in+malignant+pleural+mesothelioma+cells. assertion.
- assertion asSentence Tumor+suppressor+activity+of+RUNX3+is+associated+with+its+ability+to+induce+p21+%28WAF1%2FCip10%29+expression. assertion.
- assertion asSentence This+is+the+first+demonstration+of+GSK-3beta+as+the+missing+link+between+UV-induced+ATR+activation+and+p21+degradation. assertion.
- assertion asSentence The+combined+phenotype+of+RHAMM+and+p21+expression+is+an+invaluable+independent+prognostic+immunohistochemical+profile+in+microsatellite+instability-high+colorectal+cancer. assertion.
- assertion asSentence ROCK-mediated+up-regulation+of+p21%28Cip1%29+and+the+cytoskeleton+in+PKCdelta-dependent+apoptosis+in+prostate+cancer+cells. assertion.
- assertion asSentence Immunoreactivity+index+of+p21+and+cyclin+D1+is+independent+of+the+morphological+pattern+of+human+endometrium%2C+patients%27+age+and+gynaecological+history+of+patients. assertion.
- assertion asSentence p21+regulates+the+interaction+between+PARP-1+and+base+excision+repair+factors%2C+to+promote+efficient+DNA+repair. assertion.
- assertion asSentence Hypermethylation+does+not+contribute+to+Cip1+silencing+in+gastric+cancer+in+a+northern+Brazil+population. assertion.
- assertion asSentence p21+deregulation+is+associated+with+the+activation+of+stromal+fibroblasts+of+oral+cancers+by+a+mechanism+that+involves+the+stimulation+of+SMA+expression. assertion.
- assertion asSentence p21%2C+especially+cytoplasmic+phosphorylated+p21%2C+has+an+oncogenic+role+in+promoting+mammary+tumorigenesis+and+metastasis. assertion.
- assertion asSentence Genetic+variations+in+the+cell+cycle+genes+encoding+p53+and+p21+are+associated+with+idiopathic+pulmonary+fibrosis+disease+development+and+progression. assertion.
- assertion asSentence Akt+activation+promotes+cell+cycle+progression+through+inactivation+of+p27+in+anaplastic+large+cell+lymphoma. assertion.
- assertion asSentence TIMP-1-mediates+cell-cycle+arrest+via+cyclin+D1+downregulation+%26+p27KIP1+upregulation. assertion.
- assertion asSentence p27Kip1+is+required+during+induction+of+T+cell+tolerance. assertion.
- assertion asSentence Pim+kinases+directly+phsophorylate+p27Kip1+at+threonine-157+and+threonine-198+residues. assertion.
- assertion asSentence S10+phosphorylation+of+p27+mediates+all+trans+retinoic+acid+induced+growth+arrest+in+ovarian+carcinoma+cell+lines. assertion.
- assertion asSentence All+patients+of+Monoclonal+gammopathy+of+undetermined+significance+%28MGUS%29+and+multiple+myeloma+%28MM%29lacked+methylation+at+p27+KIP1+gene. assertion.
- assertion asSentence Glutathione+S-transferase+P1+and+NADPH+quinone+oxidoreductase+polymorphisms+are+associated+with+aberrant+promoter+methylation+of+P16%28INK4a%29+and+O%286%29-methylguanine-DNA+methyltransferase+in+sputum. assertion.
- assertion asSentence Differential+p16+patterns+by+interphase+cytogenetics+in+malignant+peripheral+nerve+sheath+tumor+and+morphologically+similar+spindle+cell+neoplasms. assertion.
- assertion asSentence Ink4a%2Farf+plays+a+critical+role+in+UV-induced+melanomagenesis. assertion.
- assertion asSentence Use+of+p16INKra+immunocytochemistry+can+improve+the+prognostic+statement+in+routine+procedure+for+patients+with+cervical+intraepithelial+neoplasia. assertion.
- assertion asSentence The+stabilization+effect+exerted+by+TBP-1+requires+an+intact+N-terminal+39+amino+acids+in+ARF+and+occurs+independently+from+N-terminal+ubiquitination+of+the+protein. assertion.
- assertion asSentence Variants+are+associated+with+multiple+primary+cutaneous+melanomas+in+a+Norwegian+population. assertion.
- assertion asSentence Epigallocatechin-3-gallate+can+activate+and+up-regulate+the+expression+of+p16+in+the+malignant+lymphoma+cell+line+CA46. assertion.
- assertion asSentence High+frequency+of+CDKN2A+mutations+are+associated+with+multiple+primary+melanoma. assertion.
- assertion asSentence Alterations+in+both+the+p53+and+p16-Rb+pathways+are+associated+with+squamous+cell+carcinoma+arising+in+mature+cystic+teratoma. assertion.
- assertion asSentence Loss+of+p16+and+increased+incidence+of+autosomal+aneuploidy+and+chromatid+breaks%2C+along+with+other+chromosomal+alterations%2C+can+contribute+to+the+progression+of+lung+cancer. assertion.
- assertion asSentence Psoriasis+is+associated+with+a+SNP+haplotype+of+the+corneodesmosin+gene. assertion.
- assertion asSentence Cdx2+is+a+highly+sensitive+marker+for+Barrett%27s+esophagus. assertion.
- assertion asSentence Cdx2+regulates+intestinal+villin+expression+through+recruiting+Brm-type+SWI%2FSNF+complex+to+the+villin+promoter. assertion.
- assertion asSentence Increased+CDX2+expression+is+associated+with+cutaneous+metastatic+carcinomas+and+extramammary+Paget%27s+Disease. assertion.
- assertion asSentence Early+postoperative+CEA+concentration+is+an+independent+prognostic+factor+for+colorectal+cancer. assertion.
- assertion asSentence C%2FEBP+alpha+binds+to+the+lactoferrin+promoter+in+nonexpressing+cells. assertion.
- assertion asSentence C%2FEBPalpha+binds+and+activates+the+PU.1+distal+enhancer+to+induce+monocyte+lineage. assertion.
- assertion asSentence Conserved+amino+acids+regulationregulate+phosphoenolpyruvate+carboxykinase+%28PEPCK%29+gene+expression. assertion.
- assertion asSentence Calreticulin+interacts+with+C%2FEBPalpha+and+C%2FEBPbeta+mRNAs+and+represses+translation+of+C%2FEBP+proteins. assertion.
- assertion asSentence ERalpha+is+involved+in+the+transcriptional+regulation+of+HSD17B8+gene+in+response+to+E2+through+its+interaction+with+C%2FEBPbeta. assertion.
- assertion asSentence IL-6+increases+hepatic+PAI-1+expression+mediated+by+the+-232-+to+-210-bp+region+of+the+promoter+containing+a+C%2FEBPdelta+binding+site. assertion.
- assertion asSentence Small+interfering+RNA+of+C%2FEBPdelta+suppressed+COX-2+expression%2C+strengthening+the+role+of+C%2FEBPdelta+in+COX-2+gene+transcription. assertion.
- assertion asSentence CEBPG+regulates+ERCC5+expression+and+this+regulation+is+modified+by+E2F1%2FYY1+interactions. assertion.
- assertion asSentence BSDL+plays+a+role+in+optimal+platelet+activation+and+thrombus+formation+by+interacting+with+CXCR4+on+platelets. assertion.
- assertion asSentence Carboxylesterase+1A1+mRNA+expression+level+is+much+higher+than+the+expression+of+carboxylesterase+1A2+mRNA+in+the+liver+and+lung. assertion.
- assertion asSentence CETN2+localizes+to+the+vertebrate+nuclear+pore+and+plays+a+role+in+mRNA+and+protein+export. assertion.
- assertion asSentence The+stability+of+centrin+is+regulated+in+part+by+Aurora+A. assertion.
- assertion asSentence Cen2+influences+the+binding+of+RPA+and+XPA+with+damaged+DNA. assertion.
- assertion asSentence The+combined+T+allele+of+LIPC+-514C%2FT+and+V+allele+of+CETP+I405V+are+associated+with+the+risk+of+coronary+artery+disease. assertion.
- assertion asSentence Physical+inactivity+decreases+high+density+cholestrol%2C+at+least+in+part+through+CETP+regulation. assertion.
- assertion asSentence Cofilin-1+occupies+a+central+position+in+RhoA-actin+pathway+mediating+nuclear+translocation+of+RelA%2Fp65+and+expression+of+ICAM-1+in+endothelial+cells. assertion.
- assertion asSentence The+overexpression+of+CFL1+in+stromal+cells+derived+from+eutopic+endometria+of+women+with+endometriosis+is+associated+with+enhanced+proliferation%2C+adhesion%2C+invasion+and+angiogenesis+and+reduced+apoptosis+in+eutopic+endometria+with+endometriosis. assertion.
- assertion asSentence Substitution+of+two+residues+eliminates+aggregation+of+a+111-amino+acid+peptide+derived+from+the+C-terminal+portion+of+the+cystic+fibrosis+transmembrane+conductance+regulator+%28CFTR%29. assertion.
- assertion asSentence The+interaction+between+syntaxin+1A+and+this+chloride+channel+is+different+from+syntaxin+1A-SNARE+interactions. assertion.
- assertion asSentence Protein+kinase+C+phosphorylation+disrupts+Na%2B%2FH%2B+exchanger+regulatory+factor+1+autoinhibition+and+promotes+cystic+fibrosis+transmembrane+conductance+regulator+macromolecular+assembly. assertion.
- assertion asSentence NHERF1+overexpression+in+CFBE41o-+rescues+CFTR-dependent+chloride+secretion+by+forming+the+multiprotein+complex+RhoA-ROCK-ezrin-actin+that+tethers+F508del+CFTR+to+the+cytoskeleton+stabilizing+it+on+the+apical+membrane. assertion.
- assertion asSentence It+is+evident+that+Delta-F508+mutation+and+5T+allele+play+important+roles+in+the+pathogenesis+of+congenital+bilateral+absent+vas+deferens+in+Egyptians. assertion.
- assertion asSentence The+pulmonary+phenotype+of+BALB+Cftr%28tm1UNC%29+transgenic+mice+includes+airway+hyperresponsiveness+and+increased+lymphocyte+numbers%2C+with+the+latter+trait+being+influenced+by+a+chromosome+7+locus. assertion.
- assertion asSentence miRNA-138+regulates+CFTR+expression+through+its+interactions+with+the+transcriptional+regulatory+protein+SIN3A. assertion.
- assertion asSentence Secretory+trafficking+signal+encoded+in+the+carboxyl-terminal+region+of+the+CGbeta-subunit. assertion.
- assertion asSentence CHEK1+interacts+with+XIAP+protein+during+mitosis. assertion.
- assertion asSentence HSP90+inhibition+abrogates+the+topoisomerase+I+poison-induced+G2%2FM+checkpoint+in+p53-null+tumor+cells+by+depleting+CHK1+and+WEE1. assertion.
- assertion asSentence Inhibition+of+checkpoint+kinase+1+abrogates+G2%2FM+checkpoint+activation+and+promotes+apoptosis+under+heat+stress. assertion.
- assertion asSentence Hypoxia+can+activate+p53+through+inactivation+of+MDMX+by+the+ATR-Chk1-MDMX-14-3-3gamma+pathway. assertion.
- assertion asSentence CHGA+acts+through+the+glomerular+endothelium+to+regulate+renal+function. assertion.
- assertion asSentence Overexpression+of+vasostatin-1+in+cardiomyocytes+limits+hypoxia-reoxygenation+injuries+at+molecular+level+independently+of+endothelial+cells. assertion.
- assertion asSentence A+candidate+autoantigen+in+rheumatoid+arthritis+found+in+synovial+fluid+cells. assertion.
- assertion asSentence 2122C%3ET+of+CHI3L1%2C+a+promoter+single+nucleotide+polymorphisms+which+affects+the+mRNA+expression+and+nuclear+factor+binding%2C+is+significantly+associated+with+serum+LDL+cholesterol+levels+in+Korean+subjects. assertion.
- assertion asSentence When+over-expressed+in+cells%2C+REP+wild-type+and+mutants+are+unable+to+form+stable+cytosolic+complexes+with+endogenous+unprenylated+Rabs. assertion.
- assertion asSentence All+three+of+the+Kir2+channels+are+similarly+inhibited+by+m1+muscarinic+receptor+stimulation+through+calcium-dependent+activation+of+the+small+GTPase+Rho. assertion.
- assertion asSentence The+M%281%29+receptor+is+the+predominant+mAChR+subtype+coupling+to+the+Galpha%28q%2F11%29+G+protein+in+the+cerebral+cortex. assertion.
- assertion asSentence The+binding+mode+of+MT7+and+human+muscarinic+acetylcholine+receptor+1+consists+of+three+interaction+regions+in+five+residue+interaction+clusters. assertion.
- assertion asSentence The+DEP+domain+of+RGS7+can+directly+bind+to+the+third+intracellular+loop+of+the+M3R+and+attenuate+receptor-induced+Ca2%2B+mobilization+in+a+M3+subtype-selective+manner. assertion.
- assertion asSentence The+alpha5+and+alpha3+subunits+play+a+significant+role+in+both+nicotine+dependence+and+alcohol+abuse%2Fdependence. assertion.
- assertion asSentence The+CHRNA+3%2F5+and+the+HHIP+loci+make+a+significant+contribution+to+the+risk+of+COPD. assertion.
- assertion asSentence Single+Nucleotide+Polymorphism+in+CHRNA3+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence CHRNA3+polymorphism+on+chromosome+15q25+is+associated+with+early+stage+non-small-cell+lung+cancer. assertion.
- assertion asSentence CHRNA5-CHRNA3-CHRNB4+is+involved+in+the+transition+toward+heavy+smoking+in+mid-adulthood+and+in+smoking+persistence. assertion.
- assertion asSentence Expression+and+regulation+of+alpha7-nAChR+nicotine+receptor+and+osteopontin+isoforms+in+pancreatic+ductal+adenocarcinoma. assertion.
- assertion asSentence alpha7+nicotinic+acetylcholine+receptor-mediated+signaling+through+caveolin-1-enriched+lipid+rafts%2Fcaveolae+is+required+for+nicotine-enhanced+Escherichia+coli+K1+invasion+of+human+brain+microvascular+endothelial+cells. assertion.
- assertion asSentence Extracellular+beta1-beta2+and+cysteine-loops+bridge+the+pre-M1+transmembrane+domain+and+M2-M3+linker+to+transduce+agonist+binding+into+channel+gating. assertion.
- assertion asSentence Mutations+cxause+lethal+and+nonlethal+forms+of+multiple+pterygium+syndrome. assertion.
- assertion asSentence IKKalpha+regulates+growth+pathway+involving+the+p52%2FRelB-dependent+transcriptional+regulation+of+the+skp2+gene. assertion.
- assertion asSentence EBNA1+inhibits+the+canonical+NF-kappaB+pathway+in+carcinoma+lines+by+inhibiting+the+phosphorylation+of+IKKalpha%2Fbeta. assertion.
- assertion asSentence Creatine+kinase+MM+TaqI+and+methylenetetrahydrofolate+reductase+C677T+and+A1298C+gene+polymorphisms+influence+exercise-induced+C-reactive+protein+levels. assertion.
- assertion asSentence Weak+cooperativity+in+the+core+causes+a+switch+in+folding+mechanism+between+two+proteins+of+the+cks+family. assertion.
- assertion asSentence Arkadia+complexes+with+clathrin+adaptor+AP2+mu2+subunit+and+regulates+EGF+signalling. assertion.
- assertion asSentence Downregulated+in+whole+blood+of+infants+hospitalised+with+respiratory+syncytial+virus+%28RSV%29%2C+subtype+B%2C+bronchiolitis. assertion.
- assertion asSentence Threonine+change+to+serine+at+position+481+in+CLCNKB+is+associated+with+essential+hypertension+in+males+within+the+Ghanaian+population. assertion.
- assertion asSentence Clusterin+staining+supports+a+diagnosis+of+follicular+dendritic+cell+tumor+and+helps+classify+them. assertion.
- assertion asSentence Clusterin+and+bcl-2+are+upregulated+in+laryngeal+carcinomas+and+their+expression+is+related+to+invasiveness+of+these+tumors. assertion.
- assertion asSentence CLU+downregulation+in+fibroblast-like+synoviocytes+alters+their+aggressiveness+in+rheumatoid+arthritis+synovitis. assertion.
- assertion asSentence ICln+interacts+with+integrin+alphaIIbbeta3+and+regulates+platelet+activation. assertion.
- assertion asSentence CCR1+signalling+induced+by+RANTES+or+Met-RANTES+has+no+effect+on+proliferation+and+apoptosis+of+mesangial+cells. assertion.
- assertion asSentence Two+HIV-1+variants+resistant+to+small+molecule+CCR5+inhibitors+differ+in+how+they+use+CCR5+for+entry. assertion.
- assertion asSentence Allosteric+and+orthosteric+sites+in+CC+chemokine+receptor+%28CCR5%29%2C+a+chimeric+receptor+approach. assertion.
- assertion asSentence Isoleucine%2Fleucine+in+the+N-terminal+alpha-helix+region+of+this+beta-defensin+is+essential+for+CCR6-mediated+chemotaxis. assertion.
- assertion asSentence ABCC2+polymorphism+contributes+to+variability+of+methotrexate+kinetics. assertion.
- assertion asSentence There+is+an+association+of+the+variants+of+CNR1+with+obesity-related+phenotypes+in+Polish+postmenopausal+women. assertion.
- assertion asSentence Absence+of+a+conserved+proline+and+presence+of+a+conserved+tyrosine+in+the+CB2+cannabinoid+receptor+are+crucial+for+its+function. assertion.