Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Expression and selectivity of OCT1 is regulated. For example, after expression in human embryonic kidney cells (HEK-293), transport by rOCT1 was stimulated by PKC, PKA and tyrosine kinase and inhibited by cGMP [31, 40], and stimulation by PKC was associated with altered substrate selectivity" provenance.
- _3 value "Tables 2 and 4. Genes upregulated in mouse uterus at the oestrous stage" provenance.
- _3 value "Tables 2 and 4. Genes upregulated in mouse uterus at the oestrous stage" provenance.
- _3 value "Tables 2 and 4. Genes upregulated in mouse uterus at the oestrous stage" provenance.
- _3 value "Tables 2 and 4. Genes upregulated in mouse uterus at the oestrous stage" provenance.
- _3 value "Tables 2 and 4. Genes upregulated in mouse uterus at the oestrous stage" provenance.
- _3 value "Tables 3 and 5. Genes downregulated in mouse uterus at the oestrous stage " provenance.
- _3 value "Tables 3 and 5. Genes downregulated in mouse uterus at the oestrous stage " provenance.
- _3 value "Tables 3 and 5. Genes downregulated in mouse uterus at the oestrous stage " provenance.
- _3 value "Readministration of testosterone immediately following orchidectomy restored the expression of all four genes. Substitution of testosterone by the non-aromatizable androgen dihydrotestosterone gave rise to comparable changes in the mRNA and protein levels of the lipogenic genes under investigation, confirming the involvement of the androgen receptor in the observed effects" provenance.
- _6 value "Modified assertion" provenance.
- _6 value "GPx1 also functions as a substrate for c-Abl- and Arg-mediated phosphorylation on Tyr-96. The results further show that c-Abl and Arg stimulate GPx activity and that these kinases contribute to GPx-mediated protection of cells against oxidative stress" provenance.
- _3 value "A total of 11 RA-induced species were validated by reverse transcription polymerase chain reaction (RT-PCR), Western or Northern analyses. Three of these species were novel candidate RA-target genes in human bronchial epithelial cells. These included: placental bone morphogenetic protein (PLAB), polyamine oxidase isoform 1 (PAOh1) and E74-like factor 3 (ELF3). " provenance.
- _5 value "HSP27 overexpression increases NF-kappaB nuclear relocalization, DNA binding, and transcriptional activity induced by etoposide, TNF-alpha, and interleukin 1beta." provenance.
- _3 value "estrogen agonists inhibit glucocorticoid induction of p21 mRNA and protein levels" provenance.
- _5 value "Raf-1 activity, measured by the abundance of phosphorylated S217/221 MEK1 2, a direct target of Raf-1 (30) , was consistently elevated in Cdc37 overexpressing cells, whereas total MEK1 2 levels were unchanged." provenance.
- _5 value "Raf-1 activity, measured by the abundance of phosphorylated S217/221 MEK1 2, a direct target of Raf-1 (30) , was consistently elevated in Cdc37 overexpressing cells, whereas total MEK1 2 levels were unchanged." provenance.
- _4 value "Activation of caspases and induction of apoptosis were also observed in cells overexpressing these proteins. Conversely, small-interfering RNA-mediated reduction of ZIPK, Daxx, or Par-4 expression decreased activation of caspase and apoptosis" provenance.
- _8 value "# Ariadne: As shown above (Fig. 5C ), expression of wild-type ER81 in the presence of p300 or P/CAF resulted in significant levels of MMP-1 mRNA, detectable in our RT-PCR analyses (Fig. 8C ). [Expression]" provenance.
- _5 value "# Ariadne: As shown above (Fig. 5C ), expression of wild-type ER81 in the presence of p300 or P/CAF resulted in significant levels of MMP-1 mRNA, detectable in our RT-PCR analyses (Fig. 8C ). [Expression]" provenance.
- _5 value "This indicated that prostate tumor cells could secrete IL-18 in response to IFN-gamma in the tumor microenvironment" provenance.
- _3 value "NADH could not only eliminate the apoptosis induced by X-ray irradiation, but also up-regulate expression of bcl-2 protein and down-regulate expression of p53, bax, fas and fasL proteins (P<0.05). At the same time, NADH could reduce level of intracellular ROS in radiated L02 cells" provenance.
- _3 value "Of the three Ath diet components examined here, cholate affected expression levels of the greatest number of genes, with 81 genes induced and 23 repressed by cholate (Table II; see examples in Fig. 2, c and d)." provenance.
- _3 value "Of the three Ath diet components examined here, cholate affected expression levels of the greatest number of genes, with 81 genes induced and 23 repressed by cholate (Table II; see examples in Fig. 2, c and d)." provenance.
- _3 value "Of the three Ath diet components examined here, cholate affected expression levels of the greatest number of genes, with 81 genes induced and 23 repressed by cholate (Table II; see examples in Fig. 2, c and d)." provenance.
- _5 value ", whereas no significant changes were observed in the total amount of this protein (Fig. 5, D and E). Therefore, the phosphorylation of p90rsk may be the link between ERK activation and GSK3{beta} phosphorylation. The stimulation of glycogen synthesis by insulin is triggered by the phosphorylation of GSK3{beta} at serine 9 and its concomitant inactivation." provenance.
- _5 value "Adhesion of NCI-H446 cells also increased with FN (4.47-fold) which was abrogated with LY294002 treatment. This correlated with phosphorylation of the cytoskeletal protein p125FAK, on Tyr397, Tyr861 and Ser843 residues with FN." provenance.
- _2 value "Table 1. Stimulatory and inhibitory factors for apoptosis in the development of atherosclerosisa,b" provenance.
- _4 value "The induction of C/EBP DNA binding activity by LPS and glucose was attributable mainly to the increase in C/EBP-delta protein." provenance.
- _4 value "expression of CTIP2 in mammalian cells resulted in deacetylation of histones H3 and/or H4" provenance.
- _3 value "High glucose (20 mmol/L) increased VSMC TGF-beta1 and TGF-beta-R1 expression" provenance.
- _4 value "histone deacetylase inhibitor trichostatin A. Consistent with the generally accepted model, trichostatin A enhanced activation of c-FOS and NUR77 by cAMP. Surprisingly, trichostatin A blocked activation of ICER and NOR-1" provenance.
- _3 value "Cyr61 was hypoxia-inducible" provenance.
- _4 value "hypoxia-inducible factor-1alpha interacts with c-Jun/AP-1 and may thereby contribute to Cyr61 transcriptional regulation under hypoxia" provenance.
- _5 value "Functional significance of this interaction was demonstrated using ChIP assays where a truncated TR2 protein (lacking the LBD) recruited HDACs 3 and 4 to the target DNA causing demonstrable histone deacetylation." provenance.
- _5 value "We conclude that beta-arrestin2 can bind to and enhance endocytosis of the LDLR, both in vitro and in vivo, and may thereby influence lipoprotein metabolism" provenance.
- _3 value "glypican-1 mRNA was expressed in the region surrounding necrotic tissue, and that the signal intensity peaked 7 days after the cryo-injury. In addition, both FGF-2 and amyloid precursor protein (APP) were concurrently upregulated and colocalized with glypican-1 mRNA. Since FGF-2 and APP can bind to glypican-1 in vitro" provenance.
- _6 value "caspase activation may function to amplify the effects of calpain activation." provenance.
- _5 value "From Table 1" provenance.
- _4 value "Hydrophobic bile acids induce CD95-dependent hepatocyte apoptosis." provenance.
- _3 value "TNF-{alpha} has been shown to increase plasma triglycerides and very low density lipoprotein concentrations as well as lipolysis in mouse, rat, and human fat cells" provenance.
- _3 value "The link between IL-6 and insulin resistance in man was further corroborated by the finding that the expression of IL-6, like that of TNF-alpha and IL-8, was markedly increased ( approximately 15-fold) in human fat cells from insulin-resistant individuals." provenance.
- _3 value "A disintegrin and metalloprotease 12 (ADAM12/meltrin alpha) is a key enzyme implicated in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor (EGF)-like growth factor (proHB-EGF)-dependent epidermal growth factor receptor (EGFR) transactivation." provenance.
- _3 value "from full text - Figure 5. TRF2 deltaB deltaM-Induced Senescence in A-T Fibroblasts" provenance.
- _5 value "Ang-4 was also induced by hypoxia or Ad2/HIF-1alpha/VP16 in human cardiac cells" provenance.
- _4 value "contraction increases both GLUT4 translocation to the cell surface and p38 mitogen-activated protein kinase (p38 MAPK) activity." provenance.
- _4 value "NRF-1 overexpression results in increased expression of GLUT4." provenance.
- _4 value "The increase in GLUT4 was associated with a proportional increase in insulin-stimulated glucose transport" provenance.
- _7 value "The data in Fig. 4, E to G, further support the idea that PKC phosphorylates Dvl2 to increase its interactions with betaarr2." provenance.
- _5 value "Binding of betaarr2 to TbetaRIII was also triggered by phosphorylation of the receptor on its cytoplasmic domain (likely at threonine 841). However, such phosphorylation was mediated by the type II TGF-beta receptor (TbetaRII), which is itself a kinase, rather than by a GRK. Association with betaarr2 led to internalization of both receptors and down-regulation of TGF-beta signaling" provenance.
- _3 value "Estrogens are known to regulate the proliferation of breast cancer cells and to alter their cytoarchitectural and phenotypic properties, but the gene networks and pathways by which estrogenic hormones regulate these events are only partially understood. We used global gene expression profiling by Affymetrix GeneChip microarray analysis, with quantitative PCR verification in many cases, to identify patterns and time courses of genes that are either stimulated or inhibited by estradiol (E2) in estrogen receptor (ER)-positive MCF-7 human breast cancer cells. Of the >12,000 genes queried, over 400 showed a robust pattern of regulation, and, notably, the majority (70%) were down-regulated. We observed a general up-regulation of positive proliferation regulators, including survivin, multiple growth factors, genes involved in cell cycle progression, and regulatory factor-receptor loops, and the down-regulation of transcriptional repressors, such as Mad4 and JunB, and of antiproliferative and proapoptotic genes, including B cell translocation gene-1 and -2, cyclin G2, BCL-2 antagonist/killer 1, BCL 2-interacting killer, caspase 9, and TGFbeta family growth inhibitory factors. These together likely contribute to the stimulation of proliferation and the suppression of apoptosis by E2 in these cells. Of interest, E2 appeared to modulate its own activity through the enhanced expression of genes involved in prostaglandin E production and signaling, which could lead to an increase in aromatase expression and E2 production, as well as the decreased expression of several nuclear receptor coactivators that could impact ER activity. Our studies highlight the diverse gene networks and metabolic and cell regulatory pathways through which this hormone operates to achieve its widespread effects on breast cancer cells." provenance.
- _3 value "TABLE 5A. Genes with decreased expression in DIO mouse adipose tissue #DIO = Diet induced obesity#" provenance.
- _4 value "In this study, we demonstrated that NF-kappaB-dependent gene expression was inhibited by E1A in poly(ADP)-ribose polymerase-1 knock out (PARP-1 (-/-)) cells complemented with wild type PARP-1 after tumor necrosis factor alpha (TNFalpha) or lipopolysaccharide (LPS) treatment. PARP-1 and p300 synergistically coactivated NF-kappaB-dependent gene expression in response to TNFalpha and LPS. Furthermore, PARP-1 interacted directly with p300 and enhanced the interaction of NF-kappaB1/p50 to p300. The C terminus, harboring the catalytic domain of PARP-1 but not its enzymatic activity, was required for complete transcriptional coactivation of NF-kappaB by p300 in response to TNFalpha and LPS." provenance.
- _6 value "PARP-1 and p300 synergistically coactivated NF-kappaB-dependent gene expression in response to TNFalpha and LPS. Furthermore, PARP-1 interacted directly with p300 and enhanced the interaction of NF-kappaB1/p50 to p300." provenance.
- _8 value "Interestingly, the interaction of CH-ILKBP with ILK is regulated by the Pi3 kinase pathway, because inhibition of Pi3 kinase activity by pharmacological inhibitors, or by the tumor suppressor PTEN, inhibits this interaction as well as cell attachment and signaling." provenance.
- _5 value "Cell cycle analysis confirms that Myostatin up-regulated p21, a Cdk inhibitor, and decreased the levels and activity of Cdk2 protein in satellite cells" provenance.
- _4 value "Here we show that myostatin, a TGF-beta member, signals satellite cell quiescence and also negatively regulates satellite cell self-renewal" provenance.
- _4 value "Ribonuclease protection and Western analysis has shown that hypoxia induces EndoPDI mRNA and protein expression." provenance.
- _7 value "\"Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.\" In the current study, we demonstrate that various PPARalpha (nafenopin) and gamma (ciglitazone and troglitazone) agonists rapidly induced extracellular signal-regulated kinase (Erk) and/or p38 phosphorylation in rat liver epithelial cells (GN4). The selective epidermal growth factor receptor (EGFR) kinase inhibitors, PD153035 and ZD1839 (Iressa), abolished PPARalpha and gamma agonist-dependent Erk activation." provenance.
- _6 value "\"Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.\" In the current study, we demonstrate that various PPARalpha (nafenopin) and gamma (ciglitazone and troglitazone) agonists rapidly induced extracellular signal-regulated kinase (Erk) and/or p38 phosphorylation in rat liver epithelial cells (GN4). The selective epidermal growth factor receptor (EGFR) kinase inhibitors, PD153035 and ZD1839 (Iressa), abolished PPARalpha and gamma agonist-dependent Erk activation." provenance.
- _5 value "Interestingly, PPARalpha and gamma agonists caused rapid activation of proline-rich tyrosine kinase or Pyk2; Pyk2 as well as p38 phosphorylation was reduced by intracellular Ca2+ chelation without an observable effect on EGFR and Erk activation, suggesting a possible role for Pyk2 as an upstream activator of p38." provenance.
- _4 value "Loss of Nrf1 and Nrf2 leads to marked oxidative stress in cells that is indicated by elevated intracellular reactive oxygen species levels and cell death that is reversed by culturing under reduced oxygen tension or the addition of antioxidants." provenance.
- _2 value "Treatment of human endometrial tissue with PGE(2) for 24 h resulted in increased incorporation of 5-bromo-2'-deoxyuridine (a marker of cellular proliferation) in glandular epithelial cells." provenance.
- _3 value "Treatment of proliferative phase endometrium with PGE(2) induced rapid phosphorylation of ERK1/2 proteins in glandular epithelial and endothelial cells." provenance.
- _4 value "ICln is critically involved in the generation of ion currents activated during regulatory volume decrease after cell swelling (RVDC)" provenance.
- _5 value "overexpression of Hsp10 or Hsp60 increased the abundance of IGF-1R and IGF-1-stimulated receptor autophosphorylation." provenance.
- _6 value "Transfected promoter constructs containing up to 4.1 kb of 5'-flanking DNA were not induced by activated glucocorticoid or progesterone receptor. In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression" provenance.
- _3 value "This resulted in the increased constitutive expression of the FKHRL1 targets Fas ligand and Bim, and promoted apoptosis." provenance.
- _3 value "This resulted in the increased constitutive expression of the FKHRL1 targets Fas ligand and Bim, and promoted apoptosis." provenance.
- _5 value "Taken together, our results suggest that estradiol treatment results in binding to membrane ER-alpha and interaction with a heterodimer containing ErbB2, leading to tyrosine phosphorylation. This results in the activation of PI 3-K and Akt. Akt, in turn, may interact with nuclear ER-alpha, altering its expression and activity." provenance.
- _5 value "Muscle-type creatine kinase (MM-CK) is a member of the CK isoenzyme family with key functions in cellular energetics. MM-CK interacts in an isoform-specific manner with the M-band of sarcomeric muscle, where it serves as an efficient intramyofibrillar ATP-regenerating system for the actin-activated myosin ATPase located nearby on both sides of the M-band. A yeast two-hybrid screen led to the identification of MM-CK as a binding partner of a central portion of myomesin (My7-8)." provenance.
- _5 value "Based on the Cot knock-out mouse data (17), it is believed that intact Cot kinase activity is required for the production of LPS-induced production of inflammatory cytokines such as TNF- and IL-1 and other inflammatory mediators, such as prostaglandin E2, produced by cyclooxygenase-2 (COX-2) Cot knock-out mouse in which Cot mediates LPS-induced TNF- and IL-1 production in monocytes and macrophages" provenance.
- _6 value "Cot expression has been shown to induce ERK and JNK activation" provenance.
- _6 value "Cot expression has been shown to induce ERK and JNK activation" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Here we describe the identification and regulation of five Fos-responsive genes encoding a transcription factor (Fra-1), a secreted protein (Fit-1), a biosynthetic enzyme (ODC) and two membrane-associated proteins (annexin II and V), respectively." provenance.
- _4 value "HIF-1 can be viewed as a messenger that is sent to the nucleus to activate transcriptional responses to hypoxia." provenance.
- _5 value "In addition to effects on HIF-1a synthesis, activation of the RAF MEK ERK signalling pathway has also been shown to stimulate HIF-1a transactivation-domain function. This effect is due at least in part to phosphorylation by ERK of the co-activator p300, with which the transactivation domains interact." provenance.
- _5 value "growth factors, cytokines and other signalling molecules stimulate HIF-1a synthesis via activation of the phosphatidylinositol 3-kinase (PI3K) or mitogen- activated protein kinase (MAPK) pathways (FIG. 1)." provenance.
- _6 value "Like phorbol esters, okadaic acid treatment also activates AP-1 enhancer activity and induces the phosphorylation of c-Jun protein." provenance.
- _3 value "Cotransfection of an MCAD promoter-chloramphenicol acetyltransferase (CAT) reporter plasmid with retinoic acid receptor (RAR)alpha, beta, or retinoid X receptor alpha (RXR alpha) resulted in 10-15-fold transcriptional activation in response to retinoic acid" provenance.
- _8 value "Activation was inhibited by the antioxidants, vitamin E and nordihydroguaiaretic acid, and by superoxide dismutase and catalase, which metabolize SOR and H2O2 to remove reactive oxygen species from the cell." provenance.
- _4 value "Activation was inhibited by the antioxidants, vitamin E and nordihydroguaiaretic acid, and by superoxide dismutase and catalase, which metabolize SOR and H2O2 to remove reactive oxygen species from the cell." provenance.
- _3 value "DB-cAMP decreases the expression of both proteins in U937, slightly inhibits the IL-6R expression in U266, but is uneffective in BMNH." provenance.
- _3 value "Addition of bombesin (10 nM) to confluent quiescent cultures of these cells induced a dramatic and sustained down-regulation of 80-kDa mRNA and protein levels to a minimum of 5% of control within 8 and 48 h, respectively, without depletion of PKC activity." provenance.
- _5 value "Replacement of T160 with alanine abolishes the kinase activity of CDK2, indicating that phosphorylation at this site (as in CDC2) is required for kinase activity. Mutation of Y15 and T14 stimulates kinase activity, demonstrating that phosphorylation at these sites (as in CDC2) is inhibitory. Similarly, CDK2 is activated in vitro by dephosphorylation of Y15 and T14 by the phosphatase CDC25." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "The results indicate that estrogen at pharmacological doses stimulates hepatic LDL-receptor expression and HMG-CoA reductase activity in men" provenance.
- _4 value "LS-174 was serum deprived and treated with PGE2 (0.1 micromolar) and TGF-alpha (100ng/ml), Western blot analysis showed that both PGE2 and TGF-alpha induced the levels of pAKT, and even combined treatment with PGE2 and TGFA resutled in a marked induction of PI3K activity." provenance.
- _3 value "The chemotherapeutic drugs (paclitaxel, vincristine, vinblastine, etoposide, camptothecin, and Adriamycin) induced death receptors (DRs) TRAIL receptor 1/DR4 and TRAIL receptor 2/DR5, and successive treatment with TRAIL resulted in apoptosis of both TRAIL-sensitive and -resistant cells." provenance.
- _4 value "NADPH oxidase inhibitor PH2I, xanthine oxidase inhibitor allopurinol, and free-radical scavenger catalase also prevented TCDC-induced contraction TCDC caused H2O2 production, lipid peroxidation, and increased PGE2 synthesis and activities of catalase and SOD." provenance.
- _4 value "TNF-alpha treatment for 6 hours alone stimulated ICAM1, VCAM1 and E-selectin expression significantly." provenance.
- _8 value "Rb interacts with HDAC or BRG1/BRM to repress E2F-mediated transcription" provenance.
- _4 value "The incubation of activated monocytes with oligomycin, an inhibitor of oxidative phosphorylation, or under hypoxic conditions activated AMPK and further increased iPFK-2 activity, fructose 2,6-bisphosphate content, and glycolysis." provenance.
- _3 value "Atorvastatin...markedly reduced plasma triglyceride, but decreased apoB levels only at the highest dose tested (50%)." provenance.
- _9 value "Pbx2-Prep1 heterodimer can bind to the UGT2B17 Pbx site and interfere with the binding of HNF1alpha to its site adjacent to the Pbx site. This interaction of Pbx2-Prep1 and HNF1alpha results in down-regulation of HNF1alpha-mediated activation of the UGT2B17 promoter" provenance.
- _5 value "Pbx2/Prep1 down-regulates HNF1alpha-mediated activation of the UGT2B17 promoter." provenance.
- _5 value "Pbx2/Prep1 down-regulates HNF1alpha-mediated activation of the UGT2B17 promoter. In this study, we used gel shift and functional assays to show that a Pbx2-Prep1 heterodimer can bind to the UGT2B17 Pbx site and interfere with the binding of HNF1alpha to its site adjacent to the Pbx site. " provenance.
- _5 value "Pbx2/Prep1 down-regulates HNF1alpha-mediated activation of the UGT2B17 promoter.In this study, we used gel shift and functional assays to show that a Pbx2-Prep1 heterodimer can bind to the UGT2B17 Pbx site and interfere with the binding of HNF1alpha to its site adjacent to the Pbx site." provenance.
- _3 value "In contradiction, in breast, lung and brain tumors, Egr1 expression is often absent or reduced and when re-expressed, results in growth suppression" provenance.