Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "expression of GSK3a, which has previously been shown to be deactivated by Akt (16) and in rat skeletal muscle is inhibited by both IGF1 and insulin and increased by stretch and contraction" provenance.
- _3 value "mutations in the calpain 3 gene, leading to complete loss of calpain 3 protein, have been found to be responsible for Limb Girdle Muscular Dystrophy type IIA (LGMDIIA), GSK3-a expression increased by 28% following two weeks immobilization (P < 0.01), and remained significantly greater than basal after 24 h of exercise rehabilitation. However, after 1 week of rehabilitation, GSK3-a expression had significantly declined (P < 0.01) from the 24 h exercise time point back to basal expression levels" provenance.
- _6 value "Co-transfection of Smad3, JunB, and Cbfa1/Runx2 constructs along with a constitutively active TGF-beta type I receptor construct identified functional interaction of these proteins and transcriptional activation of the collagenase-3 gene by TGF-beta1." provenance.
- _8 value "Co-transfection of Smad3, JunB, and Cbfa1/Runx2 constructs along with a constitutively active TGF-beta type I receptor construct identified functional interaction of these proteins and transcriptional activation of the collagenase-3 gene by TGF-beta1." provenance.
- _8 value "Co-transfection of Smad3, JunB, and Cbfa1/Runx2 constructs along with a constitutively active TGF-beta type I receptor construct identified functional interaction of these proteins and transcriptional activation of the collagenase-3 gene by TGF-beta1." provenance.
- _5 value "Elevated mRNA levels in sham-operated NOS-3 KO mice compared with sham-operated WT mice were demonstrated for CB-1, NOS-1 and the adrenomedullin receptor" provenance.
- _3 value "# Ariadne: The present data demonstrate that high glucose increases cellular ROS in HPMC through activation of PKC, NADPH oxidase, and mitochondrial metabolism and that ROS, thus generated, up-regulate fibronectin expression by HPMC. [Expression]" provenance.
- _5 value "# Ariadne: The present data demonstrate that high glucose increases cellular ROS in HPMC through activation of PKC, NADPH oxidase, and mitochondrial metabolism and that ROS, thus generated, up-regulate fibronectin expression by HPMC. [Expression]" provenance.
- _4 value "# Ariadne: The present data demonstrate that high glucose increases cellular ROS in HPMC through activation of PKC, NADPH oxidase, and mitochondrial metabolism and that ROS, thus generated, up-regulate fibronectin expression by HPMC. [Expression]" provenance.
- _6 value "We previously reported that c-Jun binds directly to the N-terminal 163 amino acids of Homo sapiens TATA-binding protein-associated factor-1 (hsTAF1), causing a derepression of transcription factor IID (TFIID)-driven transcription" provenance.
- _3 value "Using colon carcinoma cells that express a temperature-sensitive variant of p53 and undergo p53-dependent apoptosis after UV irradiation, we found that the number of p53-induced genes Table 3. The size of genes induced at the permissive temperature" provenance.
- _3 value "Using colon carcinoma cells that express a temperature-sensitive variant of p53 and undergo p53-dependent apoptosis after UV irradiation, we found that the number of p53-induced genes Table 3. The size of genes induced at the permissive temperature" provenance.
- _5 value "Pretreatment of mice with geldanamycin (GA) 16 h before hemorrhage effectively inhibited the expression of the proteins KLF6 and iNOS," provenance.
- _6 value "Tuberous sclerosis complex protein 2 is a GTPase activator protein for Rheb that is inhibited by amino acids, allowing Rheb to activate mTOR through a mechanism still to be delineated." provenance.
- _4 value "Leptin stimulates MAPK 1 and MAPK 2 phosphorylation in a time dependent manner with a maximal activation detected at 5 min, then this activation greatly diminishes. PD98059, an inhibitor of MAPK1 and MAPK2 totally inhibits the leptin induced cell proliferation." provenance.
- _5 value "Immunoblotting following transfection of RFL6 fibroblasts with Thy-1 demonstrates that Thy-1 expression inhibits src-family protein tyrosine kinase (SFK) activation, resulting in decreased phosphorylation of p190 Rho GTPase-activating protein (GAP)." provenance.
- _3 value "Using differential display reverse transcription-polymerase chain reaction (DDRT-PCR), seven upregulated genes including S100 calcium binding protein A9 (S100A9) mRNA and antigenic determinant for rec-A protein mRNA and five downregulated genes including caseinolytic protease X (ClpX) mRNA and ceruloplasmin (CP) mRNA by cisplatin were identified. A" provenance.
- _3 value "Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. Hypoxia was identified as a strong transcriptional regulator of GPx-3 expression, in part through the presence of the hypoxia-inducible factor- 1-binding site, leading to an almost 3-fold increase in expression levels" provenance.
- _6 value "Interestingly, activation of PKA abrogates the inhibitory effect of Rab13 on the recruitment of vasodilator-stimulated phosphoprotein, ZO-1, and claudin1 to cell-cell junctions. Rab13 is, therefore, the first GTPase that controls PKA activity and provides an unexpected link between PKA signaling and the dynamics of TJ assembly." provenance.
- _5 value "Treatment with H(2)O(2) induced the tyrosine phosphorylation of VEGFR-3 and its association with the signaling adaptor proteins Shc, growth factor receptor binding protein 2, Sos, p85, SHP-2, and phospholipase C-gamma." provenance.
- _2 value "transcription from the human C/EBPbeta gene is induced in response to endoplasmic reticulum stress, such as glucose deprivation, or treatment of cells with tunicamycin or thapsigargin." provenance.
- _4 value "p53-dependent induction of BOK and NOXA genes," provenance.
- _3 value "Through isolation and analysis of the SIVA promoter, we have identified response elements for both p53 and E2F1. Like p53, E2F1 is another tumor suppressor gene involved in the regulation of apoptosis, including neuronal injury models. We have identified E2F consensus sites in the promoter region, whereas p53 recognition sequences were found in intron1. Sequence analysis has shown that these consensus sites are also conserved between mouse and human SIVA genes. Electrophoretic mobility shift assays reveal that both transcription factors are capable of binding to putative consensus sites, and luciferase reporter assays reveal that E2F1 and p53 can activate transcription from the SIVA promoter. " provenance.
- _5 value "Overexpression of Pyk2 alone led to its spontaneous activation and tyrosine phosphorylation, resulting in activation of Stat5B, indicated by the reporter GFP-Stat5B." provenance.
- _3 value "Exposure of human smooth muscle cells with LDL (100 micro g cholesterol/mL) caused a 4-8 fold increase in PDGF-A levels. The maximal level was found after 8 hour of LDL-incubation. However, addition of BHT, an antioxidant, caused no significant increase in PDGFA mRNA, indicating that oxidative modification of LDL is required for modulating PDGFA transcript levels." provenance.
- _4 value "Cells infected with active ALK7 adenovirus showed an apoptotic-positive phenotype, as opposed to those that were infected with a control protein" provenance.
- _5 value "Investigation into the downstream targets and mechanisms involved in ALK7-induced apoptosis revealed that the TGF-beta signaling intermediates, Smad2 and -3, were activated, as well as the MAPKs JNK and p38. In addition, caspase-3 and -9 were also activated, and cytochrome c release from the mitochondria was observed" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth." provenance.
- _4 value "p18(INK4c), a member of INK4 family of cyclin-dependent kinase inhibitors, negatively regulates the cyclin D-cyclin-dependent kinase 4/6 complexes which promote G1/S transition by phosphorylating the retinoblastoma" provenance.
- _5 value "We identified an interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifier enzyme. Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes.... Biochemical studies in mammalian cells demonstrated that Smad5 binds to both known mammalian isoforms of Suv39h proteins, and that Smad proteins activated by the TGF-beta signaling pathway, Smad2 and Smad3, do not bind with significant affinity." provenance.
- _4 value "We identify the transcription factor ATF4 as a critical substrate of RSK2 that is required for the timely onset of osteoblast differentiation" provenance.
- _4 value "we show that RSK2 is required for osteoblast differentiation" provenance.
- _5 value "IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression." provenance.
- _7 value "When Foxo activation is blocked by a dominant-negative construct in myotubes or by RNAi in mouse muscles in vivo, atrogin-1 induction during starvation and atrophy of myotubes induced by glucocorticoids are prevented." provenance.
- _5 value "we show that in cultured myotubes undergoing atrophy, the activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction." provenance.
- _4 value "Akt exerts its antiapoptotic function by its ability to phosphorylate many key components of the cellular apoptotic regulatory circuit, such as BAD, MDM2, FOXO Forkhead transcription factors, and PED?PEA-15 as well as by its role in activating NF-kappaB" provenance.
- _4 value "Akt exerts its antiapoptotic function by its ability to phosphorylate many key components of the cellular apoptotic regulatory circuit, such as BAD, MDM2, FOXO Forkhead transcription factors, and PED?PEA-15 as well as by its role in activating NF-kappaB" provenance.
- _5 value "The PTEN tumor suppressor is a phosphatase that dephosphorylates the phospholipids phosphorylated by PI-3 kinase, thereby opposing the action of PI 3-kinase, and acts as the primary negative regulator of the PI-3 kinase?Akt pathway in the cell" provenance.
- _4 value "The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7" provenance.
- _5 value "Gel shift assays showed that the Sox1 and Sox2 proteins preferentially bound to E2 and E4. Moreover, disruption of E2 and E4 abolished the reporter gene expression in the lens. These results indicate that the newly identified enhancer with Sox elements activates the alphaB-crystallin promoter in the lens," provenance.
- _4 value "In this study, we found that H-Ras interacted with ASK1 to cause the inhibition of both ASK1 activity and ASK1-induced apoptosis in vivo" provenance.
- _6 value "In Rat1/vector cells, PDGF-induced phosphorylation of ERK was completely inhibited by pretreatment with PD98059, a MEK inhibitor." provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 1. Genes upregulated by androgen throughout the entire epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 5. Genes upregulated by androgen in the corpus epididymis" provenance.
- _3 value "FIG. 5. Genes upregulated by androgen in the corpus epididymis" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 9. Genes upregulated by androgen in the cauda epididymis" provenance.
- _3 value "FIG. 9. Genes upregulated by androgen in the cauda epididymis" provenance.
- _4 value "The induction of ER stress by p73 was further supported by the transcriptional induction of Gadd 153, a transcription factor induced under ER stress conditions" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "These data suggest that upregulation of Fas expression and downregulation of FLIP is a mechanism through which Hcy induces EC apoptosis" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "ACL, ACC1, and FAS mRNA levels also were significantly lower in ChREBP-/- mice on the standard diet. Of all lipogenic enzyme mRNA levels examined, the greatest reduction (59%) was measured in the mRNA for malic enzyme." provenance.
- _4 value "These results demonstrate that expression of AM and PAMP is regulated by NGF along with time-dependent differentiation: AM gene transcription is transiently activated by NGF, whereas it was suppressed during neuronal differentiation of the cells." provenance.
- _3 value "Hypoxia increased PN and OPN mRNA expression in rat lung" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Insulin deficiency induced by streptozotocin increased and insulin replenishment reduced the expression of AdipoR1/R2 in vivo. Thus, the expression of AdipoR1/R2 appears to be inversely correlated with plasma insulin levels in vivo" provenance.
- _4 value "fld mice exhibited 2 fold reductions in expression of ... PPARG and CEBPA and in ... aP2. The expression of DGAT was reduced 3 fold in fld tissue" provenance.
- _4 value "fld mice exhibited 2 fold reductions in expression of ... PPARG and CEBPA and in ... aP2. The expression of DGAT was reduced 3 fold in fld tissue" provenance.
- _3 value "inhibitors of deacetylase activity sensitized colon cancer cells to IFNgamma-induced apoptosis through cooperative negative regulation of Bcl-x expression" provenance.
- _5 value "inhibitors of deacetylase activity sensitized colon cancer cells to IFNgamma-induced apoptosis through cooperative negative regulation of Bcl-x expression" provenance.
- _6 value "inhibitors of deacetylase activity sensitized colon cancer cells to IFNgamma-induced apoptosis through cooperative negative regulation of Bcl-x expression" provenance.
- _4 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _4 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _5 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _5 value "silencing of HDAC1, HDAC2, and HDAC3 through RNA interference markedly decreased IFNgamma-driven gene activation and that overexpression of HDAC1, HDAC2, and HDAC3 enhanced STAT1-dependent transcriptional activity." provenance.
- _5 value "silencing of HDAC1, HDAC2, and HDAC3 through RNA interference markedly decreased IFNgamma-driven gene activation and that overexpression of HDAC1, HDAC2, and HDAC3 enhanced STAT1-dependent transcriptional activity." provenance.
- _5 value "silencing of HDAC1, HDAC2, and HDAC3 through RNA interference markedly decreased IFNgamma-driven gene activation and that overexpression of HDAC1, HDAC2, and HDAC3 enhanced STAT1-dependent transcriptional activity." provenance.
- _5 value "In response to genotoxic stresses, E2F1 is stabilized by signals that include ATM-dependent phosphorylation. We recently demonstrated that DNA damage induces also E2F1 acetylation, which is required for its recruitment onto apoptotic gene promoters. We found that acetylation of E2F1 is, instead, required to stabilize the protein in response to doxorubicin. Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not p300 HAT activity, is required for a significant E2F1 stabilization and accumulation." provenance.
- _7 value "Mutant analysis of the GM-CSF promoter shows that the Ets1 binding site of the promoter is essential for the synergy between AML1 and CN in Jurkat T cells." provenance.
- _3 value "Decreased blood-glucose level and improved glucose metabolism in SOCS-6 transgenic mice" provenance.
- _5 value "expression of ATIP1 in eukaryotic cells leads to inhibition of insulin, basic fibroblast growth factor, and epidermal growth factor-induced ERK2 activation and DNA synthesis, and attenuates insulin receptor autophosphorylation" provenance.
- _4 value "In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels." provenance.
- _4 value "PBEF is also upregulated in neutrophils by IL-1beta" provenance.
- _5 value "Prevention of PBEF translation with an antisense oligonucleotide completely abrogates the inhibitory effects of LPS, IL-1, GM-CSF, IL-8, and TNF-alpha on neutrophil apoptosis." provenance.
- _2 value "Prevention of PBEF translation with an antisense oligonucleotide completely abrogates the inhibitory effects of LPS, IL-1, GM-CSF, IL-8, and TNF-alpha on neutrophil apoptosis." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Akt-mediated inhibition of the FoxO family of transcription factors Akt-mediated inhibition of MuRF1 and MAFbx upregulatio" provenance.
- _3 value "A later peak of follistatin expression (2- to 3-fold increase) was noted starting from day 10 and persisted until day 30. To deter- mine whether follistatin activation coincides with the appearance of activated satellite cells, we analyzed the expression of several markers of satellite cells activation. Msx1 is transcribed in quiescent satellite cells and its expression is extinguished upon cell activation (Cor- nelison et al., 2000). On the other hand, only activated satellite cells express MyoD (Cornelison and Wold, 1997), Numb (Conboy and Rando, 2002), and, at later stages, myogenin (Cornelison and Wold, 1997). Twelve hours after muscle injury, we noted that expression of Msx1 was reduced while MyoD and Numb expression increased." provenance.
- _5 value "Gene reporter experiments with proximal promoters revealed that HNF-3 gamma transactivated CYP2C8, CYP2C9, and CYP2C19 (25-, 4-, and 4-fold, respectively)" provenance.
- _6 value "Platelet incubation with a natural PPARgamma agonist, 15d-PGJ(2), or with a potent synthetic PPARgamma ligand, rosiglitazone, prevented thrombin-induced CD40L surface expression and release of CD40L and thromboxane B(2) (TXB(2))." provenance.
- _6 value "Platelet incubation with a natural PPARgamma agonist, 15d-PGJ(2), or with a potent synthetic PPARgamma ligand, rosiglitazone, prevented thrombin-induced CD40L surface expression and release of CD40L and thromboxane B(2) (TXB(2))." provenance.
- _6 value "Moreover, we observed that expression of dominant-interfering mutants of MSK1 blocked the binding of Smad3 to the coactivator p300 in response to TGF-beta signaling." provenance.
- _9 value "Moreover, we observed that expression of dominant-interfering mutants of MSK1 blocked the binding of Smad3 to the coactivator p300 in response to TGF-beta signaling." provenance.
- _7 value "We report here that inhibition of the p38alpha isoform suppressed the ability of Smad3 to mediate TGF-beta-induced transcriptional responses. The inhibition of p38 activity blocked TGF-beta-mediated phosphorylation of the MSK1 kinase, a substrate of p38 that plays an important role in the remodeling of chromatin." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Forced expression of SIK1 inhibited the ACTH-dependent expression of CYP11A- and StAR protein-genes." provenance.