Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAGfuaM1XCcsexf4cGPwAZT9DE8M-7a-6owrvoz8teLe8#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 value "In response to genotoxic stresses, E2F1 is stabilized by signals that include ATM-dependent phosphorylation. We recently demonstrated that DNA damage induces also E2F1 acetylation, which is required for its recruitment onto apoptotic gene promoters. We found that acetylation of E2F1 is, instead, required to stabilize the protein in response to doxorubicin. Finally, we report that the formation of E2F1-p300/CREB-binding protein-associated factor (P/CAF) complexes is preferentially induced in doxorubicin-treated cells, and that P/CAF acetyltransferase (HAT), but not p300 HAT activity, is required for a significant E2F1 stabilization and accumulation." provenance.
- _5 wasQuotedFrom 15123636 provenance.