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- drugbank:DB00066 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00066 label "Follitropin beta [drugbank:DB00066]" assertion.
- drugbank:DB00066 seeAlso DB00066 assertion.
- drugbank:DB00066 seeAlso follitropin-alfa-powder.html assertion.
- drugbank:DB00066 seeAlso follitrop.htm assertion.
- drugbank:DB00066 identifier "drugbank:DB00066" assertion.
- drugbank:DB00066 description "Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH." assertion.
- drugbank:DB00066 title "Follitropin beta" assertion.
- drugbank:DB00066 bio2rdf_vocabulary:identifier "DB00066" assertion.
- drugbank:DB00066 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00066 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00066" assertion.
- drugbank:DB00066 bio2rdf_vocabulary:x-identifiers.org DB00066 assertion.
- drugbank:DB00066 drugbank_vocabulary:drugbank-id "BIOD00064" assertion.
- drugbank:DB00066 drugbank_vocabulary:drugbank-id "BIOD00099" assertion.
- drugbank:DB00066 drugbank_vocabulary:drugbank-id "BTD00064" assertion.
- drugbank:DB00066 drugbank_vocabulary:drugbank-id "BTD00099" assertion.
- drugbank:DB00066 drugbank_vocabulary:drugbank-id "DB00066" assertion.
- drugbank:DB00066 drugbank_vocabulary:x-cas cas:9002-68-0 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-atc atc:G03GA06 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-dpd dpd:2243949 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449693 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-wikipedia wikipedia:Follicle-stimulating_hormone assertion.
- drugbank:DB00066 drugbank_vocabulary:x-ndc ndc:0052-0306-31 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-genbank genbank:M16647 assertion.
- drugbank:DB00066 drugbank_vocabulary:x-uniprot uniprot:P01225 assertion.