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- drugbank:DB00215 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00215 label "Citalopram [drugbank:DB00215]" assertion.
- drugbank:DB00215 seeAlso DB00215 assertion.
- drugbank:DB00215 seeAlso citalopram.html assertion.
- drugbank:DB00215 seeAlso citalo.htm assertion.
- drugbank:DB00215 identifier "drugbank:DB00215" assertion.
- drugbank:DB00215 description "Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Citalopram and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-citalopram and S-demthylcitalopram. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Citalopram is approved for treatment of depression. Unlabeled indications include mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy. Citalopram has the fewest drug-drug interactions of the SSRIs." assertion.
- drugbank:DB00215 title "Citalopram" assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00285 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB06700 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00582 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00976 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00208_DB00215 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00669 assertion.
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- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00656 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01125 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00952 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB00215 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00216 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00315 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB08919 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00752 assertion.
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- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00264 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB06708 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00682 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00998 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00571 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01361 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01136 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01105 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00199_DB00215 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01009 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB08920 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00780 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01323 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01624 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00953 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00500 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01367 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00601 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB06414 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01247 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00427 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01037 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00918 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01100 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00363 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01381 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB06697 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00246 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01321 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01211 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00726 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB00266 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01418 assertion.
- drugbank:DB00215 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00215_DB01600 assertion.
- drugbank:DB00215 drugbank_vocabulary:food-interaction drugbank_resource:4f8e7d7b7a03f80525934a074d9e985b assertion.
- drugbank:DB00215 bio2rdf_vocabulary:identifier "DB00215" assertion.
- drugbank:DB00215 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00215 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00215" assertion.
- drugbank:DB00215 bio2rdf_vocabulary:x-identifiers.org DB00215 assertion.
- drugbank:DB00215 drugbank_vocabulary:drugbank-id "APRD00147" assertion.
- drugbank:DB00215 drugbank_vocabulary:drugbank-id "DB00215" assertion.
- drugbank:DB00215 drugbank_vocabulary:x-cas cas:59729-33-8 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-chemspider chemspider:2669 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2771 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508746 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-ahfs ahfs:28:16.04.20 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-atc atc:N06AB04 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-chebi chebi:3723 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-dpd dpd:2248051 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-kegg kegg:C07572 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-kegg kegg:D07704 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449015 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-wikipedia wikipedia:Citalopram assertion.
- drugbank:DB00215 drugbank_vocabulary:x-bindingdb bindingdb:25870 assertion.
- drugbank:DB00215 drugbank_vocabulary:x-ndc ndc:0378-6231-01 assertion.