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Matches in Nanopublications for { <http://bio2rdf.org/drugbank:DB00227> ?p ?o ?g. }

• drugbank:DB00227 type drugbank_vocabulary:Drug assertion.
• drugbank:DB00227 label "Lovastatin [drugbank:DB00227]" assertion.
• drugbank:DB00227 seeAlso DB00227 assertion.
• drugbank:DB00227 seeAlso lovastatin.html assertion.
• drugbank:DB00227 seeAlso altocor.htm assertion.
• drugbank:DB00227 identifier "drugbank:DB00227" assertion.
• drugbank:DB00227 description "Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi <i>Aspergillus terreus</i>. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from <i>Monascus ruber</i> four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by <i>in vivo</i> hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today." assertion.
• drugbank:DB00227 title "Lovastatin" assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00220_DB00227 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00207_DB00227 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB00615 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB00682 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB08827 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01045 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB00266 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB00661 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB00582 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01167 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01039 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01418 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01319 assertion.
• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01264 assertion.
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• drugbank:DB00227 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00227_DB01026 assertion.
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• drugbank:DB00227 bio2rdf_vocabulary:identifier "DB00227" assertion.
• drugbank:DB00227 bio2rdf_vocabulary:namespace "drugbank" assertion.
• drugbank:DB00227 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00227" assertion.
• drugbank:DB00227 bio2rdf_vocabulary:x-identifiers.org DB00227 assertion.
• drugbank:DB00227 drugbank_vocabulary:drugbank-id "APRD00370" assertion.
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• drugbank:DB00227 drugbank_vocabulary:x-cas cas:75330-75-5 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-chemspider chemspider:48085 assertion.
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• drugbank:DB00227 drugbank_vocabulary:x-atc atc:C10AA02 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-chebi chebi:40303 assertion.
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• drugbank:DB00227 drugbank_vocabulary:x-kegg kegg:C07074 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-kegg kegg:D00359 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-pharmgkb pharmgkb:PA450272 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-wikipedia wikipedia:Lovastatin assertion.
• drugbank:DB00227 drugbank_vocabulary:x-ndc ndc:0378-6510-91 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-gtp gtp:2739 assertion.
• drugbank:DB00227 drugbank_vocabulary:x-iuphar iuphar:2739 assertion.