Matches in Nanopublications for { <http://bio2rdf.org/drugbank:DB00321> ?p ?o ?g. }
- drugbank:DB00321 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00321 label "Amitriptyline [drugbank:DB00321]" assertion.
- drugbank:DB00321 seeAlso DB00321 assertion.
- drugbank:DB00321 seeAlso amitriptyline.html assertion.
- drugbank:DB00321 seeAlso amitrip.htm assertion.
- drugbank:DB00321 identifier "drugbank:DB00321" assertion.
- drugbank:DB00321 description "Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use)." assertion.
- drugbank:DB00321 title "Amitriptyline" assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00476 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00388 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01366 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01624 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00852 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00752 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01363 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00908 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00472 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00674 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00397 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01623 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB02546 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB06708 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01365 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01105 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01001 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00382 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB06700 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00209_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB08919 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00575 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01208 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB06697 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00656 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB08920 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00615 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00988 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00679 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00871 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB06684 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01064 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00237_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00723 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00246_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB06704 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00816 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00564 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01045 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00176_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01364 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00342 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00662 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00501 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00610 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00241_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00726 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01247 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00285_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01026 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00857 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01072 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00368 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00864 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01341 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01291 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00843 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01346 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00989 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00365 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00315_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00539 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00427 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00780 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00668 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00604 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00841 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB05039 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00582 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01367 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01170 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00196_DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00503 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00933 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01288 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB00488 assertion.
- drugbank:DB00321 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00321_DB01171 assertion.
- drugbank:DB00321 drugbank_vocabulary:food-interaction drugbank_resource:4f8e7d7b7a03f80525934a074d9e985b assertion.
- drugbank:DB00321 bio2rdf_vocabulary:identifier "DB00321" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00321" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:x-identifiers.org DB00321 assertion.
- drugbank:DB00321 drugbank_vocabulary:drugbank-id "APRD00227" assertion.
- drugbank:DB00321 drugbank_vocabulary:drugbank-id "DB00321" assertion.
- drugbank:DB00321 drugbank_vocabulary:x-cas cas:50-48-6 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-chemspider chemspider:2075 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2160 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508798 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-ahfs ahfs:28:16.04.28 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-atc atc:N06AA09 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-chebi chebi:2666 assertion.