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- drugbank:DB00344 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00344 label "Protriptyline [drugbank:DB00344]" assertion.
- drugbank:DB00344 seeAlso DB00344 assertion.
- drugbank:DB00344 seeAlso protriptyline.html assertion.
- drugbank:DB00344 seeAlso viv1617.shtml assertion.
- drugbank:DB00344 identifier "drugbank:DB00344" assertion.
- drugbank:DB00344 description "Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression." assertion.
- drugbank:DB00344 title "Protriptyline" assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00575 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00176_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01624 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01367 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00908 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00241_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00388 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00382 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00342_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00472 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01170 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00365 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00604 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00852 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00209_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01171 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00285_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB08919 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00615 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB06697 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00674 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00656 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00662 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00501 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00539 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01623 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00780 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB08920 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00752 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01045 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB02546 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00397 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01288 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00315_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00246_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01247 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00857 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB06700 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00864 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB06708 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00871 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00816 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00427 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00726 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00237_DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB01072 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00582 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00668 assertion.
- drugbank:DB00344 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00344_DB00843 assertion.
- drugbank:DB00344 bio2rdf_vocabulary:identifier "DB00344" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00344" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:x-identifiers.org DB00344 assertion.
- drugbank:DB00344 drugbank_vocabulary:drugbank-id "APRD00441" assertion.
- drugbank:DB00344 drugbank_vocabulary:drugbank-id "DB00344" assertion.
- drugbank:DB00344 drugbank_vocabulary:x-cas cas:438-60-8 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-chemspider chemspider:4805 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pubchemcompound pubchem.compound:4976 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46505128 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-atc atc:N06AA11 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-chebi chebi:8597 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-dpd dpd:322741 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-kegg kegg:C07408 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451168 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-wikipedia wikipedia:Protriptyline assertion.
- drugbank:DB00344 drugbank_vocabulary:x-ndc ndc:0555-0595-02 assertion.