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• drugbank:DB00540 type drugbank_vocabulary:Drug assertion.
• drugbank:DB00540 label "Nortriptyline [drugbank:DB00540]" assertion.
• drugbank:DB00540 seeAlso DB00540 assertion.
• drugbank:DB00540 seeAlso nortriptyline.html assertion.
• drugbank:DB00540 seeAlso nortrip.htm assertion.
• drugbank:DB00540 identifier "drugbank:DB00540" assertion.
• drugbank:DB00540 description "Nortriptyline hydrochloride, the <i>N</i>-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use)." assertion.
• drugbank:DB00540 title "Nortriptyline" assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01247 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01072 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00857 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00668 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00539_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00196_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00488_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00501_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01624 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB06700 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00397_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB02546 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01171 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00472_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01064 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB06697 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00723 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00816 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01026 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00780 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB08919 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01208 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01363 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00610 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00852 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01170 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00209_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00388_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB08920 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00564 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01045 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01346 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01366 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00582 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00237_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00427_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01291 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00285_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00662 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01623 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01341 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00752 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00604 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00365_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00843 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00989 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00841 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01105 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01367 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00246_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB06708 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00871 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01288 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00864 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00176_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00368_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01365 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00726 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01364 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00476_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00674 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00988 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00315_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB01001 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00241_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00575 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00908 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00503_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB06684 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00656 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00342_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00540_DB00615 assertion.
• drugbank:DB00540 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00382_DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:food-interaction drugbank_resource:4f8e7d7b7a03f80525934a074d9e985b assertion.
• drugbank:DB00540 bio2rdf_vocabulary:identifier "DB00540" assertion.
• drugbank:DB00540 bio2rdf_vocabulary:namespace "drugbank" assertion.
• drugbank:DB00540 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00540" assertion.
• drugbank:DB00540 bio2rdf_vocabulary:x-identifiers.org DB00540 assertion.
• drugbank:DB00540 drugbank_vocabulary:drugbank-id "APRD00602" assertion.
• drugbank:DB00540 drugbank_vocabulary:drugbank-id "DB00540" assertion.
• drugbank:DB00540 drugbank_vocabulary:x-cas cas:72-69-5 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-chemspider chemspider:4384 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-pubchemcompound pubchem.compound:4543 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46507783 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-ahfs ahfs:28:16.04.28 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-atc atc:N06AA10 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-chebi chebi:7640 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-dpd dpd:2240789 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-kegg kegg:C07274 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-pharmgkb pharmgkb:PA450657 assertion.
• drugbank:DB00540 drugbank_vocabulary:x-wikipedia wikipedia:Nortriptyline assertion.

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