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• drugbank:DB00543 type drugbank_vocabulary:Drug assertion.
• drugbank:DB00543 label "Amoxapine [drugbank:DB00543]" assertion.
• drugbank:DB00543 seeAlso DB00543 assertion.
• drugbank:DB00543 seeAlso amoxapine.html assertion.
• drugbank:DB00543 seeAlso amoxapine.htm assertion.
• drugbank:DB00543 identifier "drugbank:DB00543" assertion.
• drugbank:DB00543 description "Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amoxapine may be used to treat neurotic and reactive depressive disorders, endogenous and psychotic depression, and mixed symptoms of depression and anxiety or agitation." assertion.
• drugbank:DB00543 title "Amoxapine" assertion.
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• drugbank:DB00543 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00543_DB01367 assertion.
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• drugbank:DB00543 bio2rdf_vocabulary:identifier "DB00543" assertion.
• drugbank:DB00543 bio2rdf_vocabulary:namespace "drugbank" assertion.
• drugbank:DB00543 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00543" assertion.
• drugbank:DB00543 bio2rdf_vocabulary:x-identifiers.org DB00543 assertion.
• drugbank:DB00543 drugbank_vocabulary:drugbank-id "APRD00142" assertion.
• drugbank:DB00543 drugbank_vocabulary:drugbank-id "DB00543" assertion.
• drugbank:DB00543 drugbank_vocabulary:x-cas cas:14028-44-5 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-chemspider chemspider:2085 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2170 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46509117 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-atc atc:N06AA17 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-chebi chebi:2675 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-dpd dpd:527106 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-kegg kegg:D00228 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-pharmgkb pharmgkb:PA448405 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-wikipedia wikipedia:Amoxapine assertion.
• drugbank:DB00543 drugbank_vocabulary:x-bindingdb bindingdb:22870 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-ndc ndc:0591-5713-01 assertion.
• drugbank:DB00543 drugbank_vocabulary:x-gtp gtp:201 assertion.
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