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- drugbank:DB01124 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01124 label "Tolbutamide [drugbank:DB01124]" assertion.
- drugbank:DB01124 seeAlso DB01124 assertion.
- drugbank:DB01124 seeAlso tolbutamide.html assertion.
- drugbank:DB01124 identifier "drugbank:DB01124" assertion.
- drugbank:DB01124 description "Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Tolbutamide appears to be metabolized in the liver. Tolbutamide and its metabolites are excreted in urine (75-85%) and feces." assertion.
- drugbank:DB01124 title "Tolbutamide" assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00636_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01050_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00678_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01198 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00582_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00446_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00559_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01067_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01241 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00682_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01418 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01026_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00471_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00712_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00571_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00250_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00187_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00322_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00945_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00675_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00252_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00263_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00960_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00544_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01193 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01580 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00214_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00052_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00472_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00622_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00784_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00335_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01101_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01357 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00390_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00598_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01221 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00731_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01045_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01110_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01229 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00373_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01015_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00222_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00812_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00196_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00359_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01320 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00554_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00440_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00705_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00612_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00328_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01283 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00264_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00482_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01136 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00549_DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01203 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB06268 assertion.
- drugbank:DB01124 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01124_DB01138 assertion.
- drugbank:DB01124 bio2rdf_vocabulary:identifier "DB01124" assertion.
- drugbank:DB01124 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01124 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01124" assertion.
- drugbank:DB01124 bio2rdf_vocabulary:x-identifiers.org DB01124 assertion.
- drugbank:DB01124 drugbank_vocabulary:drugbank-id "APRD00267" assertion.
- drugbank:DB01124 drugbank_vocabulary:drugbank-id "DB01124" assertion.
- drugbank:DB01124 drugbank_vocabulary:x-cas cas:64-77-7 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-chemspider chemspider:5304 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-pubchemcompound pubchem.compound:5505 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508421 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-ahfs ahfs:68:20.20 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-atc atc:A10BB03 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-chebi chebi:27999 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-dpd dpd:156663 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-kegg kegg:C07148 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-kegg kegg:D00380 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451718 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-wikipedia wikipedia:Tolbutamide assertion.
- drugbank:DB01124 drugbank_vocabulary:x-ndc ndc:0378-0215-01 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-gtp gtp:2415 assertion.
- drugbank:DB01124 drugbank_vocabulary:x-iuphar iuphar:2415 assertion.