Matches in Nanopublications for { <http://bio2rdf.org/drugbank:DB05143> ?p ?o ?g. }
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- drugbank:DB05143 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05143 label "OXI4503 [drugbank:DB05143]" assertion.
- drugbank:DB05143 seeAlso DB05143 assertion.
- drugbank:DB05143 identifier "drugbank:DB05143" assertion.
- drugbank:DB05143 description "OXi4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular disrupting agent (VDA). Like its structural analog, ZYBRESTAT, OXi4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. In addition, however, preclinical data demonstrates that OXi4503 is metabolized by oxidative enzymes (e.g., tyrosinase and peroxidases), which are elevated in many solid tumors and tumor infiltrates, to an orthoquinone chemical species that has direct cytotoxic effects on tumor cells. Preclinical studies have demonstrated that OXi4503 has (i) single-agent activity against a range of xenograft tumor models; and (ii) synergistic or additive effects when incorporated in various combination regimens with chemotherapy, molecularly-targeted therapies (including tumor-angiogenesis inhibitors), and radiation therapy." assertion.
- drugbank:DB05143 title "OXI4503" assertion.
- drugbank:DB05143 bio2rdf_vocabulary:identifier "DB05143" assertion.
- drugbank:DB05143 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05143 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05143" assertion.
- drugbank:DB05143 bio2rdf_vocabulary:x-identifiers.org DB05143 assertion.
- drugbank:DB05143 drugbank_vocabulary:drugbank-id "DB05143" assertion.
- drugbank:DB05143 drugbank_vocabulary:x-cas cas: assertion.
- drugbank:DB05143 drugbank_vocabulary:x-chemspider chemspider:5293742 assertion.
- drugbank:DB05143 drugbank_vocabulary:x-pubchemcompound pubchem.compound:6918545 assertion.
- drugbank:DB05143 drugbank_vocabulary:x-bindingdb bindingdb:50236033 assertion.