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- drugbank:DB05528 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05528 label "Mipomersen [drugbank:DB05528]" assertion.
- drugbank:DB05528 seeAlso DB05528 assertion.
- drugbank:DB05528 seeAlso mipomersen.html assertion.
- drugbank:DB05528 seeAlso kynamro-drug.htm assertion.
- drugbank:DB05528 identifier "drugbank:DB05528" assertion.
- drugbank:DB05528 description "Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications. It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity. Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported. Due to this serious risk of liver toxicity, mipomersen sodium is only available to patients under the restricted program called Kynamro™ Risk Evaluation and Mitigation Strategy program." assertion.
- drugbank:DB05528 title "Mipomersen" assertion.
- drugbank:DB05528 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00898_DB05528 assertion.
- drugbank:DB05528 drugbank_vocabulary:food-interaction drugbank_resource:0550858c70419aa8c700e23650b5504b assertion.
- drugbank:DB05528 bio2rdf_vocabulary:identifier "DB05528" assertion.
- drugbank:DB05528 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05528 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05528" assertion.
- drugbank:DB05528 bio2rdf_vocabulary:x-identifiers.org DB05528 assertion.
- drugbank:DB05528 drugbank_vocabulary:drugbank-id "DB05528" assertion.
- drugbank:DB05528 drugbank_vocabulary:x-cas cas:629167-92-6 assertion.
- drugbank:DB05528 drugbank_vocabulary:x-atc atc:C10AX11 assertion.
- drugbank:DB05528 drugbank_vocabulary:x-kegg kegg:D08946 assertion.
- drugbank:DB05528 drugbank_vocabulary:x-wikipedia wikipedia:Mipomersen assertion.
- drugbank:DB05528 drugbank_vocabulary:x-ndc ndc:58468-0191-1 assertion.